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Chemical Research in Toxicology, ISSN 0893-228X, 09/2008, Volume 21, Issue 9, pp. 1814 - 1822
In vitro covalent binding assessments of drugs have been useful in providing retrospective insights into the association between drug metabolism and a... 
ACYL GLUCURONIDES | CHEMISTRY, MEDICINAL | PROTEIN | RAT | REACTIVE METABOLITES | TIENILIC ACID | HEPATIC-NECROSIS | BIOACTIVATION | IDENTIFICATION | CHEMISTRY, MULTIDISCIPLINARY | MASS-SPECTROMETRY | TOXICOLOGY | HUMAN URINE | Buspirone - chemistry | Raloxifene Hydrochloride - pharmacology | Thiazoles - metabolism | Acetaminophen - metabolism | Humans | Microsomes, Liver - metabolism | Indomethacin - metabolism | Simvastatin - pharmacology | Diclofenac - chemistry | Thiazines - metabolism | Propranolol - pharmacology | Toxicity Tests - methods | Binding Sites | Simvastatin - metabolism | Microsomes, Liver - chemistry | Indomethacin - pharmacology | Paroxetine - metabolism | Raloxifene Hydrochloride - metabolism | Triazoles - metabolism | Ticrynafen - metabolism | Paroxetine - pharmacology | Diclofenac - metabolism | Paroxetine - chemistry | Diphenhydramine - pharmacology | Diclofenac - pharmacology | Triazoles - chemistry | Buspirone - metabolism | Ticrynafen - pharmacology | Structure-Activity Relationship | Buspirone - pharmacology | Hepatocytes - metabolism | Dose-Response Relationship, Drug | Carbamazepine - chemistry | Diphenhydramine - metabolism | Acetaminophen - pharmacology | Microsomes, Liver - drug effects | Propranolol - metabolism | Carbamazepine - metabolism | Thiazines - pharmacology | Molecular Structure | Drug Evaluation, Preclinical | Hepatocytes - drug effects | Carbamazepine - pharmacology | Simvastatin - chemistry | Acetaminophen - chemistry | Ticrynafen - chemistry | Propranolol - chemistry | Diphenhydramine - chemistry | Thiazines - chemistry | Triazoles - pharmacology | Indomethacin - chemistry | Thiazoles - chemistry | Thiazoles - pharmacology | Raloxifene Hydrochloride - chemistry | Index Medicus
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 08/2007, Volume 35, Issue 8, pp. 1308 - 1314
Hepatic uptake carriers of the organic anion-transporting peptide (OATP) family of solute carriers are more and more recognized as being involved in hepatic... 
RAT | SEVERE RHABDOMYOLYSIS | COMBINATION THERAPY | LIVER | PHARMACOLOGY & PHARMACY | CERIVASTATIN | HEPATIC-UPTAKE | TRANSPLANT RECIPIENTS | ROSUVASTATIN | POLYPEPTIDE | FAMILY | Organic Anion Transporters, Sodium-Independent - genetics | Fatty Acids, Monounsaturated - pharmacology | Cricetulus | Hypolipidemic Agents - metabolism | Hypoglycemic Agents - metabolism | Taurocholic Acid - metabolism | Humans | Hepatocytes - metabolism | Simvastatin - pharmacology | Organic Anion Transporters - metabolism | Chromans - metabolism | Hepatocytes - cytology | Indoles - metabolism | Organic Anion Transporters - genetics | Drug Interactions | Anticholesteremic Agents - metabolism | Chromans - pharmacology | Fatty Acids, Monounsaturated - metabolism | Organic Anion Transporters, Sodium-Independent - metabolism | Indoles - pharmacology | Biological Transport - drug effects | Thiazolidinediones - pharmacology | Hepatocytes - drug effects | Solute Carrier Organic Anion Transporter Family Member 1B3 | CHO Cells | Pravastatin - pharmacology | Recombinant Proteins - metabolism | Taurocholic Acid - pharmacology | Cell Line | Cricetinae | Pravastatin - metabolism | Simvastatin - metabolism | Gemfibrozil - pharmacokinetics | Gemfibrozil - pharmacology | Hypolipidemic Agents - pharmacology | Thiazolidinediones - metabolism | Hypoglycemic Agents - pharmacology | Animals | Estrone - analogs & derivatives | Estrone - metabolism | Protein Binding | Fatty Acids, Monounsaturated - pharmacokinetics | Indoles - pharmacokinetics | Kinetics | Solute Carrier Organic Anion Transporter Family Member 1b1 | Anticholesteremic Agents - pharmacology | Gemfibrozil - metabolism
