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Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 07/2017, Volume 114, Issue 27, pp. 7160 - 7165
The σ2 receptor is an enigmatic protein that has attracted significant attention because of its involvement in diseases as diverse as cancer and neurological... 
Sigma receptors | TMEM97 | NPC1 | Sigma-2 receptor | Cholesterol regulation | Index Medicus | sigma receptors | Biological Sciences | sigma-2 receptor | cholesterol regulation
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2018, Volume 144, pp. 359 - 371
The aggressiveness of pancreatic cancer urgently requires more efficient treatment options. Because the sigma-2 (σ ) receptor was recently proposed as a... 
Sigma-2 receptors | Mithocondrial superoxide | Pancreatic cancer | Thiosemicarbazones | Multifunctional compounds | COLLATERAL SENSITIVITY | CHEMISTRY, MEDICINAL | CELL-LINES | IDENTIFICATION | PGRMC1 PROTEIN | CANCER | STRUCTURE-AFFINITY | LIGANDS | MEMBRANE COMPONENT 1 | BINDING | DERIVATIVES | Pancreatic Neoplasms - metabolism | Antineoplastic Agents - chemical synthesis | Humans | Receptors, sigma - antagonists & inhibitors | Structure-Activity Relationship | Dose-Response Relationship, Drug | Neoplasms, Experimental - pathology | Pancreatic Neoplasms - drug therapy | Thiosemicarbazones - chemistry | Female | Antineoplastic Agents - pharmacology | Molecular Structure | Thiosemicarbazones - pharmacology | Cell Death - drug effects | Receptors, sigma - metabolism | Disease Models, Animal | Cell Survival - drug effects | Mice, Inbred C57BL | Pancreatic Neoplasms - pathology | Chelating Agents - chemistry | Thiosemicarbazones - chemical synthesis | Chelating Agents - pharmacology | Antineoplastic Agents - chemistry | ATP Binding Cassette Transporter, Subfamily B, Member 1 - antagonists & inhibitors | ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism | Animals | Cell Proliferation - drug effects | Mice | Neoplasms, Experimental - metabolism | Chelating Agents - chemical synthesis | Neoplasms, Experimental - drug therapy | Drug Screening Assays, Antitumor | Index Medicus
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 07/2017, Volume 114, Issue 27, pp. 7160 - 7165
The sigma(2) receptor is an enigmatic protein that has attracted significant attention because of its involvement in diseases as diverse as cancer and... 
TUMOR-CELL LINES | PROGESTERONE | MULTIDISCIPLINARY SCIENCES | TMEM97 | PGRMC1 PROTEIN | CANCER | sigma receptors | sigma-2 receptor | NPC1 | LIGANDS | cholesterol regulation | MAC30 | DISEASE | BINDING-SITE | MEMBRANE COMPONENT 1 | EXPRESSION
Journal Article
Neuroscience Letters, ISSN 0304-3940, 01/2019, Volume 691, pp. 3 - 10
The sigma-1 (σ ) receptor is a chaperone protein located on the mitochondria-associated membrane of the endoplasmic reticulum, while the sigma-2 receptor (σ )... 
Sigma-2 receptors | Brain | Sigma-1 receptors | Alzheimer’s disease | PET imaging
Journal Article
Neuropharmacology, ISSN 0028-3908, 07/2019, Volume 152, pp. 102 - 111
Stress is one of the factors underlying drug seeking behavior that often goes in parallel with loss of appetite. We here demonstrate that orexin 1 receptors... 
Sigma receptors | Addiction | G-protein-coupled receptor | Heteromers | GPCR | GPCR heteromer | Stress | Orexin | SIGMA-2 RECEPTOR | DOPAMINE RELEASE | COCAINE | NEUROSCIENCES | VENTRAL TEGMENTAL AREA | NUCLEUS-ACCUMBENS | GLUTAMATERGIC TRANSMISSION | NEURONS | PHARMACOLOGY & PHARMACY | RAT-BRAIN | BINDING | MODULATION
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 03/2019, Volume 165, pp. 250 - 257
Sigma receptors (σRs) are considered to be a significant and valid target for developing new medications to address several diseases. Their potential... 
Sigma-2 ligands | Sigma receptors | Cocaine-induced convulsions | Cocaine's toxicity | Structure-affinity relationships | Sigma-2 receptors | Benzimidazolone | Index Medicus
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2017, Volume 25, Issue 14, pp. 3792 - 3802
We have designed and synthesized a series of indole-based σ receptor ligands containing 5,6-dimethoxyisoindoline or... 
Sigma-2 receptors | Brain | Indole-based analogs | 18F | Index Medicus
Journal Article
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY, ISSN 0968-0896, 07/2017, Volume 25, Issue 14, pp. 3792 - 3802
We have designed and synthesized a series of indole-based sigma(2) receptor ligands containing 5,6-dimethoxyisoindoline or... 
Brain | CELLS | CHEMISTRY, MEDICINAL | PROTEIN | SOLID TUMORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | Sigma-2 receptors | CHEMISTRY, ORGANIC | PROLIFERATION | CANCER | F-18 | AGENT | Indole-based analogs | LIGANDS | CALCIUM | BINDING
Journal Article
European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 08/2017, Volume 106, pp. 94 - 101
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 07/2019, Volume 174, pp. 226 - 235
A new set of 5-chlorobenzoxazole- and 5-chlorobenzothiazole-based derivatives containing the azepane ring as a basic moiety was designed, synthesized and... 
Pain | Sigma-1 receptors | Benzothiazole | Benzoxazole | Sigma-2 receptors | Cancer | Apoptosis | CHEMISTRY, MEDICINAL | ANTAGONIST | HIGH-AFFINITY | MODEL | IDENTIFICATION | SELECTIVE LIGANDS | POTENT | 5-HT1A | DERIVATIVES | BINDING | SCAFFOLD | Index Medicus
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 05/2010, Volume 20, Issue 9, pp. 2954 - 2957
In this work we developed a 3D-pharmacophore model for σ receptor based on 19 benzooxazolone derivatives. The best 3D-pharmacophore hypothesis, consisting of... 
Sigma-2 receptor ligands | 3D-Pharmacophore modeling | Catalyst
Journal Article