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Aging Cell, ISSN 1474-9718, 12/2012, Volume 11, Issue 6, pp. 1065 - 1073
We explored molecular events associated with aging‐induced matrix changes in the kidney. C 57 BL 6 mice were studied in youth, middle age, and old age.... 
albuminuria | TGF | RNA | micro | collagen | fibrosis | SMAD | beta | SMAD3 | Albuminuria | TGF beta | Collagen | MicroRNAs | Fibrosis | microRNAs | GLOMERULOSCLEROSIS | MESSENGER-RNA TRANSLATION | KINASE | RENAL-FUNCTION | DIABETIC-NEPHROPATHY | MICRORNA-21 | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | HIGH GLUCOSE | MIR-21 | GENE-TRANSFER | EXPRESSION | Cystatin C - blood | Kidney Cortex - metabolism | Homeodomain Proteins - metabolism | Humans | Collagen Type III - metabolism | Extracellular Matrix - metabolism | Smad3 Protein - metabolism | Phosphoproteins - metabolism | Zinc Finger E-box Binding Homeobox 2 | RNA, Messenger - biosynthesis | Smad3 Protein - genetics | Collagen Type I - genetics | Aging - genetics | Gene Expression Regulation, Developmental | Glomerular Mesangium - metabolism | Kruppel-Like Transcription Factors - metabolism | Proteolysis | Female | Membrane Proteins - metabolism | Repressor Proteins - metabolism | Promoter Regions, Genetic | Collagen Type I - metabolism | Glomerular Filtration Rate | Membrane Proteins - genetics | Mice, Inbred C57BL | Repressor Proteins - genetics | Kidney Cortex - pathology | Collagen Type III - genetics | Phosphoproteins - genetics | Homeodomain Proteins - genetics | Aging - pathology | Adaptor Proteins, Signal Transducing | Glomerular Mesangium - pathology | Animals | Transforming Growth Factor beta - genetics | Protein Binding | Mice | MicroRNAs - genetics | Extracellular Matrix - pathology | Kruppel-Like Transcription Factors - genetics | Transforming Growth Factor beta - metabolism | Aging - metabolism | Serum Albumin - metabolism | Zinc Finger E-box-Binding Homeobox 1 | Fibronectins | Messenger RNA | MicroRNA | Physiological aspects | Protein biosynthesis | Transforming growth factors | Proteins | Aging | Age | Index Medicus
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 06/2009, Volume 296, Issue 6, pp. 1258 - 1270
Myostatin is a negative regulator of skeletal muscle size, previously shown to inhibit muscle cell differentiation. Myostatin requires both Smad2 and Smad3... 
MAFbx | Mammalian target of rapamycin complex signaling | MuRF1 | S6 kinase | Smad signaling | Human skeletal muscle cells | Transducer of regulated Ca | responsive element-binding protein activity | MuRF-1 | Atrogin | Transforming growth factor-β-like molecules | IGF-I | PHYSIOLOGY | ATROPHY | RAPID DISUSE | human skeletal muscle cells | transforming growth factor-beta-like molecules | SKELETAL-MUSCLE HYPERTROPHY | FOXO TRANSCRIPTION FACTORS | UBIQUITIN LIGASES | transducer of regulated Ca2+-responsive element-binding protein activity | CELL BIOLOGY | atrogin | PATHWAY | GROWTH | GENE-EXPRESSION | mammalian target of rapamycin complex signaling | CONDITIONAL ACTIVATION | Activin Receptors, Type I - antagonists & inhibitors | Protein Kinases - metabolism | Phosphorylation | Protein Kinases - genetics | Humans | Smad3 Protein - metabolism | Muscle Fibers, Skeletal - drug effects | Tripartite Motif Proteins | Smad3 Protein - genetics | Transfection | RNA Interference | Myoblasts, Skeletal - pathology | Smad2 Protein - genetics | Muscle Proteins - metabolism | Dioxoles - pharmacology | Regulatory-Associated Protein of mTOR | Benzamides - pharmacology | Myostatin - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Rapamycin-Insensitive Companion of mTOR Protein | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Signal Transduction | Cell Size - drug effects | Cells, Cultured | Smad2 Protein - metabolism | Ubiquitin-Protein Ligases - metabolism | Organ Size | Activin Receptors, Type I - metabolism | Myoblasts, Skeletal - enzymology | SKP Cullin F-Box Protein Ligases - metabolism | Mice, SCID | Myostatin - antagonists & inhibitors | Adaptor Proteins, Signal Transducing | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Cell Differentiation - drug effects | Follistatin - pharmacology | Muscle Fibers, Skeletal - pathology | Creatine Kinase - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | TOR Serine-Threonine Kinases | Myoblasts, Skeletal - drug effects | Insulin-Like Growth Factor I - metabolism | Muscle Fibers, Skeletal - enzymology | RNA, Small Interfering - metabolism | Abdominal surgery | Musculoskeletal system | Signal transduction | Cell growth | Kinases | Gene expression | Cells | Index Medicus
Journal Article
Nature Biotechnology, ISSN 1087-0156, 06/2002, Volume 20, Issue 6, pp. 619 - 622
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 10/2010, Volume 207, Issue 11, pp. 2331 - 2341
Foxp3-expressing regulatory T (T reg) cells have been implicated in parasite-driven inhibition of host immunity during chronic infection. We addressed whether... 
B-CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | TH2 RESPONSES | PROTECTIVE IMMUNITY | TRANSCRIPTION FACTOR FOXP3 | IN-VIVO | AIRWAY INFLAMMATION | NEMATODE INFECTION | POLYGYRUS INFECTION | IMMUNOLOGY | ORAL ANTIGEN | AUTOIMMUNE-DISEASE | Receptors, Transforming Growth Factor beta - genetics | Strongylida Infections - metabolism | Receptors, Transforming Growth Factor beta - immunology | Smad3 Protein - immunology | Nematospiroides dubius - metabolism | Th2 Cells - immunology | T-Lymphocytes, Regulatory - immunology | Th1 Cells - metabolism | Host-Parasite Interactions - genetics | Phosphorylation - genetics | Smad2 Protein - genetics | Dioxoles - pharmacology | Phosphorylation - immunology | Protein-Serine-Threonine Kinases - metabolism | Smad2 Protein - metabolism | Mice, Transgenic | Signal Transduction - genetics | Antigens, Helminth - immunology | Receptors, Transforming Growth Factor beta - antagonists & inhibitors | Signal Transduction - drug effects | Mice | Mice, Inbred BALB C | Chronic Disease | Forkhead Transcription Factors - immunology | T-Lymphocytes, Regulatory - metabolism | Antigens, Helminth - metabolism | Strongylida Infections - genetics | Smad3 Protein - metabolism | Th1 Cells - immunology | Nematospiroides dubius - immunology | Signal Transduction - immunology | Smad3 Protein - genetics | Strongylida Infections - immunology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Benzamides - pharmacology | Transforming Growth Factor beta - immunology | Forkhead Transcription Factors - biosynthesis | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | Protein-Serine-Threonine Kinases - genetics | Host-Parasite Interactions - immunology | Forkhead Transcription Factors - genetics | Th2 Cells - metabolism | Gene Expression Regulation - drug effects | Host-Parasite Interactions - drug effects | Smad2 Protein - immunology | Animals | Transforming Growth Factor beta - genetics | Receptors, Transforming Growth Factor beta - metabolism | Protein-Serine-Threonine Kinases - immunology | Cell Proliferation - drug effects | Transforming Growth Factor beta - metabolism | Index Medicus
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 07/2012, Volume 32, Issue 14, pp. 2904 - 2916
Journal Article
Nature Medicine, ISSN 1078-8956, 02/2016, Volume 22, Issue 2, pp. 154 - 162
Although the lung can undergo self-repair after injury, fibrosis in chronically injured or diseased lungs can occur at the expense of regeneration. Here we... 
