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Atherosclerosis, ISSN 0021-9150, 2016, Volume 255, pp. 156 - 163
Abstract Background and aims Chinese dragon's blood has been used to treat blood stasis for thousands of years. Its total phenolic extract (Longxuetongluo... 
Cardiovascular | Endothelial dysfunction | Chinese dragon's blood | Longxuetongluo capsule | Anti-atherosclerosis | CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | KINASE | LOW-DENSITY-LIPOPROTEIN | OXIDIZED LDL | INSULIN-RESISTANCE | MONOCYTE ADHESION | VASCULAR INFLAMMATION | PERIPHERAL VASCULAR DISEASE | NF-KAPPA-B | UP-REGULATION | EXPRESSION | Apolipoproteins E - deficiency | Human Umbilical Vein Endothelial Cells - metabolism | Atherosclerosis - genetics | Coculture Techniques | Drugs, Chinese Herbal - pharmacology | Endothelium, Vascular - drug effects | Male | NF-kappa B - metabolism | Aortic Diseases - metabolism | Dose-Response Relationship, Drug | Sinus of Valsalva - metabolism | Time Factors | Diet, High-Fat | Aortic Diseases - prevention & control | Nitric Oxide Synthase Type III - metabolism | Sinus of Valsalva - pathology | Aortic Diseases - pathology | Disease Models, Animal | Atherosclerosis - pathology | Genetic Predisposition to Disease | Human Umbilical Vein Endothelial Cells - drug effects | Lipoproteins, LDL - pharmacology | Cell Adhesion - drug effects | Plaque, Atherosclerotic | Atherosclerosis - metabolism | Disease Progression | Mice, Knockout | Aortic Diseases - genetics | Phenotype | Animals | Signal Transduction - drug effects | Sinus of Valsalva - drug effects | Endothelium, Vascular - metabolism | Apolipoproteins E - genetics | Cell Line, Tumor | Endothelium, Vascular - pathology | Nitric Oxide - metabolism | Atherosclerosis - prevention & control | Cell Line, Transformed | Mitogen-Activated Protein Kinases - metabolism | Index Medicus
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 08/2016, Volume 311, Issue 2, pp. E335 - E345
It has been argued whether insulin accelerates or prevents atherosclerosis. Although results from in vitro studies have been conflicting, recent in vivo mice... 
Apolipoprotein E-null mice | Nitric oxide synthase | Insulin | Atherosclerosis | atherosclerosis | PHYSIOLOGY | insulin | ATTENUATES ATHEROSCLEROSIS | apolipoprotein E-null mice | ACCELERATES ATHEROSCLEROSIS | HEART-DISEASE | E-KNOCKOUT MICE | ENDOTHELIAL-CELLS | ENDOCRINOLOGY & METABOLISM | CARDIOVASCULAR-DISEASE | SMOOTH-MUSCLE-CELLS | nitric oxide synthase | E-DEFICIENT MICE | NEOINTIMAL GROWTH | CORONARY-ARTERY-DISEASE | Phosphoproteins - drug effects | Actins - metabolism | Nitric Oxide Synthase - drug effects | Actins - drug effects | Male | Aorta - metabolism | Phosphoproteins - metabolism | Necrosis | Sinus of Valsalva - metabolism | Collagen - drug effects | Nitric Oxide Synthase Type III - metabolism | Sinus of Valsalva - pathology | Plaque, Atherosclerotic - pathology | NG-Nitroarginine Methyl Ester - pharmacology | Insulin - pharmacology | Macrophages - pathology | Plaque, Atherosclerotic - metabolism | Aorta - drug effects | Enzyme Inhibitors - pharmacology | Hypoglycemic Agents - pharmacology | Mice, Knockout | Aorta - pathology | Collagen - metabolism | Animals | Sinus of Valsalva - drug effects | Apolipoproteins E - genetics | Nitric Oxide Synthase Type I - metabolism | Macrophages - drug effects | Mice | Nitric Oxide Synthase - metabolism | Nitric Oxide Synthase Type I - drug effects | Nitric Oxide Synthase Type III - drug effects | Physiological aspects | Atherosclerotic plaque | Nitric oxide | Enzymes | Apolipoproteins | Rodents | Cholesterol | Index Medicus
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 01/2018, Volume 38, Issue 1, pp. 26 - 39
Objective Rosuvastatin has been widely used in the primary and secondary prevention of coronary heart disease. However, its antiatherosclerotic properties have... 
