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Biochemical journal, ISSN 0264-6021, 2000, Volume 351, Issue 1, pp. 95 - 105
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 09/2011, Volume 301, Issue 3, pp. C559 - C565
Deliu E, Tica AA, Motoc D, Brailoiu GC, Brailoiu E. Intracellular angiotensin II activates rat myometrium. Am J Physiol Cell Physiol 301: C559-C565, 2011.... 
Calcium imaging | Microinjection | Cytosolic calcium concentration | Endoplasmic reticulum | CYCLIC ADP-RIBOSE | PHYSIOLOGY | ANG-II | LIVER LYSOSOMES | RECEPTOR | microinjection | METABOLIC-CLEARANCE | BLOOD-PRESSURE | UTERINE | CELL BIOLOGY | SIGNAL-TRANSDUCTION | RENAL ENDOSOMES | SMOOTH-MUSCLE-CELLS | calcium imaging | cytosolic calcium concentration | endoplasmic reticulum | Myometrium - drug effects | Type C Phospholipases - metabolism | Brefeldin A - pharmacology | Angiotensin II Type 1 Receptor Blockers - pharmacology | Autophagy - drug effects | Endosomes - metabolism | Angiotensin II Type 2 Receptor Blockers - pharmacology | Macrocyclic Compounds - pharmacology | Saralasin - pharmacology | Endoplasmic Reticulum - drug effects | Estrenes - pharmacology | Myometrium - metabolism | Inositol 1,4,5-Trisphosphate Receptors - antagonists & inhibitors | Ryanodine - pharmacology | Angiotensin II - pharmacology | Pyridines - administration & dosage | Endocytosis - drug effects | Enzyme Inhibitors - pharmacology | Losartan - pharmacology | Saralasin - administration & dosage | Rats | Imidazoles - pharmacology | Piperazines - pharmacology | Rats, Sprague-Dawley | Receptor, Angiotensin, Type 2 - metabolism | Signal Transduction - drug effects | Calcium Signaling - drug effects | Models, Biological | Receptor, Angiotensin, Type 1 - metabolism | Oxazoles - pharmacology | Losartan - administration & dosage | Angiotensin II - administration & dosage | Calcium Signaling - physiology | Endoplasmic Reticulum - metabolism | Imidazoles - administration & dosage | Type C Phospholipases - antagonists & inhibitors | Lysosomes - metabolism | Inositol 1,4,5-Trisphosphate Receptors - metabolism | Pyrrolidinones - pharmacology | Macrolides - pharmacology | NADP - analogs & derivatives | Female | NADP - metabolism | Heparin - pharmacology | Angiotensin II - metabolism | Arsenicals - pharmacology | Cells, Cultured | Sirolimus - pharmacology | Myometrium - cytology | Animals | Egtazic Acid - pharmacology | Uterus - cytology | Signal Transduction - physiology | Pyridines - pharmacology | Carbolines - pharmacology | Myometrium | Cell receptors | Calcium channels | Genetic aspects | Properties | Angiotensin | Receptors and Signal Transduction
Journal Article
Journal Article
by Zhou, S and Liu, L and Li, H and Eilers, G and Kuang, Y and Shi, S and Yan, Z and Li, X and Corson, J M and Meng, F and Zhou, H and Sheng, Q and Fletcher, J A and Ou, W-B
British journal of cancer, ISSN 1532-1827, 2014, Volume 110, Issue 10, pp. 2479 - 2488
Background: Mesothelioma is a notoriously chemotherapy-resistant neoplasm, as is evident in the dismal overall survival for patients with those of... 
