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European Journal of Pharmacology, ISSN 0014-2999, 2001, Volume 423, Issue 1, pp. 71 - 83
Prucalopride is a novel enterokinetic compound and is the first representative of the benzofuran class. We set out to establish its pharmacological profile in... 
Enterokinetic | Prucalopride | 5-HT 4 receptor | receptor | 5-HT | prucalopride | enterokinetic | LONGITUDINAL MUSCLE | R093877 | CHRONIC CONSTIPATION | STIMULATION | 5-HYDROXYTRYPTAMINE | GASTROINTESTINAL TRANSIT | 5-HT4 receptor | PIG PROXIMAL COLON | CIRCULAR SMOOTH-MUSCLE | PHARMACOLOGY & PHARMACY | HEALTHY-VOLUNTEERS | 5-HT4 RECEPTORS | Esophagus - drug effects | Electric Stimulation | Receptors, Cholecystokinin - antagonists & inhibitors | Gallbladder - drug effects | Humans | Colon - drug effects | Male | Esophagus - physiology | Serotonin Receptor Agonists - pharmacology | Ileum - drug effects | Piperidines - pharmacology | Dioxanes - pharmacology | Granisetron - pharmacology | Rabbits | Guinea Pigs | Rats | Sulfonamides - pharmacology | Indomethacin - pharmacology | Receptors, Gastrointestinal Hormone - antagonists & inhibitors | Muscle Contraction - drug effects | Receptors, Dopamine D4 | Serotonin Receptor Agonists - metabolism | Gallbladder - physiology | Benzofurans - metabolism | Colon - physiology | Rats, Wistar | Sincalide - pharmacology | Benzofurans - pharmacology | Stomach - physiology | Receptors, Dopamine D2 - metabolism | Serotonin - pharmacology | Dose-Response Relationship, Drug | Motilin - analogs & derivatives | Female | Indoles - pharmacology | Stomach - drug effects | CHO Cells | Binding, Competitive | Cell Line | Cricetinae | Vasodilator Agents - pharmacology | Acetylcholine - pharmacology | Receptors, Neuropeptide - antagonists & inhibitors | Motilin - pharmacology | Serotonin Antagonists - pharmacology | Receptors, Serotonin - metabolism | Carbachol - pharmacology | Gastrointestinal Agents - pharmacology | Animals | Dogs | Ileum - physiology | In Vitro Techniques | Gastrointestinal Agents - metabolism
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 03/2009, Volume 108, Issue 5, pp. 1116 - 1125
Acetylcholinesterase inhibitors (AChE‐inhibitors) are used for the treatment of Alzheimer’s disease. Recently, the AChE‐inhibitor donepezil was found to have... 
donepezil | amyloid‐β | glycogen synthase kinase‐3 | nicotinic acetylcholine receptors | neuroprotection | phosphoinositide 3 kinase | Neuroprotection | Amyloid-β | Glycogen synthase kinase-3 | Donepezil | Nicotinic acetylcholine receptors | Phosphoinositide 3 kinase | SURVIVAL | MEDIATED NEUROPROTECTION | ALZHEIMERS-DISEASE | PHOSPHATIDYLINOSITOL 3-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RAT CORTICAL-NEURONS | GLYCOGEN-SYNTHASE KINASE-3 | TAU-PHOSPHORYLATION | NEUROSCIENCES | amyloid-beta | glycogen synthase kinase-3 | EXTRACELLULAR ACETYLCHOLINE | NICOTINIC ACETYLCHOLINE-RECEPTOR | HYDROCHLORIDE E2020 | Apoptosis - drug effects | Embryo, Mammalian | Peptide Fragments - toxicity | Nicotinic Antagonists - pharmacology | Cerebral Cortex - cytology | Sincalide - metabolism | Nicotine - pharmacology | Dose-Response Relationship, Drug | Neuroprotective Agents - pharmacology | Piperidines - pharmacology | Mecamylamine - pharmacology | Neurons - physiology | Indoles | Phosphorylation - drug effects | Chromones - pharmacology | Neurons - drug effects | Nicotinic Agonists - pharmacology | Amyloid beta-Peptides - toxicity | Cell Survival | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Cells, Cultured | Morpholines - pharmacology | Rats | Glycogen Synthase Kinase 3 - metabolism | Rats, Sprague-Dawley | Serine - metabolism | Animals | Analysis of Variance | Cholinesterase Inhibitors - pharmacology | Indans - pharmacology | Index Medicus
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 07/2010, Volume 35, Issue 8, pp. 1693 - 1707
Stress facilitates the development of psychiatric disorders in vulnerable individuals. It affects physiological functions of hippocampal excitatory neurons,... 
