X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (227) 227
animals (174) 174
smad3 protein - metabolism (170) 170
humans (153) 153
smad3 protein (115) 115
signal transduction (111) 111
mice (107) 107
tgf-beta (98) 98
fibrosis (93) 93
phosphorylation (82) 82
male (79) 79
cell biology (76) 76
smad2 protein - metabolism (73) 73
cells, cultured (69) 69
smad3 (69) 69
expression (65) 65
smad3 protein - genetics (64) 64
transforming growth factor beta - metabolism (64) 64
gene expression (63) 63
signal transduction - drug effects (61) 61
fibroblasts (55) 55
growth-factor-beta (54) 54
transforming growth factor beta1 - metabolism (53) 53
female (50) 50
rats (50) 50
transforming growth factors (50) 50
biochemistry & molecular biology (49) 49
inflammation (49) 49
activation (47) 47
proteins (46) 46
rodents (45) 45
collagen (43) 43
fibroblasts - metabolism (42) 42
growth factors (42) 42
smad2 protein (42) 42
cell line (41) 41
kinases (41) 41
apoptosis (36) 36
article (36) 36
medicine (35) 35
phosphorylation - drug effects (35) 35
research article (35) 35
inhibition (33) 33
multidisciplinary sciences (32) 32
mice, inbred c57bl (31) 31
tgf-β (31) 31
cells (29) 29
fibroblasts - drug effects (29) 29
science (29) 29
signaling (29) 29
cell line, tumor (28) 28
transcription (28) 28
transforming growth factor beta1 - pharmacology (28) 28
blotting, western (26) 26
differentiation (26) 26
research (26) 26
rats, sprague-dawley (25) 25
smad2 protein - genetics (25) 25
transforming growth factor (25) 25
analysis (24) 24
biology (24) 24
gene-expression (24) 24
medicine, research & experimental (24) 24
smad protein (24) 24
smooth muscle (24) 24
transforming growth factor beta - pharmacology (24) 24
cell proliferation (23) 23
cytokines (23) 23
disease (23) 23
disease models, animal (23) 23
heart (23) 23
receptors, transforming growth factor beta - metabolism (23) 23
bone morphogenetic proteins (22) 22
ligands (22) 22
transcription factors (22) 22
actins - metabolism (21) 21
cell proliferation - drug effects (21) 21
extracellular matrix (21) 21
gene expression regulation (21) 21
mechanisms (21) 21
oncology (21) 21
ppar gamma - metabolism (21) 21
proliferation (21) 21
promoter regions, genetic (21) 21
dna-binding proteins - metabolism (20) 20
stem cells (20) 20
physiology (19) 19
receptor (19) 19
transforming growth factor beta - genetics (19) 19
biochemistry (18) 18
mice, knockout (18) 18
oxidative stress (18) 18
cell differentiation (17) 17
endocrinology & metabolism (17) 17
gene expression - drug effects (17) 17
rna, messenger - metabolism (17) 17
signal transduction - physiology (17) 17
smad (17) 17
smad7 protein (17) 17
trans-activators - metabolism (17) 17
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal of Biological Chemistry, ISSN 0021-9258, 08/2017, Volume 292, Issue 34, pp. 14165 - 14175
Circadian clock and Smad2/3/4-mediated Nodal signaling regulate multiple physiological and pathological processes. However, it remains unknown whether Clock... 
VERTEBRATE DEVELOPMENT | TGF-BETA | SMAD3 | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | INDUCTION | nodal | mesoderm | MOUSE EMBRYO | CIRCADIAN CLOCK | GASTRULATION | LOOP-HELIX PROTEINS | hematopoiesis | SMAD transcription factor | zebrafish | clock gene | transcription promoter | CELL | Embryo, Nonmammalian - cytology | Humans | Embryo, Nonmammalian - metabolism | Mesoderm - drug effects | Nodal Protein - metabolism | Smad3 Protein - metabolism | Mesoderm - cytology | Embryo, Nonmammalian - drug effects | Recombinant Fusion Proteins - metabolism | Hematopoiesis - drug effects | DNA-Binding Proteins - metabolism | Smad3 Protein - genetics | In Situ Hybridization | Mesoderm - abnormalities | Nodal Protein - genetics | Nodal Protein - agonists | Gene Expression Regulation, Developmental | HEK293 Cells | Zebrafish Proteins - agonists | Recombinant Proteins - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Microinjections | Zebrafish Proteins - metabolism | Zebrafish Proteins - antagonists & inhibitors | Recombinant Proteins - chemistry | Zebrafish | Recombinant Fusion Proteins - chemistry | DNA-Binding Proteins - genetics | Smad3 Protein - antagonists & inhibitors | Response Elements - drug effects | Smad3 Protein - agonists | Embryo, Nonmammalian - abnormalities | Animals | Signal Transduction - drug effects | Morpholinos - pharmacology | Luminescent Proteins - genetics | Mesoderm - metabolism | Mutation | Zebrafish Proteins - genetics | Embryonic Development - drug effects | Microscopy, Fluorescence | Luminescent Proteins - metabolism | Developmental Biology
Journal Article
Journal Article
Nature Medicine, ISSN 1078-8956, 03/2012, Volume 18, Issue 3, pp. 396 - 404
Molecules associated with the transforming growth factor beta (TGF-beta) superfamily, such as bone morphogenic proteins (BMPs) and TGF-beta, are key regulators... 
