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Nature Medicine, ISSN 1078-8956, 02/2016, Volume 22, Issue 2, pp. 154 - 162
Although the lung can undergo self-repair after injury, fibrosis in chronically injured or diseased lungs can occur at the expense of regeneration. Here we... 
MEDICINE, RESEARCH & EXPERIMENTAL | STEM-CELLS | ANGIOGENESIS | MACROPHAGE REGULATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | NOTCH | SIGNALING PROMOTES | CELL BIOLOGY | TO-MESENCHYMAL TRANSITION | ENDOTHELIAL-CELLS | DISEASE | SMOOTH-MUSCLE-CELLS | DIFFERENTIATION | Antibiotics, Antineoplastic - toxicity | Receptors, Notch - metabolism | Humans | Calcium-Binding Proteins - antagonists & inhibitors | Capillaries - drug effects | Hydrochloric Acid - toxicity | Smad3 Protein - metabolism | Pulmonary Circulation - physiology | Intercellular Signaling Peptides and Proteins - metabolism | Pulmonary Artery - metabolism | Receptors, CXCR - metabolism | Serrate-Jagged Proteins | Lung Injury - metabolism | Lung - metabolism | Membrane Proteins - metabolism | Pulmonary Fibrosis - metabolism | Capillaries - metabolism | Endothelial Cells - physiology | Wnt Signaling Pathway | Bleomycin - toxicity | Fibroblasts - metabolism | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Lung - pathology | Endothelial Cells - metabolism | RNA, Small Interfering - pharmacology | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Pulmonary Artery - drug effects | Lung - physiology | Regeneration - physiology | Macrophages - metabolism | Regeneration - drug effects | Animals | Membrane Proteins - antagonists & inhibitors | Smad3 Protein - drug effects | Fibroblasts - drug effects | Lung - drug effects | Fibrosis | Fluorescent Antibody Technique | Macrophages - drug effects | Mice | Pulmonary Circulation - drug effects | Oligopeptides - pharmacology | Receptors, CXCR - agonists | Endothelial Cells - drug effects | Physiological aspects | Regeneration (Biology) | Lung diseases | Blood vessels | Angiogenesis | Pulmonary fibrosis | Cellular biology | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 2014, Volume 20, Issue 4, pp. 408 - 414
Journal Article
Endocrinology, ISSN 0013-7227, 12/2015, Volume 156, Issue 12, pp. 4684 - 4694
Journal Article
Molecular Endocrinology, ISSN 0888-8809, 03/2004, Volume 18, Issue 3, pp. 653 - 665
Growth differentiation factor-9 (GDF-9) is an oocyte-derived growth factor and a member of the TGF-β superfamily that includes TGF-β, activin, and bone... 
ALK7 SIGNALS | BONE MORPHOGENETIC PROTEIN | MAD-RELATED PROTEIN | ENDOCRINOLOGY & METABOLISM | OSTEOGENIC PROTEIN-1 | FOLLICULAR-GROWTH | TGF-BETA RECEPTOR | OVARIAN GRANULOSA-CELLS | IDENTIFICATION | HOMOLOG GDF-9B | LUTEAL CELLS | Phosphorylation | Receptors, Transforming Growth Factor beta - genetics | Trans-Activators - drug effects | Protein-Serine-Threonine Kinases | Activin Receptors - drug effects | Activins - metabolism | COS Cells - drug effects | Activin Receptors - genetics | Granulosa Cells - drug effects | Granulosa Cells - metabolism | COS Cells - metabolism | DNA-Binding Proteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Bone Morphogenetic Proteins - metabolism | Growth Differentiation Factor 9 | Trans-Activators - genetics | Female | Smad7 Protein | Promoter Regions, Genetic | Signal Transduction | Smad6 Protein | Cells, Cultured | DNA-Binding Proteins - drug effects | Rats | Activin Receptors, Type I - metabolism | DNA-Binding Proteins - genetics | Activin Receptors, Type I - genetics | Rats, Sprague-Dawley | Activin Receptors, Type I - drug effects | Transforming Growth Factor beta - pharmacology | Bone Morphogenetic Protein 15 | Smad3 Protein | Activin Receptors - metabolism | Animals | Activins - pharmacology | Receptors, Transforming Growth Factor beta - drug effects | Receptors, Transforming Growth Factor beta - metabolism | Intercellular Signaling Peptides and Proteins - pharmacology | Smad Proteins | Trans-Activators - metabolism | RNA, Small Interfering | Transforming Growth Factor beta - metabolism | Smad2 Protein | Index Medicus
Journal Article
Osteoarthritis and Cartilage, ISSN 1063-4584, 2014, Volume 23, Issue 3, pp. 478 - 486
Summary Objective Pain is the main problem for patients with osteoarthritis (OA). Pain is linked to inflammation, but in OA a subset of patients suffers from... 
