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animals (781) 781
humans (692) 692
smad7 protein - metabolism (562) 562
signal transduction (435) 435
mice (421) 421
smad7 protein - genetics (391) 391
smad7 protein (384) 384
transforming growth factor beta - metabolism (384) 384
smad7 (381) 381
male (373) 373
tgf-beta (345) 345
growth-factor-beta (277) 277
expression (261) 261
female (253) 253
biochemistry & molecular biology (249) 249
rats (243) 243
cells, cultured (218) 218
cell biology (211) 211
phosphorylation (201) 201
cell line (200) 200
dna-binding proteins - metabolism (199) 199
trans-activators - metabolism (183) 183
fibrosis (180) 180
transforming growth factor beta1 - metabolism (177) 177
smad3 protein - metabolism (164) 164
signal transduction - drug effects (158) 158
dna-binding proteins - genetics (157) 157
gene expression (155) 155
signal transduction - physiology (152) 152
trans-activators - genetics (148) 148
rna, messenger - metabolism (147) 147
activation (142) 142
proteins (142) 142
smad2 protein - metabolism (140) 140
apoptosis (138) 138
receptor (134) 134
receptors, transforming growth factor beta - metabolism (132) 132
oncology (126) 126
transforming growth factor beta - pharmacology (124) 124
smad3 protein (122) 122
tgf-β (122) 122
blotting, western (120) 120
smad2 protein (119) 119
cell line, tumor (115) 115
cancer (114) 114
transfection (114) 114
transforming growth factor beta - genetics (111) 111
adult (109) 109
reverse transcriptase polymerase chain reaction (108) 108
cells (107) 107
middle aged (106) 106
immunohistochemistry (105) 105
transforming growth factors (105) 105
disease models, animal (101) 101
mice, inbred c57bl (100) 100
rats, sprague-dawley (99) 99
gene expression regulation (96) 96
fibroblasts - metabolism (93) 93
rna, messenger - genetics (93) 93
bone morphogenetic proteins (90) 90
cell proliferation (89) 89
inhibition (89) 89
smad proteins - metabolism (89) 89
protein-serine-threonine kinases - metabolism (86) 86
gene-expression (82) 82
up-regulation (82) 82
integumentary system (81) 81
research article (81) 81
transforming growth factor beta - physiology (81) 81
inflammation (79) 79
smad (79) 79
smad3 protein - genetics (79) 79
article (78) 78
down-regulation (78) 78
identification (78) 78
micrornas - genetics (77) 77
protein binding (77) 77
mice, knockout (76) 76
time factors (76) 76
rodents (75) 75
transforming growth factor beta1 - genetics (75) 75
pathway (74) 74
degradation (73) 73
abridged index medicus (72) 72
medicine, research & experimental (72) 72
growth factors (71) 71
aged (70) 70
analysis (70) 70
smad proteins (70) 70
micrornas - metabolism (69) 69
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collagen (68) 68
medicine (68) 68
differentiation (67) 67
research (67) 67
transforming growth factor beta1 (67) 67
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Endocrinology, ISSN 0013-7227, 02/2016, Volume 157, Issue 2, pp. 883 - 899
TGFβ has been implicated in preeclampsia, but its intracellular signaling via phosphorylated mothers against decapentaplegic (SMADs) and SMAD-independent... 
