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Cell Metabolism, ISSN 1550-4131, 2006, Volume 3, Issue 5, pp. 343 - 353
Although the class I phosphoinositide 3-kinase (PI3K) pathway is central to the metabolic actions of insulin, its mechanism of action is not well understood.... 
SIGNALING
Journal Article
Science Signaling, ISSN 1945-0877, 01/2018, Volume 11, Issue 513, p. eaas9779
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, pp. e47936 - e47936
Glucagon-like peptide-1 (GLP-1) released from intestinal L cells in response to nutrients has many physiological effects but particularly enhances... 
PATHWAYS | CELLS | ACTIVATION | HEALTHY-SUBJECTS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | DEGRADATION | SMALL-MOLECULE AGONISTS | SECRETION | GASTRIC-INHIBITORY POLYPEPTIDE | TYPE-2 DIABETES-MELLITUS | Receptors, Glucagon - antagonists & inhibitors | Calcium - metabolism | Allosteric Regulation | Humans | Peptide Fragments - pharmacology | Extracellular Signal-Regulated MAP Kinases - metabolism | Sulfones - pharmacology | Extracellular Signal-Regulated MAP Kinases - genetics | Quinoxalines - pharmacology | Peptides - metabolism | Transfection | Biotransformation | Adenosine Monophosphate - biosynthesis | Receptors, Glucagon - agonists | Cell Line | Gene Expression | Peptide Fragments - metabolism | Glucagon-Like Peptide 1 - metabolism | Glucagon-Like Peptide 1 - analogs & derivatives | Glucagon-Like Peptide 1 - pharmacology | Rats | Receptors, Glucagon - metabolism | Peptides - pharmacology | Insulin - metabolism | Animals | Glucagon-Like Peptide-1 Receptor | Calcium Signaling - drug effects | Type 2 diabetes | Care and treatment | Glucagon | Metabolites | Physiological aspects | Research | Risk factors | Physiological effects | Peptides | Insulinoma | Systematic review | Hormones | Glucose | Peptide hormones | Calcium signalling | Proteins | Allosteric properties | Intestine | Penicillin | Nutrients | Physiology | Glucagon-like peptide 1 | Recombinant | Peptidase | AMP | Diabetes mellitus | Extracellular signal-regulated kinase | Pharmacology | L cells | Insulin | Affinity | Ligands | Diabetes | Calcium (extracellular) | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2012, Volume 7, Issue 5, pp. e36800 - e36800
The dysregulation of receptor protein tyrosine kinase (RPTK) function can result in changes in cell proliferation, cell growth and metastasis leading to... 
TYROSINE KINASE TYRO3 | APOPTOTIC CELLS | PI3 KINASE | BIOLOGY | SURVIVAL ACTIVITIES | FAMILY RECEPTORS | SMOOTH-MUSCLE-CELLS | TAM RECEPTORS | GROWTH-FACTOR | PROTEIN-S | ARREST-SPECIFIC GENE | Proto-Oncogene Proteins - metabolism | Cell Line | Up-Regulation | Phosphorylation | Cell Proliferation | Signal Transduction | Intercellular Signaling Peptides and Proteins - genetics | Rats | Proto-Oncogene Proteins - genetics | Phosphatidylinositol 3-Kinases - metabolism | Receptor Protein-Tyrosine Kinases - metabolism | MAP Kinase Signaling System | Intercellular Signaling Peptides and Proteins - metabolism | Animals | Transfection | Receptor Protein-Tyrosine Kinases - genetics | c-Mer Tyrosine Kinase | Tyrosine | Protein kinases | Mitogens | Analysis | Cell proliferation | Transformation | Immunoprecipitation | Kinases | Metastases | Axl protein | Skin cancer | Proteins | Signal transduction | Receptors | Cell activation | Cell growth | Rodents | Fibroblasts | Protein-tyrosine kinase receptors | Growth factors | Protein-tyrosine kinase | Immunoglobulins | Immune response | Melanoma | Extracellular signal-regulated kinase | MAP kinase | 1-Phosphatidylinositol 3-kinase | Polymerase chain reaction | Studies | Signaling | Molecular modelling | Inhibitors | Mutagenesis | Transformations (mathematics) | Receptor mechanisms | Tumors | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 2016, Volume 11, Issue 4, pp. e0154638 - e0154638
[This corrects the article DOI: 10.1371/journal.pone.0147830.]. 
Signaling
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 6, pp. e21549 - e21549
Background: Acidification of the cytoplasm and the extracellular environment is associated with many physiological and pathological conditions, such as intense... 