Rheumatology | Cartilage | TGF-β | Smad | Pain | NGF | KNEE | CHONDROCYTES | OSTEOARTHRITIS PAIN | FACTOR EXPRESSION | RELEASE | RHEUMATOLOGY | FACTOR NGF | TANEZUMAB | HIP | PHASE-III TRIAL | TGF-beta | DOUBLE-BLIND | ORTHOPEDICS | Interleukin-1beta - pharmacology | Receptors, Transforming Growth Factor beta - genetics | Humans | Smad3 Protein - metabolism | Pain - metabolism | RNA, Messenger - metabolism | Chondrocytes - drug effects | Smad3 Protein - genetics | Pain - genetics | Cartilage, Articular - metabolism | Cattle | Smad2 Protein - genetics | Pain - etiology | Nerve Growth Factor - drug effects | Smad2 Protein - drug effects | Real-Time Polymerase Chain Reaction | Chondrocytes - metabolism | Protein-Serine-Threonine Kinases - metabolism | Transforming Growth Factor beta1 - pharmacology | Osteoarthritis - complications | Cell Line | Nerve Growth Factor - metabolism | Signal Transduction | Protein-Serine-Threonine Kinases - genetics | Smad2 Protein - metabolism | Osteoarthritis - metabolism | Nerve Growth Factor - genetics | Osteoarthritis - genetics | Animals | Receptors, Transforming Growth Factor beta - drug effects | Receptors, Transforming Growth Factor beta - metabolism | Smad3 Protein - drug effects | Protein-Serine-Threonine Kinases - drug effects | Mice | Cartilage, Articular - drug effects | Index Medicus
Journal Article
Burns, ISSN 0305-4179, 2016, Volume 42, Issue 6, pp. 1277 - 1286
Highlights • Vitamin D increases the effect of TGFβ1 signaling in dermal fibroblasts in vitro. • VDR gene silencing blocked the synergistic effect of vitamin D... 
Critical Care | Cross talk of vitamin D and transforming growth factor beta | Wound healing | SURGERY | CELLS | TGF-BETA | transforming growth factor beta | D DEFICIENCY | MODEL | DERMATOLOGY | RENAL FIBROSIS | IN-VITRO | Cross talk of vitamin D and | FIBROTIC RESPONSE | GENE-EXPRESSION | EXTRACELLULAR-MATRIX | D-RECEPTOR | CRITICAL CARE MEDICINE | Humans | Receptors, Calcitriol - genetics | Vitamins - pharmacology | Dermis - drug effects | Smad3 Protein - genetics | Mass Spectrometry | Smad2 Protein - genetics | Chromatography, Liquid | Transforming Growth Factor beta1 - drug effects | Adult | Female | Smad2 Protein - drug effects | Smad7 Protein - genetics | Real-Time Polymerase Chain Reaction | Wound Healing - drug effects | Transforming Growth Factor beta1 - pharmacology | Fibroblasts - metabolism | Dermis - metabolism | Hydroxyproline - metabolism | Cells, Cultured | Receptors, Calcitriol - drug effects | Transforming Growth Factor beta1 - genetics | Connective Tissue Growth Factor - drug effects | Fibronectins - drug effects | Myofibroblasts - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Drug Synergism | Cell Movement - drug effects | Smad3 Protein - drug effects | Cell Differentiation - drug effects | Calcitriol - pharmacology | Fibroblasts - drug effects | Smad7 Protein - drug effects | Connective Tissue Growth Factor - genetics | Fibronectins - genetics | In Vitro Techniques | Surgery, Plastic | Vitamin D | Calcifediol | Genetic engineering | Alfacalcidol | Transforming growth factors | Index Medicus
Journal Article
Journal of the American Society of Nephrology, ISSN 1046-6673, 09/2013, Volume 24, Issue 9, pp. 1387 - 1398
Journal Article
Molecular Endocrinology, ISSN 0888-8809, 03/2004, Volume 18, Issue 3, pp. 606 - 623
Journal Article
by He, W and Zhang, J and Niu, Z and Yu, Q and Wang, Z and Zhang, R and Su, L and Fu, L and Smith, A.J and Cooper, P.R
Journal of Dental Research, ISSN 0022-0345, 5/2014, Volume 93, Issue 5, pp. 496 - 501
Journal Article
Journal Article
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 06/2012, Volume 302, Issue 11, pp. 2211 - 2219
Transforming growth factor-β (TGF-β) is upregulated at the time of arterial injury; however, the mechanism through which TGF-β enhances the development of... 
P38 mitogen-activated protein kinase | Phosphoinositide-3 kinase/akt | Intimal hyperplasia | Transforming growth factor-β | RAPAMYCIN | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | intimal hyperplasia | PROLIFERATION | CORONARY-ARTERIES | P27(KIP1) | phosphoinositide-3 kinase/Akt | transforming growth factor-beta | IN-VITRO | PHOSPHATIDYLINOSITOL 3-KINASE/AKT PATHWAY | TRANSFORMING GROWTH-FACTOR-BETA-1 | PERIPHERAL VASCULAR DISEASE | p38 mitogen-activated protein kinase | GROWTH-FACTOR | Phosphorylation - physiology | Male | Time Factors | Models, Animal | Muscle, Smooth, Vascular - physiology | Muscle, Smooth, Vascular - drug effects | p38 Mitogen-Activated Protein Kinases - physiology | RNA, Small Interfering - pharmacology | Cells, Cultured | Transforming Growth Factor beta - physiology | Rats | Proto-Oncogene Proteins c-akt - physiology | Muscle, Smooth, Vascular - cytology | Rats, Sprague-Dawley | Smad3 Protein - antagonists & inhibitors | Transforming Growth Factor beta - pharmacology | p38 Mitogen-Activated Protein Kinases - drug effects | Animals | Smad3 Protein - drug effects | Carotid Artery Injuries - physiopathology | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - physiology | Signal Transduction - physiology | Cell Proliferation - drug effects | In Vitro Techniques | Smad3 Protein - physiology | Index Medicus | Vascular Biology and Microcirculation | Akt | transforming growth factor-β | phosphoinositide-3 kinase
Journal Article