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11/2013
SIRT1 has emerged as a critical regulator of glucose homeostasis and metabolism in the past decade. Glucose homeostasis is tightly regulated by insulin... 
0719 | Diabetes | SIRT1
Dissertation
The Journal of Physiology, ISSN 0022-3751, 01/2019, Volume 597, Issue 2, pp. 369 - 370
Journal Article
Environmental Toxicology, ISSN 1520-4081, 04/2019, Volume 34, Issue 4, pp. 539 - 547
The mechanism of manganism caused by manganese (Mn), an important environmental risk factor for Parkinson's disease, is still unclear. Recent evidence... 
autophagy | MicroRNA-138-5p | manganese | SIRT1
Journal Article
Journal of Cell Science, ISSN 0021-9533, 02/2017, Volume 130, Issue 4, pp. e1.2 - e1.2
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 05/2019, Volume 234, Issue 5, pp. 7560 - 7568
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 07/2019, Volume 116, Issue 27, pp. 13173 - 13173
Journal Article
Clinical Science, ISSN 0143-5221, 02/2013, Volume 124, Issue 3, pp. 153 - 164
Sirtuins are members of the Sir2 (silent information regulator 2) family, a group of class III deacetylases. Mammals have seven different sirtuins,... 
SIRT1 (sirtuin 1) | Aging | Diabetic nephropathy | Sirtuin | MEDICINE, RESEARCH & EXPERIMENTAL | HYPOXIA-INDUCIBLE FACTOR | LIFE-SPAN | LIPID-METABOLISM | B-DEPENDENT TRANSCRIPTION | SIRT1 DEACETYLASE | CELL-SURVIVAL | SIRT1(sirtuin 1) | sirtuin | STRESS-RESPONSIVE DEACETYLASE | GENE-EXPRESSION | aging | CHRONIC KIDNEY-DISEASE | diabetic nephropathy | CALORIE RESTRICTION | Sirtuin 1 - metabolism | Animals | Sirtuin 3 - metabolism | Caloric Restriction | Diabetic Nephropathies - metabolism | Humans | Sirtuins - metabolism | Aging - metabolism | Kidney Diseases - metabolism | Atg, autophagy-related gene | Idh2, isocitrate dehydrogenase 2 | WFR, Wistar fatty diabetic rat | adenovirus E1V 19-kDa interacting protein 3 | PGC-1α, PPAR-γ co-activator-1α | LC3, light chain 3 | PTP1B, protein tyrosine phosphatase 1B | TNF-α, tumour necrosis factor α | ICAM-1, intercellular adhesion molecule 1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | CKD, chronic kidney disease | RAS, renin–angiotensin system | FOXO, forkhead box O | H3K9, histone H3 Lys9 | eNOS, endothelial NO synthase | PER2, Period 2 | PPAR, peroxisome-proliferator-activated receptor | HIF, hypoxia-inducible factor | UUO, unilateral ureteral obstruction | Mn-SOD, manganese superoxide dismutase | Bnip3, BCL2 | LXR, liver X receptor | CRP, C-reactive protein | AGE, advanced glycation end-product | PARP, poly(ADP-ribose) polymerase | IRS, insulin receptor substrate | CR, calorie restriction | AMPK, AMP-activated protein kinase | Review | VCAM-1, vascular cell adhesion protein 1 | SREBP, sterol-regulatory-element-binding protein | BMAL1, brain and muscle ARNT (aryl hydrocarbon receptor nuclear translocator)-like 1 | TGF, transforming growth factor | ROS, reactive oxygen species | AT1R, angiotensin type 1 receptor | SIRT1 etc., sirtuin 1 etc., SNP, single nucleotide polymorphism | H3K9me3, H3K9 trimethylation | COX2, cyclo-oxygenase 2 | FXR, farnesoid X receptor | PKC, protein kinase C | α-ENaC, epithelial Na+ channel α-subunit | Sir2, silent information regulator 2 | NF-κB, nuclear factor-κB | AngII, angiotensin II | ER, endoplasmic reticulum | MCP-1, monocyte chemotactic protein-1
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 10/2018, Volume 72, Issue 16, pp. C70 - C71
Journal Article
Cellular & molecular biology letters, ISSN 1425-8153, 2019, Volume 24, Issue 1, pp. 36 - 10
Common environmental pollutants and drugs encountered in everyday life can cause toxic damage to the body through oxidative stress, inflammatory stimulation,... 
SIRT1 activator | Toxicant | Signaling pathway | SIRT1
Journal Article
BBA - Proteins and Proteomics, ISSN 1570-9639, 2010, Volume 1804, Issue 8, pp. 1676 - 1683
Mammals possess an intricate regulatory system for controlling flux through fuel utilization pathways in response to the dietary availability of particular... 
GCN5 | PGC-1α | Sirt1 | Acetylation
Journal Article
BBA - Molecular Cell Research, ISSN 0167-4889, 08/2019, Volume 1866, Issue 8, pp. 1272 - 1281
Diabetic nephropathy (DN) is the leading cause of end stage renal disease, posing a severe threat to public health. Previous studies reported the protective... 
Oxidative stress | Diabetic nephropathy | NRF2 | SIRT1 | P53
Journal Article
Progress in Neuropsychopharmacology & Biological Psychiatry, ISSN 0278-5846, 12/2019, Volume 95, p. 109673
Depressive symptoms are commonly seen in schizophrenia. Increasing evidence implicates that both SIRT1 and BDNF closely related to the development of... 
Schizophrenia | Depression | Cognition | BDNF | SIRT1
Journal Article
Journal of Inherited Metabolic Disease, ISSN 0141-8955, 12/2018, Volume 41, Issue 6, pp. 997 - 1006
Glycogen storage disease type Ia (GSD‐Ia) deficient in glucose‐6‐phosphatase‐α (G6Pase‐α) is a metabolic disorder characterized by impaired glucose homeostasis... 
Glucose‐6‐phosphatase‐α | Mitochondria | Liver homeostasis | SIRT1/ PGC‐1α signaling | SIRT1/ PGC-1α signaling | Glucose-6-phosphatase-α | Phosphorylation | Glycogen | DNA damage | Liver | Homeostasis | Mitochondrial DNA | Adenoma | SIRT1 protein | Autophagy | NAD | Electron transport chain | Oxidative phosphorylation | Glucose-6-phosphatase | Phagocytosis | Metabolic disorders
Journal Article