ACTIVATION | GROWTH-FACTOR-RECEPTOR | FACTOR SCATTER FACTOR | MALIGNANT PLEURAL MESOTHELIOMA | PHASE-II | tyrosine kinases | ANTITUMOR-ACTIVITY | MET RECEPTOR | PI3K/AKT/MDM2 | PI3K/AKT/mTOR | INHIBITION | ONCOLOGY | C-MET | mesothelioma | Mesothelioma - pathology | Nitriles - pharmacology | Humans | Neoplasm Proteins - physiology | Receptor Protein-Tyrosine Kinases - physiology | Neoplasm Proteins - antagonists & inhibitors | Molecular Targeted Therapy | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Quinolines - pharmacology | MAP Kinase Signaling System | TOR Serine-Threonine Kinases - antagonists & inhibitors | raf Kinases - physiology | RNA Interference | TOR Serine-Threonine Kinases - physiology | Antineoplastic Agents - pharmacology | Chromones - pharmacology | Everolimus | Butadienes - pharmacology | Sirolimus - analogs & derivatives | RNA, Small Interfering - pharmacology | Morpholines - pharmacology | Imidazoles - pharmacology | Enzyme Activation - drug effects | Sulfonamides - pharmacology | Sirolimus - pharmacology | Indazoles - pharmacology | Signal Transduction - drug effects | Mesothelioma - enzymology | Cell Line, Tumor | Phosphatidylinositol 3-Kinases - physiology | Protein Kinase Inhibitors - pharmacology | Cell Cycle - drug effects | Drug Screening Assays, Antitumor | Translational Therapeutics | PI3K | mTOR | MDM2 | AKT
Journal Article
Nature (London), ISSN 1476-4687, 2013, Volume 497, Issue 7448, pp. 217 - 223
The mammalian target of rapamycin (mTOR), a phosphoinositide 3-kinase-related protein kinase, controls cell growth in response to nutrients and growth factors... 
MAMMALIAN TARGET | RAPAMYCIN | RAPTOR | BINDING PARTNER | RAG GTPASES | RHEB | PATHWAY | TOR | MULTIDISCIPLINARY SCIENCES | CELL-GROWTH | P70 S6 KINASE | Adaptor Proteins, Signal Transducing - chemistry | Catalytic Domain - drug effects | TOR Serine-Threonine Kinases - metabolism | Pyridines - chemistry | Furans - pharmacology | Humans | Crystallography, X-Ray | Structure-Activity Relationship | Pyrimidines - chemistry | TOR Serine-Threonine Kinases - antagonists & inhibitors | Indoles - metabolism | Furans - chemistry | Adenosine Triphosphate - metabolism | Indoles - pharmacology | Tacrolimus Binding Protein 1A - pharmacology | Naphthyridines - chemistry | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Purines - metabolism | Purines - pharmacology | MTOR Associated Protein, LST8 Homolog | Tacrolimus Binding Protein 1A - chemistry | Models, Molecular | Magnesium - metabolism | Pyrimidines - pharmacology | Sirolimus - metabolism | Sirolimus - pharmacology | Magnesium - chemistry | Purines - chemistry | TOR Serine-Threonine Kinases - chemistry | Tacrolimus Binding Protein 1A - metabolism | Pyridines - pharmacology | Sirolimus - chemistry | Adaptor Proteins, Signal Transducing - metabolism | Adenosine Triphosphate - chemistry | Indoles - chemistry | Naphthyridines - pharmacology | Naphthyridines - metabolism | Protein Structure, Tertiary - drug effects | Proteins | Enzymes | Kinases | Crystal structure
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 02/2009, Volume 296, Issue 2, pp. 470 - 479
Bacterial endotoxin lipopolysaccharide (LPS) is responsible for the multiorgan dysfunction that characterizes septic shock and is causal in the myocardial... 
Green fluorescent protein- Microtubule-associated protein light chain 3 | Lipopolysaccharide | Oxidative stress | Hl-1 cardiac myocyte | TRANSCRIPTIONAL ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | HL-1 cardiac myocyte | CARDIAC MYOCYTES | ENDOTOXIN | MYOCARDIAL DEPRESSION | CELL-DEATH | IN-VITRO | SCAVENGER RECEPTOR | green fluorescent protein-microtubule-associated protein light chain 3 | PERIPHERAL VASCULAR DISEASE | TNF-ALPHA | lipopolysaccharide | EXPRESSION | oxidative stress | Tumor Necrosis Factor-alpha - metabolism | Mitochondria, Heart - metabolism | Glutathione - metabolism | Mitochondria, Heart - pathology | Nitric Oxide Synthase - antagonists & inhibitors | omega-N-Methylarginine - pharmacology | Mitochondria, Heart - drug effects | Nitroprusside - pharmacology | Autophagy - drug effects | p38 Mitogen-Activated Protein Kinases - metabolism | Nitric Oxide Donors - pharmacology | Cytoprotection | Animals, Newborn | Cells, Cultured | Enzyme Inhibitors - pharmacology | Rats | Mice, Transgenic | Imidazoles - pharmacology | Tyrphostins - pharmacology | Antioxidants - pharmacology | Sirolimus - pharmacology | Hydrogen Peroxide - metabolism | Myocytes, Cardiac - pathology | Animals | Myocytes, Cardiac - drug effects | Signal Transduction - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Acetylcysteine - pharmacology | Lipopolysaccharides - pharmacology | Myocytes, Cardiac - metabolism | Mice | Nitric Oxide Synthase - metabolism | Pyridines - pharmacology | Oxidative Stress - drug effects | Nitric Oxide - metabolism | Index Medicus
Journal Article
International journal of molecular sciences, ISSN 1422-0067, 2017, Volume 18, Issue 9, p. 1959
Journal Article
Journal Article
Circulation research, ISSN 1524-4571, 2004, Volume 94, Issue 7, pp. 960 - 966
ABSTRACT—Glycogen synthase kinase (GSK) inhibition produced by ischemic preconditioning has been previously shown to be regulated through... 
