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index medicus (1772) 1772
humans (1182) 1182
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sirtuin 1 - metabolism (809) 809
mice (692) 692
sirt1 (585) 585
sirtuin 1 - genetics (511) 511
male (483) 483
hormones, hormone substitutes, and hormone antagonists (477) 477
cell biology (473) 473
biochemistry & molecular biology (472) 472
sirtuin 1 - antagonists & inhibitors (407) 407
apoptosis (372) 372
sirtuins (366) 366
resveratrol (352) 352
oxidative stress (346) 346
acetylation (335) 335
sirtuins - metabolism (321) 321
proteins (298) 298
signal transduction (286) 286
article (285) 285
calorie restriction (279) 279
expression (275) 275
metabolism (275) 275
rats (264) 264
cell line, tumor (263) 263
sirtuins - antagonists & inhibitors (262) 262
endocrine system diseases (257) 257
sirtuin 1 (257) 257
stilbenes - pharmacology (257) 257
female (255) 255
cells, cultured (252) 252
cancer (250) 250
activation (243) 243
gene expression (242) 242
enzymes and coenzymes (233) 233
rodents (233) 233
cell line (229) 229
mice, inbred c57bl (226) 226
sirt1 protein (204) 204
food and beverages (203) 203
physiological aspects (199) 199
research (198) 198
multidisciplinary sciences (190) 190
signal transduction - drug effects (188) 188
inflammation (187) 187
nad (187) 187
apoptosis - drug effects (181) 181
analysis (177) 177
inhibition (173) 173
research article (173) 173
phosphorylation (171) 171
p53 (168) 168
deacetylase (167) 167
sirtuins - genetics (166) 166
enzymes (162) 162
enzyme inhibitors - pharmacology (159) 159
life-span (158) 158
physiology (156) 156
histone deacetylase (155) 155
transcription factors (155) 155
pharmacology & pharmacy (154) 154
mice, knockout (152) 152
oncology (151) 151
rna interference (150) 150
cells (147) 147
aging (146) 146
biological phenomena, cell phenomena, and immunity (144) 144
disease models, animal (141) 141
gene-expression (141) 141
transcription (136) 136
tumor suppressor protein p53 - metabolism (136) 136
kinases (133) 133
medicine (133) 133
gene expression regulation (131) 131
genetic aspects (131) 131
health aspects (131) 131
neurosciences (129) 129
biology (128) 128
sirtuin 2 - antagonists & inhibitors (127) 127
disease (126) 126
endocrinology & metabolism (126) 126
nf-kappa-b (121) 121
rats, sprague-dawley (121) 121
sirtuin (120) 120
protein (119) 119
protein binding (119) 119
mitochondria - metabolism (117) 117
saccharomyces-cerevisiae (117) 117
chemistry, medicinal (116) 116
mitochondria (116) 116
science (116) 116
dose-response relationship, drug (113) 113
reactive oxygen species - metabolism (113) 113
cell proliferation - drug effects (107) 107
structure-activity relationship (107) 107
down-regulation (106) 106
biophysics (105) 105
blotting, western (105) 105
nad - metabolism (105) 105
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Haematologica, ISSN 0390-6078, 04/2012, Volume 97, Issue 4, pp. 551 - 559
Journal Article
Oncogene, ISSN 0950-9232, 01/2015, Volume 34, Issue 2, pp. 188 - 198
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 2013, Volume 20, Issue 3, pp. 503 - 514
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2015, Volume 10, Issue 4, pp. e0124670 - e0124670
Background Sirtuin 1 (SIRT1) and sirtuin 2 (SIRT2) are NAD+-dependent protein deacetylases involved in the regulation of key cancer-associated genes. In this... 
BREAST-CANCER | REGULATES SIRT1 | BRONCHIAL EPITHELIAL-CELLS | DEACETYLASE | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | GROWTH | SENESCENCE | DEPENDENT PATHWAY | CARCINOMA | P53 | Sirtuin 1 - metabolism | RNA, Small Interfering - genetics | Prognosis | Lung Neoplasms - mortality | Humans | Middle Aged | Lung Neoplasms - pathology | Male | Thiourea - pharmacology | Sirtuin 1 - genetics | Sirtuin 2 - metabolism | Neoplasm Grading | RNA Interference | Female | Sirtuin 2 - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Acetanilides - pharmacology | Gene Expression | Carcinoma, Non-Small-Cell Lung - genetics | Tumor Suppressor Protein p53 - metabolism | Carcinoma, Non-Small-Cell Lung - mortality | Sirtuin 1 - antagonists & inhibitors | Sirtuin 2 - genetics | Cell Line, Tumor | Aged | Cell Proliferation - drug effects | Neoplasm Staging | Thiourea - analogs & derivatives | Proteins | Squamous cell carcinoma | Lung cancer, Small cell | Genetic aspects | Lung cancer, Non-small cell | Cancer | Sirtuins | Cell proliferation | Biotechnology | Epithelial cells | Gene regulation | Lung | Lung cancer | Kinases | Cell growth | Non-small cell lung carcinoma | siRNA | Tumor cell lines | Gene expression | Patients | Survival | SIRT1 protein | NAD | Pathology | Cell lines | Apoptosis | Tumors | Index Medicus
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 05/2016, Volume 137, Issue 3, pp. 371 - 383
The mechanism underlying pre‐gestational diabetes‐induced neural tube defects (NTDs) is still elusive. Our study unravels a new epigenetic mechanism in which... 
sirtuin deacetylase | neural tube defects | epigenetic mechanism | maternal diabetes | histone acetylation | oxidative stress | DIABETIC EMBRYOPATHY | APOPTOSIS | ACTIVATION | TRIGGERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOPLASMIC-RETICULUM STRESS | NEUROSCIENCES | CELLULAR STRESS | TERATOGENESIS | UNFOLDED PROTEIN RESPONSE | IN-VIVO | DIFFERENTIATION | Group III Histone Deacetylases - genetics | Superoxide Dismutase - genetics | Superoxide Dismutase - biosynthesis | Epigenesis, Genetic | Neural Tube Defects - genetics | Heterocyclic Compounds, 4 or More Rings - pharmacology | Sirtuin 2 - biosynthesis | Female | Glucose - toxicity | Sirtuin 2 - antagonists & inhibitors | Acetylation | Group III Histone Deacetylases - antagonists & inhibitors | Sirtuins - genetics | Diabetes, Gestational - pathology | Group III Histone Deacetylases - biosynthesis | Naphthoquinones - pharmacology | Neural Tube Defects - prevention & control | Pregnancy | Sirtuin 2 - genetics | Sirtuins - biosynthesis | Animals | Neural Tube Defects - chemically induced | Mice | Histones - metabolism | Oxidative Stress - drug effects | Superoxide Dismutase-1 | Sirtuins - antagonists & inhibitors | Neural Stem Cells - metabolism | Epigenetic inheritance | Oxidative stress | Neural tube | Abnormalities | Superoxide | Glucose | Dextrose | Neurochemistry | Antioxidants | Enzymes | Diabetes | Index Medicus
Journal Article
Biological Psychiatry, ISSN 0006-3223, 2014, Volume 76, Issue 1, pp. 47 - 56
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2016, Volume 59, Issue 7, pp. 2928 - 2941
Journal Article