MEDICINE, RESEARCH & EXPERIMENTAL | STEM-CELLS | ANGIOGENESIS | MACROPHAGE REGULATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | NOTCH | SIGNALING PROMOTES | CELL BIOLOGY | TO-MESENCHYMAL TRANSITION | ENDOTHELIAL-CELLS | DISEASE | SMOOTH-MUSCLE-CELLS | DIFFERENTIATION | Antibiotics, Antineoplastic - toxicity | Receptors, Notch - metabolism | Humans | Calcium-Binding Proteins - antagonists & inhibitors | Capillaries - drug effects | Hydrochloric Acid - toxicity | Smad3 Protein - metabolism | Pulmonary Circulation - physiology | Intercellular Signaling Peptides and Proteins - metabolism | Pulmonary Artery - metabolism | Receptors, CXCR - metabolism | Serrate-Jagged Proteins | Lung Injury - metabolism | Lung - metabolism | Membrane Proteins - metabolism | Pulmonary Fibrosis - metabolism | Capillaries - metabolism | Endothelial Cells - physiology | Wnt Signaling Pathway | Bleomycin - toxicity | Fibroblasts - metabolism | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Lung - pathology | Endothelial Cells - metabolism | RNA, Small Interfering - pharmacology | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Pulmonary Artery - drug effects | Lung - physiology | Regeneration - physiology | Macrophages - metabolism | Regeneration - drug effects | Animals | Membrane Proteins - antagonists & inhibitors | Smad3 Protein - drug effects | Fibroblasts - drug effects | Lung - drug effects | Fibrosis | Fluorescent Antibody Technique | Macrophages - drug effects | Mice | Pulmonary Circulation - drug effects | Oligopeptides - pharmacology | Receptors, CXCR - agonists | Endothelial Cells - drug effects | Physiological aspects | Regeneration (Biology) | Lung diseases | Blood vessels | Angiogenesis | Pulmonary fibrosis | Cellular biology | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2017, Volume 127, Issue 10, pp. 3770 - 3783
The master cytokine TGF-beta mediates tissue fibrosis associated with inflammation and tissue injury. TGF-beta induces fibroblast activation and... 
GENETIC MANIPULATION | MEDICINE, RESEARCH & EXPERIMENTAL | HYPERTROPHY | GROWTH-FACTOR-BETA | HEART-DISEASE | TGF-BETA | SMAD3 | MYOCARDIAL-INFARCTION | IN-VIVO | MYOFIBROBLAST DIFFERENTIATION | PROTECTS | Receptors, Transforming Growth Factor beta - genetics | Heart Diseases - metabolism | Male | Smad3 Protein - metabolism | Myofibroblasts - metabolism | Smad3 Protein - genetics | Gene Deletion | Myocardium - metabolism | Smad2 Protein - genetics | Protein-Serine-Threonine Kinases - metabolism | Myofibroblasts - pathology | Signal Transduction | Protein-Serine-Threonine Kinases - genetics | Smad2 Protein - metabolism | Mice, Transgenic | Myocardium - pathology | Organ Specificity | Myocytes, Cardiac - pathology | Animals | Transforming Growth Factor beta - genetics | Receptors, Transforming Growth Factor beta - metabolism | Fibrosis | Myocytes, Cardiac - metabolism | Mice | Transforming Growth Factor beta - metabolism | Heart Diseases - genetics | Heart Diseases - pathology | Transcription factors | Phosphorylation | Heart attacks | Disease | Homeostasis | Smad3 protein | Gene deletion | Kinases | Proteins | Clonal deletion | Smad2 protein | Rodents | Fibroblasts | Extracellular matrix | Heart diseases | Growth factors | Heart failure | Cytokines | Cardiomyocytes | Gene expression | Pressure | Latency | Adenoviruses | Genetic engineering | Apoptosis | Index Medicus | Abridged Index Medicus
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 10/2018, Volume 293, Issue 41, pp. 15867 - 15886
Transforming growth factor-beta (TGF beta) signaling through SMAD2/3 is an important driver of pathological fibrosis in multiple organ systems. TGF signaling... 