HUMAN PLACENTAL TROPHOBLAST | IN-VITRO | BEWO CELLS | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | TRANSFORMING-GROWTH-FACTOR | EPITHELIAL-MESENCHYMAL TRANSITIONS | E-CADHERIN | CELL-LINES | TRANSCRIPTION FACTOR | SYNCYTIAL FUSION | Pre-Eclampsia - genetics | Oncogene Proteins - genetics | Phosphorylation | Cyclin-Dependent Kinase 4 - genetics | Humans | Pregnancy Proteins - genetics | Male | rhoA GTP-Binding Protein - metabolism | Pregnancy Proteins - metabolism | rhoA GTP-Binding Protein - genetics | RNA, Messenger - metabolism | Cyclin E - genetics | Case-Control Studies | Gene Products, env - metabolism | Young Adult | Cell Differentiation - genetics | Smad2 Protein - genetics | Gene Products, env - genetics | Adult | Female | Pre-Eclampsia - metabolism | Nuclear Proteins - genetics | Smad7 Protein - genetics | Real-Time Polymerase Chain Reaction | Infant, Newborn | Smad7 Protein - metabolism | Cell Proliferation - genetics | Trophoblasts - metabolism | Signal Transduction | Oncogene Proteins - metabolism | Smad2 Protein - metabolism | Ubiquitin-Protein Ligases - metabolism | Nuclear Proteins - metabolism | Transcription Factors - genetics | Cyclin-Dependent Kinase 4 - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Gestational Age | Placenta - metabolism | Pregnancy | Transcription Factors - metabolism | Transforming Growth Factor beta - genetics | Adaptor Proteins, Signal Transducing - genetics | Adolescent | Cyclin E - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin-Protein Ligases - genetics | Transforming Growth Factor beta - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
Neuron, ISSN 0896-6273, 02/2012, Volume 73, Issue 4, pp. 713 - 728
Myelination by oligodendrocytes in the central nervous system (CNS) is essential for proper brain function, yet the molecular determinants that control this... 
TRANSCRIPTION FACTORS | IN-VITRO | MULTIPLE-SCLEROSIS | BONE MORPHOGENETIC PROTEIN | OLIGODENDROCYTE PRECURSOR CELLS | DEMYELINATED LESIONS | MOWAT-WILSON-SYNDROME | DIFFERENTIATION | BETA-CATENIN | CNS MYELINATION | NEUROSCIENCES | Central Nervous System - ultrastructure | Microcephaly - genetics | Oligonucleotide Array Sequence Analysis | Embryo, Mammalian | Homeodomain Proteins - metabolism | Humans | Nerve Tissue Proteins - deficiency | Caspase 3 - metabolism | Ki-67 Antigen - metabolism | Gene Expression Profiling | Green Fluorescent Proteins - genetics | RNA, Messenger - metabolism | Zinc Finger E-box Binding Homeobox 2 | Central Nervous System - physiology | Bone Morphogenetic Proteins - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Facies | Repressor Proteins - metabolism | Smad7 Protein - metabolism | Animals, Newborn | Basic Helix-Loop-Helix Transcription Factors - genetics | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Hirschsprung Disease - pathology | Intellectual Disability - pathology | Models, Molecular | Smad Proteins - genetics | Oligodendrocyte Transcription Factor 2 | Signal Transduction - genetics | Mice, Knockout | Central Nervous System - cytology | Mice | Optic Nerve - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Oligodendroglia - metabolism | Immunoprecipitation | Age Factors | Hirschsprung Disease - genetics | Gene Expression Regulation, Developmental - genetics | Intellectual Disability - genetics | Myelin Sheath - metabolism | Cell Differentiation - genetics | Transfection | Microcephaly - pathology | Optic Nerve - embryology | Smad7 Protein - genetics | Optic Nerve - growth & development | Microscopy, Electron, Transmission | Cells, Cultured | Nerve Tissue Proteins - genetics | Organogenesis | Nerve Tissue Proteins - metabolism | Animals | Signal Transduction - physiology | Smad Proteins - metabolism | Medical colleges | Neurosciences | Neurons | Central nervous system | Bone morphogenetic proteins | Universities and colleges | DNA binding proteins | Proteins | Multiple sclerosis | Transcription factors | Rodents | Nervous system | Genomes | Kinases | Gene expression | Index Medicus | Antagonism
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 08/2010, Volume 207, Issue 8, pp. 1589 - 1597
Uncontrolled extracellular matrix production by fibroblasts in response to tissue injury contributes to fibrotic diseases, such as idiopathic pulmonary... 