Phosphatidylinositol-3 kinase | Reperfusion | Glycogen synthase kinase | Target of rapamycin | Opioids | LOCALIZATION | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PROTECTION | PHOSPHORYLATION | phosphatidylinositol-3 kinase | PHOSPHATIDYLINOSITOL 3-KINASE | CELL-SURVIVAL | KINASE-3-BETA | INSULIN | P70S6 KINASE | INDUCED DELAYED CARDIOPROTECTION | glycogen synthase kinase | PERIPHERAL VASCULAR DISEASE | target of rapamycin | HEMATOLOGY | reperfusion | opioids | Glycogen Synthase Kinase 3 - physiology | Maleimides - pharmacology | Receptors, Retinoic Acid - physiology | Glycogen Synthase Kinase 3 beta | Male | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Receptors, Thyroid Hormone - antagonists & inhibitors | Aminophenols - pharmacology | Cardiotonic Agents - therapeutic use | Myocardial Infarction - pathology | Indoles - pharmacology | Benzamides - pharmacology | Chromones - pharmacology | Nuclear Receptor Subfamily 1, Group F, Member 3 | Morphine - pharmacology | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Morpholines - pharmacology | Rats | Receptors, Retinoic Acid - antagonists & inhibitors | Cardiotonic Agents - pharmacology | Myocardial Infarction - metabolism | Receptors, Opioid, delta - drug effects | Piperazines - pharmacology | Rats, Sprague-Dawley | Receptors, Thyroid Hormone - physiology | Sirolimus - pharmacology | Animals | Androstadienes - pharmacology | Signal Transduction - drug effects | Narcotic Antagonists - pharmacology | Phosphatidylinositol 3-Kinases - physiology | Premedication
Journal Article
Cancer Letters, ISSN 0304-3835, 2012, Volume 320, Issue 1, pp. 104 - 110
Abstract Molecularly targeted therapies have emerged as the leading theme in cancer therapeutics. Multi-cytotoxic drug regimens have been highly successful,... 
Hematology, Oncology and Palliative Medicine | Combination index | Dasatinib | Molecular targeted therapy | Rapamycin | ACTIVATION | SRC | BCR-ABL | TUMOR | MECHANISMS | SIMULATION | CHEMOTHERAPY | ONCOLOGY | RESISTANCE | SYSTEMS | KINASES | Niacinamide - analogs & derivatives | Paclitaxel - pharmacology | Nitriles - pharmacology | Humans | Epothilones - pharmacology | Thiazoles - administration & dosage | Chromones - administration & dosage | Phenylurea Compounds | Benzenesulfonates - administration & dosage | Tamoxifen - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | Nitriles - administration & dosage | Benzenesulfonates - pharmacology | Female | Chromones - pharmacology | Paclitaxel - administration & dosage | Butadienes - pharmacology | Pyridines - administration & dosage | Pyrimidines - administration & dosage | Morpholines - administration & dosage | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Pyrimidines - pharmacology | Breast Neoplasms - drug therapy | Sirolimus - pharmacology | Drug Synergism | Sirolimus - administration & dosage | Signal Transduction - drug effects | Butadienes - administration & dosage | Epothilones - administration & dosage | Tamoxifen - pharmacology | Cell Line, Tumor | Pyridines - pharmacology | Thiazoles - pharmacology | Care and treatment | Oncology, Experimental | Genes | Breast cancer | Research | Tamoxifen | Cancer | Index Medicus
Journal Article