atherosclerosis | coronary artery disease | foam cells | cholesterol | macrophages | SR-BI | MYOCARDIAL-INFARCTION | SUBTILISIN/KEXIN TYPE 9 | DEEP-VEIN THROMBOSIS | OXIDIZED LDL | CARDIAC DYSFUNCTION | SCAVENGER RECEPTOR | DENSITY-LIPOPROTEIN | MONOCLONAL AUTOANTIBODIES | APOE-DEFICIENT MICE | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | Atherosclerosis - genetics | Cholesterol - blood | Aortic Diseases - metabolism | Foam Cells - drug effects | Coronary Vessels - metabolism | Sinus of Valsalva - metabolism | Liver - drug effects | Coronary Artery Disease - pathology | Aortic Diseases - prevention & control | Lipoproteins, LDL - metabolism | Sinus of Valsalva - pathology | Foam Cells - pathology | Foam Cells - metabolism | Aortic Diseases - pathology | Disease Models, Animal | Atherosclerosis - pathology | Coronary Vessels - drug effects | Coronary Vessels - pathology | Scavenger Receptors, Class B - deficiency | Coronary Artery Disease - metabolism | Liver - metabolism | Rosuvastatin Calcium - pharmacology | Cells, Cultured | Coronary Artery Disease - prevention & control | Receptors, LDL - metabolism | Scavenger Receptors, Class B - genetics | Biomarkers - blood | Mice, Knockout, ApoE | Proprotein Convertase 9 - metabolism | Plaque, Atherosclerotic | Atherosclerosis - metabolism | Aortic Diseases - genetics | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Sinus of Valsalva - drug effects | Coronary Artery Disease - genetics | Atherosclerosis - prevention & control | Index Medicus | 10007 | 10035 | 10012 | 10034 | 10014 | Basic Sciences
Journal Article
Circulation, ISSN 0009-7322, 11/2002, Volume 106, Issue 22, pp. 2827 - 2835
Background-Previous studies suggested that blockade of RAGE in diabetic apolipoprotein (apo) E-null mice suppressed early acceleration of atherosclerosis. A... 
Inflammation | Muscle, smooth | Diabetes mellitus | Atherosclerosis | atherosclerosis | COLLAGEN CONTENT | CARDIAC & CARDIOVASCULAR SYSTEMS | muscle, smooth | MACROPHAGES | RECEPTOR | diabetes mellitus | MATRIX METALLOPROTEINASE ACTIVITY | CORONARY HEART-DISEASE | LESIONS | N-EPSILON-(CARBOXYMETHYL)LYSINE | inflammation | PERIPHERAL VASCULAR DISEASE | TISSUE FACTOR | GLYCATION END-PRODUCTS | Apolipoproteins E - deficiency | Arteriosclerosis - drug therapy | Streptozocin | Cell Count | Vasculitis - pathology | Male | Phagocytes - pathology | Receptors, Immunologic - antagonists & inhibitors | Vasculitis - complications | Diabetes Mellitus, Experimental - chemically induced | Diabetes Mellitus, Experimental - complications | Sinus of Valsalva - pathology | Receptor for Advanced Glycation End Products | Disease Models, Animal | Injections, Intraperitoneal | Myocardium - pathology | Treatment Outcome | Arteriosclerosis - complications | Cell Division - drug effects | Disease Progression | Mice, Knockout | Cell Movement - drug effects | Leukocytes, Mononuclear - pathology | Muscle, Smooth, Vascular - pathology | Animals | Sinus of Valsalva - drug effects | Apolipoproteins E - genetics | Vasculitis - drug therapy | Mice | Receptors, Immunologic - administration & dosage | Arteriosclerosis - pathology | Index Medicus | Abridged Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, pp. e92095 - e92095
Background: The lipid milleu exacerbates the inflammatory response in atherosclerosis but its effect on T cell mediated immune response has not been fully... 
