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Nature Biotechnology, ISSN 1087-0156, 06/2002, Volume 20, Issue 6, pp. 619 - 622
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 06/2009, Volume 296, Issue 6, pp. 1258 - 1270
Myostatin is a negative regulator of skeletal muscle size, previously shown to inhibit muscle cell differentiation. Myostatin requires both Smad2 and Smad3... 
MAFbx | Mammalian target of rapamycin complex signaling | MuRF1 | S6 kinase | Smad signaling | Human skeletal muscle cells | Transducer of regulated Ca | responsive element-binding protein activity | MuRF-1 | Atrogin | Transforming growth factor-β-like molecules | IGF-I | PHYSIOLOGY | ATROPHY | RAPID DISUSE | human skeletal muscle cells | transforming growth factor-beta-like molecules | SKELETAL-MUSCLE HYPERTROPHY | FOXO TRANSCRIPTION FACTORS | UBIQUITIN LIGASES | transducer of regulated Ca2+-responsive element-binding protein activity | CELL BIOLOGY | atrogin | PATHWAY | GROWTH | GENE-EXPRESSION | mammalian target of rapamycin complex signaling | CONDITIONAL ACTIVATION | Activin Receptors, Type I - antagonists & inhibitors | Protein Kinases - metabolism | Phosphorylation | Protein Kinases - genetics | Humans | Smad3 Protein - metabolism | Muscle Fibers, Skeletal - drug effects | Tripartite Motif Proteins | Smad3 Protein - genetics | Transfection | RNA Interference | Myoblasts, Skeletal - pathology | Smad2 Protein - genetics | Muscle Proteins - metabolism | Dioxoles - pharmacology | Regulatory-Associated Protein of mTOR | Benzamides - pharmacology | Myostatin - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Rapamycin-Insensitive Companion of mTOR Protein | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Signal Transduction | Cell Size - drug effects | Cells, Cultured | Smad2 Protein - metabolism | Ubiquitin-Protein Ligases - metabolism | Organ Size | Activin Receptors, Type I - metabolism | Myoblasts, Skeletal - enzymology | SKP Cullin F-Box Protein Ligases - metabolism | Mice, SCID | Myostatin - antagonists & inhibitors | Adaptor Proteins, Signal Transducing | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Cell Differentiation - drug effects | Follistatin - pharmacology | Muscle Fibers, Skeletal - pathology | Creatine Kinase - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | TOR Serine-Threonine Kinases | Myoblasts, Skeletal - drug effects | Insulin-Like Growth Factor I - metabolism | Muscle Fibers, Skeletal - enzymology | RNA, Small Interfering - metabolism
Journal Article
by Schormair, Barbara and Zhao, Chen and Bell, Steven and Bell, Robert K and Tilch, Erik and Salminen, Aaro V and Pütz, Benno and Dauvilliers, Yves and Stefani, Ambra and Högl, Birgit and Poewe, Werner and Kemlink, David and Sonka, Karel and Bachmann, Cornelius G and Paulus, Walter and Trenkwalder, Claudia and Oertel, Wolfgang H and Hornyak, Magdolna and Teder-Laving, Maris and Metspalu, Andres and Hadjigeorgiou, Georgios M and Polo, Olli and Fietze, Ingo and Ross, Owen A and Wszolek, Zbigniew and Butterworth, Adam S and Soranzo, Nicole and Ouwehand, Willem H and Roberts, David J and Danesh, John and Allen, Richard P and Earley, Christopher J and Ondo, William G and Xiong, Lan and Montplaisir, Jacques and Gan-Or, Ziv and Perola, Markus and Vodicka, Pavel and Dina, Christian and Franke, Andre and Tittmann, Lukas and Stewart, Alexandre F R and Shah, Svati H and Gieger, Christian and Peters, Annette and Rouleau, Guy A and Berger, Klaus and Oexle, Konrad and Di Angelantonio, Emanuele and Hinds, David A and Müller-Myhsok, Bertram and Winkelmann, Juliane and Balkau, B and Ducimetière, P and Eschwège, E and Rancière, F and Alhenc-Gelas, F and Gallois, Y and Girault, A and Fumeron, F and Marre, M and