MEDICINE, RESEARCH & EXPERIMENTAL | RESPONSES | PHOSPHATASE | INJURY | TENSIN HOMOLOG | MECHANISMS | GROWTH-FACTOR | IMMUNOLOGY | MYOFIBROBLAST DIFFERENTIATION | EXPRESSION | CANCER | MICRORNA | Oligonucleotides - genetics | Pulmonary Fibrosis - therapy | Idiopathic Pulmonary Fibrosis - genetics | Gene Expression - drug effects | Gene Expression - genetics | Humans | Actins - metabolism | MicroRNAs - metabolism | Pulmonary Fibrosis - genetics | Idiopathic Pulmonary Fibrosis - metabolism | Actins - genetics | Antisense Elements (Genetics) - therapeutic use | Collagen - genetics | Lung - metabolism | Phosphorylation - drug effects | Smad7 Protein - genetics | Extracellular Matrix Proteins - metabolism | Transforming Growth Factor beta1 - pharmacology | Fibroblasts - metabolism | Smad7 Protein - metabolism | Cell Line | Lung - pathology | Extracellular Matrix Proteins - genetics | Mice, Inbred C57BL | Smad2 Protein - metabolism | Mice, Transgenic | Pulmonary Fibrosis - pathology | Transforming Growth Factor beta1 - genetics | Fibroblasts - pathology | Fibronectins - metabolism | Collagen - metabolism | Animals | Fibroblasts - drug effects | Antisense Elements (Genetics) - genetics | Idiopathic Pulmonary Fibrosis - pathology | Pulmonary Fibrosis - chemically induced | Bleomycin - pharmacology | Fibronectins - genetics | Mice | MicroRNAs - genetics | Index Medicus | Brief Definitive Report
Journal Article
Blood, ISSN 0006-4971, 08/2008, Volume 112, Issue 4, pp. 1503 - 1509
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2013, Volume 8, Issue 7, pp. e70195 - e70195
Journal Article
NATURE MEDICINE, ISSN 1078-8956, 03/2012, Volume 18, Issue 3, pp. 429 - U192
Journal Article
Cardiovascular research, ISSN 0008-6363, 2014, Volume 104, Issue 1, pp. 61 - 71
The overloaded heart remodels by cardiomyocyte hypertrophy and interstitial fibrosis, which contributes to the development of heart failure. Signalling via the... 
miRNA-15 family | TGFβ-pathway | Fibrosis | Hypertrophy | PRESSURE-OVERLOAD | CARDIAC & CARDIOVASCULAR SYSTEMS | TGF-BETA | LEFT-VENTRICULAR FIBROSIS | IMPROVES SURVIVAL | TGF beta-pathway | MIR-15 FAMILY | FAILURE | MYOCARDIAL FIBROSIS | CARDIAC-HYPERTROPHY | GENE-EXPRESSION | TRANSGENIC MICE | Up-Regulation | Receptors, Transforming Growth Factor beta - genetics | Humans | Cercopithecus aethiops | Cardiomegaly - pathology | MicroRNAs - metabolism | Smad3 Protein - metabolism | Case-Control Studies | Cardiomyopathies - genetics | Smad3 Protein - genetics | Cardiomyopathies - physiopathology | Ventricular Remodeling | Transfection | p38 Mitogen-Activated Protein Kinases - metabolism | 3' Untranslated Regions | Smad7 Protein - genetics | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Smad7 Protein - metabolism | Rats, Transgenic | Signal Transduction | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Cardiomegaly - physiopathology | p38 Mitogen-Activated Protein Kinases - genetics | Cardiomyopathies - pathology | Hep G2 Cells | Animals | Receptors, Transforming Growth Factor beta - metabolism | Cardiomyopathies - metabolism | Myocytes, Cardiac - metabolism | MicroRNAs - genetics | Cardiomegaly - genetics | COS Cells | Transforming Growth Factor beta - metabolism | Cardiomegaly - metabolism | Index Medicus
Journal Article
Kidney International, ISSN 0085-2538, 12/2013, Volume 84, Issue 6, pp. 1129 - 1144
The TGF-β/Smad3 pathway plays a major role in tissue fibrosis, but the precise mechanisms are not fully understood. Here we identified microRNA miR-433 as an... 
