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sinomenine (359) 359
index medicus (164) 164
animals (143) 143
pharmacology & pharmacy (136) 136
morphinans - pharmacology (98) 98
rats (90) 90
mice (84) 84
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expression (68) 68
activation (67) 67
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sinomenine hydrochloride (56) 56
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immunology (43) 43
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pharmacokinetics (41) 41
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rats, sprague-dawley (36) 36
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cells (32) 32
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alkaloid sinomenine (29) 29
medicine, research & experimental (27) 27
nf-kappa-b (27) 27
chemistry, multidisciplinary (26) 26
dose-response relationship, drug (25) 25
cells, cultured (24) 24
morphinans - pharmacokinetics (24) 24
oncology (24) 24
sinomenium - chemistry (23) 23
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plant sciences (22) 22
health aspects (21) 21
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arthritis, rheumatoid - drug therapy (20) 20
chemistry, analytical (20) 20
pharmacology (20) 20
acutum (19) 19
disease models, animal (19) 19
rats, wistar (19) 19
anti-inflammatory agents - pharmacology (18) 18
cancer (18) 18
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chromatography, high pressure liquid (17) 17
collagen-induced arthritis (17) 17
integrative & complementary medicine (17) 17
neurosciences (17) 17
rheumatoid factor (17) 17
signal transduction - drug effects (17) 17
sinomenium acutum (17) 17
anti-inflammatory agents, non-steroidal - pharmacology (16) 16
chemistry (16) 16
proteins (16) 16
rodents (16) 16
cell proliferation - drug effects (15) 15
medicine, botanic (15) 15
medicine, herbal (15) 15
mice, inbred balb c (15) 15
mice, inbred c57bl (15) 15
molecular structure (15) 15
research (15) 15
cell line, tumor (14) 14
cell survival - drug effects (14) 14
flow cytometry (14) 14
mechanisms (14) 14
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paeoniflorin (14) 14
apoptosis - drug effects (13) 13
cell biology (13) 13
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arthritis, experimental - drug therapy (12) 12
bioavailability (12) 12
biochemistry, general (12) 12
biomedicine (12) 12
gene expression (12) 12
morphine (12) 12
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osteoarthritis (12) 12
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International Immunopharmacology, ISSN 1567-5769, 03/2020, Volume 80, p. 106201
•Illustrated the potential underlying mechanisms by constructing a network of sinomenine and rheumatoid arthritis target interactions.•16 key targets, which... 
Sinomenine | Network pharmacology | Enrichment analysis | Rheumatoid arthritis
Journal Article
Chinese Journal of New Drugs, ISSN 1003-3734, 09/2018, Volume 27, Issue 18, pp. 2159 - 2163
Journal Article
Anti-Cancer Drugs, ISSN 0959-4973, 11/2019, Volume 30, Issue 10, pp. 983 - 990
Sinomenine (SIN) has been reported its antitumor effects on various types of human cancers, but there is no available information regarding the antitumor... 
APOPTOSIS | ACTIVATION | gastric cancer | sinomenine | AKT | 5-FLUOROURACIL | PI3K | PHARMACOKINETICS | ONCOLOGY | PHARMACOLOGY & PHARMACY | Wnt signaling pathways | cisplatin | CARCINOMA | Flow cytometry | Usage | Research | Diagnosis | Stomach cancer | Cancer cells | Preclinical Reports | Wnt signaling pathways, sinomenine
Journal Article
by Yi, L and Luo, JF and Xie, BB and Liu, JX and Wang, JY and Liu, L and Wang, PX and Zhou, H and Dong, Y
SHOCK, ISSN 1073-2322, 08/2015, Volume 44, Issue 2, pp. 188 - 195
Sinomenine (SIN), an alkaloid derived from the plant Sinomenium acutum, has anti-inflammatory and analgesic effects and has been used for rheumatoid arthritis... 
VAGUS NERVE | SURGERY | CELLS | ACTIVATION | anti-inflammation | ALKALOID SINOMENINE | ARTHRITIS | interleukin-6 | tumor necrosis factor-alpha | REGULATOR | alpha 7 nicotinic acetylcholine receptor | macrophages | NF-kappa B | THERAPY | Sinomenine | PERIPHERAL VASCULAR DISEASE | MICE | HEMATOLOGY | NF-KAPPA-B | EXPRESSION | CRITICAL CARE MEDICINE
Journal Article
International Immunopharmacology, ISSN 1567-5769, 03/2018, Volume 56, pp. 65 - 70
Fibroblast like synoviocyte (FLS) is a crucial in the pathogenesis of rheumatoid arthritis (RA), and involved in inflammation and joint destruction. Sinomenine... 
Sinomenine | α7nAChR | Fibroblast-like synoviocyte | Proliferation | ERK
Journal Article
Journal of Veterinary Pharmacology and Therapeutics, ISSN 0140-7783, 11/2019, Volume 42, Issue 6, pp. 732 - 737
The aim of the research was to investigate the anti‐endotoxin and anti‐inflammatory effects of Sinomenine, an agent commonly found in Chinese herbal medicines.... 
