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Blood, ISSN 0006-4971, 08/2008, Volume 112, Issue 4, pp. 1503 - 1509
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2010, Volume 107, Issue 43, pp. 18404 - 18409
Journal Article
Neuron, ISSN 0896-6273, 02/2012, Volume 73, Issue 4, pp. 713 - 728
Myelination by oligodendrocytes in the central nervous system (CNS) is essential for proper brain function, yet the molecular determinants that control this... 
TRANSCRIPTION FACTORS | IN-VITRO | MULTIPLE-SCLEROSIS | BONE MORPHOGENETIC PROTEIN | OLIGODENDROCYTE PRECURSOR CELLS | DEMYELINATED LESIONS | MOWAT-WILSON-SYNDROME | DIFFERENTIATION | BETA-CATENIN | CNS MYELINATION | NEUROSCIENCES | Central Nervous System - ultrastructure | Microcephaly - genetics | Oligonucleotide Array Sequence Analysis | Embryo, Mammalian | Homeodomain Proteins - metabolism | Humans | Nerve Tissue Proteins - deficiency | Caspase 3 - metabolism | Ki-67 Antigen - metabolism | Gene Expression Profiling | Green Fluorescent Proteins - genetics | RNA, Messenger - metabolism | Zinc Finger E-box Binding Homeobox 2 | Central Nervous System - physiology | Bone Morphogenetic Proteins - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Facies | Repressor Proteins - metabolism | Smad7 Protein - metabolism | Animals, Newborn | Basic Helix-Loop-Helix Transcription Factors - genetics | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Hirschsprung Disease - pathology | Intellectual Disability - pathology | Models, Molecular | Smad Proteins - genetics | Oligodendrocyte Transcription Factor 2 | Signal Transduction - genetics | Mice, Knockout | Central Nervous System - cytology | Mice | Optic Nerve - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Oligodendroglia - metabolism | Immunoprecipitation | Age Factors | Hirschsprung Disease - genetics | Gene Expression Regulation, Developmental - genetics | Intellectual Disability - genetics | Myelin Sheath - metabolism | Cell Differentiation - genetics | Transfection | Microcephaly - pathology | Optic Nerve - embryology | Smad7 Protein - genetics | Optic Nerve - growth & development | Microscopy, Electron, Transmission | Cells, Cultured | Nerve Tissue Proteins - genetics | Organogenesis | Nerve Tissue Proteins - metabolism | Animals | Signal Transduction - physiology | Smad Proteins - metabolism | Medical colleges | Neurosciences | Neurons | Central nervous system | Bone morphogenetic proteins | Universities and colleges | DNA binding proteins | Proteins | Multiple sclerosis | Transcription factors | Rodents | Nervous system | Genomes | Kinases | Gene expression | Antagonism
Journal Article
Trends in Immunology, ISSN 1471-4906, 2004, Volume 25, Issue 10, pp. 513 - 517
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 11, p. e15151
Background: Development of molecules chemically modifying the expression of crucial orchestrator(s) of stem cell commitment may have significant biomedical... 
MIXED ESTERS | HEART | IN-VITRO | TGF-BETA | MESODERM | HIGH-THROUGHPUT | TRANSCRIPTION | BIOLOGY | DIFFERENTIATION | NKX2-5 | DROSOPHILA | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Humans | Esters | Hyaluronic Acid - pharmacology | Smad3 Protein - metabolism | Smad3 Protein - genetics | Mesenchymal Stromal Cells - cytology | RNA Interference | Smad4 Protein - genetics | HEK293 Cells | Smad1 Protein - genetics | Butyric Acid - pharmacology | Smad7 Protein - genetics | Smad7 Protein - metabolism | Tretinoin - pharmacology | Myocytes, Cardiac - cytology | Cells, Cultured | Hyaluronic Acid - chemistry | Mesenchymal Stromal Cells - metabolism | Smad Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Smad4 Protein - metabolism | Blotting, Western | Gene Expression Regulation - drug effects | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Myocytes, Cardiac - metabolism | Smad1 Protein - metabolism | Mice | Smad Proteins - metabolism | Analysis | Genes | Stem cells | Genetic research | Transplantation | Genetic transcription | Precipitation (Meteorology) | Hyaluronic acid | Saturated fatty acids | Heart | Pattern formation | Actinin | Embryo cells | Nuclei | Smad4 protein | Proteins | Hyaluronan | Growth factors | Nkx2.5 protein | Medical research | Fetuses | Conductors | Gene expression | Embryos | Studies | Polymerase chain reaction | Placenta | Insects | Runoff | Biotechnology | Chromatin | Membranes | Smad protein | Transcription | Mesenchyme | Laboratories | Fluorescence | Stem cell transplantation | Kinases | Engineering | Embryogenesis | Allografts | Cell fate | Transgenic animals | Rodents | Mathematical models | Gene transfer | Cardiomyocytes | Medicine | Signaling | Acids | Smad7 protein | Molecular biology | Immunofluorescence | Combinatorial analysis | Cancer
Journal Article
Journal Article
Developmental Dynamics, ISSN 1058-8388, 01/2008, Volume 237, Issue 1, pp. 259 - 269
textabstractAlthough transforming growth factor-beta (TGF-β) signaling negatively regulates branching morphogenesis in early lung development, few studies to... 
