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Blood, ISSN 0006-4971, 08/2008, Volume 112, Issue 4, pp. 1503 - 1509
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 06/2009, Volume 296, Issue 6, pp. 1258 - 1270
Myostatin is a negative regulator of skeletal muscle size, previously shown to inhibit muscle cell differentiation. Myostatin requires both Smad2 and Smad3... 
MAFbx | Mammalian target of rapamycin complex signaling | MuRF1 | S6 kinase | Smad signaling | Human skeletal muscle cells | Transducer of regulated Ca | responsive element-binding protein activity | MuRF-1 | Atrogin | Transforming growth factor-β-like molecules | IGF-I | PHYSIOLOGY | ATROPHY | RAPID DISUSE | human skeletal muscle cells | transforming growth factor-beta-like molecules | SKELETAL-MUSCLE HYPERTROPHY | FOXO TRANSCRIPTION FACTORS | UBIQUITIN LIGASES | transducer of regulated Ca2+-responsive element-binding protein activity | CELL BIOLOGY | atrogin | PATHWAY | GROWTH | GENE-EXPRESSION | mammalian target of rapamycin complex signaling | CONDITIONAL ACTIVATION | Activin Receptors, Type I - antagonists & inhibitors | Protein Kinases - metabolism | Phosphorylation | Protein Kinases - genetics | Humans | Smad3 Protein - metabolism | Muscle Fibers, Skeletal - drug effects | Tripartite Motif Proteins | Smad3 Protein - genetics | Transfection | RNA Interference | Myoblasts, Skeletal - pathology | Smad2 Protein - genetics | Muscle Proteins - metabolism | Dioxoles - pharmacology | Regulatory-Associated Protein of mTOR | Benzamides - pharmacology | Myostatin - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Rapamycin-Insensitive Companion of mTOR Protein | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Signal Transduction | Cell Size - drug effects | Cells, Cultured | Smad2 Protein - metabolism | Ubiquitin-Protein Ligases - metabolism | Organ Size | Activin Receptors, Type I - metabolism | Myoblasts, Skeletal - enzymology | SKP Cullin F-Box Protein Ligases - metabolism | Mice, SCID | Myostatin - antagonists & inhibitors | Adaptor Proteins, Signal Transducing | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Cell Differentiation - drug effects | Follistatin - pharmacology | Muscle Fibers, Skeletal - pathology | Creatine Kinase - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | TOR Serine-Threonine Kinases | Myoblasts, Skeletal - drug effects | Insulin-Like Growth Factor I - metabolism | Muscle Fibers, Skeletal - enzymology | RNA, Small Interfering - metabolism
Journal Article
Developmental Cell, ISSN 1534-5807, 03/2012, Volume 22, Issue 3, pp. 501 - 514
Gradients of vascular endothelial growth factor (VEGF) induce single endothelial cells to become leading tip cells of emerging angiogenic sprouts. Tip cells... 
DEFECTS | TIP CELLS | ANGIOGENESIS | VEGF | ENDOTHELIAL-CELLS | ID PROTEINS | HES1 | DEVELOPMENTAL BIOLOGY | DIFFERENTIATION | EXPRESSION | INHIBITS TUMOR-GROWTH | CELL BIOLOGY | Transcription Factor HES-1 | Humans | Intercellular Signaling Peptides and Proteins - biosynthesis | Intracellular Signaling Peptides and Proteins - metabolism | Inhibitor of Differentiation Proteins - biosynthesis | Inhibitor of Differentiation Protein 1 - biosynthesis | Serrate-Jagged Proteins | Smad5 Protein - metabolism | Basic Helix-Loop-Helix Transcription Factors - biosynthesis | Smad1 Protein - genetics | Membrane Proteins - metabolism | Smad5 Protein - genetics | Intracellular Signaling Peptides and Proteins - genetics | Jagged-1 Protein | Calcium-Binding Proteins - biosynthesis | Homeodomain Proteins - biosynthesis | Signal Transduction | Inhibitor of Differentiation Protein 2 - biosynthesis | Membrane Proteins - genetics | Down-Regulation | Cells, Cultured | Mice, Transgenic | Cell Cycle Proteins - biosynthesis | Vascular Endothelial Growth Factor Receptor-1 - biosynthesis | Mice, Knockout | Membrane Proteins - biosynthesis | Phenotype | Animals | Smad1 Protein - metabolism | Mice | Neovascularization, Physiologic | Proteins | Endothelial growth factors | Genes | Genetic aspects | Transforming growth factors | Vascular endothelial growth factor | Endothelium | Dll4 | tip cell | lateral inhibition | sprouting angiogenesis | BMP | directed migration | Notch | stalk cell | mouse embryo | Smad | polarity
Journal Article
Cancer Research, ISSN 0008-5472, 12/2009, Volume 69, Issue 23, pp. 8844 - 8852
Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates cell growth, differentiation, and apoptosis of various types of cells.... 
