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silent information regulator proteins, saccharomyces cerevisiae - genetics (99) 99
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histones - metabolism (67) 67
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amino acid sequence (64) 64
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physiological aspects (58) 58
gene (57) 57
silent information regulator proteins, saccharomyces cerevisiae (57) 57
analysis (55) 55
deacetylase (55) 55
mutation (55) 55
sirtuin 2 - metabolism (55) 55
heterochromatin (54) 54
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enzymes (51) 51
transcription, genetic (51) 51
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multidisciplinary sciences (46) 46
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Circulation Research, ISSN 0009-7330, 11/2004, Volume 95, Issue 10, pp. 971 - 980
Yeast silent information regulator 2 (Sir2), a nicotinamide adenine dinucleotide–dependent histone deacetylase (HDAC) and founding member of the HDAC class III... 
Cardiac hypertrophy | Histone deacetylase | Sir2 | Apoptosis | p53 | TRANSCRIPTION FACTORS | CARDIAC & CARDIOVASCULAR SYSTEMS | PROTEIN | P300 | HEART-FAILURE | apoptosis | DEATH | histone deacetylase | ACETYLTRANSFERASE ACTIVITY | HYPERTROPHY | NITRIC-OXIDE | PERIPHERAL VASCULAR DISEASE | cardiac hypertrophy | HEMATOLOGY
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2006, Volume 281, Issue 28, pp. 19369 - 19377
In this study we have shown that the histone variant H(2)A.z is up-regulated during cardiac hypertrophy. Upon its knockdown with RNA interference, hypertrophy... 
RNA-POLYMERASE-II | UBIQUITINATION | SIR2 | EARLY MAMMALIAN DEVELOPMENT | ACTIVATION | RAS | DEACETYLASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HETEROCHROMATIN | VARIANT H2A.Z | CELL-SURVIVAL
Journal Article
Journal of Neuropathology and Experimental Neurology, ISSN 0022-3069, 01/2009, Volume 68, Issue 1, pp. 48 - 58
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 03/2007, Volume 27, Issue 10, pp. 2606 - 2616
Journal Article
Biochemical Journal, ISSN 0264-6021, 11/2007, Volume 407, Issue 3, pp. 451 - 460
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2006, Volume 397, Issue 3, pp. 519 - 527
Resveratrol mimics calorie restriction to extend lifespan of Caenorhabditis elegans, yeast and Drosophila, possibly through activation of Sir2 (silent... 
Insulin receptor substrate (IRS) | Insulin signalling pathway | p85 | Lifespan | SirT1 histone deacetylase | Resveratrol | LIFE-SPAN | lifespan | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | PROTEIN DEACETYLASES | RECEPTOR | SACCHAROMYCES-CEREVISIAE | SNELL DWARF MOUSE | SIR2 | insulin receptor substrate (IRS) | LONGEVITY | insulin signalling pathway | SIGNALING PATHWAY | resveratrol | CALORIE RESTRICTION | Fatty Acid Synthases - metabolism | Insulin - physiology | Humans | Depression, Chemical | Phosphatidylinositol 3-Kinases - metabolism | Hepatocytes - metabolism | Stilbenes - pharmacology | Phosphoproteins - metabolism | Protein Subunits - metabolism | RNA Interference | Sirtuin 1 | Insulin Receptor Substrate Proteins | Sirtuins - genetics | Hepatocytes - drug effects | Signal Transduction | Cells, Cultured | Sirtuins - physiology | Rats | Glucokinase - metabolism | Glucose-6-Phosphatase - metabolism | Sirtuins - biosynthesis | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Histone Deacetylase Inhibitors | GRB2 Adaptor Protein - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Index Medicus | EGFR, EGF receptor | RNAi, RNA interference | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | HEK-293 cell, human embryonic kidney cell | PEPCK, phosphoenolpyruvate carboxykinase | ERK, extracellular-signal-regulated kinase | DMEM, Dulbecco's modified Eagle's medium | GK, glucokinase | Sir2, silent information regulator 2 | IGFBP-1, IGF-binding protein 1 | IGF-1, insulin-like growth factor type I | NGF, neuronal growth factor | FAS, fatty acid synthase | MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide | Grb2, growth factor receptor-bound protein 2 | ApoE, apolipoprotein E | IRS-1, insulin receptor substrate 1 | MAPK, mitogen-activated protein kinase
Journal Article
FEBS Letters, ISSN 0014-5793, 2007, Volume 581, Issue 5, pp. 1071 - 1078
Journal Article
FEBS Letters, ISSN 0014-5793, 11/2011, Volume 585, Issue 21, pp. 3360 - 3366
► CKII inhibition induced acetylation of p53 at K382 in HCT116 and HEK293 cells. ► This acetylation was suppressed by SIRT1 activation. ► CKII interacted with... 
