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1. Full Text Functional Neuroimaging Evidence for Hyperarousal in Insomnia
by Nofzinger, Eric A and Buysse, Daniel J and Germain, Anne and Price, Julie C and Miewald, Jean M and Kupfer, David J
American Journal of Psychiatry, ISSN 0002-953X, 11/2004, Volume 161, Issue 11, pp. 2126 - 2128
OBJECTIVE: The authors investigated the neurobiological basis of poor sleep and daytime fatigue in insomnia. METHOD: [18F]Fluorodeoxyglucose positron emission... 
CEREBRAL GLUCOSE-METABOLISM | EYE-MOVEMENT SLEEP | PSYCHIATRY | WAKING | Brain - diagnostic imaging | Humans | Prefrontal Cortex - physiopathology | Male | Sleep Arousal Disorders - diagnostic imaging | Electroencephalography | Positron-Emission Tomography | Brain - metabolism | Sleep Arousal Disorders - metabolism | Adult | Female | Neural Pathways - physiopathology | Sleep - physiology | Sleep Initiation and Maintenance Disorders - metabolism | Brain - physiopathology | Sleep Initiation and Maintenance Disorders - diagnostic imaging | Arousal - physiology | Prefrontal Cortex - metabolism | Brain Mapping | Glucose - metabolism | Wakefulness - physiology | Fluorodeoxyglucose F18 | Sleep Initiation and Maintenance Disorders - physiopathology | Prefrontal Cortex - diagnostic imaging | Sleep Arousal Disorders - diagnosis | Insomnia | Research
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2. Full Text Reduced integrity of right lateralized white matter in patients with primary insomnia: A diffusion-tensor imaging study
by Li, Shumei and Tian, Junzhang and Bauer, Andreas and Huang, Ruiwang and Wen, Hua and Li, Meng and Wang, Tianyue and Xia, Likun and Jiang, Guihua
Radiology, ISSN 0033-8419, 08/2016, Volume 280, Issue 2, pp. 520 - 528
Purpose: To analyze the integrity of white matter (WM) tracts in primary insomnia patients and provide better characterization of abnormal WM integrity and its... 
HIPPOCAMPAL VOLUME | DEPRESSION | ATTENTION | RESTING-STATE FMRI | MEMORY | SLEEP-DEPRIVATION | FUNCTIONAL CONNECTIVITY | INDEX | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | BRAIN | EPIDEMIOLOGY | White Matter - diagnostic imaging | Prospective Studies | Humans | Sleep Initiation and Maintenance Disorders - pathology | Magnetic Resonance Imaging - methods | Adult | Female | Male | Sleep Initiation and Maintenance Disorders - diagnostic imaging | Diffusion Tensor Imaging | White Matter - pathology
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3. Full Text Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: A link to major depressive disorder
by Plante, David T and Jensen, J Eric and Schoerning, Laura and Winkelman, John W
Neuropsychopharmacology, ISSN 0893-133X, 05/2012, Volume 37, Issue 6, pp. 1548 - 1557
Insomnia is closely related to major depressive disorder (MDD) both cross-sectionally and longitudinally, and as such, offers potential opportunities to refine... 
GABA | magnetic resonance spectroscopy | sleep disorders | occipital cortex | anterior cingulate cortex | insomnia | MENSTRUAL-CYCLE | YOUNG-ADULTS | MEDICATION-FREE | PSYCHIATRY | GABA LEVELS | GLUTAMIC-ACID | MAGNETIC-RESONANCE SPECTROSCOPY | NEUROSCIENCES | EMISSION COMPUTED-TOMOGRAPHY | PREFRONTAL CORTEX | PSYCHIATRIC-DISORDERS | PHARMACOLOGY & PHARMACY | GABAERGIC NEURONS | Protons | Magnetic Resonance Spectroscopy | gamma-Aminobutyric Acid - metabolism | Humans | Middle Aged | Gyrus Cinguli - diagnostic imaging | Sleep Initiation and Maintenance Disorders - pathology | Actigraphy | Depressive Disorder, Major - complications | Male | Sleep Initiation and Maintenance Disorders - diagnostic imaging | Case-Control Studies | Gyrus Cinguli - metabolism | Young Adult | Magnetic Resonance Imaging | Sleep Initiation and Maintenance Disorders - complications | Creatine - metabolism | Radionuclide Imaging | Brain Mapping | Adult | Female | Retrospective Studies | Occipital Lobe - diagnostic imaging | Occipital Lobe - metabolism | Brain | Sleep disorders | Spectroscopy | gamma -Aminobutyric acid | Cortex (cingulate) | Mood | Cortex (occipital) | Data processing | Depression | Nervous system | Thalamus | Creatine | Neurochemistry | Sleep | Chronobiology | Original | Biological Psychiatry
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4. Full Text Disruptions in resting state functional connectivity in euthymic bipolar patients with insomnia symptoms
by Yoon, Ho-Kyoung and Dev, Sheena I and Sutherland, Ashley N and Eyler, Lisa T
Psychiatry Research: Neuroimaging, ISSN 0925-4927, 05/2018, Volume 275, pp. 1 - 4
Insomnia is prevalent in bipolar disorder (BD) even during periods of euthymic mood. We compared resting state brain activity and cognitive function between... 