SURVIVAL | THERAPY | BECLIN-1 | ONCOLOGY | INDUCED APOPTOSIS | MESANGIAL CELLS | PAI-1 GENE-EXPRESSION | INDUCTION | TUMORIGENESIS | CANCER | LC3 | Microtubule-Associated Proteins - genetics | Humans | Ubiquitin-Activating Enzymes - biosynthesis | Cell Growth Processes - physiology | JNK Mitogen-Activated Protein Kinases - metabolism | Autophagy - physiology | Proto-Oncogene Proteins - biosynthesis | Transforming Growth Factor beta - biosynthesis | Breast Neoplasms - metabolism | Transfection | Bcl-2-Like Protein 11 | Carcinoma, Hepatocellular - genetics | Apoptosis Regulatory Proteins - genetics | Liver Neoplasms - pathology | Apoptosis Regulatory Proteins - biosynthesis | Beclin-1 | Ubiquitin-Activating Enzymes - genetics | Liver Neoplasms - genetics | Membrane Proteins - genetics | Transforming Growth Factor beta - physiology | Proto-Oncogene Proteins - genetics | Microtubule-Associated Proteins - antagonists & inhibitors | Microtubule-Associated Proteins - biosynthesis | Autophagy-Related Protein 7 | Membrane Proteins - biosynthesis | Breast Neoplasms - genetics | Transforming Growth Factor beta - genetics | Autophagy-Related Protein 5 | Membrane Proteins - antagonists & inhibitors | Receptors, Transforming Growth Factor beta - metabolism | Breast Neoplasms - pathology | Ubiquitin-Activating Enzymes - antagonists & inhibitors | Adaptor Proteins, Signal Transducing - genetics | Apoptosis Regulatory Proteins - antagonists & inhibitors | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Line, Tumor | Adaptor Proteins, Signal Transducing - biosynthesis | Smad Proteins - metabolism | Carcinoma, Hepatocellular - metabolism
Journal Article
Journal Article
Developmental Cell, ISSN 1534-5807, 06/2013, Volume 25, Issue 6, pp. 636 - 644
Journal Article
Neuron, ISSN 0896-6273, 02/2012, Volume 73, Issue 4, pp. 713 - 728
Myelination by oligodendrocytes in the central nervous system (CNS) is essential for proper brain function, yet the molecular determinants that control this... 
TRANSCRIPTION FACTORS | IN-VITRO | MULTIPLE-SCLEROSIS | BONE MORPHOGENETIC PROTEIN | OLIGODENDROCYTE PRECURSOR CELLS | DEMYELINATED LESIONS | MOWAT-WILSON-SYNDROME | DIFFERENTIATION | BETA-CATENIN | CNS MYELINATION | NEUROSCIENCES | Central Nervous System - ultrastructure | Microcephaly - genetics | Oligonucleotide Array Sequence Analysis | Embryo, Mammalian | Homeodomain Proteins - metabolism | Humans | Nerve Tissue Proteins - deficiency | Caspase 3 - metabolism | Ki-67 Antigen - metabolism | Gene Expression Profiling | Green Fluorescent Proteins - genetics | RNA, Messenger - metabolism | Zinc Finger E-box Binding Homeobox 2 | Central Nervous System - physiology | Bone Morphogenetic Proteins - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Facies | Repressor Proteins - metabolism | Smad7 Protein - metabolism | Animals, Newborn | Basic Helix-Loop-Helix Transcription Factors - genetics | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Hirschsprung Disease - pathology | Intellectual Disability - pathology | Models, Molecular | Smad Proteins - genetics | Oligodendrocyte Transcription Factor 2 | Signal Transduction - genetics | Mice, Knockout | Central Nervous System - cytology | Mice | Optic Nerve - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Oligodendroglia - metabolism | Immunoprecipitation | Age Factors | Hirschsprung Disease - genetics | Gene Expression Regulation, Developmental - genetics | Intellectual Disability - genetics | Myelin Sheath - metabolism | Cell Differentiation - genetics | Transfection | Microcephaly - pathology | Optic Nerve - embryology | Smad7 Protein - genetics | Optic Nerve - growth & development | Microscopy, Electron, Transmission | Cells, Cultured | Nerve Tissue Proteins - genetics | Organogenesis | Nerve Tissue Proteins - metabolism | Animals | Signal Transduction - physiology | Smad Proteins - metabolism | Medical colleges | Neurosciences | Neurons | Central nervous system | Bone morphogenetic proteins | Universities and colleges | DNA binding proteins | Proteins | Multiple sclerosis | Transcription factors | Rodents | Nervous system | Genomes | Kinases | Gene expression | Antagonism
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2017, Volume 292, Issue 34, pp. 14165 - 14175
Circadian clock and Smad2/3/4-mediated Nodal signaling regulate multiple physiological and pathological processes. However, it remains unknown whether Clock... 
