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International journal of biological sciences, ISSN 1449-2288, 01/2018, Volume 14, Issue 2, pp. 111 - 123
TGF-β | SMAD4 | Mouse model | Tumorigenesis | Prognosis | Biochemistry & Molecular Biology | Biology | Life Sciences & Biomedicine - Other Topics | Life Sciences & Biomedicine | Science & Technology | Neoplasms - metabolism | Signal Transduction | Smad4 Protein - physiology | Transforming Growth Factor beta - physiology | Models, Molecular | Epithelial-Mesenchymal Transition - genetics | Smad4 Protein - metabolism | Animals | Neoplasms - genetics | Smad4 Protein - genetics | DNA Repair | DNA Damage - genetics | Mice | Mutation | Transforming Growth Factor beta - metabolism | Adenocarcinoma | Deactivation | Stability | Transforming growth factor | DNA damage | Colorectal carcinoma | Inactivation | DNA repair | Smad4 protein | Biological activity | Skin cancer | Genomic instability | Adenomatous polyposis coli | Signal transduction | Signaling | Transcription activation | Skin | Pancreas | Cell migration | Deoxyribonucleic acid--DNA | Cancer | Tumors | Apoptosis | Index Medicus
Journal Article
Blood, ISSN 0006-4971, 08/2008, Volume 112, Issue 4, pp. 1503 - 1509
Life Sciences & Biomedicine | Hematology | Science & Technology | Bone Morphogenetic Protein 6 | Phosphorylation | Basic Helix-Loop-Helix Transcription Factors - genetics | Iron Overload - genetics | Signal Transduction | Liver - metabolism | Smad4 Protein - physiology | Male | Smad Proteins - genetics | Gene Expression Profiling | Mice, Knockout | Animals | Iron - physiology | Diet | Smad5 Protein - metabolism | Smad1 Protein - metabolism | Transcription, Genetic | Mice | Smad4 Protein - deficiency | Active Transport, Cell Nucleus | Smad8 Protein - metabolism | Smad7 Protein - genetics | Bone Morphogenetic Proteins - genetics | Smad Proteins - metabolism | Index Medicus | Abridged Index Medicus | Smad7 Protein | Liver | Smad4 Protein | Iron | Cellular Biology | Smad5 Protein | Life Sciences | Smad1 Protein | Smad Proteins | Bone Morphogenetic Proteins | Basic Helix-Loop-Helix Transcription Factors | Smad8 Protein | Iron Overload
Journal Article
Nature cell biology, ISSN 1465-7392, 08/2009, Volume 11, Issue 8, pp. 943 - 950
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Epithelial Cells - metabolism | Epithelial Cells - drug effects | Humans | Mesoderm - drug effects | Smad3 Protein - metabolism | Mammary Neoplasms, Experimental - metabolism | Promoter Regions, Genetic - genetics | Mammary Neoplasms, Experimental - genetics | Smad3 Protein - genetics | Cell Nucleus - metabolism | Chromatin Immunoprecipitation | Smad4 Protein - genetics | Mammary Neoplasms, Experimental - pathology | Tumor Cells, Cultured | Cadherins - genetics | Snail Family Transcription Factors | Intercellular Junctions - metabolism | Epithelial Cells - pathology | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Smad4 Protein - metabolism | Blotting, Western | Transcription Factors - metabolism | Transforming Growth Factor beta - pharmacology | Animals | Protein Binding | Mesoderm - metabolism | Mice | Mice, Inbred BALB C | Mesoderm - pathology | Cell Line, Transformed | Microscopy, Fluorescence | Index Medicus | Smad3 | Factor de creixement transformant beta | Smad4 | Metabolisme | Factors de transcripció | Medicin och hälsovetenskap
Journal Article
Molecular medicine reports, ISSN 1791-2997, 07/2015, Volume 12, Issue 1, pp. 192 - 198