Insomnia | Bipolar disorder | Resting state | DEFAULT MODE NETWORK | PSYCHIATRY | SLEEP-DEPRIVATION | SCHIZOPHRENIA | NEUROIMAGING | CLINICAL NEUROLOGY | DISTORTION | MEMORY | DISORDER | BRAIN | Sleep Initiation and Maintenance Disorders - etiology | Humans | Bipolar Disorder - physiopathology | Bipolar Disorder - complications | Male | Cognitive Dysfunction - etiology | Cognitive Dysfunction - physiopathology | Sleep Initiation and Maintenance Disorders - diagnostic imaging | Cerebral Cortex - diagnostic imaging | Cerebral Cortex - physiopathology | Magnetic Resonance Imaging | Bipolar Disorder - diagnostic imaging | Connectome - methods | Adult | Female | Sleep Initiation and Maintenance Disorders - physiopathology | Cognitive Dysfunction - diagnostic imaging | Medical colleges
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5. Full Text Magnetic resonance study on the brain structure and resting-state brain functional connectivity in primary insomnia patients
by Li, Gang and Zhang, Xiaoqi and Zhang, Jiewen and Wang, Enfeng and Zhang, Hongju and Li, Yongli
Medicine, ISSN 0025-7974, 08/2018, Volume 97, Issue 34, p. e11944
The aim of the study was to study the changes in brain structure and functional connectivity in primary insomnia (PI) patients, as well as to explore the... 
cognitive function | DEPRESSION | GRAY | TEMPORAL-LOBE EPILEPSY | ATROPHY | ALZHEIMERS-DISEASE | voxel-based morphometry | DEFAULT-MODE NETWORK | primary insomnia | MEDICINE, GENERAL & INTERNAL | CORTEX | depressive disorder | resting-state functional connectivity | MOOD-REGULATING CIRCUIT | functional magnetic resonance | anterior cingulate cortex | SEVERITY | Brain - diagnostic imaging | Depression - physiopathology | Brain - physiopathology | Humans | Middle Aged | Gyrus Cinguli - diagnostic imaging | Magnetic Resonance Imaging - methods | Male | Brain Mapping - methods | Sleep Initiation and Maintenance Disorders - diagnostic imaging | Case-Control Studies | Cerebral Cortex - diagnostic imaging | Cerebral Cortex - physiopathology | Rest - physiology | Young Adult | Neural Pathways - diagnostic imaging | Brain - pathology | Gyrus Cinguli - physiopathology | Adult | Female | Sleep Initiation and Maintenance Disorders - physiopathology | Depression - diagnostic imaging | Neural Pathways - physiopathology | Sleep Initiation and Maintenance Disorders - psychology | Care and treatment | Usage | Magnetic resonance imaging | Insomnia
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6. Full Text Changes in subcortical shape and cognitive function in patients with chronic insomnia
by Koo, Dae Lim and Shin, Jeong-Hyeon and Lim, Jae-Sung and Seong, Joon-Kyung and Joo, Eun Yeon
Sleep Medicine, ISSN 1389-9457, 2017, Volume 35, pp. 23 - 26
Abstract Objective The aim of this study was to examine morphological changes in subcortical structures via surface-based analysis and to correlate local shape... 
