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Journal of Clinical Investigation, ISSN 0021-9738, 12/2007, Volume 117, Issue 12, pp. 3765 - 3773
S-phase kinase-associated protein 2 (SKP2) is a component of the E3 ubiquitin ligase SKP1-Cul1-Fbox complex. Overexpression of SKP2 results in cell cycle... 
MEDICINE, RESEARCH & EXPERIMENTAL | UBIQUITIN-MEDIATED DEGRADATION | BOX PROTEIN SKP2 | ENTEROPATHY | DISRUPTION | P27 | MOUSE | SCURFY | EXPRESSION | CELL-CYCLE INHIBITION | P27(KIP1) | Oncogene Proteins - genetics | RNA, Small Interfering - genetics | Receptor, ErbB-2 - genetics | Tumor Suppressor Proteins - antagonists & inhibitors | Humans | Receptor, ErbB-2 - metabolism | Repressor Proteins - antagonists & inhibitors | Breast Neoplasms - metabolism | Genes, X-Linked | S-Phase Kinase-Associated Proteins - antagonists & inhibitors | Cell Transformation, Neoplastic - genetics | Forkhead Transcription Factors - metabolism | Mice, Mutant Strains | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Cullin Proteins - metabolism | Female | Forkhead Transcription Factors - antagonists & inhibitors | Gene Expression Regulation, Neoplastic - drug effects | Gene Expression Regulation, Neoplastic - genetics | Repressor Proteins - metabolism | Tumor Suppressor Proteins - metabolism | RNA, Small Interfering - pharmacology | Cell Cycle Proteins - metabolism | Gene Silencing | Oncogene Proteins - metabolism | Repressor Proteins - genetics | Forkhead Transcription Factors - genetics | S-Phase Kinase-Associated Proteins - metabolism | Cell Transformation, Neoplastic - metabolism | Oncogene Proteins - antagonists & inhibitors | Cullin Proteins - genetics | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Ploidies | Cell Line, Tumor | Heterozygote | S-Phase Kinase-Associated Proteins - genetics | Mice | Mice, Inbred BALB C | Cell Transformation, Neoplastic - pathology | Tumor suppressor genes | Breast cancer | Genetic aspects | Research | DNA binding proteins | Identification and classification | Health aspects | Risk factors | Index Medicus | Abridged Index Medicus
Journal Article
Cancer Letters, ISSN 0304-3835, 2017, Volume 401, pp. 53 - 62
Abstract Tumor-initiating cells (TICs) play an important role in tumorigenesis and development for many various tissue origin cancers including non-small cell... 
Hematology, Oncology and Palliative Medicine | c-Myc | NDRG1 | Skp2 | Cancer initiating cells | Lung cancer | SUPPRESSOR | PROTEIN | ANGIOGENESIS | PHOSPHORYLATION | PLURIPOTENCY | IDENTIFICATION | ONCOLOGY | DEGRADATION | INHIBITOR | Phosphorylation | Prognosis | Lung Neoplasms - mortality | Humans | Lung Neoplasms - metabolism | Middle Aged | Gene Expression Regulation, Neoplastic | Lung Neoplasms - pathology | Male | Intracellular Signaling Peptides and Proteins - metabolism | Ubiquitination | Transfection | Neoplastic Stem Cells - metabolism | RNA Interference | Proteolysis | Cell Cycle Proteins - genetics | Neoplastic Stem Cells - pathology | Adult | Female | Protein Stability | Tumor Cells, Cultured | Spheroids, Cellular | Intracellular Signaling Peptides and Proteins - genetics | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | A549 Cells | Cyclin-Dependent Kinase 2 - metabolism | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Cell Cycle Proteins - metabolism | S-Phase Kinase-Associated Proteins - metabolism | Carcinoma, Non-Small-Cell Lung - mortality | Proto-Oncogene Proteins c-myc - metabolism | Phenotype | Survival Analysis | Aged | Proto-Oncogene Proteins c-myc - genetics | Ubiquitin | Medical colleges | RNA | Analysis | Genes | Stem cells | Genetic aspects | Lung cancer, Non-small cell | Cancer | Cancer cells | Development and progression | Respiratory agents | Enrichment | Biotechnology | Correlation | Genomics | Oct-4 protein | Lung | c-Myc protein | Metastasis | Myc protein | Kinases | Inactivation | Degradation | Proteins | KLF4 protein | Cell cycle | Tumorigenesis | Deactivation | Mortality | Non-small cell lung carcinoma | Forming | Breast cancer | Tumorigenicity | Gene expression | Survival | Patients | Cyclin-dependent kinase 2 | Polymerase chain reaction | Properties (attributes) | Skp2 protein | Cell lines | Kidney cancer | Laboratory animals | Pluripotency | Tumors | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 2782 - 13
Cell cycle progression in mammals is modulated by two ubiquitin ligase complexes, CRL4 and SCF, which facilitate degradation of chromatin substrates involved... 