MEDICINE, RESEARCH & EXPERIMENTAL | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TISSUE FIBROSIS | DIABETIC-NEPHROPATHY | CELL BIOLOGY | RENAL FIBROSIS | TO-MESENCHYMAL TRANSITION | GROWTH-FACTOR-BETA | TRANSFORMING GROWTH-FACTOR-BETA-2 | BONE MORPHOGENETIC PROTEIN-7 | EXPRESSION | PROGRESSION | Captopril - pharmacology | Bone Morphogenetic Proteins - agonists | Bone Morphogenetic Protein Receptors - genetics | Peptides - pharmacokinetics | Apoptosis - genetics | Smad3 Protein - metabolism | Structure-Activity Relationship | Peptide Library | Fibrosis - metabolism | Smad3 Protein - genetics | Bone Morphogenetic Proteins - metabolism | Inflammation - metabolism | Kidney - metabolism | Peptides - chemical synthesis | Peptides - metabolism | Regeneration - genetics | Epithelial-Mesenchymal Transition | Angiotensin-Converting Enzyme Inhibitors - pharmacology | Kidney Tubules - metabolism | Diabetic Nephropathies - pathology | Bone Morphogenetic Protein Receptors, Type II - genetics | Signal Transduction | Diabetic Nephropathies - metabolism | Bone Morphogenetic Protein Receptors - metabolism | Bone Morphogenetic Protein Receptors, Type I - genetics | Rats | Bone Morphogenetic Protein Receptors, Type I - metabolism | Kidney - injuries | Rats, Sprague-Dawley | Bone Morphogenetic Protein Receptors, Type II - metabolism | Animals | Transforming Growth Factor beta - genetics | Inflammation - genetics | Mice | Transforming Growth Factor beta - metabolism | Physiological aspects | Cellular signal transduction | Research | Kidney diseases | Protein kinases | Risk factors | Signal transduction | Pharmacology | Kinases | Gene expression | Rodents
Journal Article
Biology of Reproduction, ISSN 0006-3363, 2013, Volume 89, Issue 4, p. 84
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, p. e90807
Objective: Increasing evidence shows that TGF-beta 1 is a key mediator in diabetic nephropathy (DN) and induces renal fibrosis positively by Smad3 but... 
RENAL FIBROSIS | GROWTH-FACTOR-BETA | ACTIVATION | TGF-BETA | SMAD3 | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | DIVERSE ROLES | RECEPTOR | NEPHROPATHY | MICRORNA | Receptors, Transforming Growth Factor beta - genetics | Rats, Wistar | Transforming Growth Factor beta1 - antagonists & inhibitors | Smad7 Protein - agonists | Transforming Growth Factor beta1 - metabolism | Diabetes Mellitus, Experimental - genetics | Diabetic Nephropathies - drug therapy | Drugs, Chinese Herbal - pharmacology | Male | Smad3 Protein - metabolism | Diabetes Mellitus, Experimental - blood | Smad3 Protein - genetics | Smad7 Protein - genetics | Smad7 Protein - metabolism | Diabetic Nephropathies - pathology | Diabetic Nephropathies - metabolism | Gene Expression Regulation | Rats | Diabetic Nephropathies - genetics | Transforming Growth Factor beta1 - genetics | Smad3 Protein - antagonists & inhibitors | Hypoglycemic Agents - pharmacology | Animals | Receptors, Transforming Growth Factor beta - antagonists & inhibitors | Receptors, Transforming Growth Factor beta - metabolism | Signal Transduction - drug effects | Diabetes Mellitus, Experimental - pathology | Blood Glucose - metabolism | Health sciences | Smad protein | Collagen (type I) | Syngeneic grafts | Streptozocin | Body weight | Smad3 protein | Fibronectin | Receptors | Chinese medicine | Rodents | Extracellular matrix | Inhibition | Drug dosages | Growth factors | Solvents | Diabetes mellitus | MiRNA | Traditional Chinese medicine | Pharmacology | Chemical compounds | Signaling | Hospitals | Nephropathy | Acids | Granular materials | MicroRNAs | Fibrosis | Smad7 protein | Research design | Diabetes | Kidney diseases | Proteinuria
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2017, Volume 292, Issue 34, pp. 14270 - 14278
Smooth muscle cell (SMC) differentiation is essential for vascular development, and TGF-β signaling plays a critical role in this process. Although long... 