Neurology | Sleep Medicine | Chronic insomnia | Cognitive function | Shape analysis | SLEEP | ONSET ALZHEIMERS-DISEASE | CLINICAL NEUROLOGY | Brain - diagnostic imaging | Humans | Middle Aged | Organ Size | Male | Cognition | Sleep Initiation and Maintenance Disorders - diagnostic imaging | Atrophy | Neuropsychological Tests | Magnetic Resonance Imaging | Female | Chronic Disease | Sleep Initiation and Maintenance Disorders - psychology | Medical colleges | Care and treatment | Insomnia | Analysis | Biomedical engineering
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7. Full Text Increased interhemispheric resting-state functional connectivity in healthy participants with insomnia symptoms A randomized clinical consort study
by Li, XH and Guo, SG and Wang, CJ and Wang, BJ and Sun, H and Zhang, XT
MEDICINE, ISSN 0025-7974, 07/2017, Volume 96, Issue 27, p. e7037
Background: Abnormalities within the insular cortex of the salience and thalamus of the hyperarousal network have been increasingly reported in healthy... 
DEFAULT MODE NETWORK | DEPRESSION | WHITE-MATTER | SLEEP-DEPRIVATION | NEUROIMAGING INSIGHTS | DISTURBANCE | resting-state | PREFRONTAL CORTEX | insomnia | fMRI | MEDICINE, GENERAL & INTERNAL | INTEGRITY | DISORDER | voxel-mirrored homotopic connectivity | thalamus | Brain - diagnostic imaging | Prospective Studies | Brain - physiopathology | Humans | Male | Functional Laterality | Sleep Initiation and Maintenance Disorders - diagnostic imaging | Magnetic Resonance Imaging | Rest | Neural Pathways - diagnostic imaging | Brain Mapping | Adult | Female | Sleep Initiation and Maintenance Disorders - physiopathology | Neural Pathways - physiopathology | Usage | Care and treatment | Electroencephalography | Magnetic resonance imaging | Insomnia
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8. Full Text Gender differences in regional brain activity in patients with chronic primary insomnia: Evidence from a resting-state fMRI study
by Dai, Xi-Jian and Nie, Xiao and Liu, Xuming and Pei, Li and Jiang, Jian and Peng, De-Chang and Gong, Hong-Han and Zeng, Xian-Jun and Wáng, Yì-Xiáng J and Zhan, Yang
Journal of Clinical Sleep Medicine, ISSN 1550-9389, 2016, Volume 12, Issue 3, pp. 363 - 374
Study Objectives: To explore the regional brain activities in patients with chronic primary insomnia (PCPIs) and their sex differences. Methods: Forty-two... 
Functional magnetic resonance imaging | Blood oxygen level-dependent | Amplitude of low frequency fluctuation | Insomnia | Gender difference | amplitude of low frequency fluctuation | OBSTRUCTIVE SLEEP-APNEA | HOMOGENEITY | FUNCTIONAL CONNECTIVITY | gender difference | CLINICAL NEUROLOGY | insomnia | HIPPOCAMPAL VOLUME | blood oxygen level-dependent | MEMORY | DEPRIVATION | FLUCTUATIONS | HYPERAROUSAL | DEFICITS | CORRELATE | functional magnetic resonance imaging | Brain - diagnostic imaging | Reproducibility of Results | Brain - physiopathology | Humans | Middle Aged | Male | Sleep Initiation and Maintenance Disorders - diagnostic imaging | Magnetic Resonance Imaging | Rest | Sex Factors | Female | Sleep Initiation and Maintenance Disorders - physiopathology | Chronic Disease
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9. Research Advances in Insomnia Disorder Based on Magnetic Resonance Imaging
by Zhou, Ping and Yan, Chao-Qun and Zhang, Shuai and Huo, Jian-Wei and Liu, Cun-Zhi
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, ISSN 1000-503X, 08/2018, Volume 40, Issue 4, p. 543
As the most common sleep disorder,insomnia decreases the quality of life and is the high risk for cardiovascular disease,neurological disease,and psychiatric... 
