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Neuron, ISSN 0896-6273, 02/2012, Volume 73, Issue 4, pp. 713 - 728
Myelination by oligodendrocytes in the central nervous system (CNS) is essential for proper brain function, yet the molecular determinants that control this... 
TRANSCRIPTION FACTORS | IN-VITRO | MULTIPLE-SCLEROSIS | BONE MORPHOGENETIC PROTEIN | OLIGODENDROCYTE PRECURSOR CELLS | DEMYELINATED LESIONS | MOWAT-WILSON-SYNDROME | DIFFERENTIATION | BETA-CATENIN | CNS MYELINATION | NEUROSCIENCES | Central Nervous System - ultrastructure | Microcephaly - genetics | Oligonucleotide Array Sequence Analysis | Embryo, Mammalian | Homeodomain Proteins - metabolism | Humans | Nerve Tissue Proteins - deficiency | Caspase 3 - metabolism | Ki-67 Antigen - metabolism | Gene Expression Profiling | Green Fluorescent Proteins - genetics | RNA, Messenger - metabolism | Zinc Finger E-box Binding Homeobox 2 | Central Nervous System - physiology | Bone Morphogenetic Proteins - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Facies | Repressor Proteins - metabolism | Smad7 Protein - metabolism | Animals, Newborn | Basic Helix-Loop-Helix Transcription Factors - genetics | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Hirschsprung Disease - pathology | Intellectual Disability - pathology | Models, Molecular | Smad Proteins - genetics | Oligodendrocyte Transcription Factor 2 | Signal Transduction - genetics | Mice, Knockout | Central Nervous System - cytology | Mice | Optic Nerve - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Oligodendroglia - metabolism | Immunoprecipitation | Age Factors | Hirschsprung Disease - genetics | Gene Expression Regulation, Developmental - genetics | Intellectual Disability - genetics | Myelin Sheath - metabolism | Cell Differentiation - genetics | Transfection | Microcephaly - pathology | Optic Nerve - embryology | Smad7 Protein - genetics | Optic Nerve - growth & development | Microscopy, Electron, Transmission | Cells, Cultured | Nerve Tissue Proteins - genetics | Organogenesis | Nerve Tissue Proteins - metabolism | Animals | Signal Transduction - physiology | Smad Proteins - metabolism | Medical colleges | Neurosciences | Neurons | Central nervous system | Bone morphogenetic proteins | Universities and colleges | DNA binding proteins | Proteins | Multiple sclerosis | Transcription factors | Rodents | Nervous system | Genomes | Kinases | Gene expression | Index Medicus | Antagonism
Journal Article
Cancer Research, ISSN 0008-5472, 12/2009, Volume 69, Issue 23, pp. 8844 - 8852
Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates cell growth, differentiation, and apoptosis of various types of cells.... 
SURVIVAL | THERAPY | BECLIN-1 | ONCOLOGY | INDUCED APOPTOSIS | MESANGIAL CELLS | PAI-1 GENE-EXPRESSION | INDUCTION | TUMORIGENESIS | CANCER | LC3 | Microtubule-Associated Proteins - genetics | Humans | Ubiquitin-Activating Enzymes - biosynthesis | Cell Growth Processes - physiology | JNK Mitogen-Activated Protein Kinases - metabolism | Autophagy - physiology | Proto-Oncogene Proteins - biosynthesis | Transforming Growth Factor beta - biosynthesis | Breast Neoplasms - metabolism | Transfection | Bcl-2-Like Protein 11 | Carcinoma, Hepatocellular - genetics | Apoptosis Regulatory Proteins - genetics | Liver Neoplasms - pathology | Apoptosis Regulatory Proteins - biosynthesis | Beclin-1 | Ubiquitin-Activating Enzymes - genetics | Liver Neoplasms - genetics | Membrane Proteins - genetics | Transforming Growth Factor beta - physiology | Proto-Oncogene Proteins - genetics | Microtubule-Associated Proteins - antagonists & inhibitors | Microtubule-Associated Proteins - biosynthesis | Autophagy-Related Protein 7 | Membrane Proteins - biosynthesis | Breast Neoplasms - genetics | Transforming Growth Factor beta - genetics | Autophagy-Related Protein 5 | Membrane Proteins - antagonists & inhibitors | Receptors, Transforming Growth Factor beta - metabolism | Breast Neoplasms - pathology | Ubiquitin-Activating Enzymes - antagonists & inhibitors | Adaptor Proteins, Signal Transducing - genetics | Apoptosis Regulatory Proteins - antagonists & inhibitors | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Line, Tumor | Adaptor Proteins, Signal Transducing - biosynthesis | Smad Proteins - metabolism | Carcinoma, Hepatocellular - metabolism | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2008, Volume 105, Issue 29, pp. 10073 - 10078
Journal Article
Cancer Research, ISSN 0008-5472, 08/2013, Volume 73, Issue 16, pp. 5016 - 5028
TGF-beta has limited effects on ovarian cancer cells, but its contributions to ovarian tumor growth might be mediated through elements of the tumor... 