CULLIN-RING LIGASES | TARGETING PR-SET7/SET8 | PCNA | MULTIDISCIPLINARY SCIENCES | HISTONE METHYLTRANSFERASE SET8 | S-PHASE | DOMAIN-INTERACTING PROTEIN | NEDD8-ACTIVATING ENZYME | CELL-GROWTH | HUMAN CDT1 | DNA-REPLICATION | Cell Cycle - genetics | Chromatin - metabolism | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Stem Cell Factor - genetics | S-Phase Kinase-Associated Proteins - antagonists & inhibitors | Cullin Proteins - metabolism | Osteoblasts - cytology | Intracellular Signaling Peptides and Proteins - genetics | Chromatin - chemistry | Gene Expression | Stem Cell Factor - metabolism | HCT116 Cells | Osteoblasts - drug effects | Ubiquitin-Protein Ligases - metabolism | DNA Replication | Cyclopentanes - pharmacology | Pyrimidines - pharmacology | S-Phase Kinase-Associated Proteins - metabolism | Protein Transport | Cullin Proteins - genetics | Replication Origin | K562 Cells | Cell Line, Tumor | Protein Binding | S-Phase Kinase-Associated Proteins - genetics | Cell Cycle - drug effects | Osteoblasts - metabolism | Ubiquitin-Protein Ligases - genetics | Ubiquitin | Origins | Chromatin | Replication initiation | Genomes | Substrates | Proteins | DNA biosynthesis | Eukaryotes | Replication origins | Skp2 protein | Cell cycle | Replication | Chromosomes | Deoxyribonucleic acid--DNA | Ubiquitin-protein ligase | Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 11/2018, Volume 201, Issue 10, pp. 2885 - 2898
BCR engagement leads to activation and clonal expansion of B cells. The I-A(12%) mutant mouse possesses a branch site point mutation in the H2-Aa gene that... 
SIGNAL-TRANSDUCTION | PROGENITOR CELLS | UBIQUITIN LIGASE | BONE-MARROW | S PHASE | MOUSE | DEFICIENT MICE | IMMUNOLOGY | SKP2 | ANTIGEN RECEPTOR | G1 PHASE | Index Medicus | Abridged Index Medicus
Journal Article
Oncogene, ISSN 0950-9232, 03/2013, Volume 32, Issue 10, pp. 1284 - 1295
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, pp. e79201 - e79201
Wogonin is a plant monoflavonoid which has been reported to inhibit cell growth and/or induce apoptosis in various tumors. The present study examined the... 
CANCER-CELLS | CARCINOMA-CELLS | BREAST-CANCER | PROTEIN | MULTIDISCIPLINARY SCIENCES | IN-VIVO | C-MYC | DOWN-REGULATION | DEGRADATION | TRANSCRIPTION FACTOR | EXPRESSION | F-Box-WD Repeat-Containing Protein 7 | Adenocarcinoma of Lung | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Glycogen Synthase Kinase 3 beta | RNA, Messenger - metabolism | Adenocarcinoma - metabolism | Membrane Potential, Mitochondrial | Adenocarcinoma - genetics | Gene Expression Regulation, Neoplastic - drug effects | Histone Deacetylase 1 - genetics | Lung Neoplasms - genetics | Cell Survival - drug effects | Histone Deacetylase 2 - genetics | F-Box Proteins - metabolism | Flavanones - pharmacology | RNA, Messenger - genetics | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Glycogen Synthase Kinase 3 - metabolism | S-Phase Kinase-Associated Proteins - metabolism | Proto-Oncogene Proteins c-myc - metabolism | Signal Transduction - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Proto-Oncogene Proteins c-myc - genetics | Histone Deacetylase 2 - metabolism | Cell Cycle - drug effects | Histone Deacetylase 1 - metabolism | Adenocarcinoma | Ubiquitin | Histone deacetylase | Phosphorylation | Change detection | Leukemia | Lung | Lung cancer | c-Myc protein | Multiple myeloma | XIAP protein | Biology | mRNA | Myc protein | Drug resistance | Kinases | Cell adhesion & migration | Anticancer properties | Degradation | Proteins | Liver cancer | Angiogenesis | Pathways | Tumor necrosis factor-TNF | HDAC2 protein | Medical research | Enzymes | Immunoglobulins | Cyclin-dependent kinases | Apoptosis-inducing factor | Poly(ADP-ribose) polymerase | Exposure | Breast cancer | Gene expression | Mcl-1 protein | Skp2 protein | Ligands | Viability | Tumors | Apoptosis | Cancer | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 03/2010, Volume 464, Issue 7287, pp. 374 - 379
Cellular senescence has been recently shown to have an important role in opposing tumour initiation and promotion. Senescence induced by oncogenes or by loss... 