Senescence | Tumor suppression | p53 Acetylation | SIRT1 | Protein kinase CKII | ribofuranosylbenzimidazole | phosphate-buffered saline | senescent-associated β-galactosidase | phenylmethylsulfonyl fluoride | SA-β-gal | Sir2 | silent information regulator 2 | NADPH oxidase | CKII | reactive oxygen species | sodium dodecyl sulfate | MBP | protein kinase CKII (also known as casein kinase II) | PBS | SDS | siRNA | small-interfering RNA | 5,6-dichloro-1-β | histone deacetylase | DRB | PMSF | NOX | ROS | maltose binding protein | HDAC | CANCER-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CK2 | P16(INK4A) | CELL BIOLOGY | PREMATURE SENESCENCE | BIOPHYSICS | ONCOGENIC RAS | HUMAN FIBROBLASTS | INHIBITORS | TUMORIGENESIS | Sirtuin 1 - metabolism | Cellular Senescence - genetics | RNA, Small Interfering - genetics | HCT116 Cells | Humans | Tumor Suppressor Protein p53 - metabolism | Cellular Senescence - drug effects | Casein Kinase II - genetics | Sirtuin 1 - antagonists & inhibitors | Down-Regulation - genetics | Protein Subunits - metabolism | Acetylation - drug effects | Phosphorylation - genetics | RNA Interference | Protein Stability - drug effects | Casein Kinase II - deficiency | HEK293 Cells | Histone Deacetylase Inhibitors - pharmacology | Lysine - metabolism | Tumor Suppressor Protein p53 - chemistry | Phosphorylation - drug effects | Casein Kinase II - metabolism | Index Medicus
Journal Article
RNA Biology, ISSN 1547-6286, 11/2014, Volume 11, Issue 11, pp. 1347 - 1354
Overexpression of SIRT1 is frequently observed in various types of cancers, suggesting its potential role in malignancies. However, the molecular basis of how... 
DNA methylation | cancer | MicroRNA | SIRT1 | epigenetics | Epigenetics | Cancer | SURVIVAL | DEACETYLASE | E2F transcription factor 1 | myogenic differentiation 1 | nonsense mediated mRNA decay factor (C | p53 | SMG6 | forkhead box O | primary miRNA | 3UTR | liver X receptor | FOXO | MyoD | BIOCHEMISTRY & MOLECULAR BIOLOGY | HIC1 | CGIs | protein 53 | hypermethylated in cancer 1 | ovarian cancer-associated gene 1 protein | LXR | NF-B | peroxisome proliferative activated receptor | PARP | OVCA2 | p53-upregulated modulator of apoptosis | OVCA1 | nicotinamide adenine dinucleotide | Sir2 | GENES | E2F1 | PGC-1 | cerevisiae | 5-Aza-dC | pri-miRNA | elegans | Silent information regulator 2 | CpG islands | MOUSE | coactivator 1 alpha | poly(ADP-ribose) polymerase-1 | NAD | sirtuin (silent mating type information regulation 2 homolog) 1 (S | smg-6 homolog | nuclear factor kappa-B | 3 untranslated region | ovarian cancer-associated gene 2 protein | PUMA | EXPRESSION | TUMORIGENESIS | gamma | 5-aza-2'-deoxycytidine | Neoplasms - metabolism | Sirtuin 1 - metabolism | Apoptosis - drug effects | Humans | Gene Expression Regulation, Neoplastic | 3' Untranslated Regions - genetics | Apoptosis - genetics | Gene Expression Profiling | Sirtuin 1 - genetics | Tumor Suppressor Protein p53 - genetics | DNA Methylation | Neoplasms - genetics | RNA Interference | Tumor Suppressor Protein p53 - metabolism | Etoposide - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Animals | Cell Line, Tumor | CpG Islands - genetics | Mice | MicroRNAs - genetics | HeLa Cells | Antineoplastic Agents, Phytogenic - pharmacology | Neoplasms - pathology | Index Medicus
Journal Article