Magnetic Resonance Imaging | Brain - diagnostic imaging | Humans | Quality of Life | Sleep Initiation and Maintenance Disorders - diagnostic imaging
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10. Full Text Distinctive time-lagged resting-state networks revealed by simultaneous EEG-fMRI
by Feige, Bernd and Spiegelhalder, Kai and Kiemen, Andrea and Bosch, Oliver G and Tebartz van Elst, Ludger and Hennig, Jürgen and Seifritz, Erich and Riemann, Dieter
NeuroImage, ISSN 1053-8119, 01/2017, Volume 145, Issue Pt A, pp. 1 - 10
Functional activation as evidenced by blood oxygen level-dependent (BOLD) functional MRI changes or event-related EEG is known to closely follow patterns of... 
Resting state | EEG-fMRI | EEG frequency bands | Insomnia | Spontaneous activity | ALPHA-RHYTHM | HUMAN BRAIN | FUNCTIONAL CONNECTIVITY | PERCEPTUAL SUPPRESSION | CORRELATED FLUCTUATIONS | INDEPENDENT COMPONENTS | NEUROSCIENCES | NEUROIMAGING | HEMODYNAMIC-RESPONSE | ATTENTION-DEFICIT/HYPERACTIVITY DISORDER | DEFAULT-MODE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | FOCAL EPILEPSY | Brain Waves - physiology | Brain - diagnostic imaging | Nerve Net - diagnostic imaging | Humans | Middle Aged | Magnetic Resonance Imaging - methods | Male | Functional Neuroimaging - methods | Sleep Initiation and Maintenance Disorders - diagnostic imaging | Brain - physiology | Nerve Net - physiology | Time Factors | Adult | Female | Psychiatric hospital care | Magnetic resonance imaging | Segregation | Analysis | Mental illness | Psychiatric hospitals | Psychophysiology | Attention deficit disorder | Studies | Brain research | Sleep | Metabolism | Information processing
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11. Full Text Quantitative magnetic resonance abnormalities in creutzfeldt-jakob disease and fatal insomnia
by Grau-Rivera, Oriol and Calvo, Anna and Bargalló, Núria and Monté, Gemma C and Nos, Carlos and Lladó, Albert and Molinuevo, José Luis and Gelpi, Ellen and Sánchez-Valle, Raquel
Journal of Alzheimer's Disease, ISSN 1387-2877, 2016, Volume 55, Issue 1, pp. 431 - 443
Background: Quantitative neuroimaging might unveil abnormalities in prion diseases that are not perceivable at visual inspection. On the other hand, scarce... 
fatal familial insomnia | diffusion tensor imaging | prion diseases | Creutzfeldt-Jakob syndrome | neuroimaging | DIAGNOSIS | MRI | PRION DISEASE | INVOLVEMENT | NEUROSCIENCES | DEGENERATION | SPORADIC CJD | BRAIN | Brain - diagnostic imaging | Prospective Studies | Humans | Middle Aged | Organ Size | Male | Sleep Initiation and Maintenance Disorders - diagnostic imaging | Diffusion Tensor Imaging | Gray Matter - diagnostic imaging | Atrophy | Magnetic Resonance Imaging | Phenotype | White Matter - diagnostic imaging | Sleep Initiation and Maintenance Disorders - genetics | Female | Creutzfeldt-Jakob Syndrome - genetics | Creutzfeldt-Jakob Syndrome - diagnostic imaging | Cerebellum | Neuroimaging | Brain | Nuclear magnetic resonance--NMR | Spatial discrimination | Creutzfeldt-Jakob disease | Nuclei | Visual perception | Thalamic nuclei | Sleep disorders | Neostriatum | Thalamus | Phenotypes | Medical imaging | Abnormalities | Brain mapping | Inspection | Fatal | Substantia alba | Patients | Diseases | Neurology | Magnetic resonance imaging | Insomnia | Resonance
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12. Full Text The neurophysiological basis of the discrepancy between objective and subjective sleep during the sleep onset period: An EEG-fMRI study
by Hsiao, Fan-Chi and Tsai, Pei-Jung and Wu, Changwei W and Yang, Chien-Ming and Lane, Timothy Joseph and Lee, Hsin-Chien and Chen, Ling-Chun and Lee, We-Kang and Lu, Lu-Hsin and Wu, Yu-Zu
Sleep, ISSN 0161-8105, 06/2018, Volume 41, Issue 6
Subjective perception of sleep is not necessarily consistent with electroencephalography (EEG) indications of sleep. The mismatch between subjective reports... 