Roussel, R and Bonnet, F and Bonnefond, A and Cauchi, S and Froguel, P and Cogneau, J and Born, C and Caces, E and Cailleau, M and Lantieri, O and Moreau, JG and Rakotozafy, F and Tichet, J and Vol, S and Agee, Michelle and Alipanahi, Babak and Auton, Adam and Bryc, Katarzyna and Elson, Sarah L and Fontanillas, Pierre and Furlotte, Nicholas A and Hromatka, Bethann S and Huber, Karen E and Kleinman, Aaron and Litterman, Nadia K and McIntyre, Matthew H and Mountain, Joanna L and Northover, Carrie AM and Pitts, Steven J and Sathirapongsasuti, J Fah and Sazonova, Olga V and Shelton, Janie F and Shringarpure, Suyash and Tian, Chao and Tung, Joyce Y and Vacic, Vladimir and Wilson, Catherine H and Collaboration 23andMe Res Team and DESIR Study Grp and DESIR study group and 23andMe Research Team
The Lancet Neurology, ISSN 1474-4422, 11/2017, Volume 16, Issue 11, pp. 898 - 907
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 07/2012, Volume 32, Issue 14, pp. 2904 - 2916
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2012, Volume 287, Issue 10, pp. 7026 - 7038
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 998 - 10
Radiation-induced lung injury has restricted radiotherapy for thoracic cancer. The purpose of this study was to investigate the radioprotective effects of... 
CANCER PATIENTS | BROMODOMAINS | TGF-BETA | THERAPY | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | BRD4 INHIBITION | PNEUMONITIS | MECHANISMS | PULMONARY-FIBROSIS | NORMAL TISSUE-INJURY | Humans | NF-kappa B - metabolism | Smad2 Protein - antagonists & inhibitors | Collagen Type I - genetics | MCF-7 Cells | Smad2 Protein - genetics | Lung - radiation effects | Pulmonary Fibrosis - etiology | Fibroblasts - metabolism | NF-kappa B - antagonists & inhibitors | Smad2 Protein - metabolism | Rats | Pulmonary Fibrosis - pathology | Rats, Sprague-Dawley | Smad3 Protein - antagonists & inhibitors | Fibroblasts - drug effects | Proto-Oncogene Proteins c-myc - antagonists & inhibitors | Pulmonary Fibrosis - prevention & control | Cell Line, Tumor | Gene Expression Regulation - radiation effects | Fibroblasts - cytology | Proto-Oncogene Proteins c-myc - genetics | Hydroxyproline - antagonists & inhibitors | Proteins - antagonists & inhibitors | Gamma Rays - adverse effects | Hydroxyproline - biosynthesis | Pulmonary Fibrosis - genetics | Smad3 Protein - metabolism | Molecular Targeted Therapy | Smad3 Protein - genetics | Transforming Growth Factor beta - antagonists & inhibitors | Female | Lung - metabolism | Nuclear Proteins - genetics | Lung - pathology | Collagen Type I - metabolism | Collagen Type I - antagonists & inhibitors | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Proto-Oncogene Proteins c-myc - metabolism | Azepines - pharmacology | Gene Expression Regulation - drug effects | Proteins - genetics | Transcription Factors - metabolism | Triazoles - pharmacology | Animals | Proteins - metabolism | Transforming Growth Factor beta - genetics | Fibroblasts - radiation effects | NF-kappa B - genetics | Nuclear Proteins - antagonists & inhibitors | Cell Proliferation - drug effects | Transforming Growth Factor beta - metabolism | NF-κB protein | Collagen (type I) | Animal models | Cell survival | Lung diseases | Hydroxyproline | Radiation | c-Myc protein | Smad3 protein | Thorax | Breast cancer | Inflammation | Radiation therapy | Myc protein | Esophagus | Computed tomography | Smad2 protein | Rodents | Fibrosis | Fibroblasts | Cancer
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2017, Volume 292, Issue 34, pp. 14165 - 14175
Circadian clock and Smad2/3/4-mediated Nodal signaling regulate multiple physiological and pathological processes. However, it remains unknown whether Clock... 