Muscle, Smooth, Vascular - metabolism | Transforming Growth Factor beta1 - antagonists & inhibitors | Transforming Growth Factor beta1 - metabolism | Smad3 Protein - metabolism | Transforming Growth Factor beta1 - chemistry | Mesenchymal Stromal Cells - cytology | Isoquinolines - pharmacology | RNA Interference | Muscle Proteins - metabolism | Nucleic Acid Conformation | Muscle, Smooth, Vascular - drug effects | RNA - metabolism | Binding, Competitive | Biomarkers - metabolism | Mesenchymal Stromal Cells - drug effects | RNA, Long Noncoding - chemistry | Gene Expression Regulation, Developmental - drug effects | Mesenchymal Stromal Cells - metabolism | In Situ Hybridization, Fluorescence | Transforming Growth Factor beta1 - genetics | Muscle, Smooth, Vascular - cytology | Smad3 Protein - antagonists & inhibitors | Muscle Proteins - genetics | Response Elements - drug effects | Muscle Proteins - agonists | Pyrroles - pharmacology | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Cell Line, Tumor | Genes, Reporter - drug effects | Smad3 Protein - chemistry | Mice | Pyridines - pharmacology | RNA, Long Noncoding - antagonists & inhibitors | RNA, Long Noncoding - metabolism | Smad3 | differentiation | signal transduction | smooth muscle | TGF-β | GAS5 | Cell Biology | long non-coding RNA (long ncRNA, lncRNA)
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 2968 - 14
Journal Article
Journal of Biomolecular Screening, ISSN 1087-0571, 4/2016, Volume 21, Issue 4, pp. 333 - 341
Pulmonary arterial hypertension is a complex disease with multiple etiologic factors. PDLIM5, a member of the Enigma subfamily of PDZ and LIM domain protein... 
luciferase reporter assay | PDLIM5 | high-throughput screening | TGF/Smad | CANCER-CELLS | MIGRATION | CHEMISTRY, ANALYTICAL | PROTEIN-KINASE | PDZ | BIOCHEMICAL RESEARCH METHODS | BETA SIGNALING PATHWAY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ARTERIAL-HYPERTENSION | GROWTH | INHIBITORS | LIM DOMAINS | ENH | RNA, Small Interfering - genetics | Antihypertensive Agents - pharmacology | Epithelial Cells - metabolism | Luciferases - metabolism | Paclitaxel - pharmacology | Epithelial Cells - drug effects | Humans | Smad3 Protein - metabolism | LIM Domain Proteins - metabolism | Smad2 Protein - antagonists & inhibitors | Genetic Vectors - antagonists & inhibitors | Luciferases - genetics | Lentivirus - metabolism | Smad3 Protein - genetics | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Smad2 Protein - genetics | LIM Domain Proteins - agonists | Lentivirus - genetics | Hypertension, Pulmonary - drug therapy | Lung - metabolism | Phosphorylation - drug effects | Mink | Genes, Reporter | A549 Cells | Gene Expression | Lung - pathology | Genetic Vectors - chemistry | LIM Domain Proteins - antagonists & inhibitors | Smad2 Protein - metabolism | Genetic Vectors - metabolism | Epithelial Cells - pathology | Adaptor Proteins, Signal Transducing - agonists | Smad3 Protein - antagonists & inhibitors | Animals | High-Throughput Screening Assays | Transforming Growth Factor beta - genetics | Lung - drug effects | Adaptor Proteins, Signal Transducing - genetics | LIM Domain Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | Transforming Growth Factor beta - metabolism | RNA, Small Interfering - metabolism | Usage | Analysis | Luciferase | Diagnosis | High-throughput screening (Biochemical assaying) | Causes and theories of causation | Health aspects | Pulmonary hypertension | Diseases
Journal Article
Endocrinology, ISSN 0013-7227, 05/2014, Volume 155, Issue 5, pp. 1970 - 1981
FSH is an essential regulator of mammalian reproduction. Its synthesis by pituitary gonadotrope cells is regulated by multiple endocrine and paracrine factors,... 