VERTEBRATE DEVELOPMENT | TGF-BETA | SMAD3 | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | INDUCTION | nodal | mesoderm | MOUSE EMBRYO | CIRCADIAN CLOCK | GASTRULATION | LOOP-HELIX PROTEINS | hematopoiesis | SMAD transcription factor | zebrafish | clock gene | transcription promoter | CELL | Embryo, Nonmammalian - cytology | Humans | Embryo, Nonmammalian - metabolism | Mesoderm - drug effects | Nodal Protein - metabolism | Smad3 Protein - metabolism | Mesoderm - cytology | Embryo, Nonmammalian - drug effects | Recombinant Fusion Proteins - metabolism | Hematopoiesis - drug effects | DNA-Binding Proteins - metabolism | Smad3 Protein - genetics | In Situ Hybridization | Mesoderm - abnormalities | Nodal Protein - genetics | Nodal Protein - agonists | Gene Expression Regulation, Developmental | HEK293 Cells | Zebrafish Proteins - agonists | Recombinant Proteins - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Microinjections | Zebrafish Proteins - metabolism | Zebrafish Proteins - antagonists & inhibitors | Recombinant Proteins - chemistry | Zebrafish | Recombinant Fusion Proteins - chemistry | DNA-Binding Proteins - genetics | Smad3 Protein - antagonists & inhibitors | Response Elements - drug effects | Smad3 Protein - agonists | Embryo, Nonmammalian - abnormalities | Animals | Signal Transduction - drug effects | Morpholinos - pharmacology | Luminescent Proteins - genetics | Mesoderm - metabolism | Mutation | Zebrafish Proteins - genetics | Embryonic Development - drug effects | Microscopy, Fluorescence | Luminescent Proteins - metabolism | Developmental Biology
Journal Article
PLoS Genetics, ISSN 1553-7390, 07/2017, Volume 13, Issue 7, p. e1006887
MicroRNA cluster mirn23a has previously been shown to promote myeloid development at the expense of lymphoid development in overexpression and knockout mouse... 
Guanylate Kinases - genetics | NIH 3T3 Cells | Up-Regulation | Cell Proliferation | MicroRNAs - metabolism | Mitochondrial Proteins - genetics | Phosphatidylinositol 3-Kinases - metabolism | Mitochondrial Proteins - metabolism | Trans-Activators - genetics | Cell Cycle Proteins - genetics | Cell Differentiation | Membrane Proteins - metabolism | B-Lymphocytes - metabolism | Cell Line | Forkhead Box Protein O1 - metabolism | Promoter Regions, Genetic | Signal Transduction | Membrane Proteins - genetics | Down-Regulation | Mice, Inbred C57BL | Cell Cycle Proteins - metabolism | Hematopoiesis - genetics | Phosphatidylinositol 3-Kinases - genetics | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Guanylate Kinases - metabolism | Trans-Activators - metabolism | Mice | MicroRNAs - genetics | Forkhead Box Protein O1 - genetics | Apoptosis | RNA sequencing | MicroRNA | Hematopoiesis | Physiological aspects | Genetic aspects | Genetic transcription | Observations | Methods | Cell culture | Flow cytometry | Polarization | Smad protein | Animal models | Transcription factors | Gene regulation | AKT protein | Kinases | Pax5 protein | Proteins | Signal transduction | Immunology | Pathways | FOXO1 protein | Bone marrow | Clusters | Bone morphogenetic proteins | Buffers | Medical research | MiRNA | Transplants | Cell lineage | Runx1 protein | Pharmacology | Ribonucleic acid--RNA | 1-Phosphatidylinositol 3-kinase | Hemopoiesis | Cytometry | Inhibitors | Lymphocytes B | MicroRNAs | Stem cells | In vivo methods and tests | Differentiation | In vitro methods and tests | Cancer | Visualization | In vitro testing | Research centers | Ribonucleic acids
Journal Article
Nature Cell Biology, ISSN 1465-7392, 08/2017, Volume 19, Issue 8, pp. 996 - 1002
The Hippo pathway controls organ size and tissue homeostasis, with deregulation leading to cancer. The core Hippo components in mammals are composed of the... 