TUMOR PH | ACTIVATED PROTEIN-KINASE | CARDIAC-ARREST | CYTOPLASMIC PH | MULTIDISCIPLINARY SCIENCES | INTRACELLULAR PH | PHOSPHATIDIC-ACID | TUBEROUS SCLEROSIS | CELL-GROWTH | EXTRACELLULAR PH | HUMAN CANCER | Phosphorylation - physiology | Cell Line | Tumor Suppressor Proteins - metabolism | Humans | Multiprotein Complexes | Signal Transduction - genetics | Mechanistic Target of Rapamycin Complex 1 | Proteins - genetics | Phosphorylation - genetics | Animals | Proteins - metabolism | Tumor Suppressor Proteins - genetics | Cell Line, Tumor | Signal Transduction - physiology | TOR Serine-Threonine Kinases | Hydrogen-Ion Concentration | Tuberous sclerosis | Protein biosynthesis | Hydrogen-ion concentration | Protein kinases | Tuberous sclerosis 2 protein | Drugs | Cell culture | Phosphorylation | Brain cancer | Acidification | Raf protein | AKT protein | Cytotoxicity | Hamartin | Biosynthesis | Biochemistry | Kinases | pH effects | TSC1 protein | Autophagy | Sclerosis | Proteins | Breast carcinoma | Signal transduction | Pathways | Energy | Hydrogen ions | Immunotherapy | Fibroblasts | Physiology | Inhibition | Vascular endothelial growth factor | Starvation | Extracellular signal-regulated kinase | Energy expenditure | Substrate inhibition | Embryo fibroblasts | Metabolism | TSC2 protein | Signaling | Acids | Perfusion | Protein synthesis | Protein kinase | Signal processing | Hypoxia | Molecular biology | Biosensors | Cytoplasm | Tumors | Index Medicus | pH
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 3, pp. e16781 - e16781
Icaritin, a compound from Epimedium Genus, has selective estrogen receptor (ER) modulating activities, and posses antitumor activity. Here, we examined... 
CYCLIN-DEPENDENT KINASES | SIGNALING PATHWAYS | INHIBITION | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | MAP KINASES | DEATH | STRESS | TRANSIENT | ESTROGEN-RECEPTOR | Endometrial Neoplasms - enzymology | Apoptosis - drug effects | Humans | Enzyme Activation - drug effects | Flavonoids - therapeutic use | Proto-Oncogene Proteins c-bcl-2 - metabolism | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Caspases - biosynthesis | Cell Line, Tumor | Enzyme Induction - drug effects | Endometrial Neoplasms - drug therapy | Endometrial Neoplasms - pathology | Female | Cell Proliferation - drug effects | Flavonoids - pharmacology | Cell Cycle - drug effects | Flavonoids - chemistry | Mitogen-Activated Protein Kinase 1 - metabolism | Cytochrome c | Endometrial cancer | Health aspects | Estrogen | Cancer | Apoptosis | Cell proliferation | Cytochrome | Phosphorylation | Bax protein | Bcl-2 protein | Estrogens | Estrogen receptors | Activation | Kinases | ADP | MAP kinase kinase | Anticancer properties | Cell activation | Cell growth | Antitumor agents | Ribose | Inhibition | Pretreatment | Endometrium | Cyclin-dependent kinases | Extracellular signal-regulated kinase | Caspase | Poly(ADP-ribose) polymerase | MAP kinase | Polymerase | Inhibitors | Cyclin-dependent kinase inhibitor p27 | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, pp. e35826 - e35826
Receptor tyrosine kinase signaling cooperates with WNT/beta-catenin signaling in regulating many biological processes, but the mechanisms of their interaction... 
INSULIN | MECHANISM | BIOLOGY | DYSPLASIA | MUTATIONS | WNT | FGFR3 | CANCER | LRP6 | Phosphorylation | Humans | Gene Expression Regulation | Phosphatidylinositol 3-Kinases - metabolism | Glycogen Synthase Kinase 3 - metabolism | Wnt Proteins - metabolism | Receptor Protein-Tyrosine Kinases | beta Catenin - metabolism | Proto-Oncogene Proteins c-akt - genetics | beta Catenin - genetics | Phosphatidylinositol 3-Kinases - genetics | Low Density Lipoprotein Receptor-Related Protein-6 - genetics | Low Density Lipoprotein Receptor-Related Protein-6 - metabolism | MAP Kinase Signaling System - genetics | Wnt Proteins - genetics | Glycogen Synthase Kinase 3 - genetics | Wnt Signaling Pathway - genetics | HEK293 Cells | Mitogen-Activated Protein Kinases - genetics | Proto-Oncogene Proteins c-akt - metabolism | Mitogen-Activated Protein Kinases - metabolism | Wnt protein | AKT protein | Biology | Kinases | Throat cancer | Proteins | Signal transduction | β-catenin | Immunology | TrkA protein | Protein-tyrosine kinase receptors | Physiology | Standard deviation | Protein-tyrosine kinase | Fibroblast growth factor receptor 2 | Tyrosine | Epidermal growth factor receptors | Extracellular signal-regulated kinase | MAP kinase | Biophysics | Cadherin | Biological activity | 1-Phosphatidylinositol 3-kinase | Golgi apparatus | Medicine | Signaling | Low density lipoprotein receptors | Mutation | Prostate cancer | Fibroblast growth factor receptors | Tumors | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, pp. e62705 - e62705
Background: A-kinase anchoring proteins (AKAPs) are scaffolding molecules that coordinate and integrate G-protein signaling events to regulate development,... 
