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Drug Metabolism and Disposition, ISSN 0090-9556, 12/2007, Volume 35, Issue 12, pp. 2166 - 2176
Olmesartan, a novel angiotensin II AT1-receptor antagonist, is excreted into both bile and urine, with minimal metabolism. Because olmesartan is a hydrophilic... 
PHARMACOKINETICS | INVOLVEMENT | PHARMACOLOGY & PHARMACY | RESISTANCE-ASSOCIATED PROTEIN-4 | ORGANIC ANION TRANSPORTERS | EXCRETION | IDENTIFICATION | MEDOXOMIL | EXPRESSION | OATP1B1 | BLOCKER | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Membrane Transport Proteins - drug effects | Hepatocytes - metabolism | Imidazoles - pharmacokinetics | Neoplasm Proteins - metabolism | Angiotensin II Type 1 Receptor Blockers - pharmacokinetics | Sincalide - metabolism | Angiotensin II Type 1 Receptor Blockers - metabolism | Organic Anion Transporters - metabolism | Prodrugs - metabolism | Tetrazoles - metabolism | Dose-Response Relationship, Drug | Kidney - metabolism | Protein Isoforms - metabolism | Transfection | Liver - drug effects | Membrane Transport Proteins - genetics | Organic Anion Transporters, Sodium-Independent - metabolism | Adenosine Triphosphate - metabolism | ATP-Binding Cassette Transporters - metabolism | Female | Membrane Transport Proteins - metabolism | Hepatocytes - drug effects | Solute Carrier Organic Anion Transporter Family Member 1B3 | Imidazoles - metabolism | Olmesartan Medoxomil | Cell Line | Liver - metabolism | Probenecid - pharmacology | Penicillin G - pharmacology | Mice, Knockout | p-Aminohippuric Acid - pharmacology | Animals | Estrone - analogs & derivatives | Multidrug Resistance-Associated Proteins - deficiency | Prodrugs - pharmacokinetics | Estrone - metabolism | Dogs | Protein Binding | ATP Binding Cassette Transporter, Sub-Family B | Mice | Kinetics | In Vitro Techniques | Solute Carrier Organic Anion Transporter Family Member 1b1 | Multidrug Resistance-Associated Proteins - metabolism | Tetrazoles - pharmacokinetics | Index Medicus
Journal Article
Neurotoxicology, ISSN 0161-813X, 03/2017, Volume 59, pp. 88 - 97
The oxysterol 27-Hydroxycholesterol (27-OHC) is a major cholesterol metabolite that can cross the blood brain barrier (BBB) from peripheral circulation to the... 
Brain | Synthesis | Astrocyte | 27-hydroxycholesterol | Transport | Cholesterol | TRAFFICKING | NEUROSCIENCES | IMPAIRMENT | EFFLUX | METABOLISM | PATHWAY | NEURONS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | ALZHEIMERS | LIVER-X-RECEPTOR | OXYSTEROLS | Apoptosis - drug effects | PPAR gamma - metabolism | RNA, Messenger - metabolism | Apolipoproteins E - metabolism | Sincalide - metabolism | ATP Binding Cassette Transporter 1 - metabolism | Hydroxymethylglutaryl CoA Reductases - metabolism | Time Factors | Glioma - pathology | Gene Expression Regulation, Neoplastic - drug effects | Sterol Regulatory Element Binding Protein 1 - metabolism | PPAR gamma - genetics | Receptors, LDL - genetics | Receptors, LDL - metabolism | Liver X Receptors - metabolism | Cholesterol - metabolism | Hydroxycholesterols - pharmacology | Animals | Apolipoproteins E - genetics | Cell Line, Tumor | Mice | Filipin - metabolism | Hydroxymethylglutaryl CoA Reductases - genetics | Liver X Receptors - genetics | ATP Binding Cassette Transporter 1 - genetics | Apolipoproteins | Gliomas | Metabolites | Brain tumors | Physiological aspects | Protein binding | Liver | Genes | Homeostasis | ABCA1 protein | Proteins | Receptors | Blood-brain barrier | Apolipoprotein E | Glioma cells | Sterol regulatory element-binding protein | Lipoprotein (low density) receptors | Lipid metabolism | Protein transport | Enzyme-linked immunosorbent assay | Peripheral circulation | Liver X receptors | Astrocytes | Metabolism | Cells | Blood circulation | ATP-binding protein | Receptor density | Peroxisome proliferator-activated receptors | Cholecystokinin | Viability | Transporter | Apoptosis | Reductase | Index Medicus
Journal Article
Journal Article
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 06/2007, Volume 292, Issue 6, pp. 1804 - 1812
Endoplasmic reticulum (ER) stress leads to the accumulation of misfolded proteins in the ER lumen and initiates the unfolded protein response (UPR). Components... 