VERTEBRATE DEVELOPMENT | TGF-BETA | SMAD3 | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | INDUCTION | nodal | mesoderm | MOUSE EMBRYO | CIRCADIAN CLOCK | GASTRULATION | LOOP-HELIX PROTEINS | hematopoiesis | SMAD transcription factor | zebrafish | clock gene | transcription promoter | CELL | Embryo, Nonmammalian - cytology | Humans | Embryo, Nonmammalian - metabolism | Mesoderm - drug effects | Nodal Protein - metabolism | Smad3 Protein - metabolism | Mesoderm - cytology | Embryo, Nonmammalian - drug effects | Recombinant Fusion Proteins - metabolism | Hematopoiesis - drug effects | DNA-Binding Proteins - metabolism | Smad3 Protein - genetics | In Situ Hybridization | Mesoderm - abnormalities | Nodal Protein - genetics | Nodal Protein - agonists | Gene Expression Regulation, Developmental | HEK293 Cells | Zebrafish Proteins - agonists | Recombinant Proteins - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Microinjections | Zebrafish Proteins - metabolism | Zebrafish Proteins - antagonists & inhibitors | Recombinant Proteins - chemistry | Zebrafish | Recombinant Fusion Proteins - chemistry | DNA-Binding Proteins - genetics | Smad3 Protein - antagonists & inhibitors | Response Elements - drug effects | Smad3 Protein - agonists | Embryo, Nonmammalian - abnormalities | Animals | Signal Transduction - drug effects | Morpholinos - pharmacology | Luminescent Proteins - genetics | Mesoderm - metabolism | Mutation | Zebrafish Proteins - genetics | Embryonic Development - drug effects | Microscopy, Fluorescence | Luminescent Proteins - metabolism | Developmental Biology
Journal Article
Endocrinology, ISSN 0013-7227, 05/2014, Volume 155, Issue 5, pp. 1970 - 1981
FSH is an essential regulator of mammalian reproduction. Its synthesis by pituitary gonadotrope cells is regulated by multiple endocrine and paracrine factors,... 
PATHWAYS | GROWTH-FACTOR-BETA | ACTIVATION | ACTIVIN-A INDUCTION | TGF-BETA | L45 LOOP | II RECEPTOR | TRANSCRIPTION | KINASE | ENDOCRINOLOGY & METABOLISM | HORMONE BETA-SUBUNIT | Phosphorylation | Humans | Activins - antagonists & inhibitors | Activins - metabolism | Gonadotrophs - metabolism | Smad3 Protein - metabolism | Smad2 Protein - antagonists & inhibitors | Smad3 Protein - genetics | Bone Morphogenetic Protein 2 - metabolism | Smad2 Protein - genetics | Follicle Stimulating Hormone, beta Subunit - metabolism | Bone Morphogenetic Protein Receptors, Type I - agonists | Transcription, Genetic | Follicle Stimulating Hormone, beta Subunit - biosynthesis | Genes, Reporter | Bone Morphogenetic Protein Receptors, Type I - antagonists & inhibitors | Recombinant Proteins - metabolism | Bone Morphogenetic Protein 2 - agonists | Bone Morphogenetic Protein 2 - genetics | Cell Line | Signal Transduction | Bone Morphogenetic Protein 2 - antagonists & inhibitors | Gene Silencing | Smad2 Protein - metabolism | Bone Morphogenetic Protein Receptors, Type I - genetics | Recombinant Proteins - chemistry | Bone Morphogenetic Protein Receptors, Type I - metabolism | Smad3 Protein - antagonists & inhibitors | Animals | Follicle Stimulating Hormone, beta Subunit - genetics | Mice | Protein Processing, Post-Translational | RNA, Small Interfering
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 10/2018, Volume 293, Issue 41, pp. 15867 - 15886
Transforming growth factor-beta (TGF beta) signaling through SMAD2/3 is an important driver of pathological fibrosis in multiple organ systems. TGF signaling... 