CROSS-TALK | MATRIX | STEM-CELLS | CONTRIBUTE | INHIBITION | ONCOLOGY | MEMBRANE | TRANSCRIPTION | STROMAL CELLS | EXPRESSION | FIBROBLASTS | Up-Regulation | Receptors, Transforming Growth Factor beta - genetics | Epithelial Cells - metabolism | Stromal Cells - pathology | Humans | Ovarian Neoplasms - pathology | Transcriptome | NF-kappa B - metabolism | Cell Movement - genetics | Ovarian Neoplasms - genetics | Matrix Metalloproteinase 9 - metabolism | Versicans - genetics | Tumor Microenvironment - genetics | Matrix Metalloproteinase 9 - genetics | Hyaluronan Receptors - metabolism | Female | Ovarian Neoplasms - metabolism | Extracellular Matrix Proteins - metabolism | Protein-Serine-Threonine Kinases - metabolism | Fibroblasts - metabolism | Signal Transduction | Neoplasm Invasiveness | Extracellular Matrix Proteins - genetics | Stromal Cells - metabolism | Protein-Serine-Threonine Kinases - genetics | Epithelial Cells - pathology | Smad Proteins - genetics | Fibroblasts - pathology | Hyaluronan Receptors - genetics | Disease Progression | Transforming Growth Factor beta - genetics | NF-kappa B - genetics | Receptors, Transforming Growth Factor beta - metabolism | Cell Line, Tumor | Versicans - metabolism | Smad Proteins - metabolism | Transforming Growth Factor beta - metabolism | Index Medicus | cancer-associated fibroblast | TGF-β | versican | tumor microenvironment | ovarian cancer
Journal Article
Nature Cell Biology, ISSN 1465-7392, 08/2017, Volume 19, Issue 8, pp. 996 - 1002
The Hippo pathway controls organ size and tissue homeostasis, with deregulation leading to cancer. The core Hippo components in mammals are composed of the... 
LOCALIZATION | HOMEOSTASIS | PHOSPHORYLATION | YAP/TAZ | YAP | STRESS | NLK | TAZ | CANCER | KINASES | CELL BIOLOGY | Osmotic Pressure | Phosphorylation | Cell Proliferation | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Phosphoproteins - metabolism | DNA-Binding Proteins - metabolism | Transfection | Neoplasms - genetics | Time Factors | HEK293 Cells | Muscle Proteins - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Cytoplasm - enzymology | Signal Transduction | Neoplasms - enzymology | p38 Mitogen-Activated Protein Kinases - genetics | Phosphoproteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Protein Transport | Muscle Proteins - genetics | Transcription Factors - metabolism | Animals | Mice, Nude | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Protein Binding | Adaptor Proteins, Signal Transducing - metabolism | Neoplasms - pathology | Smad protein | Deregulation | Transcription factors | Gene regulation | Serine | Homeostasis | Dephosphorylation | NF-AT protein | Kinases | Inactivation | Signal transduction | Localization | Deoxyribonucleic acid--DNA | Translocation | Transducers | Deactivation | Threonine | MAP kinase | Gene expression | Nuclear transport | Environmental stress | Yes-associated protein | Tea | Signaling | Cancer | Index Medicus
Journal Article
Developmental Cell, ISSN 1534-5807, 06/2013, Volume 25, Issue 6, pp. 636 - 644
The Cubitus interruptus (Ci)/Gli family of transcription factors can be degraded either completely or partially from a full-length form (Ci155/Gli ) to a... 