mouse | development | septation | rat | TGF‐β, transforming growth factor | human | alveolarization | Human | Mouse | Rat | Transforming growth factor | Development | TGF-β | Alveolarization | Septation | BRONCHIAL EPITHELIAL-CELLS | ANATOMY & MORPHOLOGY | BRANCHING MORPHOGENESIS | BRONCHOPULMONARY-DYSPLASIA | EMBRYONIC LUNG | DEVELOPMENTAL BIOLOGY | INDUCTION | II-RECEPTOR | TGF-beta | TRANSFORMING-GROWTH-FACTOR | DIFFERENTIATION | transforming growth factor | EXPRESSION | MOUSE LUNG | Immunohistochemistry | Receptors, Transforming Growth Factor beta - genetics | Humans | Immunoblotting | Intracellular Signaling Peptides and Proteins - metabolism | Smad4 Protein - genetics | Smad2 Protein - genetics | Activin Receptors, Type I - physiology | Smad6 Protein - genetics | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Smad7 Protein - metabolism | Smad2 Protein - metabolism | Proteoglycans - metabolism | Smad6 Protein - physiology | Signal Transduction - genetics | Reverse Transcriptase Polymerase Chain Reaction | Proteoglycans - physiology | Activin Receptors, Type II - genetics | Lung - embryology | Mice | Smad6 Protein - metabolism | Intracellular Signaling Peptides and Proteins - physiology | Smad3 Protein - physiology | Proteoglycans - genetics | Activin Receptors, Type II - metabolism | Smad3 Protein - metabolism | Receptors, Transforming Growth Factor beta - physiology | Endoglin | Smad3 Protein - genetics | Smad7 Protein - physiology | Gene Expression Regulation, Developmental | Lung - metabolism | Smad7 Protein - genetics | Smad2 Protein - physiology | Protein-Serine-Threonine Kinases - physiology | Mice, Inbred C57BL | Smad4 Protein - physiology | Protein-Serine-Threonine Kinases - genetics | Transforming Growth Factor beta - physiology | Activin Receptors, Type I - metabolism | Activin Receptors, Type I - genetics | Smad4 Protein - metabolism | Animals | Transforming Growth Factor beta - genetics | Receptors, Transforming Growth Factor beta - metabolism | Signal Transduction - physiology | Activin Receptors, Type II - physiology | Transforming Growth Factor beta - metabolism
Journal Article
Biochemical Journal, ISSN 0264-6021, 03/2005, Volume 386, Issue 3, pp. 461 - 470
Inhibitory Smad, Smad7, is a potent inhibitor of TGF-beta (transforming growth factor-beta) superfamily signalling. By binding to activated type I receptors,... 
Developmentally down-regulated 4-2 (NEDD4-2) | Bone morphogenetic protein (BMP) | Smad | Neural precursor cell expressed | Homologous to the E6-accessory protein C-terminus (HECT) | Transforming growth factor-β (TGF-β) | Humans | Protein-Serine-Threonine Kinases | Ubiquitin - metabolism | Cytoplasm - metabolism | RNA, Messenger - metabolism | DNA-Binding Proteins - metabolism | Bone Morphogenetic Proteins - metabolism | Cell Nucleus - metabolism | Trans-Activators - genetics | Nedd4 Ubiquitin Protein Ligases | Transcription, Genetic | Proto-Oncogene Proteins - metabolism | Smad7 Protein | Cell Line | Signal Transduction | Smad6 Protein | Endosomal Sorting Complexes Required for Transport | RNA, Messenger - genetics | Ubiquitin-Protein Ligases - metabolism | Intracellular Signaling Peptides and Proteins | Activin Receptors, Type I - metabolism | DNA-Binding Proteins - genetics | Protein Transport | Two-Hybrid System Techniques | Smad3 Protein | Animals | Receptors, Transforming Growth Factor beta - metabolism | Cell Line, Tumor | Protein Binding | Ligands | Trans-Activators - metabolism | Mice | Ubiquitin-Protein Ligases - genetics | Transforming Growth Factor beta - metabolism | Smad2 Protein | BMPR-IB, BMP type IB receptor | TβR-I, transforming growth factor-β type I receptor | developmentally down-regulated 4-2 (NEDD4-2) | Ski-related novel protein N (SnoN) | I-Smad, inhibitory Smad | transforming growth factor-β (TGF-β) | homologous to the E6-accessory protein C-terminus (HECT) | R-Smad, receptor-regulated Smad | SnoN, Ski-related novel protein N | RING, really interesting new gene | F-box protein | bone morphogenetic protein (BMP) | ROC1, regulator of Cullins 1 | HECT, homologous to the E6-accessory protein C-terminus | siRNA, small interfering RNA | NEDD4-2, neural precursor cell expressed, developmentally down-regulated 4-2 | SCF, Skp1 | neural precursor cell expressed | Smurf, Smad ubiquitin regulatory factor | TGF-β, transforming growth factor-β | Cullin1 | BMP, bone morphogenetic protein | Co-Smad, common-partner Smad
Journal Article
Endocrinology, ISSN 0013-7227, 02/2016, Volume 157, Issue 2, pp. 883 - 899
TGFβ has been implicated in preeclampsia, but its intracellular signaling via phosphorylated mothers against decapentaplegic (SMADs) and SMAD-independent... 
