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The Journal of biological chemistry, ISSN 1083-351X, 2012, Volume 287, Issue 31, pp. 25758 - 25769
...(+) activation of deacetylase sirtuin 1 (SirT1). Here, we tested whether NAD(+) sensing by sirtuins couples metabolic polarity with the acute inflammatory response... 
MACROPHAGE-MEDIATED INFLAMMATION | HOMEOSTASIS | T-CELL MEMORY | METABOLISM | ADIPONECTIN | INSULIN-RESISTANCE | IMMUNOSUPPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOTOXIN TOLERANCE | SEPSIS | DIFFERENTIATION | Sirtuin 1 - metabolism | Humans | Monocyte-Macrophage Precursor Cells - immunology | Glucose Transporter Type 1 - metabolism | Monocyte-Macrophage Precursor Cells - metabolism | Leukocytes - immunology | Heat-Shock Proteins - genetics | Monocyte-Macrophage Precursor Cells - physiology | Nicotinamide Phosphoribosyltransferase - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Sepsis - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | NAD - biosynthesis | Fatty Acids - metabolism | Cell Line | Sepsis - immunology | Cytokines - metabolism | Oxidation-Reduction | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Heat-Shock Proteins - metabolism | Mice, Inbred C57BL | Transcription Factors - genetics | Toll-Like Receptor 4 - metabolism | Transcription Factors - metabolism | Carrier Proteins - genetics | Adaptation, Physiological - immunology | Animals | Carrier Proteins - metabolism | Energy Metabolism | Lipopolysaccharides - pharmacology | Glucose - metabolism | Glycolysis | Mice | Leukocytes - metabolism | Sirtuins - metabolism | NAD | Sirtuins | Immunology | Acute Inflammation | Bioenergetics | PGC-1 | Sepsis | HIF-1α | Biosensors | Macrophages | Metabolism
Journal Article
Journal Article
Journal of Hypertension, ISSN 0263-6352, 05/2018, Volume 36, Issue 5, pp. 1164 - 1177
Journal Article
Cell metabolism, ISSN 1550-4131, 2012, Volume 15, Issue 5, pp. 665 - 674
Nonalcoholic fatty liver disease (NAFLD) is associated with increased cardiovascular and liver-related mortality. NAFLD is characterized by both triglyceride... 
RAT-LIVER | RISK-FACTORS | MACROPHAGE APOPTOSIS | PROTEIN-KINASE | ENDOCRINOLOGY & METABOLISM | HMG-COA REDUCTASE | STEATOHEPATITIS | 3-HYDROXY-3-METHYLGLUTARYL COENZYME | PREVALENCE | MICRORNA EXPRESSION | MODULATION | CELL BIOLOGY | Sirtuin 1 - metabolism | Up-Regulation | Cholesterol - blood | Humans | Middle Aged | Sterol Esterase - metabolism | Male | MicroRNAs - metabolism | Desmosterol - metabolism | Cardiovascular Diseases - genetics | Cholesterol - genetics | Sirtuin 1 - genetics | Case-Control Studies | Phosphorylation - genetics | Hydroxymethylglutaryl CoA Reductases - metabolism | Adenylate Kinase - metabolism | Non-alcoholic Fatty Liver Disease | Sterol O-Acyltransferase - metabolism | Adult | Female | Lipid Metabolism - genetics | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Fatty Liver - genetics | Receptors, LDL - genetics | Gene Expression | Fatty Liver - metabolism | Cardiovascular Diseases - metabolism | Fatty Liver - blood | Liver - metabolism | Receptors, LDL - metabolism | Cholesterol - metabolism | Cholesterol, LDL - genetics | Phenotype | Sterol Esterase - genetics | Desmosterol - blood | Cholesterol, LDL - metabolism | MicroRNAs - genetics | Sterol O-Acyltransferase - genetics | Adenylate Kinase - genetics | Hydroxymethylglutaryl CoA Reductases - genetics | Enzymes | Liver diseases | Low density lipoproteins | Genes | Esters | Triglycerides | Cholesterol | MicroRNA | Fatty liver | Blood cholesterol | Physiological aspects | Hydrolases | Blood lipids | Health aspects | Statins | atherosclerosis | Nonalcoholic steatohepatitis | cholesterol | Nonalcoholic fatty liver disease | fatty liver | lipogenesis | hypercholesterolemia | HMG CoA reductase
Journal Article
Diabetes (New York, N.Y.), ISSN 1939-327X, 2016, Volume 65, Issue 3, pp. 610 - 618
...) inflammasome controls the activation of caspase-1, and the release of proinflammatory cytokines interleukin (IL)-1 and IL-18... 
