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Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 877 - 12
HIV-1 broadly neutralizing antibodies (bNAbs) are being explored as passively administered therapeutic and preventative agents. However, the extensively... 
BISPECIFIC ANTIBODIES | SHIV INFECTION | POTENT NEUTRALIZATION | BROADLY NEUTRALIZING ANTIBODIES | MULTIDISCIPLINARY SCIENCES | IMPROVES PROTECTION | CD4 BINDING | HUMAN MONOCLONAL-ANTIBODIES | HUMAN-IMMUNODEFICIENCY-VIRUS | FITNESS COST | BREADTH | Protein Subunits - immunology | env Gene Products, Human Immunodeficiency Virus - immunology | Antiviral Agents - immunology | Humans | Epitopes - immunology | Antibodies, Neutralizing - immunology | env Gene Products, Human Immunodeficiency Virus - genetics | HIV Antibodies - immunology | Antiviral Agents - chemistry | Antibodies, Neutralizing - therapeutic use | env Gene Products, Human Immunodeficiency Virus - antagonists & inhibitors | Drug Design | Single-Chain Antibodies - therapeutic use | HIV Antibodies - therapeutic use | HIV Antibodies - pharmacology | Antiviral Agents - pharmacology | Single-Chain Antibodies - pharmacology | Antiviral Agents - therapeutic use | HIV-1 - drug effects | Antibodies, Neutralizing - pharmacology | Epitopes - genetics | HIV-1 - genetics | Microscopy, Electron | HIV Antibodies - chemistry | HIV-1 - immunology | Antibodies, Neutralizing - chemistry | HIV Infections - drug therapy | Mutation | Drug Combinations | Single-Chain Antibodies - chemistry | Single-Chain Antibodies - immunology | Antiviral agents | Antibodies | Crosslinking | Glycoproteins | Pharmacology | Epitopes | Chemical compounds | Glycan | CD4 antigen | Human immunodeficiency virus--HIV | Avidity | Binding sites | Neutralization | Index Medicus
Journal Article
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2011, Volume 286, Issue 11, pp. 8961 - 8976
Journal Article
Journal of Immunology, ISSN 0022-1767, 07/2015, Volume 195, Issue 2, pp. 602 - 610
Because of significant viral diversity, vaccines that elicit durable and broad protection against influenza have been elusive. Recent research has focused on... 
STALK ANTIBODIES | INTERVAL | INFLUENZA ANTIBODIES | HUMANS | INDUCTION | DIFFERENTIATION | IMMUNOLOGY | MONOCLONAL-ANTIBODIES | EXPRESSION | VIRUSES | Influenza Vaccines - administration & dosage | Humans | Vaccination | Vaccines, Inactivated | Molecular Sequence Data | Antigens, Viral - genetics | Vaccines, DNA | Hemagglutinin Glycoproteins, Influenza Virus - immunology | Antibodies, Viral - blood | Hemagglutinin Glycoproteins, Influenza Virus - genetics | Epitopes - immunology | Genetic Loci - immunology | Single-Chain Antibodies - genetics | B-Lymphocytes - virology | Influenza, Human - virology | Antibodies, Viral - biosynthesis | Amino Acid Sequence | Hemagglutinin Glycoproteins, Influenza Virus - chemistry | B-Lymphocytes - cytology | Recombinant Proteins - chemistry | Antigens, Viral - chemistry | Influenza, Human - blood | Recombinant Proteins - genetics | Epitopes - genetics | Antigens, Viral - immunology | B-Lymphocytes - immunology | Influenza Vaccines - immunology | Influenza Vaccines - genetics | Recombinant Proteins - immunology | Antibodies, Neutralizing - biosynthesis | Influenza A Virus, H5N1 Subtype - immunology | Influenza A Virus, H5N1 Subtype - chemistry | Immunologic Memory | Epitopes - chemistry | Influenza, Human - prevention & control | Antibodies, Neutralizing - blood | Single-Chain Antibodies - chemistry | Single-Chain Antibodies - immunology | Influenza, Human - immunology | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2016, Volume 113, Issue 4, pp. E459 - E468
Chimeric antigen receptor T (CAR-T) cell therapy has produced impressive results in clinical trials for B-cell malignancies. However, safety concerns related... 