MIGRATION | HUMAN PLACENTAL TROPHOBLAST | IN-VITRO | BEWO CELLS | PROTEIN | ENDOCRINOLOGY & METABOLISM | TRANSFORMING-GROWTH-FACTOR | E-CADHERIN | TRANSCRIPTION FACTOR | SYNCYTIAL FUSION | CELL POLARITY | Pre-Eclampsia - genetics | Oncogene Proteins - genetics | Phosphorylation | Cyclin-Dependent Kinase 4 - genetics | Humans | Pregnancy Proteins - genetics | Male | rhoA GTP-Binding Protein - metabolism | Pregnancy Proteins - metabolism | rhoA GTP-Binding Protein - genetics | RNA, Messenger - metabolism | Cyclin E - genetics | Case-Control Studies | Gene Products, env - metabolism | Young Adult | Cell Differentiation - genetics | Smad2 Protein - genetics | Gene Products, env - genetics | Adult | Female | Pre-Eclampsia - metabolism | Nuclear Proteins - genetics | Smad7 Protein - genetics | Real-Time Polymerase Chain Reaction | Infant, Newborn | Smad7 Protein - metabolism | Cell Proliferation - genetics | Trophoblasts - metabolism | Signal Transduction | Oncogene Proteins - metabolism | Smad2 Protein - metabolism | Ubiquitin-Protein Ligases - metabolism | Nuclear Proteins - metabolism | Transcription Factors - genetics | Cyclin-Dependent Kinase 4 - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Gestational Age | Placenta - metabolism | Pregnancy | Transcription Factors - metabolism | Transforming Growth Factor beta - genetics | Adaptor Proteins, Signal Transducing - genetics | Adolescent | Cyclin E - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin-Protein Ligases - genetics | Transforming Growth Factor beta - metabolism
Journal Article
Molecular Endocrinology, ISSN 0888-8809, 03/2004, Volume 18, Issue 3, pp. 653 - 665
Growth differentiation factor-9 (GDF-9) is an oocyte-derived growth factor and a member of the TGF-β superfamily that includes TGF-β, activin, and bone... 
ALK7 SIGNALS | BONE MORPHOGENETIC PROTEIN | MAD-RELATED PROTEIN | ENDOCRINOLOGY & METABOLISM | OSTEOGENIC PROTEIN-1 | FOLLICULAR-GROWTH | TGF-BETA RECEPTOR | OVARIAN GRANULOSA-CELLS | IDENTIFICATION | HOMOLOG GDF-9B | LUTEAL CELLS | Phosphorylation | Receptors, Transforming Growth Factor beta - genetics | Trans-Activators - drug effects | Protein-Serine-Threonine Kinases | Activin Receptors - drug effects | Activins - metabolism | COS Cells - drug effects | Activin Receptors - genetics | Granulosa Cells - drug effects | Granulosa Cells - metabolism | COS Cells - metabolism | DNA-Binding Proteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Bone Morphogenetic Proteins - metabolism | Growth Differentiation Factor 9 | Trans-Activators - genetics | Female | Smad7 Protein | Promoter Regions, Genetic | Signal Transduction | Smad6 Protein | Cells, Cultured | DNA-Binding Proteins - drug effects | Rats | Activin Receptors, Type I - metabolism | DNA-Binding Proteins - genetics | Activin Receptors, Type I - genetics | Rats, Sprague-Dawley | Activin Receptors, Type I - drug effects | Transforming Growth Factor beta - pharmacology | Bone Morphogenetic Protein 15 | Smad3 Protein | Activin Receptors - metabolism | Animals | Activins - pharmacology | Receptors, Transforming Growth Factor beta - drug effects | Receptors, Transforming Growth Factor beta - metabolism | Intercellular Signaling Peptides and Proteins - pharmacology | Smad Proteins | Trans-Activators - metabolism | RNA, Small Interfering | Transforming Growth Factor beta - metabolism | Smad2 Protein
Journal Article
Science Translational Medicine, ISSN 1946-6234, 07/2016, Volume 8, Issue 348, pp. 348ra98 - 348ra98
Journal Article