BOX PROTEIN SKP2 | TUMOR SUPPRESSION | PATHWAY | MULTIDISCIPLINARY SCIENCES | IN-VIVO | PTEN | ACCUMULATION | ONCOGENE-INDUCED SENESCENCE | EXPRESSION | CANCER | P53 | Proto-Oncogene Proteins p21(ras) - genetics | Cellular Senescence - drug effects | Male | Prostate - metabolism | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | S-Phase Kinase-Associated Proteins - antagonists & inhibitors | Adenovirus E1A Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Fibroblasts | Prostatic Neoplasms - prevention & control | Prostatic Neoplasms - drug therapy | Proto-Oncogene Proteins p21(ras) - metabolism | PTEN Phosphohydrolase - genetics | Prostatic Neoplasms - pathology | Cyclin-Dependent Kinase Inhibitor p16 - deficiency | PTEN Phosphohydrolase - deficiency | Cells, Cultured | Tumor Suppressor Protein p53 - metabolism | Cyclin-Dependent Kinase Inhibitor p16 - genetics | PTEN Phosphohydrolase - metabolism | SKP Cullin F-Box Protein Ligases - metabolism | S-Phase Kinase-Associated Proteins - metabolism | Tumor Suppressor Protein p53 - deficiency | Animals | Activating Transcription Factor 4 - metabolism | Adenovirus E1A Proteins - genetics | Prostate - cytology | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | S-Phase Kinase-Associated Proteins - genetics | Mice | Cell Transformation, Neoplastic - drug effects | Prevention | Care and treatment | Physiological aspects | Aging | Tumor suppressor genes | Genetic aspects | Research | Cells | Tumors | Cell cycle | Apoptosis | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, pp. e47298 - e47298
Substantial evidence supports the oncogenic role of the E3 ubiquitin ligase S-phase kinase-associated protein 2 (Skp2) in many types of cancers through its... 
ANAPHASE-PROMOTING COMPLEX | DESTRUCTION | PROTEIN | UBIQUITIN LIGASE | BETA-TRCP | COP9 SIGNALOSOME | MULTIDISCIPLINARY SCIENCES | DEGRADATION | SCFSKP2 | PHOSPHORYLATION-DEPENDENT PROTEOLYSIS | CYCLE | Sirtuin 1 - metabolism | Prostatic Neoplasms - metabolism | S-Phase Kinase-Associated Proteins - physiology | Peptide Hydrolases - genetics | Humans | Gene Expression Regulation, Neoplastic | Male | Multiprotein Complexes - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Breast Neoplasms - metabolism | Multiprotein Complexes - metabolism | Breast Neoplasms - enzymology | beta-Transducin Repeat-Containing Proteins - metabolism | Female | Binding Sites | Intracellular Signaling Peptides and Proteins - genetics | Peptide Hydrolases - metabolism | Mutagenesis, Site-Directed | COP9 Signalosome Complex | S-Phase Kinase-Associated Proteins - metabolism | beta-Transducin Repeat-Containing Proteins - chemistry | Feedback, Physiological | Energy Metabolism | Sirtuin 1 - physiology | Cell Line, Tumor | Prostatic Neoplasms - enzymology | S-Phase Kinase-Associated Proteins - genetics | Ligases | Cancer cells | Physiological aspects | Genetic aspects | Research | Properties | Prostate cancer | Risk factors | Ubiquitin | Phosphorylation | Crosstalk | Transducin | Proline | Feedback loops | Glucose | Kinases | Accumulation | Deoxyglucose | Cullin | Proteins | Cyclin-dependent kinase | Ubiquitination | Energy | Feedback | Cell cycle | Pharmaceutical sciences | Ubiquitin-protein ligase | Medical research | Enzymes | F-box protein | Breast cancer | Gene expression | Sp1 protein | SIRT1 protein | Substrates | Cyclin-dependent kinase 2 | Signaling | Skp2 protein | Skp2 gene | Medical prognosis | Pharmacy | Aberration | Drug discovery | Destabilization | Prostate | Cancer | Index Medicus
Journal Article
Oncogene, ISSN 0950-9232, 03/2012, Volume 31, Issue 12, pp. 1546 - 1557
Journal Article