TGF-BETA | INTEGRAL PROTEIN | SMAD PROTEINS | mechanotransduction | BIOCHEMISTRY & MOLECULAR BIOLOGY | MEMBRANE PROTEIN | Buschke-Ollendorff syndrome | LEMD3 | actin | IN-VITRO | MAN1 | LEM | pulmonary fibrosis | SMAD transcription factor | transforming growth factor (TGF-) | nuclear lamina | LATENT TGF-BETA-1 | EXTRACELLULAR-MATRIX | BUSCHKE-OLLENDORFF-SYNDROME | IDIOPATHIC PULMONARY-FIBROSIS | nuclear membrane | NONSENSE MUTATION | Phosphorylation | Mechanotransduction, Cellular - drug effects | Protein Phosphatase 2C - metabolism | Humans | Actins - metabolism | Extracellular Matrix - metabolism | Smad3 Protein - metabolism | Smad2 Protein - antagonists & inhibitors | Idiopathic Pulmonary Fibrosis - metabolism | Smad2 Protein - chemistry | Nuclear Lamina - metabolism | Transforming Growth Factor beta - antagonists & inhibitors | Lung - metabolism | Membrane Proteins - metabolism | Fibroblasts - metabolism | Peptide Fragments - metabolism | Smad2 Protein - metabolism | Nuclear Proteins - metabolism | Nuclear Proteins - chemistry | Smad3 Protein - antagonists & inhibitors | Peptide Fragments - chemistry | Membrane Proteins - antagonists & inhibitors | Membrane Proteins - chemistry | Nuclear Proteins - antagonists & inhibitors | Cytosol - metabolism | Smad3 Protein - chemistry | Transforming Growth Factor beta - metabolism | Signal Transduction | transforming growth factor β (TGF-β)
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, pp. e0120045 - e0120045
Cervical cancer is the major cause of cancer related deaths in women, especially in developing countries and Human Papilloma Virus infection in conjunction... 
EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER | GROWTH-FACTOR-BETA | INVASION | MULTIDISCIPLINARY SCIENCES | TRANSFORMING GROWTH-FACTOR-BETA-1 | PANCREATIC-CANCER | GENE-EXPRESSION | MECHANISMS | HUMAN-PAPILLOMAVIRUS | TRANSCRIPTION FACTOR | Receptors, Transforming Growth Factor beta - genetics | Humans | Collagen - chemistry | Epithelial-Mesenchymal Transition - drug effects | Wnt Proteins - metabolism | Smad4 Protein - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Peptidylprolyl Isomerase - metabolism | Peptidylprolyl Isomerase - genetics | Protein-Serine-Threonine Kinases - metabolism | Emodin - pharmacology | Curcumin - pharmacology | Cyclin-Dependent Kinase Inhibitor p21 - antagonists & inhibitors | Smad3 Protein - antagonists & inhibitors | beta Catenin - metabolism | Drug Synergism | Cell Movement - drug effects | Receptors, Transforming Growth Factor beta - antagonists & inhibitors | Cyclin D1 - genetics | Signal Transduction - drug effects | Cell Line, Tumor | Laminin - chemistry | HeLa Cells | Cyclin D1 - metabolism | Smad4 Protein - antagonists & inhibitors | Gene Expression Regulation, Neoplastic | Smad3 Protein - metabolism | Proteoglycans - chemistry | Smad3 Protein - genetics | Cyclin D1 - antagonists & inhibitors | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Wnt Proteins - genetics | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Transforming Growth Factor beta - antagonists & inhibitors | Female | Snail Family Transcription Factors | Protein-Serine-Threonine Kinases - genetics | Transcription Factors - antagonists & inhibitors | NIMA-Interacting Peptidylprolyl Isomerase | Transcription Factors - genetics | Smad4 Protein - metabolism | beta Catenin - genetics | Transcription Factors - metabolism | Transforming Growth Factor beta - genetics | Receptors, Transforming Growth Factor beta - metabolism | beta Catenin - antagonists & inhibitors | Cell Proliferation - drug effects | Antineoplastic Agents, Phytogenic - pharmacology | Transforming Growth Factor beta - metabolism | Drug Combinations | Biotechnology | Deregulation | Wnt protein | Mesenchyme | Downstream effects | Crosstalk | Viruses | Smad3 protein | Biochemistry | Metastasis | Kinases | Pin1 protein | Cancer therapies | Carcinogenesis | Smad4 protein | Developing countries--LDCs | Cell adhesion & migration | Proteins | β-catenin | Signal transduction | Carcinogens | Pathways | Cell cycle | Curcumin | Tumorigenesis | Inhibition | Downstream | Medical research | Breast cancer | Tumor cell lines | Gene expression | Cervix | Emodin | Signaling | Chemotherapy | Phytochemicals | Cell lines | Ligands | Cell migration | Cervical cancer | Cancer | Apoptosis | Index Medicus | Developing countries | Developing nations | LDCs
Journal Article
Biochemical Journal, ISSN 0264-6021, 03/2005, Volume 386, Issue 3, pp. 461 - 470
Inhibitory Smad, Smad7, is a potent inhibitor of TGF-beta (transforming growth factor-beta) superfamily signalling. By binding to activated type I receptors,... 
Developmentally down-regulated 4-2 (NEDD4-2) | Bone morphogenetic protein (BMP) | Smad | Neural precursor cell expressed | Homologous to the E6-accessory protein C-terminus (HECT) | Transforming growth factor-β (TGF-β) | Humans | Protein-Serine-Threonine Kinases | Ubiquitin - metabolism | Cytoplasm - metabolism | RNA, Messenger - metabolism | DNA-Binding Proteins - metabolism | Bone Morphogenetic Proteins - metabolism | Cell Nucleus - metabolism | Trans-Activators - genetics | Nedd4 Ubiquitin Protein Ligases | Transcription, Genetic | Proto-Oncogene Proteins - metabolism | Smad7 Protein | Cell Line | Signal Transduction | Smad6 Protein | Endosomal Sorting Complexes Required for Transport | RNA, Messenger - genetics | Ubiquitin-Protein Ligases - metabolism | Intracellular Signaling Peptides and Proteins | Activin Receptors, Type I - metabolism | DNA-Binding Proteins - genetics | Protein Transport | Two-Hybrid System Techniques | Smad3 Protein | Animals | Receptors, Transforming Growth Factor beta - metabolism | Cell Line, Tumor | Protein Binding | Ligands | Trans-Activators - metabolism | Mice | Ubiquitin-Protein Ligases - genetics | Transforming Growth Factor beta - metabolism | Smad2 Protein | BMPR-IB, BMP type IB receptor | TβR-I, transforming growth factor-β type I receptor | developmentally down-regulated 4-2 (NEDD4-2) | Ski-related novel protein N (SnoN) | I-Smad, inhibitory Smad | transforming growth factor-β (TGF-β) | homologous to the E6-accessory protein C-terminus (HECT) | R-Smad, receptor-regulated Smad | SnoN, Ski-related novel protein N | RING, really interesting new gene | F-box protein | bone morphogenetic protein (BMP) | ROC1, regulator of Cullins 1 | HECT, homologous to the E6-accessory protein C-terminus | siRNA, small interfering RNA | NEDD4-2, neural precursor cell expressed, developmentally down-regulated 4-2 | SCF, Skp1 | neural precursor cell expressed | Smurf, Smad ubiquitin regulatory factor | TGF-β, transforming growth factor-β | Cullin1 | BMP, bone morphogenetic protein | Co-Smad, common-partner Smad
Journal Article