Exocrine acini | Pancreas | CHOLECYSTOKININ RECEPTORS | PHYSIOLOGY | UNFOLDED-PROTEIN RESPONSE | INTRACELLULAR-TRANSPORT | RAT | ER STRESS | CERULEIN-INDUCED PANCREATITIS | EXOCRINE PANCREAS | TRANSLATIONAL CONTROL | MESSENGER-RNA | pancreas | exocrine acini | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Transcription Factor CHOP - genetics | Phosphorylation | Basic-Leucine Zipper Transcription Factors - metabolism | Molecular Chaperones - metabolism | eIF-2 Kinase - metabolism | Pancreas, Exocrine - pathology | Sincalide - pharmacology | Endoplasmic Reticulum - metabolism | Male | Neoplasm Proteins - metabolism | Pancreas, Exocrine - drug effects | RNA, Messenger - metabolism | Sincalide - metabolism | X-Box Binding Protein 1 | Amylases - metabolism | Dose-Response Relationship, Drug | Endoplasmic Reticulum - pathology | RNA Splicing | Bombesin - pharmacology | Endoplasmic Reticulum - drug effects | Stress, Physiological - metabolism | Neoplasm Proteins - genetics | DNA-Binding Proteins | Trypsinogen - metabolism | Heat-Shock Proteins - metabolism | Cells, Cultured | Sincalide - analogs & derivatives | Rats | Stress, Physiological - physiopathology | Basic-Leucine Zipper Transcription Factors - genetics | Trypsin - metabolism | Rats, Sprague-Dawley | Regulatory Factor X Transcription Factors | Protein Folding | Animals | Signal Transduction - drug effects | Stress, Physiological - pathology | Pancreas, Exocrine - metabolism | Transcription Factors | Enzyme Activation | Transcription Factor CHOP - metabolism | Proteins | Rodents | Biochemistry | Gene expression | Kinases | Cells | Binding sites | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2011, Volume 286, Issue 13, pp. 11707 - 11715
Research has shown that the synergistic interaction between vagal cholecystokinin-A receptors (CCKARs) and leptin receptors (LRbs) mediates short term satiety.... 
CCK RECEPTORS | ACTIVATION | AFFINITY | FOOD-INTAKE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INVOLVEMENT | VAGAL AFFERENT NEURONS | MICE | SECRETION | OB-R | STOMACH | Mitogen-Activated Protein Kinase Kinases - genetics | Receptors, Leptin - genetics | Leptin - metabolism | Sincalide - pharmacology | Male | Neurons - cytology | Phosphatidylinositol 3-Kinases - metabolism | Nodose Ganglion - cytology | Nodose Ganglion - metabolism | Sincalide - metabolism | Potassium Channels - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Receptors, Cholecystokinin - genetics | Time Factors | Janus Kinase 2 - metabolism | Leptin - pharmacology | Neurons - metabolism | Sincalide - genetics | Phosphorylation - drug effects | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Membrane Potentials - drug effects | Satiety Response - drug effects | Gene Silencing | Janus Kinase 2 - genetics | Rats | Leptin - genetics | Rats, Sprague-Dawley | Receptors, Cholecystokinin - metabolism | Potassium Channels - genetics | Phosphatidylinositol 3-Kinases - genetics | Animals | Signal Transduction - drug effects | Proto-Oncogene Proteins pp60(c-src) - genetics | Proto-Oncogene Proteins pp60(c-src) - metabolism | Receptors, Leptin - metabolism | Ion Channel Gating - drug effects | Index Medicus | Potassium Channels | STAT Transcription Factor | Signal Transduction | shRNA | Src | Phosphatidylinositol 3-Kinase | Neurobiology
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 07/2006, Volume 34, Issue 7, pp. 1247 - 1254
Journal Article
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 07/2010, Volume 299, Issue 1, pp. 63 - 69
The intestinal hormone cholecystokinin (CCK) inhibits food intake via stimulation of vagal afferent neurons (VAN). Recent studies suggest that CCK also... 