miR-433 | renal fibrosis | TGF-β signaling | microRNA therapy | KIDNEY-DISEASE | TGF-BETA | DIABETIC-NEPHROPATHY | MESENCHYMAL TRANSITION | TGF-beta signaling | GROWTH-FACTOR-BETA | TARGETED DISRUPTION | POLYAMINE DEPLETION | UNILATERAL URETERAL OBSTRUCTION | EPITHELIAL-CELLS | TUBULOINTERSTITIAL FIBROSIS | UROLOGY & NEPHROLOGY | Up-Regulation | Ureteral Obstruction - complications | Kidney - pathology | Transforming Growth Factor beta1 - metabolism | Male | MicroRNAs - metabolism | Smad3 Protein - metabolism | Mice, 129 Strain | Anti-Glomerular Basement Membrane Disease - metabolism | Doxorubicin | Kidney Diseases - genetics | Smad3 Protein - deficiency | Smad3 Protein - genetics | Kidney - metabolism | Transfection | RNA Interference | Time Factors | Smad2 Protein - genetics | Anti-Glomerular Basement Membrane Disease - genetics | Smad7 Protein - genetics | Binding Sites | Disease Models, Animal | Kidney Diseases - metabolism | Smad7 Protein - metabolism | Cell Line | Promoter Regions, Genetic | Signal Transduction | Kidney Diseases - pathology | Kidney Diseases - prevention & control | Anti-Glomerular Basement Membrane Disease - pathology | Mice, Inbred C57BL | Smad2 Protein - metabolism | Rats | Smad2 Protein - deficiency | Transforming Growth Factor beta1 - genetics | Mice, Knockout | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Fibrosis | Mice | MicroRNAs - genetics | Kidney Diseases - etiology | Index Medicus
Journal Article
Science Translational Medicine, ISSN 1946-6234, 07/2016, Volume 8, Issue 348, pp. 348ra98 - 348ra98
Journal Article
Hypertension, ISSN 0194-911X, 10/2009, Volume 54, Issue 4, pp. 877 - 884
Journal Article
Molecular Endocrinology, ISSN 0888-8809, 03/2004, Volume 18, Issue 3, pp. 653 - 665
Growth differentiation factor-9 (GDF-9) is an oocyte-derived growth factor and a member of the TGF-β superfamily that includes TGF-β, activin, and bone... 
ALK7 SIGNALS | BONE MORPHOGENETIC PROTEIN | MAD-RELATED PROTEIN | ENDOCRINOLOGY & METABOLISM | OSTEOGENIC PROTEIN-1 | FOLLICULAR-GROWTH | TGF-BETA RECEPTOR | OVARIAN GRANULOSA-CELLS | IDENTIFICATION | HOMOLOG GDF-9B | LUTEAL CELLS | Phosphorylation | Receptors, Transforming Growth Factor beta - genetics | Trans-Activators - drug effects | Protein-Serine-Threonine Kinases | Activin Receptors - drug effects | Activins - metabolism | COS Cells - drug effects | Activin Receptors - genetics | Granulosa Cells - drug effects | Granulosa Cells - metabolism | COS Cells - metabolism | DNA-Binding Proteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Bone Morphogenetic Proteins - metabolism | Growth Differentiation Factor 9 | Trans-Activators - genetics | Female | Smad7 Protein | Promoter Regions, Genetic | Signal Transduction | Smad6 Protein | Cells, Cultured | DNA-Binding Proteins - drug effects | Rats | Activin Receptors, Type I - metabolism | DNA-Binding Proteins - genetics | Activin Receptors, Type I - genetics | Rats, Sprague-Dawley | Activin Receptors, Type I - drug effects | Transforming Growth Factor beta - pharmacology | Bone Morphogenetic Protein 15 | Smad3 Protein | Activin Receptors - metabolism | Animals | Activins - pharmacology | Receptors, Transforming Growth Factor beta - drug effects | Receptors, Transforming Growth Factor beta - metabolism | Intercellular Signaling Peptides and Proteins - pharmacology | Smad Proteins | Trans-Activators - metabolism | RNA, Small Interfering | Transforming Growth Factor beta - metabolism | Smad2 Protein | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 04/2014, Volume 111, Issue 13, pp. E1211 - E1220
Journal Article