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Tetrahedron Letters, ISSN 0040-4039, 12/2013, Volume 54, Issue 50, pp. 6807 - 6809
Sitagliptin phosphate, a novel DPP-IV inhibitor of T2DM, has been synthesized via 12 linear steps, in an overall yield of 26%. The key step is the coupling... 
Sitagliptin phosphate | Grignard reaction | Synthesis | β-Amino acid | Aziridine | beta-Amino acid | CHEMISTRY, ORGANIC | ASYMMETRIC HYDROGENATION | Phosphates | Synthesis (chemistry) | Inhibitors | Tetrahedrons | Bromides | Chemical reactions | Derivatives
Journal Article
Enzyme and Microbial Technology, ISSN 0141-0229, 11/2019, Volume 130, p. 109362
Transaminases (TAs, EC 2.6.1.X) are a class of promising catalysts for the synthesis of chiral amines. The addition of exogenous expensive cofactor, pyridoxal... 
Sitagliptin | Pyridoxal 5′-phosphate | Co-immobilization | Continuous biosynthesis | Transaminase | Self-sufficient biocatalyst
Journal Article
Powder Diffraction, ISSN 0885-7156, 08/2015, Volume 30, Issue 4, pp. 349 - 356
The crystal structure of sitagliptin dihydrogen phosphate monohydrate (sometimes referred to as sitagliptin phosphate monohydrate) has been solved and refined... 
Januvia | sitagliptin phosphate | Rietveld refinement | density functional theory | powder diffraction | DENSITY | DATABASE | MOLECULAR-CRYSTALS | VALIDATION | MATERIALS SCIENCE, CHARACTERIZATION & TESTING | PATTERNS
Journal Article
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, ISSN 1386-1425, 10/2015, Volume 149, pp. 441 - 451
Simple, specific, accurate and precise spectrophotometric methods were developed and validated for the simultaneous determination of the oral antidiabetic... 
Amplitude subtraction method | Sitagliptin phosphate | Induced amplitude modulation method | Metformin hydrochloride | Modified amplitude subtraction method | RESOLUTION | TANDEM MASS-SPECTROMETRY | PHARMACEUTICAL TERNARY MIXTURE | EXTRACTION | PLASMA | SPECTROSCOPY | DRUGS | SPECTRA | INHIBITOR | Phosphates | Metformin | Comparative analysis | Methods
Journal Article
Scientia Pharmaceutica, ISSN 0036-8709, 2012, Volume 80, Issue 1, pp. 139 - 152
A novel approach was used to develop and validate a rapid, specific, accurate and precise reverse phase ultra performance liquid chromatographic (UPLC) method... 
Validation | UPLC | Metformin hydrochloride | Simultaneous | Sitagliptin phosphate monohydrate | Chromatography | Stability-indicating method
Journal Article
Acta Poloniae Pharmaceutica - Drug Research, ISSN 0001-6837, 2018, Volume 75, Issue 3, pp. 767 - 775
A novel floating controlled release drug delivery system of Sitagliptin phosphate was formulated in an effort to increase the gastric retention time of the... 
Psyllium husk | Sitagliptin phosphate | Sustained release | Tragacanth | Release kinetics | Floating tablets | HCL | psyllium husk | release kinetics | DESIGN | DELIVERY SYSTEM | sustained release | PHARMACOLOGY & PHARMACY | floating tablets | RELEASE | tragacanth
Journal Article
International Journal of Biomedical Science, ISSN 1550-9702, 12/2015, Volume 11, Issue 4, pp. 190 - 194
New UPLC method was developed for determination of sitagliptin and metformin using Symmetry C18 column (100 mm × 2.1 mm, 2.2 μm) and isocratic elution... 
