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1. Full Text Anti-inflammatory therapies for cardiovascular disease
by Ridker, Paul M and Lüscher, Thomas F
European heart journal, ISSN 0195-668X, 07/2014, Volume 35, Issue 27, pp. 1782 - 1791
Darapladib | Atherosclerosis | Inflammasome | Inflammation | Colchicine | Salsalate | C reactive protein | Canakinumab | Methotrexate | Interleukin-6 | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Hydroxychloroquine - therapeutic use | Interleukin-6 - antagonists & inhibitors | NLR Family, Pyrin Domain-Containing 3 Protein | Colchicine - therapeutic use | Humans | Cell Adhesion Molecules - antagonists & inhibitors | Methotrexate - therapeutic use | Sirtuins - therapeutic use | Vaccination - methods | Lipoproteins, HDL - drug effects | Interleukin-1 - physiology | Interleukin-6 - physiology | Anti-Inflammatory Agents - therapeutic use | Interleukin-1 - antagonists & inhibitors | Leukotriene Antagonists - therapeutic use | Carrier Proteins - physiology | Adaptive Immunity - physiology | Phospholipase A2 Inhibitors - therapeutic use | Atherosclerosis - drug therapy | Serpins - therapeutic use | C-Reactive Protein - physiology | Antioxidants - therapeutic use | Tumor Necrosis Factor-alpha - drug effects | Signal Transduction - drug effects | Tumor Necrosis Factor-alpha - physiology | Thrombosis - drug therapy | Receptors, Interleukin-1 - antagonists & inhibitors | Index Medicus | Review
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2. Full Text Sirtuin 1-mediated cellular metabolic memory of high glucose via the LKB1/AMPK/ROS pathway and therapeutic effects of metformin
by Zheng, Zhi and Chen, Haibing and Li, Jun and Li, Tao and Zheng, Bingqing and Zheng, Ying and Jin, Huiyi and He, Ying and Gu, Qing and Xu, N
Diabetes (New York, N.Y.), ISSN 0012-1797, 01/2012, Volume 61, Issue 1, pp. 217 - 228
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Diabetes. Impaired glucose tolerance | Medical sciences | Endocrine pancreas. Apud cells (diseases) | Retina - drug effects | Sirtuin 1 - metabolism | Gene Expression Regulation, Enzymologic - drug effects | Diabetes Mellitus, Experimental - drug therapy | Retina - metabolism | Metformin - therapeutic use | Reactive Oxygen Species - metabolism | Reactive Oxygen Species - pharmacology | NF-kappa B - metabolism | Sirtuin 1 - genetics | Diabetes Mellitus, Experimental - blood | Osmolar Concentration | Cattle | Adenylate Kinase - metabolism | Adenylate Kinase - physiology | Diabetes Mellitus, Experimental - metabolism | Endothelial Cells - physiology | Protein-Serine-Threonine Kinases - metabolism | Hypoglycemic Agents - therapeutic use | Endothelial Cells - metabolism | Protein-Serine-Threonine Kinases - physiology | Metformin - pharmacology | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Rats | Hypoglycemic Agents - pharmacology | Metabolic Networks and Pathways - genetics | Animals | Sirtuin 1 - physiology | Diabetes Mellitus, Experimental - pathology | Metabolic Networks and Pathways - drug effects | Blood Glucose - metabolism | Retina - pathology | Endothelial Cells - drug effects | Hyperglycemia | Physiological aspects | Development and progression | Research | Diabetes | Glucose | Adenylic acid | Dextrose | Sirtuins | Oxygen | Bax protein | Diabetes mellitus | Memory | Poly(ADP-ribose) polymerase | Retina | AMP-activated protein kinase | SIRT1 protein | Endothelial cells | Stress | LKB1 protein | Mitochondria | NF- Kappa B protein | Glyceraldehyde-3-phosphate dehydrogenase | Metformin | Apoptosis | Index Medicus | Abridged Index Medicus | Complications
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3. Full Text Resveratrol and cardiovascular health – Promising therapeutic or hopeless illusion?
