X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (1870) 1870
Publication (345) 345
Dissertation (3) 3
Book Chapter (2) 2
Book Review (2) 2
Data Set (1) 1
Magazine Article (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (1047) 1047
humans (1037) 1037
index medicus (1011) 1011
smad3 protein - metabolism (896) 896
biochemistry & molecular biology (840) 840
signal transduction (700) 700
smad3 protein (697) 697
mice (648) 648
tgf-beta (606) 606
cell biology (524) 524
transforming growth factor beta - metabolism (497) 497
smad3 protein - genetics (409) 409
smad2 protein - metabolism (404) 404
phosphorylation (403) 403
expression (398) 398
smad3 (385) 385
growth-factor-beta (380) 380
cell line (353) 353
male (329) 329
dna-binding proteins - metabolism (306) 306
trans-activators - metabolism (293) 293
cells, cultured (292) 292
smad2 protein (260) 260
gene expression (258) 258
proteins (254) 254
female (252) 252
signal transduction - drug effects (251) 251
fibrosis (250) 250
activation (241) 241
rats (239) 239
transforming growth factor beta - pharmacology (230) 230
transforming growth factor beta1 - metabolism (230) 230
cell line, tumor (214) 214
protein binding (210) 210
cancer (189) 189
apoptosis (180) 180
promoter regions, genetic (179) 179
oncology (176) 176
research article (173) 173
transforming growth factors (173) 173
smad4 protein (172) 172
tgf-β (172) 172
article (166) 166
transfection (166) 166
blotting, western (163) 163
dna-binding proteins - genetics (161) 161
fibroblasts - metabolism (161) 161
cells (159) 159
receptor (158) 158
mice, inbred c57bl (156) 156
transcription (154) 154
gene-expression (153) 153
growth factors (152) 152
signal transduction - physiology (152) 152
trans-activators - genetics (150) 150
smad2 protein - genetics (149) 149
biochemistry (146) 146
gene expression regulation (145) 145
medicine (145) 145
receptors, transforming growth factor beta - metabolism (144) 144
transcription, genetic (144) 144
transcriptional activation (144) 144
cell proliferation (143) 143
gene (143) 143
transforming growth factor beta - genetics (142) 142
inhibition (139) 139
fibroblasts (138) 138
collagen (137) 137
differentiation (135) 135
signaling (135) 135
kinases (133) 133
mice, knockout (133) 133
multidisciplinary sciences (128) 128
smad (128) 128
biophysics (127) 127
rna, messenger - metabolism (121) 121
transcription factors (121) 121
transforming growth factor beta - physiology (120) 120
biology (119) 119
inflammation (116) 116
science (116) 116
protein-serine-threonine kinases - metabolism (115) 115
reverse transcriptase polymerase chain reaction (115) 115
base sequence (114) 114
genetics & heredity (112) 112
transcription factors - metabolism (112) 112
phosphorylation - drug effects (111) 111
binding sites (109) 109
bone morphogenetic proteins (109) 109
molecular sequence data (108) 108
mutation (107) 107
protein (105) 105
transforming growth factor beta1 - pharmacology (105) 105
rodents (104) 104
research (99) 99
analysis (98) 98
smad protein (95) 95
smad proteins (95) 95
cell differentiation (94) 94
immunohistochemistry (93) 93
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Molecular and Cellular Biology, ISSN 0270-7306, 07/2012, Volume 32, Issue 14, pp. 2904 - 2916
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 10/2018, Volume 293, Issue 41, pp. 15867 - 15886
Transforming growth factor-beta (TGF beta) signaling through SMAD2/3 is an important driver of pathological fibrosis in multiple organ systems. TGF signaling... 
TGF-BETA | INTEGRAL PROTEIN | SMAD PROTEINS | mechanotransduction | BIOCHEMISTRY & MOLECULAR BIOLOGY | MEMBRANE PROTEIN | Buschke-Ollendorff syndrome | LEMD3 | actin | IN-VITRO | MAN1 | LEM | pulmonary fibrosis | SMAD transcription factor | transforming growth factor (TGF-) | nuclear lamina | LATENT TGF-BETA-1 | EXTRACELLULAR-MATRIX | BUSCHKE-OLLENDORFF-SYNDROME | IDIOPATHIC PULMONARY-FIBROSIS | nuclear membrane | NONSENSE MUTATION | Phosphorylation | Mechanotransduction, Cellular - drug effects | Protein Phosphatase 2C - metabolism | Humans | Actins - metabolism | Extracellular Matrix - metabolism | Smad3 Protein - metabolism | Smad2 Protein - antagonists & inhibitors | Idiopathic Pulmonary Fibrosis - metabolism | Smad2 Protein - chemistry | Nuclear Lamina - metabolism | Transforming Growth Factor beta - antagonists & inhibitors | Lung - metabolism | Membrane Proteins - metabolism | Fibroblasts - metabolism | Peptide Fragments - metabolism | Smad2 Protein - metabolism | Nuclear Proteins - metabolism | Nuclear Proteins - chemistry | Smad3 Protein - antagonists & inhibitors | Peptide Fragments - chemistry | Membrane Proteins - antagonists & inhibitors | Membrane Proteins - chemistry | Nuclear Proteins - antagonists & inhibitors | Cytosol - metabolism | Smad3 Protein - chemistry | Transforming Growth Factor beta - metabolism | Signal Transduction | transforming growth factor β (TGF-β)
Journal Article
Cellular Physiology and Biochemistry, ISSN 1015-8987, 06/2017, Volume 42, Issue 1, pp. 357 - 372
Endothelial-to-mesenchymal transition (EndMT) plays significant roles under various pathological conditions including cardiovascular diseases, fibrosis, and... 
