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Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2013, Volume 133, Issue 4, pp. 1149 - 1161
Background Signaling lymphocytic activation molecule (SLAM)–associated protein (SAP) can mediate the function of SLAM molecules, which have been proposed to be... 
Allergy and Immunology | regulatory T cells | B-cell tolerance | SLAM-associated protein | signaling lymphocytic activation molecule | SAP | SLAM | ENCODING GENE | IMMUNOLOGY | LINKED LYMPHOPROLIFERATIVE-DISEASE | DEFICIENCY | ALLERGY | INVARIANT NKT CELLS | HUMORAL IMMUNITY | MICE | ASSOCIATION | T-CELLS | T-Lymphocytes, Regulatory - metabolism | Humans | Autoimmunity - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Lymphoproliferative Disorders - immunology | Receptors, Antigen, B-Cell - metabolism | Antigens, CD - metabolism | Lymphoproliferative Disorders - metabolism | T-Lymphocytes, Regulatory - immunology | Intracellular Signaling Peptides and Proteins - deficiency | Lymphocyte Activation - immunology | Signaling Lymphocytic Activation Molecule Family Member 1 | Autoimmunity - immunology | Intracellular Signaling Peptides and Proteins - genetics | B-Lymphocytes - metabolism | Gene Expression | Signal Transduction | Immune Tolerance | Receptors, Cell Surface - metabolism | Lymphoproliferative Disorders - genetics | Signaling Lymphocytic Activation Molecule Family | Protein Transport | B-Lymphocytes - immunology | Signaling Lymphocytic Activation Molecule Associated Protein | Protein Binding | B-Cell Activating Factor - blood | Autoimmunity | Medical colleges | Parasitic diseases | Antigens | T cell receptors | Mutation | Kinases | Immune system
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2013, Volume 288, Issue 44, pp. 31423 - 31436
Journal Article
Journal of Immunology, ISSN 0022-1767, 07/2010, Volume 185, Issue 1, pp. 190 - 202
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 02/2009, Volume 182, Issue 3, pp. 1370 - 1378
Journal Article
The Journal of Immunology, ISSN 0022-1767, 09/2004, Volume 173, Issue 6, pp. 3953 - 3961
2B4 (CD244) is a receptor belonging to the CD2-signaling lymphocytic activation molecule family and is found on all murine NK cells and a subset of NKT and... 
2B4-MEDIATED ACTIVATION | IMMUNOGLOBULIN SUPERFAMILY | IMMUNE-RESPONSE | NATURAL-KILLER-CELLS | SAP | CLONING | LINKED LYMPHOPROLIFERATIVE DISEASE | IMMUNOLOGY | T-CELLS | CUTTING EDGE | MEMBER | Antigens, CD - immunology | Cytotoxicity Tests, Immunologic | Receptors, Immunologic - physiology | Membrane Glycoproteins - metabolism | Antibodies, Blocking - pharmacology | Antigens, CD - metabolism | RNA, Messenger - biosynthesis | Signal Transduction - immunology | Lymphocyte Activation - genetics | Membrane Glycoproteins - physiology | CD48 Antigen | Killer Cells, Natural - immunology | Membrane Glycoproteins - immunology | Receptors, Immunologic - immunology | Carrier Proteins - physiology | Carrier Proteins - biosynthesis | Mice, Inbred C57BL | Cells, Cultured | Receptors, Immunologic - deficiency | Intracellular Signaling Peptides and Proteins | Up-Regulation - genetics | Signal Transduction - genetics | Signaling Lymphocytic Activation Molecule Family | Down-Regulation - genetics | Protein Isoforms - physiology | Mice, Knockout | Carrier Proteins - genetics | Animals | Protein Isoforms - biosynthesis | Up-Regulation - immunology | Down-Regulation - immunology | Signaling Lymphocytic Activation Molecule Associated Protein | Cell Line, Tumor | Antigens, CD - physiology | Mice | Killer Cells, Natural - metabolism | Membrane Glycoproteins - deficiency | Receptors, Immunologic - metabolism | Protein Isoforms - genetics
Journal Article
Journal Article
The Journal of Immunology, ISSN 0022-1767, 05/2005, Volume 174, Issue 10, pp. 5977 - 5986
Ag recognition by the TCR determines the subsequent fate of the T cell and is regulated by the involvement of other cell surface molecules, termed coreceptors.... 