ATHEROSCLEROTIC LESIONS | RESPONSES | INCREASES COLLAGEN CONTENT | LOW-DENSITY LIPOPROTEINS | HYPERCHOLESTEROLEMIA LEADS | DIET | RABBIT ATHEROMA | MULTIDISCIPLINARY SCIENCES | PROLIFERATION | MICE | PLAQUE STABILIZATION | Apolipoproteins E - deficiency | Membrane Microdomains - metabolism | Cholesterol - blood | Humans | Male | Apolipoproteins E - metabolism | Sinus of Valsalva - metabolism | Dietary Fats - pharmacology | T-Lymphocytes - drug effects | Interleukin-10 - metabolism | ZAP-70 Protein-Tyrosine Kinase - metabolism | Phosphorylation - drug effects | Sinus of Valsalva - pathology | Plaque, Atherosclerotic - pathology | Enzyme-Linked Immunosorbent Assay | Cell Separation | Mice, Inbred C57BL | Cholesterol - metabolism | Blotting, Western | Esterification | Animals | Sinus of Valsalva - drug effects | T-Lymphocytes - cytology | Lymphocyte Activation - drug effects | Membrane Microdomains - drug effects | Culture Media - pharmacology | T-Lymphocytes - immunology | Cell Proliferation - drug effects | T cells | Apolipoproteins | Cholesterol | Atherosclerosis | Anticholesteremic agents | Euthanasia | Cell proliferation | Heart | CD8 antigen | Physicians | Rafts | Inflammatory response | Lipids | Cardiovascular disease | Lipid rafts | Lymphocytes T | T-cell receptor | Signal transduction | Atherogenic diet | Lymphocytes | Apolipoprotein E | Peripheral blood mononuclear cells | Bioindicators | Cardiology | Age | Plaques | Spleen | Immune response | Secretion | Interleukin 12 | T cell receptors | Inflammation | CD4 antigen | Immune systems | Studies | Signaling | Diet | Arteriosclerosis | Interleukin 10 | Biomarkers | Low density lipoprotein receptors | Laboratory animals | Index Medicus
Journal Article
Circulation, ISSN 0009-7322, 11/2002, Volume 106, Issue 22, pp. 2767 - 2770
Background-Dysregulation of adipocyte-derived bioactive molecules plays an important role in the development of atherosclerosis., We previously reported that... 
Proteins | Plasma | Remodeling | Atherosclerosis | atherosclerosis | remodeling | CARDIAC & CARDIOVASCULAR SYSTEMS | HYPERCHOLESTEROLEMIA | LESIONS | OBESITY | proteins | ADIPOSE-SPECIFIC PROTEIN | PERIPHERAL VASCULAR DISEASE | PLASMA-PROTEIN | plasma | HEMATOLOGY | EXPRESSION | Immunohistochemistry | Tumor Necrosis Factor-alpha - metabolism | Genetic Therapy | Scavenger Receptors, Class B | CD36 Antigens - genetics | Scavenger Receptors, Class A | Apolipoproteins E - deficiency | Genetic Vectors - administration & dosage | Tumor Necrosis Factor-alpha - genetics | RNA, Messenger - analysis | Male | Arteriosclerosis - genetics | RNA, Messenger - metabolism | Adiponectin | CD36 Antigens - metabolism | Vascular Cell Adhesion Molecule-1 - genetics | Sinus of Valsalva - pathology | Foam Cells - pathology | Foam Cells - metabolism | Disease Models, Animal | Macrophages - pathology | Intercellular Signaling Peptides and Proteins | Reverse Transcriptase Polymerase Chain Reaction | Disease Progression | Genetic Vectors - genetics | Mice, Knockout | Membrane Proteins | Proteins - genetics | Arteriosclerosis - prevention & control | Muscle, Smooth, Vascular - pathology | Animals | Proteins - metabolism | Receptors, Scavenger | Apolipoproteins E - blood | Sinus of Valsalva - drug effects | Apolipoproteins E - genetics | Receptors, Lipoprotein | Mice | Proteins - pharmacology | Receptors, Immunologic - genetics | Vascular Cell Adhesion Molecule-1 - metabolism | Arteriosclerosis - pathology | Receptors, Immunologic - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2015, Volume 10, Issue 5, pp. e0125126 - e0125126
There is strong epidemiological association between periodontal disease and cardiovascular disease but underlying mechanisms remain ill-defined. Because the... 