by Tang, Philip Chiu-Tsun and Ng, Yam-Fung and Ho, Susan and Gyda, Michael and Chan, Shun-Wan
Pharmacological research, ISSN 1043-6618, 12/2014, Volume 90, pp. 88 - 115
Sirtuins | Cardioprotection | Grapes | Resveratrol | Longevity | Red wine | Polyphenolic | SIRT1 | Polygonum cuspidatum | Cardiovascular health | Stilbene | Caloric restriction | Polyphenolic SIRT1 Sirtuins Stilbene Polygonum cuspidatum Longevity Caloric restriction Cardiovascular health | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Cardiotonic Agents - therapeutic use | Animals | Stilbenes - therapeutic use | Cardiovascular Diseases - prevention & control | Humans | Cardiotonic Agents - pharmacology | Stilbenes - pharmacology | Health aspects | Index Medicus
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4. Full Text Metformin and insulin impact on clinical outcome in patients with advanced hepatocellular carcinoma receiving sorafenib: Validation study and biological rationale
by Casadei Gardini, Andrea and Faloppi, Luca and De Matteis, Serena and Foschi, Francesco Giuseppe and Silvestris, Nicola and Tovoli, Francesco and Palmieri, Vincenzo and Marisi, Giorgia and Brunetti, Oronzo and Vespasiani-Gentilucci, Umberto and Perrone, Giuseppe and Valgiusti, Martina and Granato, Anna Maria and Ercolani, Giorgio and Negrini, Giulia and Tamburini, Emiliano and Aprile, Giuseppe and Passardi, Alessandro and Santini, Daniele and Cascinu, Stefano and Frassineti, Giovanni Luca and Scartozzi, Mario
European journal of cancer (1990), ISSN 0959-8049, 11/2017, Volume 86, pp. 106 - 114
Liver cancer | Type II diabetes mellitus | NAFLD | SIRT-3 | Sorafenib | Hepatocellular carcinoma | Metformin | NASH | Insulin | Life Sciences & Biomedicine | Oncology | Science & Technology | Immunohistochemistry | Niacinamide - analogs & derivatives | Carcinoma, Hepatocellular - mortality | Metformin - therapeutic use | Humans | Middle Aged | Drug Resistance, Neoplasm | Male | Antineoplastic Agents - therapeutic use | Protein Kinase Inhibitors - adverse effects | Liver Neoplasms - mortality | Metformin - adverse effects | Carcinoma, Hepatocellular - drug therapy | Drug Interactions | Time Factors | Antineoplastic Agents - adverse effects | Phenylurea Compounds - adverse effects | Aged, 80 and over | Adult | Female | Liver Neoplasms - pathology | Retrospective Studies | Liver Neoplasms - enzymology | Databases, Factual | Hypoglycemic Agents - therapeutic use | Kaplan-Meier Estimate | Liver Neoplasms - drug therapy | Niacinamide - adverse effects | Niacinamide - therapeutic use | Phenylurea Compounds - therapeutic use | Treatment Outcome | Carcinoma, Hepatocellular - enzymology | Diabetes Mellitus, Type 2 - diagnosis | Disease-Free Survival | Protein Kinase Inhibitors - therapeutic use | Diabetes Mellitus, Type 2 - mortality | Carcinoma, Hepatocellular - pathology | Italy | Aged | Sirtuin 3 - analysis | Diabetes Mellitus, Type 2 - drug therapy | Hypoglycemic Agents - adverse effects | Insulin - adverse effects | Insulin - therapeutic use | Antimitotic agents | Care and treatment | Patient outcomes | Hepatoma | Antineoplastic agents | Diabetes mellitus | Paraffin | Patients | Survival | Chemotherapy | Diabetes | Metabolic disorders | Tumors | Index Medicus
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5. Full Text NAD+: A key metabolic regulator with great therapeutic potential
by Sultani, G and Samsudeen, A. F and Osborne, B and Turner, N
Journal of neuroendocrinology, ISSN 0953-8194, 10/2017, Volume 29, Issue 10, pp. e12508 - n/a
NAD | therapeutic | ageing | metabolism | sirtuins | Endocrinology & Metabolism | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Neoplasms - metabolism | NAD - therapeutic use | Animals | Humans | Aging | Homeostasis | Neurodegenerative Diseases - metabolism | NAD - metabolism | Cell survival | Transcription | Adenine | Metabolism | Drug development | Biological activity | Signal transduction | Signaling | Metabolites | Nicotinamide adenine dinucleotide | Nutrients | Catabolism | Nicotinamide | Index Medicus
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