Column temperature | Sitagliptin | Metformin | Factorial design | UPLC | factorial design | Original
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 07/2015, Volume 373, Issue 3, pp. 232 - 242
Journal Article
Diabetic Medicine, ISSN 0742-3071, 04/2016, Volume 33, Issue 4, pp. 471 - 477
The study is unique in reporting resource use associated with severe hypoglycaemia from a randomized controlled trial setting, because resource use has... 
GLYCEMIC CONTROL | 26-WEEK | GLARGINE | NAIVE PATIENTS | ENDOCRINOLOGY & METABOLISM | NON-INFERIORITY TRIAL | OPEN-LABEL | TO-TARGET TRIAL | BASAL-BOLUS TREATMENT | TYPE-2 | DEGLUDEC/INSULIN ASPART | Hypoglycemia - therapy | Hypoglycemic Agents - economics | Dipeptidyl-Peptidase IV Inhibitors - therapeutic use | Humans | Middle Aged | Insulin Detemir - therapeutic use | Insulin Detemir - economics | Clinical Trials, Phase III as Topic | Hypoglycemic Agents - administration & dosage | Hypoglycemic Agents - therapeutic use | Sitagliptin Phosphate - administration & dosage | Costs and Cost Analysis | Administration, Oral | Drug Therapy, Combination - economics | Dipeptidyl-Peptidase IV Inhibitors - administration & dosage | Insulin Aspart - economics | Insulin, Long-Acting - adverse effects | Insulin, Long-Acting - administration & dosage | Diabetes Mellitus, Type 1 - economics | Diabetes Mellitus, Type 1 - blood | Insulin, Long-Acting - therapeutic use | Hypoglycemic Agents - adverse effects | Insulin Aspart - adverse effects | Cohort Studies | Insulin Aspart - therapeutic use | Dipeptidyl-Peptidase IV Inhibitors - adverse effects | Diabetes Mellitus, Type 2 - economics | Insulin, Long-Acting - economics | Dipeptidyl-Peptidase IV Inhibitors - economics | Insulin Glargine - administration & dosage | Drug Therapy, Combination - adverse effects | Insulin Aspart - administration & dosage | Insulin Detemir - administration & dosage | Insulin Detemir - adverse effects | Hypoglycemia - physiopathology | Adult | Hypoglycemia - economics | Hypoglycemia - chemically induced | Severity of Illness Index | Insulin Glargine - adverse effects | Drug Administration Schedule | Insulin Glargine - economics | Insulin Glargine - therapeutic use | Sitagliptin Phosphate - economics | Diabetes Mellitus, Type 1 - drug therapy | Diabetes Mellitus, Type 2 - blood | Health Care Costs | Sitagliptin Phosphate - therapeutic use | Diabetes Mellitus, Type 2 - drug therapy | Drug Combinations | Sitagliptin Phosphate - adverse effects | Type 2 diabetes | Adults | Type 1 diabetes | Insulin | Analysis | Emergency medical care | Diabetes | Hypoglycemia | Index Medicus | Complications | Research
Journal Article
Chromatographia, ISSN 0009-5893, 9/2013, Volume 76, Issue 17, pp. 1153 - 1162
A new stability-indicating high-performance liquid chromatographic method has been developed for simultaneous analysis of metformin hydrochloride (MET) and... 
RP-HPLC | Chemistry | Pharmacy | Proteomics | Sitagliptin | Laboratory Medicine | Metformin | Simultaneous | Chromatography | Stability-indicating assay | CHEMISTRY, ANALYTICAL | BIOCHEMICAL RESEARCH METHODS | Phosphates | Hydrolysis | Phosphoric acid | Analysis | Methods
Journal Article
International Journal of Pharmaceutical Sciences and Research, ISSN 0975-8232, 10/2017, Volume 8, Issue 10, p. 4454
An Accurate, sensitive, precise and stability indicating high performance thin layer chromatographic (HPTLC) method has been developed and validated for the... 
Thin layer chromatography | Pharmaceutical technology | Innovations | Sitagliptin | Methods | Testing
Journal Article