Epithelial-mesenchymal transition | Transforming growth factor β/Smad4 signaling | Colon cancer | Doxorubicin chemoresistance | RNA interference | RNA, Small Interfering - genetics | Smad4 Protein - antagonists & inhibitors | Antibiotics, Antineoplastic - pharmacology | Cadherins - metabolism | Signal Transduction | Vimentin - metabolism | HCT116 Cells | Humans | Gene Expression Regulation, Neoplastic | Epithelial-Mesenchymal Transition - drug effects | Transcription Factors - genetics | Epithelial-Mesenchymal Transition - genetics | Smad4 Protein - metabolism | Transcription Factors - metabolism | Drug Resistance, Neoplasm - genetics | Transforming Growth Factor beta - genetics | Smad4 Protein - genetics | Vimentin - genetics | Cadherins - genetics | Snail Family Transcription Factors | Transforming Growth Factor beta - metabolism | Doxorubicin - pharmacology | Drug Resistance, Neoplasm - drug effects | RNA, Small Interfering - metabolism
Journal Article
Journal of cellular biochemistry, ISSN 0730-2312, 06/2018, Volume 119, Issue 6, pp. 4496 - 4505
cell proliferation and migration | SMAD4 | bladder cancer | lncRNA AWPPH | EZH2 | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Enhancer of Zeste Homolog 2 Protein - genetics | Enhancer of Zeste Homolog 2 Protein - metabolism | Cell Proliferation | Humans | RNA, Long Noncoding - genetics | Neoplasm Proteins - metabolism | Autophagy | RNA, Neoplasm - metabolism | Smad4 Protein - metabolism | Urinary Bladder Neoplasms - genetics | Smad4 Protein - genetics | Cell Line, Tumor | RNA, Neoplasm - genetics | Neoplasm Proteins - genetics | RNA, Long Noncoding - metabolism | Urinary Bladder Neoplasms - metabolism | Apoptosis | Cell Movement | Development and progression | Bladder cancer | Measuring instruments | Cell proliferation | Chromatin | Immunoprecipitation | Colonies | Epithelial cells | Bladder | Homology | Tissues | Assaying | Ribonucleic acid--RNA | Smad4 protein | Western blotting | Cell growth | Annexin V | Cell migration | Phagocytosis | Cancer | Index Medicus
Journal Article
Nature genetics, ISSN 1061-4036, 05/2019, Volume 51, Issue 5, pp. 777 - 785
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Caco-2 Cells | Hepatocyte Nuclear Factor 4 - metabolism | Signal Transduction | Enterocytes - cytology | Enterocytes - metabolism | Humans | Hepatocyte Nuclear Factor 4 - genetics | Binding Sites - genetics | Smad4 Protein - metabolism | Mice, Knockout | Cell Differentiation - genetics | Animals | Enhancer Elements, Genetic | Smad4 Protein - genetics | Hepatocyte Nuclear Factor 4 - deficiency | Mice | Smad4 Protein - deficiency | Cell Differentiation - physiology | Transcription factors | Developmental genetics | Intestines | Physiological aspects | Bone morphogenetic proteins | Genetic aspects | Research | Transforming growth factors | Smad protein | Chromatin | Ontology | Modules | Genomics | Homeostasis | Genomes | Regulatory sequences | Gene expression | Epithelium | Smad4 protein | Signaling | Intestine | Stem cells | Hepatocyte nuclear factor 4 | Disruption | Differentiation | Feedforward | Bioinformatics | Binding sites | Deoxyribonucleic acid--DNA | Plastic foam | Index Medicus
Journal Article
Clinical cancer research, ISSN 1078-0432, 07/2018, Volume 24, Issue 13, pp. 3176 - 3185
Life Sciences & Biomedicine | Oncology | Science & Technology | Immunohistochemistry | Genomic Instability | Cell Proliferation | Pancreatic Neoplasms - metabolism | Reactive Oxygen Species - metabolism | Apoptosis - radiation effects | Autophagy - radiation effects | Humans | Cell Survival - genetics | Apoptosis - genetics | Biomarkers, Tumor | Gene Knockdown Techniques | Smad4 Protein - genetics | Antineoplastic Agents - pharmacology | Autophagy - genetics | Disease Models, Animal | Pancreatic Neoplasms - radiotherapy | Radiation Tolerance - genetics | Pancreatic Neoplasms - genetics | Cell Survival - radiation effects | Smad4 Protein - metabolism | Animals | Cell Line, Tumor | Mice | DNA Damage | Mutation | Flow cytometry | Radiation effects | Cell survival | Radiosensitivity | Chloroquine | Radiation | Radioresistance | siRNA | Radiation therapy | Assaying | Survival | Autophagy | Smad4 protein | Proteins | Depletion | Inhibitors | Experimental design | Pancreatic cancer | Point mutation | N-Acetyl-L-cysteine | Phagocytosis | Cancer | Tumors | Index Medicus | radiotherapy | pancreatic cancer | SMAD4 | autophagy | reactive oxygen species