ACTIVATION | ADIPOCYTES | METABOLISM | ADIPONECTIN | CERAMIDE CONTENT | ENDOCRINOLOGY & METABOLISM | SENSITIVITY | NLRP3 INFLAMMASOME | HEPATIC STEATOSIS | EXPRESSION | INDUCED INSULIN-RESISTANCE | Fatty Acid Synthase, Type I - genetics | Sirtuin 1 - metabolism | Glucose Transporter Type 4 - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Obesity - immunology | Humans | Leptin - metabolism | Caspase 1 - metabolism | Male | Gene Expression Profiling | Interleukin-1beta - genetics | PPAR gamma - metabolism | Sirtuin 1 - genetics | Acetyl-CoA Carboxylase - genetics | Subcutaneous Fat - immunology | Subcutaneous Fat - metabolism | Lipogenesis - genetics | Interleukin-1beta - metabolism | Adiponectin - genetics | Adiponectin - metabolism | Female | Adipogenesis - genetics | Child | Lipoprotein Lipase - metabolism | Carrier Proteins - immunology | Macrophages - immunology | Sterol Regulatory Element Binding Protein 1 - metabolism | PPAR gamma - genetics | Glucose Transporter Type 4 - genetics | Inflammasomes | Lipoprotein Lipase - genetics | Down-Regulation | Insulin Resistance | Toll-Like Receptor 4 - genetics | Intra-Abdominal Fat - metabolism | Fatty Acid Synthase, Type I - metabolism | Subcutaneous Fat - pathology | Toll-Like Receptor 4 - metabolism | Abdomen | Obesity - metabolism | Carrier Proteins - genetics | Magnetic Resonance Imaging | Sterol Regulatory Element Binding Protein 1 - genetics | Caspase 1 - genetics | Adolescent | Intra-Abdominal Fat - pathology | Acetyl-CoA Carboxylase - metabolism | Adipose tissues | Overweight persons | Care and treatment | Inflammation | Research | Health aspects | Metabolism
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2011, Volume 286, Issue 8, pp. 6049 - 6060
.... The mammalian sirtuin homolog SIRT1 is a protein deacetylase playing a role in glucose metabolism and islet function... 
OXIDATIVE STRESS | ACTIVATED PROTEIN-KINASE | METABOLISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | UNCOUPLING PROTEIN-2 | SIRTUINS | SACCHAROMYCES-CEREVISIAE | SIRT1 | INCREASED DOSAGE | CALORIE RESTRICTION | Sirtuin 1 - metabolism | Glucose Transporter Type 2 - genetics | Homeodomain Proteins - metabolism | Humans | Mitochondrial Proteins - genetics | Stilbenes - pharmacology | Oxygen Consumption - physiology | Sirtuin 1 - genetics | Glucose Transporter Type 2 - metabolism | DNA-Binding Proteins - metabolism | Insulin-Secreting Cells - metabolism | Mitochondria - genetics | Mitochondrial Proteins - metabolism | Up-Regulation - physiology | Resveratrol | Trans-Activators - genetics | Insulin-Secreting Cells - cytology | Insulin - genetics | Insulin Secretion | High Mobility Group Proteins - metabolism | Hepatocyte Nuclear Factor 1 - metabolism | Enzyme Inhibitors - pharmacology | Rats | Glucokinase - genetics | Glucose - pharmacology | Mitochondria - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Glucokinase - metabolism | Sirtuin 1 - antagonists & inhibitors | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Up-Regulation - drug effects | Insulin - metabolism | Animals | Oxygen Consumption - drug effects | Hepatocyte Nuclear Factor 1 - genetics | Cell Line, Tumor | Glucose - metabolism | Trans-Activators - metabolism | Carbazoles - pharmacology | High Mobility Group Proteins - genetics | Pancreatic Islet | Sirtuins | Glucose Metabolism | Metabolism | SIRT
Journal Article
Antioxidants & redox signaling, ISSN 1557-7716, 2013, Volume 19, Issue 13, pp. 1507 - 1521
Journal Article
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 07/2016, Volume 1861, Issue 7, pp. 584 - 593
...) in the adult offspring. However, the underlying mechanisms are unclear. Since the endogenous molecular clock can regulate hepatic lipid metabolism, we investigated whether... 