PROTEIN-KINASE-A | BREAST-CANCER | CELL INVASIVENESS | MULTIDISCIPLINARY SCIENCES | HEART-FAILURE | MOUSE | EXCHANGE FACTOR AKAP13 | RECEPTOR | INDUCED CARDIOMYOCYTE HYPERTROPHY | ANCHORING PROTEIN | SIGNALING COMPLEX | Embryo, Mammalian | Minor Histocompatibility Antigens | Heart - embryology | Myocardial Contraction - drug effects | Male | A Kinase Anchor Proteins - genetics | Gene Expression Regulation, Developmental | Guanine Nucleotide Exchange Factors - metabolism | Electrocardiography | Female | A Kinase Anchor Proteins - metabolism | Heart - physiopathology | Protein Structure, Tertiary | Guanine Nucleotide Exchange Factors - genetics | Signal Transduction | Breeding | Cardiomegaly - physiopathology | Organ Size | Stroke Volume - drug effects | Mice, Transgenic | Animals | Cardiomegaly - chemically induced | Heart - drug effects | Mice | Isoproterenol - adverse effects | Cardiomegaly - metabolism | Heart | Protein kinase A | Cell culture | Cardiovascular disease | Isoproterenol | Kinases | Guanine | Defects | Eutrophication | Proteins | Embryogenesis | Fertility | Rodents | Physiology | Guanine nucleotide exchange factor | Heart diseases | Anchoring | Pharmaceutical sciences | Heart failure | Contractility | Cardiomyocytes | Pharmacology | Breast cancer | Embryos | Muscle contraction | Signaling | Scaffolding | Isoforms | Mutation | Alzheimers disease | Viability | Binding sites | Hypertrophy | Ejection | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2012, Volume 7, Issue 5, pp. e35997 - e35997
We have recently shown that silencing of the brain/islet specific c-Jun N-terminal Kinase3 (JNK3) isoform enhances both basal and cytokine-induced beta-cell... 
FORKHEAD TRANSCRIPTION FACTOR | APOPTOSIS | HUMAN ISLETS | PROTEIN-KINASE-B | TUMOR SUPPRESSION | GLYCOGEN-SYNTHASE KINASE-3 | BIOLOGY | PANCREATIC BETA-CELLS | JUN NH2-TERMINAL KINASE | PHYSIOLOGICAL FUNCTIONS | MICE LACKING | Phosphorylation | Glycogen Synthase Kinase 3 beta | Insulinoma - genetics | Insulin Receptor Substrate Proteins - metabolism | Mitogen-Activated Protein Kinase 9 - genetics | Mitogen-Activated Protein Kinase 10 - genetics | Insulin-Secreting Cells - metabolism | RNA Interference | Forkhead Transcription Factors - metabolism | Mitogen-Activated Protein Kinase 8 - genetics | Proto-Oncogene Proteins c-akt - metabolism | Insulin Secretion | Signal Transduction | Mitogen-Activated Protein Kinase 9 - metabolism | Mitogen-Activated Protein Kinase 8 - metabolism | Rats | Glycogen Synthase Kinase 3 - metabolism | Blotting, Western | Mitogen-Activated Protein Kinase 10 - metabolism | Insulin - metabolism | Animals | Insulin-Secreting Cells - drug effects | Insulinoma - metabolism | Cell Line, Tumor | Insulinoma - pathology | Insulin-Secreting Cells - pathology | Forkhead Box Protein O3 | Cytokines - pharmacology | Pancreatic beta cells | Synthesis | Cytokines | Glycogen | Gene expression | Insulin | Apoptosis | Brain | Transcription factors | AKT1 protein | Glycogen synthase | JNK3 protein | AKT2 protein | c-Jun protein | AKT protein | Glucose | Kinases | Beta cells | Signal transduction | Signaling | Rodents | Insulin resistance | Forkhead protein | Cytoplasm | FOXO3 protein | Index Medicus
Journal Article