Neuroplasticity | GABA | Chronic stress | Cholecystokinin | Parvalbumin | Nitric oxide | SYSTEM | DEPRESSION | nitric oxide | PSYCHIATRY | PERISOMATIC INHIBITION | cholecystokinin | MAGNETIC-RESONANCE SPECTROSCOPY | NEUROSCIENCES | MOOD DISORDERS | parvalbumin | GLUTAMATE | AMINOBUTYRIC-ACID LEVELS | PHARMACOLOGY & PHARMACY | chronic stress | MODULATION | neuroplasticity | CA1 Region, Hippocampal - cytology | Calcium - metabolism | gamma-Aminobutyric Acid - metabolism | Sincalide - pharmacology | Parvalbumins - metabolism | Male | Cholecystokinin - antagonists & inhibitors | Nerve Net - drug effects | Nerve Net - physiology | CA1 Region, Hippocampal - drug effects | Patch-Clamp Techniques - methods | Cholecystokinin - metabolism | Dexamethasone - pharmacology | Time Factors | Pyramidal Cells - physiology | Restraint, Physical - methods | Pyramidal Cells - drug effects | Quinazolinones - pharmacology | Guanosine Diphosphate - pharmacology | CA1 Region, Hippocampal - physiology | Rats | Thionucleotides - pharmacology | Rats, Sprague-Dawley | Stress, Psychological - pathology | Animals | Analysis of Variance | Guanosine Diphosphate - analogs & derivatives | Nerve Net - metabolism | Glucocorticoids - pharmacology | In Vitro Techniques | Nitric Oxide - metabolism | Receptors, Glucocorticoid - physiology | Inhibitory Postsynaptic Potentials - drug effects | Stress, Psychological - etiology | Stress, Psychological - physiopathology | glucocorticoid | nongenomic | Neurophysiology | Mood | Plasticity | Anxiety | Original | Stress Disorders
Journal Article
Gastroenterology, ISSN 0016-5085, 2008, Volume 135, Issue 2, pp. 632 - 641
Journal Article
Gastroenterology, ISSN 0016-5085, 2006, Volume 131, Issue 4, pp. 1122 - 1130
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 02/2007, Volume 557, Issue 2-3, pp. 212 - 220
Journal Article
by Wen, D and Sun, D and Zang, G and Hao, L and Liu, X and Yu, F and Ma, C and Cong, B
Neuroscience, ISSN 0306-4522, 2014, Volume 277, pp. 14 - 25
Journal Article
Planta Medica, ISSN 0032-0943, 2002, Volume 68, Issue 9, pp. 794 - 798
Abstract Platycodin D administered intracerebroventricularly (I. C. V.) showed an antinociceptive effect in a dose-dependent manner as measured by the... 
Original Paper | Campanulaceae | Antinociception | GABA receptor | Glutamate receptor | CCK receptor | Descending pain inhibitory system | Platycodin D | Platycodon grandiflorum | CHOLECYSTOKININ | OPIATE ANALGESIA | CHEMISTRY, MEDICINAL | Plotycodon grandiflorum | ANTAGONIST | antinociception | PERIAQUEDUCTAL GRAY | RAT | platycodin D | BETA-ENDORPHIN | PLANT SCIENCES | glutamate receptor | GLUTAMATE | descending pain inhibitory system | PHARMACOLOGY & PHARMACY | MICE | MORPHINE ANALGESIA | Analgesics - pharmacology | Muscimol - pharmacology | Plant Extracts - chemistry | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Triterpenes - pharmacology | Receptors, Cholecystokinin - antagonists & inhibitors | Plant Extracts - pharmacology | Injections, Intraventricular | Sincalide - pharmacology | Molecular Sequence Data | Male | Methysergide - pharmacology | Saponins - chemistry | Yohimbine - pharmacology | Dose-Response Relationship, Drug | Triterpenes - chemistry | Platycodon | 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology | Tail - drug effects | Baclofen - pharmacology | Carbohydrate Sequence | Injections, Spinal | Sincalide - analogs & derivatives | Pain Measurement - drug effects | Excitatory Amino Acid Antagonists - pharmacology | Serotonin Antagonists - pharmacology | Mice, Inbred ICR | GABA Antagonists - pharmacology | Receptors, Cholecystokinin - drug effects | Animals | Naloxone - pharmacology | Narcotic Antagonists - pharmacology | GABA Agonists - pharmacology | Adrenergic alpha-Agonists - pharmacology | Mice | Adrenergic alpha-2 Receptor Antagonists | Dizocilpine Maleate - pharmacology | Saponins - pharmacology | Physiological aspects | Drug therapy | Pain
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2005, Volume 524, Issue 1, pp. 67 - 74
C-type natriuretic peptide (CNP) is the major natriuretic peptide in the brain and its mRNA has been reported in the central nervous system, which supports... 
Natriuretic peptide receptor A | Natriuretic peptide receptor B | cGMP pathway | Exocrine pancreatic secretion | Central nervous system | c-ANP-(4-23) amide | C-type natriuretic peptide | CYCLASE | GASTRIC-ACID-SECRETION | ATRIAL | CNP | BILE SECRETION | MICROINJECTION | central nervous system | MESSENGER-RNAS | exocrine pancreatic secretion | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | natriuretic peptide receptor B | RECEPTORS | natriuretic peptide receptor A | ANESTHETIZED RATS | Cyclic GMP - pharmacology | Sincalide - pharmacology | Nitric Oxide Synthase - antagonists & inhibitors | Receptors, Atrial Natriuretic Factor - agonists | Peptide Fragments - pharmacology | Ganglionic Blockers - pharmacology | Brain - physiology | Hexamethonium - pharmacology | Drug Interactions | Pancreas - innervation | Cyclic GMP - analogs & derivatives | Time Factors | Vasoactive Intestinal Peptide - pharmacology | Atrial Natriuretic Factor - pharmacology | Natriuretic Peptide, C-Type - pharmacology | Pancreas - secretion | NG-Nitroarginine Methyl Ester - pharmacology | Enzyme Inhibitors - pharmacology | Pancreas - drug effects | Rats | Atropine - pharmacology | Vagus Nerve - surgery | Thionucleotides - pharmacology | Secretin - pharmacology | Parasympatholytics - pharmacology | Rats, Sprague-Dawley | Vagotomy | Receptors, Atrial Natriuretic Factor - physiology | Brain - drug effects | Vagus Nerve - physiology | Animals | Proteins - metabolism | Nitrogen oxide | RNA | Sympathomimetic agents | Neuropeptides | Gastrointestinal hormones | Guanylate cyclase | Natriuretic peptides
Journal Article
Journal Article