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 01/2014, Volume 111, Issue 1, pp. E89 - E98
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 06/2011, Volume 31, Issue 12, pp. 2484 - 2498
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
COA REDUCTASE INHIBITORS | TUBEROUS SCLEROSIS COMPLEX | PULMONARY LYMPHANGIOLEIOMYOMATOSIS LAM | TUMOR-SUPPRESSOR TSC2 | S6 KINASE ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | RENAL-TRANSPLANT PATIENTS | SMOOTH-MUSCLE-CELLS | SIMVASTATIN INDUCES APOPTOSIS | RAPAMYCIN ANALOG CCI-779 | NF-KAPPA-B | CELL BIOLOGY | Neoplasm Transplantation | RNA, Small Interfering - genetics | Cell Proliferation | TOR Serine-Threonine Kinases - metabolism | Humans | Multiprotein Complexes - genetics | rhoA GTP-Binding Protein - metabolism | rhoA GTP-Binding Protein - genetics | Mechanistic Target of Rapamycin Complex 2 | Proto-Oncogene Proteins c-akt - genetics | Multiprotein Complexes - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | TOR Serine-Threonine Kinases - genetics | Anticholesteremic Agents - metabolism | Tumor Suppressor Proteins - genetics | Immunosuppressive Agents - metabolism | Female | Regulatory-Associated Protein of mTOR | Proto-Oncogene Proteins c-akt - metabolism | Rapamycin-Insensitive Companion of mTOR Protein | Tumor Suppressor Proteins - metabolism | Cell Survival | Simvastatin - metabolism | Cells, Cultured | Rats | Sirolimus - metabolism | Mice, Knockout | Carrier Proteins - genetics | Adaptor Proteins, Signal Transducing | Animals | Carrier Proteins - metabolism | Mice, Nude | Mice | Apoptosis - physiology | Enzyme Activation | Proto-Oncogene Proteins c-bcl-2 - genetics | RNA, Small Interfering - metabolism
Journal Article
Neuroscience, ISSN 0306-4522, 2016, Volume 333, pp. 204 - 213
Highlights • The mechanisms of simvastatin-induced amelioration of neuropathic pain were studied. • Spinal RhoA/Rho kinase signaling is activated in... 
Neurology | simvastatin | myristoylated alanine-rich protein kinase C substrate (MARCKS) | neuropathic pain | Rho kinase (ROCK) | astrocyte | RhoA | REDUCTASE INHIBITORS | SUBSTRATE PHOSPHORYLATION | THERMAL HYPERALGESIA | PROTEIN-KINASE | RHO-KINASE | NEUROSCIENCES | RAT MODEL | TRAUMATIC BRAIN-INJURY | NOCICEPTIVE TRANSMISSION | SCIATIC-NERVE LIGATION | SPINAL-CORD ASTROCYTES | Analgesics - pharmacology | Microglia - metabolism | Sciatic Nerve - injuries | Spinal Cord - drug effects | Spinal Cord - metabolism | Myristoylated Alanine-Rich C Kinase Substrate | Astrocytes - pathology | Neuralgia - metabolism | Male | Intracellular Signaling Peptides and Proteins - metabolism | Neuralgia - pathology | Glial Fibrillary Acidic Protein - metabolism | Simvastatin - pharmacology | rho-Associated Kinases - antagonists & inhibitors | Hyperalgesia - pathology | Gliosis - pathology | rho-Associated Kinases - metabolism | Spinal Cord - pathology | Microglia - pathology | Membrane Proteins - metabolism | Microfilament Proteins - metabolism | Disease Models, Animal | Calcium-Binding Proteins - metabolism | Astrocytes - drug effects | Hyperalgesia - metabolism | Microglia - drug effects | Gliosis - metabolism | Mice, Inbred ICR | Neuralgia - drug therapy | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Hyperalgesia - drug therapy | rho GTP-Binding Proteins - metabolism | Gliosis - drug therapy | Protein Kinase Inhibitors - pharmacology | Lumbar Vertebrae | Astrocytes - metabolism | Simvastatin | Antilipemic agents
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2015, Volume 112, Issue 8, pp. 2473 - 2478
The malignant progression of pancreatic ductal adenocarcinoma (PDAC) is accompanied by a profound desmoplasia, which forces proliferating tumor cells to... 