TGF-BETA | INTEGRAL PROTEIN | SMAD PROTEINS | mechanotransduction | BIOCHEMISTRY & MOLECULAR BIOLOGY | MEMBRANE PROTEIN | Buschke-Ollendorff syndrome | LEMD3 | actin | IN-VITRO | MAN1 | LEM | pulmonary fibrosis | SMAD transcription factor | transforming growth factor (TGF-) | nuclear lamina | LATENT TGF-BETA-1 | EXTRACELLULAR-MATRIX | BUSCHKE-OLLENDORFF-SYNDROME | IDIOPATHIC PULMONARY-FIBROSIS | nuclear membrane | NONSENSE MUTATION | Phosphorylation | Mechanotransduction, Cellular - drug effects | Protein Phosphatase 2C - metabolism | Humans | Actins - metabolism | Extracellular Matrix - metabolism | Smad3 Protein - metabolism | Smad2 Protein - antagonists & inhibitors | Idiopathic Pulmonary Fibrosis - metabolism | Smad2 Protein - chemistry | Nuclear Lamina - metabolism | Transforming Growth Factor beta - antagonists & inhibitors | Lung - metabolism | Membrane Proteins - metabolism | Fibroblasts - metabolism | Peptide Fragments - metabolism | Smad2 Protein - metabolism | Nuclear Proteins - metabolism | Nuclear Proteins - chemistry | Smad3 Protein - antagonists & inhibitors | Peptide Fragments - chemistry | Membrane Proteins - antagonists & inhibitors | Membrane Proteins - chemistry | Nuclear Proteins - antagonists & inhibitors | Cytosol - metabolism | Smad3 Protein - chemistry | Transforming Growth Factor beta - metabolism | Index Medicus
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 1768, Volume 289, Issue 19, pp. 13461 - 13474
Journal Article
Cell Metabolism, ISSN 1550-4131, 07/2011, Volume 14, Issue 1, pp. 67 - 79
Imbalances in glucose and energy homeostasis are at the core of the worldwide epidemic of obesity and diabetes. Here, we illustrate an important role of the... 
GROWTH-FACTOR-BETA | TARGETED DISRUPTION | WHITE FAT | TGF-BETA | GENETIC-CONTROL | TRANSFORMING GROWTH-FACTOR-BETA-1 | ENDOCRINOLOGY & METABOLISM | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | ADIPOCYTE DIFFERENTIATION | BROWN ADIPOSE-TISSUE | DIET-INDUCED OBESITY | CELL BIOLOGY | Adipose Tissue, White - metabolism | Smad3 Protein - metabolism | DNA-Binding Proteins - metabolism | Smad3 Protein - deficiency | Smad3 Protein - genetics | Mitochondria - genetics | Adipose Tissue, White - physiology | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Antibodies - immunology | Transforming Growth Factor beta - antagonists & inhibitors | Transforming Growth Factor beta - immunology | Glucose Tolerance Test | Signal Transduction | Adipose Tissue, Brown - physiology | Diabetes Mellitus - metabolism | Mitochondria - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mice, Knockout | Obesity - metabolism | Transcription Factors - metabolism | Diabetes Mellitus - prevention & control | Animals | Energy Metabolism | Obesity - prevention & control | Mice, Obese | Trans-Activators - metabolism | Adipose Tissue, Brown - metabolism | Mice | Mitochondria - physiology | Transforming Growth Factor beta - metabolism | Blood glucose | Obesity | Football (American) | Muscles | Strategy | Diabetes | Fats | Respiration | Animal subjects | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2012, Volume 287, Issue 10, pp. 7026 - 7038
Journal Article