Development | Aging | Fatty liver | High fat | Circadian | Maternal diet | DE-NOVO | REV-ERB | NUCLEAR RECEPTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | LIPOTOXICITY | NONALCOHOLIC FATTY LIVER | DEACETYLASE SIRT3 | BIOPHYSICS | CIRCADIAN-CLOCK | METABOLISM | DISEASE | MICE | Sirtuin 1 - metabolism | Liver - pathology | Sirtuin 3 - metabolism | Diet, High-Fat - adverse effects | Non-alcoholic Fatty Liver Disease - etiology | CLOCK Proteins - genetics | Sirtuin 1 - genetics | Nuclear Receptor Subfamily 1, Group F, Member 1 - metabolism | CLOCK Proteins - metabolism | Female | Lipid Metabolism - genetics | Nuclear Receptor Subfamily 1, Group D, Member 1 - metabolism | Repressor Proteins - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | Disease Models, Animal | Sirtuin 3 - genetics | Nuclear Receptor Subfamily 1, Group D, Member 1 - genetics | Non-alcoholic Fatty Liver Disease - genetics | Oxidation-Reduction | Signal Transduction | Liver - metabolism | Mice, Inbred C57BL | Circadian Rhythm - genetics | Gene Expression Regulation | Repressor Proteins - genetics | Non-alcoholic Fatty Liver Disease - metabolism | Photoperiod | Receptors, Cytoplasmic and Nuclear - genetics | Non-alcoholic Fatty Liver Disease - physiopathology | Prenatal Exposure Delayed Effects - physiopathology | Prenatal Exposure Delayed Effects - metabolism | Pregnancy | Prenatal Exposure Delayed Effects - genetics | Animals | Sterol Regulatory Element Binding Protein 1 - genetics | Mice | Nuclear Receptor Subfamily 1, Group F, Member 1 - genetics | Receptors, Cytoplasmic and Nuclear - metabolism | Gene expression | Physiological aspects | Genetic transcription | DNA binding proteins | Genes | Liver
Journal Article
Nature (London), ISSN 1476-4687, 2014, Volume 508, Issue 7495, pp. 258 - 262
In obesity and type 2 diabetes, Glut4 glucose transporter expression is decreased selectively in adipocytes(1... 
METABOLISM | MULTIDISCIPLINARY SCIENCES | MOUSE | LIVER | RESISTANCE | MICE | CDNA CLONING | EXPRESSION | SIRT1 | CANCER | ADIPOSE-TISSUE | Sirtuin 1 - metabolism | Acetyltransferases - metabolism | Adipocytes - secretion | Ornithine Decarboxylase - metabolism | Liver - enzymology | Glucose Transporter Type 4 - metabolism | Adipose Tissue, White - metabolism | Male | Diabetes Mellitus, Type 2 - metabolism | Nicotinamide N-Methyltransferase - metabolism | Glucose Intolerance | Glucose Transporter Type 4 - deficiency | Obesity - genetics | Thinness - metabolism | Gene Knockdown Techniques | Adipose Tissue - metabolism | Nicotinamide N-Methyltransferase - deficiency | Obesity - etiology | NAD - metabolism | Spermine - analogs & derivatives | Nicotinamide N-Methyltransferase - genetics | Thinness - enzymology | Glucose Transporter Type 4 - genetics | Niacinamide - metabolism | Mice, Inbred C57BL | Diabetes Mellitus, Type 2 - enzymology | Insulin Resistance | Oxidoreductases Acting on CH-NH Group Donors - metabolism | Fatty Liver | Animals | Diet | Energy Metabolism | Adipocytes - metabolism | Obesity - prevention & control | Spermine - metabolism | Adipose Tissue, White - enzymology | Adipose Tissue - enzymology | Mice | Obesity - enzymology | S-Adenosylmethionine - metabolism | Adipose tissues | Type 2 diabetes | Obesity | Care and treatment | Analysis | Transferases | Physiological aspects | Genetic aspects | Research | Gene expression | Enzymes | Body fat | Adipocytes | Polyamines | Variance analysis | Proteins | Weight control | Metabolites | Rodents | Insulin resistance | Diabetes | Mass spectrometry | Food
Journal Article