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PLoS ONE, ISSN 1932-6203, 04/2015, Volume 10, Issue 4, p. e0122373
Hepatitis B virus (HBV) pre-S2 mutant can induce hepatocellular carcinoma (HCC) via the induction of endoplasmic reticulum stress to activate mammalian target... 
HEPATOCELLULAR-CARCINOMA | S MUTANTS | X-PROTEIN | GROUND-GLASS HEPATOCYTES | MULTIDISCIPLINARY SCIENCES | C-MYC | TISSUE METABOLOMICS | CANCER-CELL METABOLISM | EXPRESSION | MTOR | TRANSGENIC MICE | Hepatitis B Surface Antigens - genetics | Immunohistochemistry | Hepatitis B - metabolism | TOR Serine-Threonine Kinases - metabolism | Humans | Hepatitis B - virology | Glucose Transporter Type 1 - metabolism | YY1 Transcription Factor - metabolism | Phosphoproteins - metabolism | Liver Neoplasms - etiology | Glycogen - metabolism | Liver Neoplasms - pathology | Carcinoma, Hepatocellular - etiology | Cell Line | Protein Precursors - genetics | Signal Transduction | Hepatitis B Surface Antigens - metabolism | Mice, Transgenic | Proto-Oncogene Proteins c-myc - metabolism | Protein Precursors - metabolism | Mutant Proteins | Animals | Carcinoma, Hepatocellular - pathology | Hepatitis B virus - genetics | Liver Neoplasms - metabolism | Glycolysis | Mice | Hepatitis B virus - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Carcinoma, Hepatocellular - metabolism | Glycogen | Development and progression | Rapamycin | Glucose | Gene expression | Dextrose | Infection | Lactates | Glucose metabolism | Analysis | Resveratrol | Genetic engineering | Hepatitis B virus | Health aspects | Protein binding | Hepatitis B | TOR protein | Metabolic rate | Chronic infection | Viruses | Hepatocellular carcinoma | Activation | Myc protein | Hepatitis | Animal tissues | Tumorigenesis | Glucose transporter | Risk groups | Transgenic mice | Translation initiation | YY1 protein | Mammals | Metabolism | Signaling | Chemotherapy | Silymarin | Lactic acid | Aberration | Endoplasmic reticulum | Transporter | Metabolic disorders
Journal Article
Medicinal Research Reviews, ISSN 0198-6325, 09/2008, Volume 28, Issue 5, pp. 746 - 772
Medicinal plants have been traditionally used for treating liver diseases since centuries. Several leads from plant sources have been found as potential... 
phyllanthin | picroside | silymarin | neoandrographolide | kutkoside | hepatoprotective | glycyrrhizin | andrographolide | curcumin | hypophyllanthin | Glycyrrhizin | Hepatoprotective | Kutkoside | Silymarin | Phyllanthin | Neoandrographolide | Curcumin | Andrographolide | Hypophyllanthin | Picroside | ANDROGRAPHIS-PANICULATA NEES | CHEMISTRY, MEDICINAL | RAT HEPATOCYTES | INDUCED HEPATIC DAMAGE | neoandrogapholide | INDUCED LIVER-DAMAGE | ANTIHEPATOTOXIC PRINCIPLES | PHYLLANTHUS-AMARUS | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | PICRORHIZA-KURROOA | INDUCED HEPATOTOXICITY | PICROSIDE-I | Silymarin - toxicity | Plant Extracts - toxicity | Diterpenes - toxicity | Plant Extracts - pharmacology | Humans | Protective Agents - chemistry | Curcumin - metabolism | Silymarin - chemistry | Lignans - pharmacology | Plant Extracts - metabolism | Glycyrrhizic Acid - pharmacology | Liver - drug effects | Glucosides - chemistry | Cinnamates - chemistry | Phytotherapy | Diterpenes - pharmacology | Glucosides - toxicity | Liver - metabolism | Curcumin - pharmacology | Lignans - metabolism | Plants | Cinnamates - pharmacology | Glucosides - metabolism | Tetrahydronaphthalenes - metabolism | Tetrahydronaphthalenes - pharmacology | Liver Diseases - drug therapy | Glycyrrhizic Acid - toxicity | Plant Extracts - therapeutic use | Curcumin - chemistry | Tetrahydronaphthalenes - toxicity | Protective Agents - metabolism | Protective Agents - therapeutic use | Lignans - toxicity | Protective Agents - pharmacology | Cinnamates - metabolism | Cinnamates - toxicity | Silymarin - metabolism | Silymarin - pharmacology | Diterpenes - metabolism | Diterpenes - chemistry | Glucosides - pharmacology | Cytokines - metabolism | Lignans - chemistry | Glycyrrhizic Acid - chemistry | Glycyrrhizic Acid - metabolism | Animals | Curcumin - toxicity | Tetrahydronaphthalenes - chemistry | Liver Diseases - metabolism | Protective Agents - toxicity
Journal Article
Journal Article
Neuroscience Letters, ISSN 0304-3940, 08/2016, Volume 629, pp. 256 - 261
Journal Article
Canadian Journal of Physiology and Pharmacology, ISSN 0008-4212, 2018, Volume 96, Issue 12, pp. 1308 - 1317
Liver fibrosis is a health concern that leads to organ failure mediated via production of inflammatory cytokines and fibrotic biomarkers. This study aimed to... 