PROTEIN | MULTIDISCIPLINARY SCIENCES | GLYCOLYSIS | pancreatic cancer | PATHWAY | PROSTATE-CANCER | LIPID RAFTS | cholesterol | S-PHASE | metabolism | gemcitabine | CELL-CYCLE | KRAS | ACCUMULATION | SIMVASTATIN | LDLR | Adenocarcinoma - pathology | Epithelial Cells - metabolism | Gene Silencing - drug effects | Pancreatic Neoplasms - metabolism | Prognosis | Epithelial Cells - drug effects | Humans | Deoxycytidine - pharmacology | Extracellular Signal-Regulated MAP Kinases - metabolism | Pancreatic Neoplasms - drug therapy | Deoxycytidine - therapeutic use | Adenocarcinoma - metabolism | Lipoproteins - metabolism | Clone Cells | Gene Expression Regulation, Neoplastic - drug effects | Receptors, LDL - genetics | Pancreatic Neoplasms - pathology | Adenocarcinoma - enzymology | Pancreatic Neoplasms - enzymology | Receptors, LDL - metabolism | Epithelial Cells - pathology | Up-Regulation - genetics | Cholesterol - metabolism | Adenocarcinoma - drug therapy | Up-Regulation - drug effects | Metabolic Networks and Pathways - genetics | Phenotype | Animals | MAP Kinase Signaling System - drug effects | Cell Compartmentation - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Metabolic Networks and Pathways - drug effects | Deoxycytidine - analogs & derivatives | Pancreatic cancer | Carcinoma, Ductal | Development and progression | Genetic aspects | Genetic transcription | Cholesterol metabolism | Health aspects | Biological Sciences
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 05/2009, Volume 296, Issue 5, pp. 1675 - 1682
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 03/2009, Volume 29, Issue 3, pp. 380 - 386
Objective-Activation of the endothelium by oxidized low-density lipoprotein (oxLDL) has been implicated in the development of atherosclerosis. Histone... 
Cytokines | Histone | Statins | Endothelium | HDAC | endothelium | DEACETYLASE ACTIVITY | LOW-DENSITY-LIPOPROTEIN | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | ATHEROSCLEROSIS | CHLAMYDOPHILA-PNEUMONIAE | TRICHOSTATIN-A | INTERLEUKIN-8 | INDUCED P38 MAPK | RECEPTOR-DEFICIENT MICE | statins | PERIPHERAL VASCULAR DISEASE | cytokines | histone | HEMATOLOGY | NF-KAPPA-B | Fatty Acids, Monounsaturated - pharmacology | Humans | Promoter Regions, Genetic - drug effects | Simvastatin - pharmacology | Repressor Proteins - antagonists & inhibitors | Fluvastatin | RNA Interference | Inflammation Mediators - metabolism | Indoles - pharmacology | Chemokine CCL2 - metabolism | Lipoproteins, LDL - metabolism | Interleukin-8 - metabolism | Cytokines - genetics | Hydroxamic Acids - pharmacology | Repressor Proteins - metabolism | Mevalonic Acid - pharmacology | Coronary Vessels - enzymology | Cytokines - metabolism | Cells, Cultured | Histone Deacetylase 2 | Histone Deacetylases - metabolism | Histone Deacetylase 1 | Endothelial Cells - immunology | Gene Expression Regulation - drug effects | Scavenger Receptors, Class E - metabolism | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Vorinostat | Histone Deacetylase Inhibitors | Histones - metabolism | Endothelial Cells - enzymology | Endothelial Cells - drug effects | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism
Journal Article
Cell Death and Disease, ISSN 2041-4889, 02/2013, Volume 4, Issue 2, pp. e518 - e518
Journal Article
Journal Article