LOCALIZATION | HOMEOSTASIS | PHOSPHORYLATION | YAP/TAZ | YAP | STRESS | NLK | TAZ | CANCER | KINASES | CELL BIOLOGY | Osmotic Pressure | Phosphorylation | Cell Proliferation | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Phosphoproteins - metabolism | DNA-Binding Proteins - metabolism | Transfection | Neoplasms - genetics | Time Factors | HEK293 Cells | Muscle Proteins - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Cytoplasm - enzymology | Signal Transduction | Neoplasms - enzymology | p38 Mitogen-Activated Protein Kinases - genetics | Phosphoproteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Protein Transport | Muscle Proteins - genetics | Transcription Factors - metabolism | Animals | Mice, Nude | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Protein Binding | Adaptor Proteins, Signal Transducing - metabolism | Neoplasms - pathology | Smad protein | Deregulation | Transcription factors | Gene regulation | Serine | Homeostasis | Dephosphorylation | NF-AT protein | Kinases | Inactivation | Signal transduction | Localization | Deoxyribonucleic acid--DNA | Translocation | Transducers | Deactivation | Threonine | MAP kinase | Gene expression | Nuclear transport | Environmental stress | Yes-associated protein | Tea | Signaling | Cancer
Journal Article
Biochemical Journal, ISSN 0264-6021, 03/2005, Volume 386, Issue 3, pp. 461 - 470
Inhibitory Smad, Smad7, is a potent inhibitor of TGF-beta (transforming growth factor-beta) superfamily signalling. By binding to activated type I receptors,... 
Developmentally down-regulated 4-2 (NEDD4-2) | Bone morphogenetic protein (BMP) | Smad | Neural precursor cell expressed | Homologous to the E6-accessory protein C-terminus (HECT) | Transforming growth factor-β (TGF-β) | Humans | Protein-Serine-Threonine Kinases | Ubiquitin - metabolism | Cytoplasm - metabolism | RNA, Messenger - metabolism | DNA-Binding Proteins - metabolism | Bone Morphogenetic Proteins - metabolism | Cell Nucleus - metabolism | Trans-Activators - genetics | Nedd4 Ubiquitin Protein Ligases | Transcription, Genetic | Proto-Oncogene Proteins - metabolism | Smad7 Protein | Cell Line | Signal Transduction | Smad6 Protein | Endosomal Sorting Complexes Required for Transport | RNA, Messenger - genetics | Ubiquitin-Protein Ligases - metabolism | Intracellular Signaling Peptides and Proteins | Activin Receptors, Type I - metabolism | DNA-Binding Proteins - genetics | Protein Transport | Two-Hybrid System Techniques | Smad3 Protein | Animals | Receptors, Transforming Growth Factor beta - metabolism | Cell Line, Tumor | Protein Binding | Ligands | Trans-Activators - metabolism | Mice | Ubiquitin-Protein Ligases - genetics | Transforming Growth Factor beta - metabolism | Smad2 Protein | BMPR-IB, BMP type IB receptor | TβR-I, transforming growth factor-β type I receptor | developmentally down-regulated 4-2 (NEDD4-2) | Ski-related novel protein N (SnoN) | I-Smad, inhibitory Smad | transforming growth factor-β (TGF-β) | homologous to the E6-accessory protein C-terminus (HECT) | R-Smad, receptor-regulated Smad | SnoN, Ski-related novel protein N | RING, really interesting new gene | F-box protein | bone morphogenetic protein (BMP) | ROC1, regulator of Cullins 1 | HECT, homologous to the E6-accessory protein C-terminus | siRNA, small interfering RNA | NEDD4-2, neural precursor cell expressed, developmentally down-regulated 4-2 | SCF, Skp1 | neural precursor cell expressed | Smurf, Smad ubiquitin regulatory factor | TGF-β, transforming growth factor-β | Cullin1 | BMP, bone morphogenetic protein | Co-Smad, common-partner Smad
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2010, Volume 107, Issue 44, pp. 18886 - 18891