PATHWAYS | GROWTH-FACTOR-BETA | ACTIVATION | ACTIVIN-A INDUCTION | TGF-BETA | L45 LOOP | II RECEPTOR | TRANSCRIPTION | KINASE | ENDOCRINOLOGY & METABOLISM | HORMONE BETA-SUBUNIT | Phosphorylation | Humans | Activins - antagonists & inhibitors | Activins - metabolism | Gonadotrophs - metabolism | Smad3 Protein - metabolism | Smad2 Protein - antagonists & inhibitors | Smad3 Protein - genetics | Bone Morphogenetic Protein 2 - metabolism | Smad2 Protein - genetics | Follicle Stimulating Hormone, beta Subunit - metabolism | Bone Morphogenetic Protein Receptors, Type I - agonists | Transcription, Genetic | Follicle Stimulating Hormone, beta Subunit - biosynthesis | Genes, Reporter | Bone Morphogenetic Protein Receptors, Type I - antagonists & inhibitors | Recombinant Proteins - metabolism | Bone Morphogenetic Protein 2 - agonists | Bone Morphogenetic Protein 2 - genetics | Cell Line | Signal Transduction | Bone Morphogenetic Protein 2 - antagonists & inhibitors | Gene Silencing | Smad2 Protein - metabolism | Bone Morphogenetic Protein Receptors, Type I - genetics | Recombinant Proteins - chemistry | Bone Morphogenetic Protein Receptors, Type I - metabolism | Smad3 Protein - antagonists & inhibitors | Animals | Follicle Stimulating Hormone, beta Subunit - genetics | Mice | Protein Processing, Post-Translational | RNA, Small Interfering
Journal Article
Molecular medicine reports, 10/2015, Volume 12, Issue 4, p. 5573
Transforming growth factor (TGF)‑β regulates the anabolic metabolism of articular cartilage and prevents cartilage degradation. TGF‑β1 influences cellular... 
Chondrocytes - cytology | Receptors, Transforming Growth Factor beta - genetics | Humans | Transforming Growth Factor beta1 - metabolism | Smad3 Protein - metabolism | Collagen Type II - metabolism | Quinoxalines - pharmacology | Chondrocytes - drug effects | Smad3 Protein - genetics | Isoquinolines - pharmacology | Cartilage, Articular - metabolism | Collagen Type II - agonists | Mitogen-Activated Protein Kinase 1 - genetics | Smad2 Protein - genetics | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Female | Flavonoids - pharmacology | Phosphorylation - drug effects | Chondrocytes - metabolism | Protein-Serine-Threonine Kinases - metabolism | Transforming Growth Factor beta1 - pharmacology | Recombinant Proteins - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Cartilage, Articular - cytology | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Smad2 Protein - metabolism | Rats | Imidazoles - pharmacology | Aggrecans - metabolism | Recombinant Proteins - pharmacology | Aggrecans - genetics | Rats, Sprague-Dawley | Collagen Type II - genetics | Smad3 Protein - agonists | Pyrroles - pharmacology | Animals | Receptors, Transforming Growth Factor beta - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - metabolism | Receptors, Transforming Growth Factor beta - metabolism | Aggrecans - agonists | Pyridines - pharmacology | Enzyme Activation | Primary Cell Culture | Cartilage, Articular - drug effects | Smad2 Protein - agonists | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, p. e81702
Mycophenolic acid (MPA) is the metabolized product and active element of mycophenolate mofetil (MMF) that has been widely used for the prevention of acute... 
APOPTOSIS | ROLES | FIBROBLAST | MULTIDISCIPLINARY SCIENCES | GROWTH | IMP DEHYDROGENASE | MECHANISMS | PROLIFERATION | PROMOTES | EXPRESSION | MOFETIL | Antibiotics, Antineoplastic - pharmacology | Oligonucleotide Array Sequence Analysis | Signal Transduction | Humans | Gastric Mucosa - pathology | Neoplasm Proteins - antagonists & inhibitors | Gene Expression Profiling | Gastric Mucosa - metabolism | Neoplasm Proteins - metabolism | Cell Movement - drug effects | Neoplasm Proteins - agonists | Mycophenolic Acid - pharmacology | Gastric Mucosa - drug effects | Cell Line, Tumor | Gene Expression Regulation, Neoplastic - drug effects | Genome, Human | Neoplasm Proteins - genetics | Platelet-derived growth factor | Oncology, Experimental | Genes | Genomics | Cancer cells | Genetic aspects | Genomes | Metastasis | Research | Mycophenolate mofetil | Stomach cancer | Cancer | Cell proliferation | Biotechnology | Mycophenolic acid | AKT protein | Smad3 protein | Inosine monophosphate | CD147 antigen | Kinases | Cell adhesion & migration | Proteins | Cell growth | Pathways | CYR61 protein | Gastric cancer | Pharmaceutical sciences | Medical research | Activating transcription factor 3 | GRP78 protein | Gene expression | Endothelial cells | Graft rejection | Polymerase chain reaction | Medicine | Acids | Cell migration | Tumors
Journal Article