MICROGLIAL ACTIVATION | STERILE INFLAMMATION | LIPOPOLYSACCHARIDE PREPARATION | FOAM CELL-FORMATION | SCAVENGER RECEPTOR CD36 | MULTIDISCIPLINARY SCIENCES | NLRP3 INFLAMMASOME ACTIVATION | TOLL-LIKE RECEPTORS | OXIDIZED PHOSPHOLIPIDS | LESION DEVELOPMENT | PERIODONTAL-DISEASE | Inflammasomes - metabolism | Apoptosis - drug effects | NLR Family, Pyrin Domain-Containing 3 Protein | Body Weight - drug effects | Male | NF-kappa B - metabolism | Porphyromonas gingivalis - physiology | Bacteroidaceae Infections - blood | CD36 Antigens - metabolism | Interleukin-1beta - metabolism | Interleukin-6 - blood | Receptors, LDL - deficiency | Female | Atherosclerosis - microbiology | Bacteroidaceae Infections - metabolism | Sinus of Valsalva - pathology | Foam Cells - metabolism | Bacteroidaceae Infections - pathology | Disease Models, Animal | Bacteroidaceae Infections - complications | Sinus of Valsalva - microbiology | Antibodies, Monoclonal - pharmacology | Mice, Inbred C57BL | Risk Factors | Lipoproteins, LDL - pharmacology | Receptors, LDL - metabolism | Atherosclerosis - complications | Feeding Behavior | Toll-Like Receptor 2 - metabolism | Atherosclerosis - blood | Animals | Carrier Proteins - metabolism | Sinus of Valsalva - drug effects | Lipopolysaccharides - pharmacology | Interferon-gamma - blood | Porphyromonas gingivalis - drug effects | Bacteria, Pathogenic | Atherosclerosis | Causes of | Physiological aspects | Toll-like receptors | Genetic aspects | Research | Lipoproteins (low density) | Lipids | Cardiovascular disease | Infections | Arthritis | Lethality | Drug development | Macrophages | Epidemiology | Lipopolysaccharides | Proteins | Receptors | Pathways | Older people | Rodents | Interleukin 1 | Bacteria | Lipoprotein (low density) receptors | Inhibition | Cell survival | Cytokines | Inflammation | CD36 antigen | Immune systems | Medicine | Oral cavity | Periodontal disease | Ostomy | Arteriosclerosis | TLR2 protein | Receptor density | Ligands | Mice | Cardiovascular diseases | Laboratory animals | Index Medicus
Journal Article
Journal Article
International Journal of Molecular Medicine, ISSN 1107-3756, 10/2016, Volume 38, Issue 4, pp. 1101 - 1110
Humulus japonicus (HJ) is used as a traditional medicine in Korea owing to its multiple properties including anti-mycobacterial, antioxidant and... 
apolipoprotein E-deficient mice | atherosclerosis | cytokines | Humulus japonicus | inflammation | Inflammation | Apolipoprotein E-deficient mice | Cytokines | Atherosclerosis | ATHEROSCLEROTIC LESIONS | MEDICINE, RESEARCH & EXPERIMENTAL | LOW-DENSITY-LIPOPROTEIN | GAMMA-INDUCING FACTOR | INDUCED INFLAMMATORY RESPONSES | ADHESION MOLECULE | DISEASE | NITRIC-OXIDE | P-SELECTIN | NF-KAPPA-B | EXPRESSION | Inflammation - pathology | Apolipoproteins E - deficiency | Dinoprostone - biosynthesis | Plant Extracts - pharmacology | Atherosclerosis - genetics | Nitrites - metabolism | Male | RNA, Messenger - metabolism | Apolipoproteins E - metabolism | Inflammation Mediators - metabolism | Monocytes - pathology | Phytotherapy | Sinus of Valsalva - pathology | Humulus - chemistry | Atherosclerosis - pathology | Atherosclerosis - drug therapy | Cytokines - metabolism | Macrophages - pathology | RNA, Messenger - genetics | Atherosclerosis - blood | Gene Expression Regulation - drug effects | Monocytes - drug effects | Animals | Sinus of Valsalva - drug effects | Inflammation - genetics | Macrophages - drug effects | RAW 264.7 Cells | Mice | Plant Extracts - therapeutic use | Prevention | Usage | Messenger RNA | Hamamelidae | Genetic aspects | Gene expression | Properties | Health aspects | Materia medica, Vegetable | Plant extracts | Cardiovascular disease | Tumor necrosis factor-TNF | Nitric oxide | Rodents | Cell adhesion & migration | Index Medicus
Journal Article