Melanin-concentrating hormone-1 receptor | Cholecystokinin | Endocannabinoid | Y2 receptor | Nodose ganglion | endocannabinoid | nodose ganglion | PHYSIOLOGY | STIMULATION | RAT | melanin-concentrating hormone-1 receptor | FOOD-INTAKE | GHRELIN | SATIATION | ANANDAMIDE | cholecystokinin | INHIBIT EMESIS | HORMONE | GASTROENTEROLOGY & HEPATOLOGY | Immunohistochemistry | Rats, Wistar | Half-Life | Receptors, Neuropeptide Y - metabolism | Male | Intracellular Signaling Peptides and Proteins - metabolism | Nodose Ganglion - metabolism | Sincalide - metabolism | Arachidonic Acids - metabolism | In Situ Hybridization | Receptor, Cannabinoid, CB1 - agonists | Food Deprivation | Receptors, Somatostatin - metabolism | Endocannabinoids | Pyrazoles - pharmacology | Eating | Orexins | Injections, Intraperitoneal | Morpholines - pharmacology | Rats | Neuropeptides - metabolism | Sincalide - administration & dosage | Polyunsaturated Alkamides - metabolism | Ghrelin - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Phenotype | Animals | Receptor, Cannabinoid, CB1 - genetics | Drug Inverse Agonism | Kinetics | Neurons, Afferent - metabolism | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Neurochemistry | Physiological aspects | Genetic aspects | Research | Gene expression | Identification and classification | Drug receptors | Proteins | Genotype & phenotype | Neurons | Rodents | Physiology | Hormones | Index Medicus | Hormones and Signaling
Journal Article
Experimental Cell Research, ISSN 0014-4827, 04/2018, Volume 365, Issue 1, pp. 138 - 144
Journal Article
Diabetes, ISSN 0012-1797, 04/2012, Volume 61, Issue 4, pp. 897 - 907
Inflammatory process is involved in the pathogenesis of diabetic nephropathy. In this article, we show that cholecystokinin (CCK) is expressed in the kidney... 
CCK-A RECEPTOR | INTERCELLULAR-ADHESION MOLECULE-1 | RAT | ENDOCRINOLOGY & METABOLISM | PULMONARY INTERSTITIAL MACROPHAGES | ANGIOTENSIN-II | MICE | NF-KAPPA-B | EXPRESSION | NEPHROPATHY | MONOCYTE MIGRATION | Tumor Necrosis Factor-alpha - metabolism | Tumor Necrosis Factor-alpha - genetics | Sincalide - pharmacology | Receptor, Cholecystokinin B - metabolism | Male | NF-kappa B - metabolism | Chemokines, CC | Gene Expression Profiling | Cholecystokinin - metabolism | Inflammation - metabolism | Kidney - metabolism | Receptors, Cholecystokinin - genetics | Macrophages - physiology | Sincalide - analogs & derivatives | Diabetes Mellitus - metabolism | Gene Expression Regulation - physiology | Chemotaxis - drug effects | Receptor, Cholecystokinin B - genetics | Receptors, Cholecystokinin - metabolism | Mice, Knockout | Intercellular Adhesion Molecule-1 - metabolism | Animals | Cholecystokinin - genetics | NF-kappa B - genetics | Intercellular Adhesion Molecule-1 - genetics | Mice | Physiological aspects | Cholecystokinin | Research | Diabetic nephropathies | Diabetes mellitus | Inflammation | Macrophages | intercellular adhesion molecule 1 | Chemotaxis | Kidney | Metastases | Cell activation | Allografts | DNA microarrays | Nephropathy | Bone marrow | octapeptides | Tumor necrosis factor- alpha | Index Medicus | Abridged Index Medicus | Complications
Journal Article
Journal Article
Gastroenterology, ISSN 0016-5085, 2009, Volume 137, Issue 4, pp. 1509 - 1517
Journal Article
Environmental Toxicology and Pharmacology, ISSN 1382-6689, 2014, Volume 39, Issue 1, pp. 339 - 346
Journal Article
Journal Article