Inflammation | LBP | sinomenine | LPS | Mac‐1 | L‐selectin
Journal Article
International Immunopharmacology, ISSN 1567-5769, 12/2019, p. 106025
Journal Article
Chinese Journal of Integrative Medicine, ISSN 1672-0415, 2019
Journal Article
Journal of Pharmaceutical and Biomedical Analysis, ISSN 0731-7085, 10/2018, Volume 160, pp. 330 - 335
•A qHNMR method for quantitation of dicentrine and sinomenine was developed.•DMSO-d6 enabled satisfactory separation of the signals to be integrated.•Dimethyl... 
Sinomenine | Dicentrine | Stephania epigeae | Determination | Quantitative 1H NMR | Quantitative | H NMR
Journal Article
Journal of integrative medicine, ISSN 2095-4964, 01/2020
Premature and ill neonates undergo painful but medically necessary procedures while hospitalized. Although opiate drugs are administered as analgesics,... 
Journal Article
AAPS PharmSciTech, ISSN 1530-9932, 2/2018, Volume 19, Issue 2, pp. 858 - 865
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 11/2019, Volume 519, Issue 3, pp. 481 - 488
Ischemic stroke is a major cause of death and disability worldwide. Hyperneuroinflammation significantly contributes to ischemic stroke. Bromodomain-containing... 
Inflammation | Pyroptosis | Ischemic stroke | JQ1 | BRD4 | PATHWAYS | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | NLRP3 INFLAMMASOME | STROKE | SINOMENINE | BIOPHYSICS | NEUROINFLAMMATION | MICROGLIA | CASPASES | NF-KAPPA-B | EXPRESSION
Journal Article
Data in Brief, ISSN 2352-3409, 12/2019, Volume 27, p. 104633
This paper contains data that can be used in interpretation of the pharmacological effects of sinomenine combined with gabapentin or ligustrazine hydrochloride... 
Sinomenine | Drug combination | Adverse effects | Ligustrazine hydrochloride | Pharmacokinetics
Journal Article
Pharmacological Research, ISSN 1043-6618, 04/2019, Volume 142, pp. 140 - 150
[Display omitted] Sinomenine (SIN) is an anti-inflammatory and antiarthritic alkaloid derived from Sinomenium acutum, and the product Zhengqing Fengtongning... 
Sinomenine | Osteoclast | Breast cancer | NFATc1 | CXCR1 | IL-8 | Sinomenine (CID:5459308) | Lipopolysaccharides (PubCID: 1347) | Zoledronic acid (CID:68740) | IL-8 (CID: 44357137) | INTERLEUKIN-8 LEVELS | METASTASIS | RESORPTION | DENOSUMAB | RANKL-INDUCED OSTEOCLASTOGENESIS | OPEN-LABEL | ZOLEDRONIC ACID | IN-VITRO | PHARMACOLOGY & PHARMACY | DIFFERENTIATION | INDUCED BONE LOSS | Interleukin-8 - genetics | Humans | Receptors, Interleukin-8A - genetics | Osteolysis - etiology | Mammary Neoplasms, Experimental - metabolism | Mammary Neoplasms, Experimental - genetics | Osteolysis - drug therapy | Female | Interleukin-8 - metabolism | Osteoclasts - physiology | Mammary Neoplasms, Experimental - complications | Morphinans - pharmacology | Mammary Neoplasms, Experimental - drug therapy | Morphinans - therapeutic use | Osteolysis - genetics | NFATC Transcription Factors - metabolism | Osteogenesis - drug effects | Proto-Oncogene Proteins c-fos - metabolism | Osteolysis - metabolism | Animals | Signal Transduction - drug effects | Receptors, Interleukin-8A - metabolism | Cell Line, Tumor | Proto-Oncogene Proteins c-fos - genetics | RAW 264.7 Cells | Mice | Mice, Inbred BALB C | Osteoclasts - drug effects | NFATC Transcription Factors - genetics | Medical research | Rheumatoid factor | Phosphatases | Interleukins | RNA | Medicine, Experimental | Bones | Arthritis | Drug discovery | T cells | Density
Journal Article
Zhongguo Zhongyao Zazhi, ISSN 1001-5302, 06/2018, Volume 43, Issue 12, pp. 2522 - 2530
Journal Article
NEUROSCIENCE LETTERS, ISSN 0304-3940, 04/2019, Volume 699, pp. 103 - 108
Sinomenine, an alkaloid originally isolated from the roots and the rhizome of Sinomenium acutum is used as a traditional Chinese herbal medicines for... 
Spinal ERK phosphorylation | ACTIVATION | RODENTS | MORPHINE | ARTHRITIS | NEUROSCIENCES | INHIBITION | Aninociception | PHARMACOLOGY | Sinomenine | mu-opioid receptor | INFLAMMATORY PAIN | ANALGESIC TOLERANCE | ERK PHOSPHORYLATION | CONTRIBUTES | Formalin test
Journal Article
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