Endothelial-to-mesenchymal transition | MALAT1 | SMAD3 | Endothelial progenitor cells | miR-145 | TGFBR2 | Receptors, Transforming Growth Factor beta - genetics | Endothelial Progenitor Cells - cytology | MicroRNAs - antagonists & inhibitors | Receptors, Transforming Growth Factor beta - chemistry | Humans | Transforming Growth Factor beta1 - metabolism | Collagen Type III - metabolism | Epithelial-Mesenchymal Transition - drug effects | MicroRNAs - metabolism | Smad3 Protein - metabolism | Smad3 Protein - genetics | Receptor, Transforming Growth Factor-beta Type II | RNA Interference | Base Sequence | 3' Untranslated Regions | Protein-Serine-Threonine Kinases - metabolism | Transforming Growth Factor beta1 - pharmacology | Endothelial Progenitor Cells - metabolism | Collagen Type I - metabolism | Signal Transduction | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | RNA, Long Noncoding - genetics | Down-Regulation - drug effects | Sequence Alignment | Receptors, Transforming Growth Factor beta - metabolism | Smad3 Protein - chemistry | MicroRNAs - genetics | Protein-Serine-Threonine Kinases - chemistry | Antagomirs - metabolism | RNA, Long Noncoding - antagonists & inhibitors | RNA, Long Noncoding - metabolism | RNA, Small Interfering - metabolism | Studies | Liver cancer | Cell growth | MicroRNAs | Rodents | Smooth muscle | Metastasis | Growth factors | Cell adhesion & migration
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2012, Volume 7, Issue 8, p. e42513
The Transforming Growth Factor-Beta (TGF-beta) family is involved in regulating a variety of cellular processes such as apoptosis, differentiation, and... 
CROSS-TALK | ACTIVATION | RAS | PHOSPHATIDYLINOSITOL 3-KINASE | MAP KINASE | SERINE 338 | MULTIDISCIPLINARY SCIENCES | II RECEPTOR | P21-ACTIVATED KINASE-2 | MYC PROTEIN STABILITY | GROWTH-FACTOR | Cell Line | Fibroblasts - enzymology | Smad2 Protein - metabolism | Structure-Activity Relationship | Extracellular Signal-Regulated MAP Kinases - metabolism | Enzyme Activation - drug effects | p21-Activated Kinases - metabolism | Proto-Oncogene Proteins c-raf - metabolism | Transforming Growth Factor beta - pharmacology | Animals | Cell Nucleus - metabolism | Smad2 Protein - chemistry | Signal Transduction - drug effects | Models, Biological | Fibroblasts - drug effects | Cell Proliferation - drug effects | Fibroblasts - cytology | Mice | Phosphorylation - drug effects | Proteasome Endopeptidase Complex - metabolism | Cell Nucleus - drug effects | Bone morphogenetic proteins | Genetic transcription | Transforming growth factors | Stem cells | Phosphorylation | Smad protein | Transcription factors | Mesenchyme | Epithelial cells | Transforming growth factor-b | Raf protein | Activation | Smad3 protein | Kinases | Nuclei | Cell adhesion & migration | Proteins | Signal transduction | Pathways | Smad2 protein | Transcription activation | Growth factors | Threonine | Melanoma | Extracellular signal-regulated kinase | Radioactive half-life | Gene expression | 1-Phosphatidylinositol 3-kinase | Signaling | Protein-serine/threonine kinase | Receptor mechanisms | Cancer | Apoptosis
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 09/2016, Volume 116, pp. 200 - 209
Smad3 is a critical signaling protein in renal fibrosis. Proteolysis targeting chimeric molecules (PROTACs) are small molecules designed to degrade target... 