Autologous cell therapy | Chimeric antigen receptor T cell | Antibody engineering | Leukemia | Cancer | ANTIBODIES | leukemia | DESIGN | RECOGNITION | MULTIDISCIPLINARY SCIENCES | chimeric antigen receptor T cell | CHIMERIC ANTIGEN RECEPTOR | antibody engineering | ADVERSE EVENT | IN-VITRO | autologous cell therapy | cancer | ADOPTIVE IMMUNOTHERAPY | SAFETY SWITCH | LYMPHOCYTES | Recombinant Fusion Proteins - immunology | T-Lymphocyte Subsets - immunology | Dose-Response Relationship, Immunologic | Phenylalanine - analogs & derivatives | Protein Engineering - methods | Humans | Basic-Leucine Zipper Transcription Factors - immunology | Sialic Acid Binding Ig-like Lectin 2 - immunology | Structure-Activity Relationship | Leukemia, B-Cell - therapy | Lymphopenia - etiology | Single-Chain Antibodies - genetics | Female | Lymphopenia - prevention & control | Receptors, Antigen, T-Cell - immunology | B-Lymphocytes - pathology | Genes, Reporter | Antigens, CD19 - immunology | Immunotherapy, Adoptive - adverse effects | Saccharomyces cerevisiae Proteins - immunology | Immunotherapy, Adoptive - methods | Antigens, Neoplasm - immunology | Lymphocyte Activation | Mice, Inbred C57BL | Cytokines - secretion | Mice, SCID | T-Lymphocyte Subsets - transplantation | Xenograft Model Antitumor Assays | Azides | Animals | B-Lymphocytes - immunology | Cell Line, Tumor | T-Cell Antigen Receptor Specificity | Mice, Inbred NOD | Mice | Receptors, Antigen, T-Cell - genetics | Genetic Vectors | Single-Chain Antibodies - immunology | Cytotoxicity, Immunologic | Cell interaction | Cellular therapy | B cells | T cells | Observations | Health aspects | Methods | Clinical trials | Antigens | T cell receptors | Cytokines | Tumors | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2016, Volume 113, Issue 11, pp. 3006 - 3011
Overexpression of TNF contributes to pathogenesis of multiple autoimmune diseases, accounting for a remarkable success of anti- TNF therapy. TNF is produced by... 
Autoimmunity | Bispecific antibody | Humanized mice | TNF | Anti-cytokine therapy | RHEUMATOID-ARTHRITIS | MYCOBACTERIUM-TUBERCULOSIS | CROHNS-DISEASE | CONTROLLED MULTICENTER | MULTIDISCIPLINARY SCIENCES | humanized mice | ULCERATIVE-COLITIS | ANKYLOSING-SPONDYLITIS | SINGLE-DOMAIN ANTIBODIES | FACTOR-ALPHA | TUMOR-NECROSIS-FACTOR | autoimmunity | bispecific antibody | anti-cytokine therapy | PLAQUE-TYPE PSORIASIS | Recombinant Fusion Proteins - immunology | Antibody Specificity | Complementarity Determining Regions - genetics | Humans | L Cells (Cell Line) | Antibodies, Bispecific - genetics | Antigen-Antibody Reactions | Camelus - immunology | Antibodies, Neutralizing - immunology | Single-Chain Antibodies - genetics | Complementarity Determining Regions - chemistry | Chemical and Drug Induced Liver Injury - etiology | Chemical and Drug Induced Liver Injury - prevention & control | Tumor Necrosis Factor-alpha - secretion | Genes, Synthetic | Macrophages, Peritoneal - immunology | Antibodies, Neutralizing - genetics | Random Allocation | Macrophages, Peritoneal - secretion | Antibodies, Bispecific - immunology | Chemical and Drug Induced Liver Injury - immunology | Animals | Chemical and Drug Induced Liver Injury - therapy | Complementarity Determining Regions - immunology | Recombinant Fusion Proteins - genetics | Antigens, Differentiation - genetics | Mice | Mutation | Antigens, Surface - immunology | Galactosamine - toxicity | Single-Chain Antibodies - immunology | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Amino Acid Substitution | Antigens, Differentiation - immunology | Care and treatment | Tumor necrosis factor | Genetic aspects | Gene expression | Observations | Autoimmune diseases | Health aspects | Molecules | Cytokines | Pathogenesis | Rodents | Cells | Binding sites | Index Medicus | Biological Sciences
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 501, Issue 7465, pp. 102 - 106
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 07/2012, Volume 209, Issue 7, pp. 1273 - 1287
Journal Article