GENE-PRODUCT SAP | NATURAL-KILLER-CELLS | EGF-RECEPTOR | CELL-SURFACE RECEPTORS | MOUSE LY-9 | IMMUNOLOGY | LINKED LYMPHOPROLIFERATIVE-DISEASE | EPSTEIN-BARR-VIRUS | T-CELLS | CUTTING EDGE | SH3 DOMAIN | Phosphorylation | Humans | Amino Acid Substitution - immunology | Glycoproteins - metabolism | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Cytoplasm - metabolism | Receptors, Cell Surface | Extracellular Signal-Regulated MAP Kinases - metabolism | Receptors, Antigen, T-Cell - antagonists & inhibitors | Antigens, CD - genetics | Antigens, CD - metabolism | Immunoglobulins - metabolism | Peptide Fragments - physiology | Protein Transport - immunology | Signal Transduction - immunology | Lymphocyte Activation - immunology | Adaptor Protein Complex 2 - metabolism | Signaling Lymphocytic Activation Molecule Family Member 1 | Binding Sites - immunology | Receptors, Antigen, T-Cell - immunology | Endocytosis - immunology | Peptide Fragments - metabolism | Cytokines - metabolism | Receptors, Antigen, T-Cell - metabolism | Jurkat Cells | Signaling Lymphocytic Activation Molecule Family | Protein Binding - immunology | src Homology Domains - physiology | Two-Hybrid System Techniques | Adaptor Proteins, Signal Transducing - physiology | GRB2 Adaptor Protein | Amino Acid Substitution - genetics | Antigens, CD - physiology | Ligands | Cytokines - antagonists & inhibitors | Adaptor Proteins, Signal Transducing - metabolism | Tyrosine - genetics
Journal Article
Immunity, ISSN 1074-7613, 2010, Volume 32, Issue 2, pp. 253 - 265
CD4 T cells deficient in signaling lymphocyte activation molecule (SLAM)-associated protein (SAP) exhibit a selective impairment in adhesion to... 
MOLIMMUNO | RESTING NK CELLS | B-CELLS | SAP | FOLLICULAR-HELPER-CELLS | AUTOIMMUNITY | HUMORAL IMMUNITY | MOLECULAR DISSECTION | IMMUNOLOGY | RECEPTORS | CUTTING EDGE | FAMILY | Antigens, CD - immunology | Cell Proliferation | Intracellular Signaling Peptides and Proteins - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Antigens, CD - genetics | Antigens, CD - metabolism | Cell Differentiation - genetics | Lymphocyte Activation - genetics | Signaling Lymphocytic Activation Molecule Family Member 1 | T-Lymphocytes - metabolism | Antigens, Ly - metabolism | B-Lymphocytes - pathology | T-Lymphocytes - pathology | Intracellular Signaling Peptides and Proteins - genetics | B-Lymphocytes - metabolism | Cell Adhesion - genetics | Interferon-gamma - secretion | Mice, Inbred C57BL | Cells, Cultured | Receptors, Cell Surface - metabolism | Germinal Center - pathology | Signaling Lymphocytic Activation Molecule Family | Receptors, Cell Surface - immunology | Mice, Knockout | Cell Adhesion - immunology | Cell Differentiation - immunology | Animals | B-Lymphocytes - immunology | Germinal Center - metabolism | Antigens, Ly - immunology | Signaling Lymphocytic Activation Molecule Associated Protein | T-Lymphocytes - immunology | Mice | Interleukins - secretion | Receptors, Cell Surface - genetics | Dendritic cells | T cells | Integrins | Proteins | Antigens | Flow cytometry | Rodents | Ligands | Software | Immune system
Journal Article
Journal of Immunology, ISSN 0022-1767, 01/2004, Volume 172, Issue 2, pp. 1177 - 1185
Production of the Th1 cytokine IFN-gamma by T cells is considered crucial for immunity against Mycobacterium tuberculosis infection. We evaluated IFN-gamma... 