MEMBRANE-FUSION | PATHWAY | AAA-ATPASE | LIGASES | DEVELOPMENTAL BIOLOGY | REPRESSOR | NF-KAPPA-B | TRANSCRIPTION FACTOR | CUBITUS-INTERRUPTUS PROTEIN | HEDGEHOG | DROSOPHILA | CELL BIOLOGY | Valosin Containing Protein | Hedgehog Proteins - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Smad Proteins, Inhibitory - genetics | Drosophila Proteins - metabolism | DNA-Binding Proteins - metabolism | Hedgehog Proteins - genetics | Cell Cycle Proteins - genetics | Cullin Proteins - metabolism | Ubiquitination - physiology | Intracellular Signaling Peptides and Proteins - genetics | Cell Cycle Proteins - metabolism | Cells, Cultured | Ubiquitin-Protein Ligases - metabolism | Adenosine Triphosphatases - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Cullin Proteins - genetics | Proteasome Endopeptidase Complex - genetics | Transcription Factors - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Signal Transduction - physiology | Adenosine Triphosphatases - genetics | Drosophila Proteins - genetics | Proteasome Endopeptidase Complex - metabolism | Ubiquitin-Protein Ligases - genetics | Drosophila melanogaster | Protein Binding - physiology | Ubiquitin | Ligases | Children's hospitals | Adenosine triphosphatase | Stem cells | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2011, Volume 286, Issue 32, pp. 28097 - 28110
In the postnatal vasculature, fully differentiated and quiescent vascular smooth muscle cells (VSMCs) in a "contractile" phenotype are required for the normal... 
TRANSCRIPTION FACTORS | MYOCARDIN | SIGNALING PATHWAYS | BIOCHEMISTRY & MOLECULAR BIOLOGY | EMBRYONIC STEM-CELLS | CARDIAC-HYPERTROPHY | SERUM RESPONSE FACTOR | ZINC-FINGER PROTEIN | GENE-EXPRESSION | DIFFERENTIATION | SMAD | Oncogene Proteins, Fusion - metabolism | Muscle, Smooth, Vascular - metabolism | Active Transport, Cell Nucleus - physiology | Bone Morphogenetic Protein 4 - genetics | Humans | MicroRNAs - metabolism | Bone Morphogenetic Protein 4 - metabolism | DNA-Binding Proteins - metabolism | Cell Nucleus - metabolism | Muscle Proteins - metabolism | Trans-Activators - genetics | Myocytes, Smooth Muscle - cytology | Myocytes, Smooth Muscle - metabolism | Cell Line | Kruppel-Like Transcription Factors - biosynthesis | DNA-Binding Proteins - genetics | Muscle, Smooth, Vascular - cytology | Down-Regulation - physiology | Muscle Proteins - genetics | Transcription, Genetic - physiology | Animals | Cell Nucleus - genetics | Oncogene Proteins, Fusion - genetics | Muscle Contraction - physiology | Trans-Activators - metabolism | Mice | MicroRNAs - genetics | Kruppel-Like Transcription Factors - genetics | Transforming Growth Factor beta - metabolism | Index Medicus | Gene Transcription | Smad Transcription Factor | Bone Morphogenetic Protein (BMP) | Transcription Regulation | Transforming Growth Factor β (TGFbeta) | MicroRNA | Signal Transduction | RNA Silencing | Cell Differentiation | Transcription Factors | Smooth Muscle
Journal Article
Blood, ISSN 0006-4971, 08/2008, Volume 112, Issue 4, pp. 1503 - 1509
Journal Article
PLoS Genetics, ISSN 1553-7390, 07/2017, Volume 13, Issue 7, pp. e1006887 - e1006887
MicroRNA cluster mirn23a has previously been shown to promote myeloid development at the expense of lymphoid development in overexpression and knockout mouse... 
