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Cell Metabolism, ISSN 1550-4131, 05/2012, Volume 15, Issue 5, pp. 665 - 674
Nonalcoholic fatty liver disease (NAFLD) is associated with increased cardiovascular and liver-related mortality. NAFLD is characterized by both triglyceride... 
RAT-LIVER | RISK-FACTORS | MACROPHAGE APOPTOSIS | PROTEIN-KINASE | ENDOCRINOLOGY & METABOLISM | HMG-COA REDUCTASE | STEATOHEPATITIS | 3-HYDROXY-3-METHYLGLUTARYL COENZYME | PREVALENCE | MICRORNA EXPRESSION | MODULATION | CELL BIOLOGY | Sirtuin 1 - metabolism | Up-Regulation | Cholesterol - blood | Humans | Middle Aged | Sterol Esterase - metabolism | Male | MicroRNAs - metabolism | Desmosterol - metabolism | Cardiovascular Diseases - genetics | Cholesterol - genetics | Sirtuin 1 - genetics | Case-Control Studies | Phosphorylation - genetics | Hydroxymethylglutaryl CoA Reductases - metabolism | Adenylate Kinase - metabolism | Non-alcoholic Fatty Liver Disease | Sterol O-Acyltransferase - metabolism | Adult | Female | Lipid Metabolism - genetics | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Fatty Liver - genetics | Receptors, LDL - genetics | Gene Expression | Fatty Liver - metabolism | Cardiovascular Diseases - metabolism | Fatty Liver - blood | Liver - metabolism | Receptors, LDL - metabolism | Cholesterol - metabolism | Cholesterol, LDL - genetics | Phenotype | Sterol Esterase - genetics | Desmosterol - blood | Cholesterol, LDL - metabolism | MicroRNAs - genetics | Sterol O-Acyltransferase - genetics | Adenylate Kinase - genetics | Hydroxymethylglutaryl CoA Reductases - genetics | Enzymes | Liver diseases | Low density lipoproteins | Genes | Esters | Triglycerides | Cholesterol | MicroRNA | Fatty liver | Blood cholesterol | Physiological aspects | Hydrolases | Blood lipids | Health aspects | Statins | Index Medicus | atherosclerosis | Nonalcoholic steatohepatitis | cholesterol | Nonalcoholic fatty liver disease | fatty liver | lipogenesis | hypercholesterolemia | HMG CoA reductase
Journal Article
PLoS Genetics, ISSN 1553-7390, 09/2011, Volume 7, Issue 9, pp. e1002253 - e1002253
Aging is characterized by the accumulation of damaged cellular macromolecules caused by declining repair and elimination pathways. An integral component... 
20S PROTEASOME | YEAST | OXIDATIVE STRESS | ENHANCES LONGEVITY | CAENORHABDITIS-ELEGANS | GENETICS & HEREDITY | GENE DISRUPTION | DEGRADATION | AUTOPHAGY | DOMAIN PROTEIN | DELETION | Saccharomyces cerevisiae - genetics | Humans | Transcriptional Activation | Ubiquitin - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Silent Information Regulator Proteins, Saccharomyces cerevisiae - genetics | Sirtuin 2 - metabolism | DNA-Binding Proteins - metabolism | Gene Expression Regulation, Fungal | Saccharomyces cerevisiae - physiology | Silent Information Regulator Proteins, Saccharomyces cerevisiae - metabolism | Oxidative Stress - genetics | Ubiquitin-Protein Ligases - metabolism | Ubiquitin - genetics | Saccharomyces cerevisiae Proteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Phosphatidylinositol 3-Kinases - genetics | Proteasome Endopeptidase Complex - genetics | Transcription Factors - metabolism | Sirtuin 2 - genetics | Saccharomyces cerevisiae Proteins - metabolism | DNA Replication - genetics | Proteasome Endopeptidase Complex - metabolism | Ubiquitin-Protein Ligases - genetics | Physiological aspects | Transcription factors | Genetic aspects | Research | Brewer's yeast | Ubiquitin-proteasome system | Index Medicus | Protein folding | Aging | Homeostasis | Software | Experiments | Age | Cytoplasm
Journal Article
Cancer Cell, ISSN 1535-6108, 10/2011, Volume 20, Issue 4, pp. 487 - 499
Journal Article
PLoS Genetics, ISSN 1553-7390, 03/2011, Volume 7, Issue 3, pp. e1001354 - e1001354
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2012, Volume 109, Issue 39, pp. 15888 - 15893
The epidemics of insulin resistance (IR) and type 2 diabetes (T2D) affect the first world as well as less-developed countries, and now affect children as well.... 