Computer-aided drug design | Ubiquitination | Proteolysis targeting chimeric molecules | Fibrosis | COMPLEX | HIF | PROLYL HYDROXYLATION | PROTACS | CANCER | DISEASE | IMATINIB | PHARMACOLOGY & PHARMACY | MICE LACKING SMAD3 | LIGASE | Surface Plasmon Resonance | Kidney - pathology | Pyridines - chemistry | Humans | Recombinant Fusion Proteins - therapeutic use | Smad3 Protein - metabolism | Molecular Targeted Therapy | Recombinant Fusion Proteins - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - therapeutic use | Renal Insufficiency, Chronic - drug therapy | Benzofurans - chemistry | Renal Insufficiency, Chronic - metabolism | Proteolysis - drug effects | Kidney - metabolism | Ubiquitination - drug effects | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Drug Design | Hypoxia-Inducible Factor 1, alpha Subunit - chemistry | Protein Interaction Domains and Motifs | Binding Sites | Pyridines - therapeutic use | Peptide Fragments - metabolism | Benzofurans - therapeutic use | Kidney - drug effects | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Recombinant Fusion Proteins - chemistry | Ubiquitin-Protein Ligases - chemistry | Smad3 Protein - antagonists & inhibitors | Amino Acid Motifs | Renal Insufficiency, Chronic - pathology | Peptide Fragments - chemistry | Pyridines - metabolism | Small Molecule Libraries | Cell Line, Tumor | Ligands | Smad3 Protein - chemistry | Molecular Docking Simulation | Peptide Fragments - therapeutic use | Benzofurans - metabolism | Ubiquitin
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 2070 - 15
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2017, Volume 292, Issue 34, pp. 14165 - 14175
Circadian clock and Smad2/3/4-mediated Nodal signaling regulate multiple physiological and pathological processes. However, it remains unknown whether Clock... 
VERTEBRATE DEVELOPMENT | TGF-BETA | SMAD3 | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | INDUCTION | nodal | mesoderm | MOUSE EMBRYO | CIRCADIAN CLOCK | GASTRULATION | LOOP-HELIX PROTEINS | hematopoiesis | SMAD transcription factor | zebrafish | clock gene | transcription promoter | CELL | Embryo, Nonmammalian - cytology | Humans | Embryo, Nonmammalian - metabolism | Mesoderm - drug effects | Nodal Protein - metabolism | Smad3 Protein - metabolism | Mesoderm - cytology | Embryo, Nonmammalian - drug effects | Recombinant Fusion Proteins - metabolism | Hematopoiesis - drug effects | DNA-Binding Proteins - metabolism | Smad3 Protein - genetics | In Situ Hybridization | Mesoderm - abnormalities | Nodal Protein - genetics | Nodal Protein - agonists | Gene Expression Regulation, Developmental | HEK293 Cells | Zebrafish Proteins - agonists | Recombinant Proteins - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Microinjections | Zebrafish Proteins - metabolism | Zebrafish Proteins - antagonists & inhibitors | Recombinant Proteins - chemistry | Zebrafish | Recombinant Fusion Proteins - chemistry | DNA-Binding Proteins - genetics | Smad3 Protein - antagonists & inhibitors | Response Elements - drug effects | Smad3 Protein - agonists | Embryo, Nonmammalian - abnormalities | Animals | Signal Transduction - drug effects | Morpholinos - pharmacology | Luminescent Proteins - genetics | Mesoderm - metabolism | Mutation | Zebrafish Proteins - genetics | Embryonic Development - drug effects | Microscopy, Fluorescence | Luminescent Proteins - metabolism | Developmental Biology
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2017, Volume 292, Issue 34, pp. 14270 - 14278
Smooth muscle cell (SMC) differentiation is essential for vascular development, and TGF-β signaling plays a critical role in this process. Although long... 
Muscle, Smooth, Vascular - metabolism | Transforming Growth Factor beta1 - antagonists & inhibitors | Transforming Growth Factor beta1 - metabolism | Smad3 Protein - metabolism | Transforming Growth Factor beta1 - chemistry | Mesenchymal Stromal Cells - cytology | Isoquinolines - pharmacology | RNA Interference | Muscle Proteins - metabolism | Nucleic Acid Conformation | Muscle, Smooth, Vascular - drug effects | RNA - metabolism | Binding, Competitive | Biomarkers - metabolism | Mesenchymal Stromal Cells - drug effects | RNA, Long Noncoding - chemistry | Gene Expression Regulation, Developmental - drug effects | Mesenchymal Stromal Cells - metabolism | In Situ Hybridization, Fluorescence | Transforming Growth Factor beta1 - genetics | Muscle, Smooth, Vascular - cytology | Smad3 Protein - antagonists & inhibitors | Muscle Proteins - genetics | Response Elements - drug effects | Muscle Proteins - agonists | Pyrroles - pharmacology | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Cell Line, Tumor | Genes, Reporter - drug effects | Smad3 Protein - chemistry | Mice | Pyridines - pharmacology | RNA, Long Noncoding - antagonists & inhibitors | RNA, Long Noncoding - metabolism | Smad3 | differentiation | signal transduction | smooth muscle | TGF-β | GAS5 | Cell Biology | long non-coding RNA (long ncRNA, lncRNA)
Journal Article