Guanylate Kinases - genetics | NIH 3T3 Cells | Up-Regulation | Cell Proliferation | MicroRNAs - metabolism | Mitochondrial Proteins - genetics | Phosphatidylinositol 3-Kinases - metabolism | Mitochondrial Proteins - metabolism | Trans-Activators - genetics | Cell Cycle Proteins - genetics | Cell Differentiation | Membrane Proteins - metabolism | B-Lymphocytes - metabolism | Cell Line | Forkhead Box Protein O1 - metabolism | Promoter Regions, Genetic | Signal Transduction | Membrane Proteins - genetics | Down-Regulation | Mice, Inbred C57BL | Cell Cycle Proteins - metabolism | Hematopoiesis - genetics | Phosphatidylinositol 3-Kinases - genetics | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Guanylate Kinases - metabolism | Trans-Activators - metabolism | Mice | MicroRNAs - genetics | Forkhead Box Protein O1 - genetics | Apoptosis | RNA sequencing | MicroRNA | Hematopoiesis | Physiological aspects | Genetic aspects | Genetic transcription | Observations | Methods | Cell culture | Flow cytometry | Polarization | Visualization | Smad protein | Animal models | Transcription factors | Gene regulation | AKT protein | In vitro testing | Kinases | Pax5 protein | Proteins | Signal transduction | Immunology | Pathways | FOXO1 protein | Bone marrow | Clusters | Bone morphogenetic proteins | Buffers | Research centers | Medical research | MiRNA | Transplants | Cell lineage | Runx1 protein | Pharmacology | 1-Phosphatidylinositol 3-kinase | Hemopoiesis | Cytometry | Inhibitors | Ribonucleic acids | Lymphocytes B | MicroRNAs | Stem cells | In vivo methods and tests | Differentiation | Cancer | Index Medicus
Journal Article
Genes and Development, ISSN 0890-9369, 04/2008, Volume 22, Issue 7, pp. 894 - 907
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2013, Volume 110, Issue 12, pp. 4640 - 4645
Embryonic nephron progenitor cells are segregated in molecularly distinct compartments of unknown function. Our study reveals an integral role for bone... 
Kidneys | Epithelial cells | Cell aggregates | Antibodies | Cultured cells | Progenitor cells | Cellular differentiation | Cells | Nephrons | Mesenchymal stem cells | Niche | Pretubular aggregate | Cap mesenchyme | Nephrogenic zone | Kidney development | MOUSE METANEPHROGENIC MESENCHYME | POPULATION | pretubular aggregate | nephrogenic zone | cap mesenchyme | NEPHROGENESIS | MULTIDISCIPLINARY SCIENCES | INDUCTION | MAMMALIAN KIDNEY | RENEWAL | kidney development | SIX2 | niche | DEFINES | MICE | Epithelial Cells - metabolism | Bone Morphogenetic Protein 7 - genetics | Homeodomain Proteins - metabolism | Wnt Signaling Pathway - physiology | Stem Cells - cytology | Stem Cells - metabolism | Wnt Proteins - metabolism | Nephrons - cytology | Wnt Proteins - genetics | Trans-Activators - genetics | Epithelial Cells - cytology | Nuclear Proteins - genetics | Cell Differentiation - physiology | Cell Line | Nuclear Proteins - metabolism | Smad Proteins - genetics | Transcription Factors - genetics | beta Catenin - metabolism | Homeodomain Proteins - genetics | beta Catenin - genetics | Mice, Knockout | Transcription Factors - metabolism | Animals | Bone Morphogenetic Protein 7 - metabolism | Trans-Activators - metabolism | Mice | Smad Proteins - metabolism | Nephrons - metabolism | Physiological aspects | Bone morphogenetic proteins | Research | Cell differentiation | Kidney tubules | Stem cells | Proteins | Viruses | Genetics | Rodents | Tumors | Index Medicus | Biological Sciences
Journal Article