Receptors | 3T3 L1 cells | Myasthenia gravis | Diet | Insulin resistance | Mice | Adipocytes | Type 2 diabetes mellitus | Diabetes | Insulin | Aging | Glycotoxins | Obesity | LIFE-SPAN | OXIDATIVE STRESS | METABOLIC SYNDROME | OXIDANT STRESS | MULTIDISCIPLINARY SCIENCES | DOWN-REGULATION | RISK-FACTOR | glycotoxins | MESANGIAL CELLS | aging | INFLAMMATORY RESPONSE | END-PRODUCTS | obesity | METHYLGLYOXAL | Sirtuin 1 - metabolism | Deoxyglucose - metabolism | Diabetes Mellitus, Type 2 - genetics | Humans | Diabetes Mellitus, Experimental - genetics | Metabolic Syndrome - metabolism | Diabetes Mellitus, Type 2 - metabolism | Insulin Receptor Substrate Proteins - metabolism | Metabolic Syndrome - chemically induced | Sirtuin 1 - genetics | Inflammation - drug therapy | Glycation End Products, Advanced - adverse effects | Diabetes Mellitus, Experimental - metabolism | Insulin Receptor Substrate Proteins - genetics | Receptor for Advanced Glycation End Products | Macrophages - pathology | Administration, Oral | Oxidative Stress - genetics | 3T3-L1 Cells | Adipocytes - pathology | Proto-Oncogene Proteins c-akt | Macrophages - metabolism | Animals | Glycation End Products, Advanced - pharmacology | Metabolic Syndrome - genetics | Adipocytes - metabolism | Deoxyglucose - genetics | Diabetes Mellitus, Experimental - pathology | Inflammation - genetics | Diabetes Mellitus, Type 2 - pathology | Metabolic Syndrome - pathology | Oxidative Stress - drug effects | Receptors, Immunologic - genetics | Receptors, Immunologic - metabolism | Type 2 diabetes | Antioxidants | Cell receptors | Physiological aspects | Glycosylation | Properties | Proteins | Oxidative stress | Genotype & phenotype | Epidemics | Index Medicus | Biological Sciences
Journal Article
Journal Article
Journal Article
Science, ISSN 0036-8075, 8/2013, Volume 341, Issue 6145, pp. 525 - 525
Pathogens dramatically affect host cell transcription programs for their own profit during infection, but in most cases, the underlying mechanisms remain... 
RESEARCH ARTICLE SUMMARY | Chromatin | Transcriptional regulatory elements | Bacterial infections | Genes | Histones | Small interfering RNA | Infections | Cytosol | Cytoplasm | LISTERIA-MONOCYTOGENES | PHOSPHORYLATION | ACETYLATION | IMMUNE-RESPONSES | IFN-GAMMA | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | PATTERNS | SIRTUINS | NF-KAPPA-B | SIRT2 | Proto-Oncogene Proteins c-met - metabolism | Chromatin - metabolism | Humans | Transcriptional Activation | Sirtuin 2 - metabolism | Cell Nucleus - metabolism | Lysine - metabolism | Acetylation | Listeriosis - metabolism | Listeriosis - genetics | Membrane Proteins - genetics | Bacterial Proteins - genetics | Mice, Knockout | Host-Pathogen Interactions | Sirtuin 2 - genetics | Listeria monocytogenes - pathogenicity | Lysine - genetics | Animals | Histones - genetics | Transcription Initiation Site | Listeria monocytogenes - genetics | Cytosol - metabolism | Listeriosis - microbiology | Mice | Mice, Inbred BALB C | Protein Processing, Post-Translational | HeLa Cells | Histones - metabolism | Pathogens | Cellular biology | Gene expression | Index Medicus | Proteins | Listeria | Listeria monocytogenes | Bacteria | Nuclei | Proto-Oncogene Proteins c-met | Listeriosis | Cellular Biology | Bacterial Proteins | Membrane Proteins | Life Sciences | Sirtuin 2 | Lysine | Cell Nucleus
Journal Article