Journal Article
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MicroRNA-20a-5p promotes colorectal cancer invasion and metastasis by downregulating Smad4
Oncotarget, ISSN 1949-2553, 2016, Volume 7, Issue 29, pp. 45199 - 45213
Prognosis | Smad4 | Metastasis | miR-20a-5p | Colorectal cancer | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Colorectal Neoplasms - mortality | Smad4 Protein - antagonists & inhibitors | Neoplasm Invasiveness | Down-Regulation | Humans | Middle Aged | Proportional Hazards Models | Male | Neoplasm Metastasis | Animals | Smad4 Protein - genetics | Colorectal Neoplasms - drug therapy | Epithelial-Mesenchymal Transition | Cell Line, Tumor | Adult | Female | Aged | Mice | Mice, Inbred BALB C | MicroRNAs - physiology | 3' Untranslated Regions | Colorectal Neoplasms - pathology | Index Medicus
Journal Article
British journal of cancer, ISSN 0007-0920, 03/2014, Volume 110, Issue 6, pp. 1645 - 1654
miR-1260b | apoptosis | Smad4 | genistein | sFRP1 | Life Sciences & Biomedicine | Oncology | Science & Technology | Tumors of the urinary system | Urinary tract. Prostate gland | Nephrology. Urinary tract diseases | Biological and medical sciences | Multiple tumors. Solid tumors. Tumors in childhood (general aspects) | Medical sciences | Tumors | Prostatic Neoplasms - metabolism | Prostatic Neoplasms - pathology | Ataxia Telangiectasia Mutated Proteins - metabolism | Tissue Array Analysis | Down-Regulation | Humans | In Situ Hybridization, Fluorescence | Male | MicroRNAs - metabolism | Smad4 Protein - metabolism | Up-Regulation - drug effects | Histones - genetics | Prostatic Neoplasms - genetics | Smad4 Protein - genetics | Ataxia Telangiectasia Mutated Proteins - biosynthesis | Genistein - pharmacology | MicroRNAs - genetics | Gene Expression Regulation, Neoplastic - drug effects | Histones - metabolism | Ataxia Telangiectasia Mutated Proteins - genetics | Smad4 Protein - biosynthesis | Anticarcinogenic Agents - pharmacology | DNA Methylation - drug effects | Prostatic Neoplasms - drug therapy | Index Medicus | Molecular Diagnostics
Journal Article
Development (Cambridge), ISSN 0950-1991, 05/2011, Volume 138, Issue 10, pp. 1977 - 1989
SMAD4 | Bone formation | Mouse | Canonical WNT signaling | WNT inhibitor | Odontoblast | TGFβ/BMP | Life Sciences & Biomedicine | Developmental Biology | Science & Technology | Male | Odontogenesis - genetics | Neural Crest - metabolism | Ameloblasts - metabolism | Cell Differentiation - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Smad4 Protein - genetics | Gene Expression Regulation, Developmental | Tooth - embryology | Tooth - cytology | Female | Membrane Proteins - metabolism | Odontoblasts - cytology | Cell Differentiation - physiology | Cell Lineage - genetics | Neural Crest - cytology | Odontoblasts - metabolism | Signal Transduction | Ameloblasts - cytology | Smad4 Protein - physiology | Intercellular Signaling Peptides and Proteins - genetics | Dentin - embryology | Mice, Transgenic | Dental Enamel - embryology | Cell Lineage - physiology | Mice, Knockout | Pregnancy | Animals | Neural Crest - embryology | Mice | Odontogenesis - physiology | Smad4 Protein - deficiency | Wnt Proteins - physiology | Tooth - metabolism | Index Medicus | Dentin | Mesenchyme | Wnt protein | catenin | Frizzled-related protein 1 | Teeth | Transforming growth factor- beta | Neural crest | Osteoblasts | Smad4 protein | Morphogenesis | Signal transduction | Dental enamel | Cell fate | Odontoblasts | Bone morphogenetic proteins | Skull | Differentiation | Dkk1 protein | s | BMP | TGFβ
Journal Article