thioacetamide | alpha-smooth muscle actin | liver fibrosis | tadalafil | fibrose hépatique | expression du collagène 1 | rats | actine du muscle lisse alpha | interleukine 10 | collagen-1 expression | interleukin-10 | thioacétamide | Tadalafil | Thioacetamide | Interleukin-10 | Rats | Alpha-smooth muscle actin | Liver fibrosis | Collagen-1 expression | PHYSIOLOGY | TGF-BETA | SILDENAFIL | NITRIC-OXIDE SYNTHASE | MODEL | HEPATIC STELLATE CELLS | ANTIOXIDANT | PHARMACOLOGY & PHARMACY | SILYMARIN | DYSFUNCTION | EXPRESSION | PDE5 INHIBITORS | Tumor Necrosis Factor-alpha - metabolism | Thioacetamide - pharmacology | Gene Expression - drug effects | Rats, Wistar | Actins - metabolism | Male | Liver Cirrhosis - chemically induced | Inflammation - metabolism | Liver - drug effects | Inflammation - drug therapy | Interleukin-1beta - metabolism | Liver Cirrhosis - metabolism | Transaminases - metabolism | Interleukin-10 - metabolism | Tadalafil - pharmacology | Interleukin-6 - metabolism | Biomarkers - metabolism | Liver Cirrhosis - drug therapy | Collagen Type I - metabolism | Cytokines - metabolism | Anti-Inflammatory Agents - pharmacology | Hydroxyproline - metabolism | Liver - metabolism | Animals | Nitric Oxide - metabolism | Transforming Growth Factor beta - metabolism | Prevention | Dosage and administration | Liver diseases | Patient outcomes | Fibrosis | Anti-inflammatory drugs | Liver | Muscle proteins | Gene expression | Antioxidants | Interleukins | Tumor necrosis factor | Collagen | Nitric oxide | Bone morphogenetic proteins | Histochemistry | Transforming growth factor-b | Interleukin | Hydroxyproline | Transforming growth factor-a | Smooth muscle | Interleukin 6 | Histopathology | Actin | Interleukin 1 | Pretreatment | Growth factors | Phosphodiesterase | Cytokines | Muscles | Inflammation | Tumor necrosis factor-α | Silymarin | Transaminases | Interleukin 10 | Biomarkers
Journal Article
世界胃肠病学杂志:英文版, ISSN 1007-9327, 2016, Volume 22, Issue 26, pp. 6016 - 6026
AIM: To investigate in vitro the therapeutic effect and mechanisms of silybin in a cellular model of hepatic steatosis.METHODS: Rat hepatoma Fa O cells were... 
disease;Steatotic | Non-alcoholic | fatty | liver | metabolism;Oxidative | hepatocytes;Silybin;Lipid | stress;Li | Oxidative stress | Lipid droplets | Silybin | Mitochondrial oxidation | Lipid metabolism | Non-alcoholic fatty liver disease | Steatotic hepatocytes | VITAMIN-E | FATTY LIVER-DISEASE | NONALCOHOLIC STEATOHEPATITIS | Mitochondrial beta-oxidation | DAMAGE | METABOLISM | REGULATORS | SILYMARIN | PROTEINS | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Catalase - drug effects | Reactive Oxygen Species - metabolism | Hepatocytes - pathology | NF-kappa B - metabolism | Fluorometry | Hepatocytes - metabolism | Oleic Acid - pharmacology | Palmitates - pharmacology | Carnitine O-Palmitoyltransferase - metabolism | Lipid Peroxidation - drug effects | Carnitine O-Palmitoyltransferase - drug effects | Silymarin - pharmacology | Lipid Droplets - metabolism | Real-Time Polymerase Chain Reaction | Hepatocytes - drug effects | Sterol Regulatory Element Binding Protein 1 - metabolism | Lipid Droplets - drug effects | Sterol Regulatory Element Binding Protein 1 - drug effects | Cells, Cultured | Rats | Antioxidants - pharmacology | Blotting, Western | Triglycerides - metabolism | Catalase - metabolism | Fatty Liver | Animals | Peroxisome Proliferator-Activated Receptors - drug effects | Lipid Metabolism - drug effects | Peroxisome Proliferator-Activated Receptors - metabolism | Cell Line, Tumor | Oxidative Stress - drug effects | Spectrophotometry | Microscopy, Fluorescence | NF-kappa B - drug effects | Vitamin E - pharmacology | Mitochondrial β-oxidation | Basic Study
Journal Article
Oncotarget, ISSN 1949-2553, 2015, Volume 6, Issue 27, pp. 24002 - 24016
Journal Article
Ecotoxicology and Environmental Safety, ISSN 0147-6513, 2011, Volume 74, Issue 4, pp. 607 - 614
We investigated the effects of silymarin and naringenin in counteracting arsenic-induced hepatic oxidative stress post exposure. Male wistar rats were... 