MYCOBACTERIUM-TUBERCULOSIS | RESPONSES | SAP | SLAM | DENDRITIC CELLS | T-CELL-ACTIVATION | INFECTION | IMMUNOLOGY | TH1 | LINKED LYMPHOPROLIFERATIVE-DISEASE | GENE-PRODUCT | Immunoglobulins - physiology | Humans | Glycoproteins - metabolism | Mycobacterium tuberculosis - immunology | Receptors, Cell Surface | Tuberculosis - microbiology | Lymphoproliferative Disorders - immunology | Immunoglobulins - metabolism | Signal Transduction - immunology | Signaling Lymphocytic Activation Molecule Family Member 1 | Adjuvants, Immunologic - metabolism | Interferon-gamma - antagonists & inhibitors | Chromosomes, Human, X - immunology | Interleukin-12 - pharmacology | Carrier Proteins - physiology | Severity of Illness Index | Adjuvants, Immunologic - physiology | Immunity, Cellular - genetics | Carrier Proteins - biosynthesis | Cells, Cultured | Intracellular Signaling Peptides and Proteins | Lymphoproliferative Disorders - genetics | Signal Transduction - genetics | Glycoproteins - physiology | Tuberculosis - immunology | Carrier Proteins - genetics | Carrier Proteins - metabolism | Tuberculosis - genetics | Up-Regulation - immunology | Down-Regulation - immunology | Signaling Lymphocytic Activation Molecule Associated Protein | Ligands | Antibodies, Monoclonal - metabolism | Interferon-gamma - biosynthesis | Interferon-gamma - pharmacology | Antigens, CD
Journal Article
Nature Reviews Immunology, ISSN 1474-1733, 01/2009, Volume 9, Issue 1, pp. 39 - 46
Journal Article
Nature Immunology, ISSN 1529-2908, 04/2019, Volume 20, Issue 4, pp. 447 - 457
Invariant natural killer T cells (iNKT cells) develop through an incompletely understood process that requires positive selection by CD4(+) CD8(+)... 
IMMUNITY | ACTIVATION | LY108 | KILLER T-CELLS | FAMILY RECEPTORS | SAP ADAPTERS | MICE | INDUCTION | IMMUNOLOGY | EXPRESSION | DELETION | Cell Proliferation | Receptors, Antigen, T-Cell - metabolism | Signal Transduction | Cell Survival | Humans | Signaling Lymphocytic Activation Molecule Family - physiology | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Natural Killer T-Cells - enzymology | Signaling Lymphocytic Activation Molecule Associated Protein - genetics | Mice, Knockout | Proto-Oncogene Proteins c-bcl-2 - metabolism | Animals | Proto-Oncogene Proteins c-fyn - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Costimulatory and Inhibitory T-Cell Receptors - metabolism | Receptors, Antigen, T-Cell - immunology | Mice | Signaling Lymphocytic Activation Molecule Family - genetics | Natural Killer T-Cells - immunology | Signaling Lymphocytic Activation Molecule Family - metabolism | Antigens | Phosphatases | T cells | Natural selection | Killer cells | Antigen receptors, T cell | Receptors | Immune response | Cellular signal transduction | Research | Gene expression | Cell survival | SHP-1 protein | PD-1 protein | CD8 antigen | Positive selection | Signal strength | Lymphocytes T | CD150 antigen | CD4 antigen | T-cell receptor | Thymocytes | Lymphocytes | Clonal selection | Natural killer cells | Fyn protein
Journal Article