Sleep state misperception | Functional brain imaging | Hyperarousal | EEG spectral analysis | SECONDARY INSOMNIA | sleep state misperception | HUMAN BRAIN | STATE FUNCTIONAL MRI | LATERAL FRONTAL-CORTEX | NETWORKS | functional brain imaging | NEUROSCIENCES | CLINICAL NEUROLOGY | CONNECTIVITY | FLUCTUATIONS | hyperarousal | OSCILLATIONS | WORKING-MEMORY | WAKEFULNESS | Brain Waves - physiology | Brain - diagnostic imaging | Electroencephalography - standards | Humans | Magnetic Resonance Imaging - methods | Perception - physiology | Male | Sleep Initiation and Maintenance Disorders - diagnostic imaging | Brain - physiology | Electroencephalography - methods | Polysomnography - standards | Polysomnography - methods | Young Adult | Sleep Stages - physiology | Wakefulness - physiology | Adult | Female | Sleep Initiation and Maintenance Disorders - physiopathology | Sleep - physiology | Goals | Surveys and Questionnaires - standards | Electroencephalography | Sleep | Nuclear magnetic resonance--NMR
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13. Full Text Association of Insomnia and Short Sleep Duration With Atherosclerosis Risk in the Elderly
by Nakazaki, Chie and Noda, Akiko and Koike, Yasuo and Yamada, Sumio and Murohara, Toyoaki and Ozaki, Norio
American Journal of Hypertension, ISSN 0895-7061, 11/2012, Volume 25, Issue 11, pp. 1149 - 1155
Background Short sleep duration is associated with an increased risk of cardiovascular disease and all-cause mortality, although a relationship with... 
atherosclerosis | blood pressure | cardiovascular disease | sleep duration | hypertension | insomnia | INTIMA-MEDIA THICKNESS | BLOOD-PRESSURE | WOMEN | GENERAL-POPULATION | APNEA SYNDROME | DEPRIVATION | CARDIOVASCULAR-DISEASE | CLINICAL-IMPLICATIONS | PERIPHERAL VASCULAR DISEASE | HEALTH | Cardiovascular Diseases - etiology | Carotid Intima-Media Thickness | Humans | Risk Factors | Male | Sleep Initiation and Maintenance Disorders - diagnostic imaging | Atherosclerosis - etiology | Sleep Initiation and Maintenance Disorders - complications | Atherosclerosis - diagnostic imaging | Sleep | Female | Aged | Blood Pressure - physiology | Hypertension | Complications and side effects | Medical research | Insomnia | Atherosclerosis | Medicine, Experimental | Research | Cardiovascular diseases | Risk factors | Geriatrics
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14. Full Text Increased insular connectivity with emotional regions in primary insomnia patients: a resting-state fMRI study
by Wang, Tianyue and Yan, Jianhao and Li, Shumei and Zhan, Wenfeng and Ma, Xiaofen and Xia, Likun and Li, Meng and Lin, Chulan and Tian, Junzhang and Li, Cheng and Jiang, Guihua
European Radiology, ISSN 0938-7994, 9/2017, Volume 27, Issue 9, pp. 3703 - 3709
To explore the abnormal connectivity patterns between the insular and the voxels of the brain in primary insomnia (PI) with insular-based functional... 
Functional connectivity | Insular | Functional integration | Medicine & Public Health | Diagnostic Radiology | Primary insomnia | Resting-state fMRI | Internal Medicine | Interventional Radiology | Imaging / Radiology | Ultrasound | Neuroradiology | INDIVIDUALS | ABNORMALITIES | NETWORKS | MAJOR DEPRESSIVE DISORDER | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Brain - diagnostic imaging | Brain - physiopathology | Humans | Middle Aged | Magnetic Resonance Imaging - methods | Male | Brain Mapping - methods | Connectome | Sleep Initiation and Maintenance Disorders - diagnostic imaging | Case-Control Studies | Adult | Female | Neural Pathways - physiopathology | Magnetic resonance imaging | Insomnia | Analysis | Brain | Cortex (cingulate) | Integration | Data acquisition | Brain mapping | Cognitive ability | Mental depression | Patients | Temporal gyrus | Emotions | Sleep disorders | Correlation analysis | Cortex (parietal) | Neural networks | Cortex (frontal) | Functional magnetic resonance imaging | Cortex (insular) | Thalamus | Connectivity | Anxiety | Aberration | Cortex (temporal)
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