Antioxidants | Oxidative stress | Arsenic toxicity | Flavonoids | Naringenin | Silymarin | Rat | Tissue arsenic concentration | Chelation | LIPID-PEROXIDATION | DNA-DAMAGE | KAPPA-B | CELL-LINES | ENVIRONMENTAL SCIENCES | INDUCED LIVER-DAMAGE | GLUTATHIONE | INDUCED OXIDATIVE STRESS | ANTIOXIDANT | SILYBUM-MARIANUM | TOXICOLOGY | DRINKING-WATER | Reactive Oxygen Species - metabolism | Rats, Wistar | Glutathione - metabolism | Male | Environmental Pollutants - metabolism | Arsenic - metabolism | Liver - drug effects | Arsenites - toxicity | Lipid Peroxidation - drug effects | Silymarin - pharmacology | Chelating Agents - therapeutic use | Superoxide Dismutase - metabolism | Glutathione Peroxidase - metabolism | Silymarin - therapeutic use | Flavanones - therapeutic use | Flavanones - pharmacology | Liver - metabolism | Glutathione Transferase - metabolism | Rats | Thiobarbituric Acid Reactive Substances - metabolism | Antioxidants - pharmacology | Arsenic Poisoning - drug therapy | Catalase - metabolism | Antioxidants - therapeutic use | Animals | Arsenic Poisoning - metabolism | Sodium Compounds - toxicity | Chemical and Drug Induced Liver Injury - metabolism | Chemical and Drug Induced Liver Injury - drug therapy | Oxidative Stress - drug effects | Arsenic | Health aspects | Arsenic compounds | Isoflavones | Catalase | Sod | Damage | Recovery
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 08/2014, Volume 73, pp. 117 - 126
The accumulation of toxic hydrophobic bile acids in hepatocytes, observed during chronic cholestasis, induces substantial modification in the redox state and... 
Citrate carrier | Peroxisome proliferator-activated receptor coactivator-1α | Lipogenic enzymes | Secondary biliary cirrhosis | Mitochondrial biogenesis | Free radicals | CARDIOLIPIN | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHOLIPIDS | PROLIFERATION | coactivator-1 alpha | PEROXIDATION | Peroxisome proliferator-activated receptor | BIOENERGETICS | PROTON LEAK | ENDOCRINOLOGY & METABOLISM | SILYMARIN | EXPRESSION | Fatty Acid Synthase, Type I - biosynthesis | Liver - pathology | Reactive Oxygen Species - metabolism | Rats, Wistar | Male | Hepatocytes - metabolism | DNA, Mitochondrial - genetics | Biological Transport | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Anti-Inflammatory Agents - therapeutic use | Cholestasis - drug therapy | Phospholipids - metabolism | Silymarin - therapeutic use | Oxidation-Reduction | Liver - metabolism | Liver Cirrhosis, Biliary - drug therapy | Rats | Cardiolipins - metabolism | Mitochondria - metabolism | Liver Cirrhosis, Biliary - pathology | Transcription Factors - metabolism | Cholestasis - pathology | Antioxidants - therapeutic use | Animals | Carrier Proteins - metabolism | Acetyl-CoA Carboxylase - biosynthesis | Citric Acid - metabolism | Enzyme Activation | Mitochondrial Turnover - physiology | Lipid Metabolism - physiology | Antioxidants | Enzymes | Membrane lipids | Synthesis | Cardiolipin | Fatty acids | Index Medicus
Journal Article
Plant Physiology and Biochemistry, ISSN 0981-9428, 09/2013, Volume 70, pp. 115 - 122
Journal Article