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Journal of Proteome Research, ISSN 1535-3893, 01/2017, Volume 16, Issue 1, pp. 3 - 13
Lung cancer has the highest mortality rate among cancer patients in the world, in particular because most patients are only diagnosed at an advanced and... 
To be checked by Faculty | lung cancer | computed tomography (CT) screening | antibody | tumor immunology | proteomics | next-generation sequencing (NGS) | antigen | early detection | biomarker | SCREENING TRIAL | PULMONARY NODULES | BIOCHEMICAL RESEARCH METHODS | DANTE TRIAL | IMMUNOGLOBULIN PEPTIDES | NELSON TRIAL | HIGH-RISK | SPIRAL COMPUTED-TOMOGRAPHY | ANTIBODY REPERTOIRE | DOSE CT | CELL | Carcinoma, Squamous Cell - blood | Early Detection of Cancer - methods | Autoantibodies - blood | Carcinoma, Squamous Cell - genetics | Humans | Tomography, X-Ray Computed | Carcinoma, Squamous Cell - diagnostic imaging | Small Cell Lung Carcinoma - blood | Carcinoma, Large Cell - immunology | Antigens, Neoplasm - blood | Adenocarcinoma - genetics | Carcinoma, Large Cell - genetics | Carcinoma, Large Cell - blood | Lung Neoplasms - genetics | Antigens, Neoplasm - genetics | Gene Expression | Antigens, Neoplasm - immunology | Carcinoma, Non-Small-Cell Lung - genetics | Adenocarcinoma - blood | Adenocarcinoma - immunology | Small Cell Lung Carcinoma - genetics | Carcinoma, Squamous Cell - immunology | Biomarkers, Tumor - blood | Carcinoma, Non-Small-Cell Lung - immunology | Lung Neoplasms - immunology | Carcinoma, Large Cell - diagnostic imaging | Small Cell Lung Carcinoma - diagnostic imaging | Carcinoma, Non-Small-Cell Lung - blood | Lung Neoplasms - diagnostic imaging | Biomarkers, Tumor - genetics | Carcinoma, Non-Small-Cell Lung - diagnostic imaging | Lung Neoplasms - blood | Adenocarcinoma - diagnostic imaging | Autoantibodies - genetics | Biomarkers, Tumor - immunology | Small Cell Lung Carcinoma - immunology
Journal Article
Open Biology, ISSN 2046-2441, 2017, Volume 7, Issue 9, p. 170070
Lung cancer is the leading cause of cancer-related death in the world. It is broadly divided into small cell (SCLC, approx. 15% cases) and non-small cell lung... 
Low-dose CT screening | NLST trial | Lung cancer | SCREENING TRIAL | BRONCHIAL GENOMIC CLASSIFIER | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLASMA DNA | EARLY-STAGE | FOLLOW-UP | lung cancer | low-dose CT screening | CIRCULATING TUMOR-CELLS | EXHALED BREATH | LOW-DOSE CT | SPIRAL COMPUTED-TOMOGRAPHY | CANINE SCENT DETECTION | Prognosis | Adenocarcinoma of Lung | Circulating Tumor DNA - genetics | Early Detection of Cancer - methods | Neoplastic Cells, Circulating - pathology | Lung Neoplasms - mortality | Carcinoma, Squamous Cell - genetics | Humans | Bronchoscopy - methods | Neoplastic Cells, Circulating - metabolism | Carcinoma, Squamous Cell - surgery | Carcinoma, Squamous Cell - diagnostic imaging | Carcinoma, Squamous Cell - mortality | Adenocarcinoma - genetics | Lung Neoplasms - genetics | Carcinoma, Non-Small-Cell Lung - surgery | Carcinoma, Non-Small-Cell Lung - genetics | Liquid Biopsy - methods | Small Cell Lung Carcinoma - surgery | Small Cell Lung Carcinoma - genetics | Carcinoma, Non-Small-Cell Lung - mortality | Biomarkers, Tumor - blood | Radiography | Survival Analysis | Small Cell Lung Carcinoma - diagnostic imaging | Lung Neoplasms - diagnostic imaging | Lung Neoplasms - surgery | Small Cell Lung Carcinoma - mortality | Biomarkers, Tumor - genetics | Carcinoma, Non-Small-Cell Lung - diagnostic imaging | Adenocarcinoma - diagnostic imaging | Circulating Tumor DNA - blood | Neoplasm Staging | Adenocarcinoma - mortality | Adenocarcinoma - surgery
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2017, Volume 114, Issue 19, pp. 4993 - 4998
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 09/2018, Volume 22, Issue 9, pp. 4328 - 4334
We aimed to compare the diagnostic efficiency of proGRP and NSE on SCLC and to investigate whether the change of proGRP level would predict therapeutic... 
neuron‐specific enolase | diagnosis | progastrin‐releasing peptide | small‐cell lung cancer | therapeutic monitoring | neuron-specific enolase | small-cell lung cancer | progastrin-releasing peptide | MEDICINE, RESEARCH & EXPERIMENTAL | ASSAY | BIOMARKER | STATISTICS | NEUROENDOCRINE | CELL BIOLOGY | BOMBESIN | PROGRP | FETAL | CARCINOMA | TUMOR-MARKER | Lung Neoplasms - drug therapy | Follow-Up Studies | Area Under Curve | Humans | Middle Aged | Lung Neoplasms - pathology | Male | Antineoplastic Agents - therapeutic use | Carcinoma, Non-Small-Cell Lung - diagnosis | Neoplasms - diagnosis | Small Cell Lung Carcinoma - drug therapy | Small Cell Lung Carcinoma - blood | Neoplasms - blood | Phosphopyruvate Hydratase - genetics | Phosphopyruvate Hydratase - blood | China | Sensitivity and Specificity | Peptide Fragments - blood | Adult | Female | Retrospective Studies | Peptide Fragments - genetics | Carcinoma, Non-Small-Cell Lung - pathology | Diagnosis, Differential | Recombinant Proteins - genetics | Biomarkers, Tumor - blood | Recombinant Proteins - blood | Small Cell Lung Carcinoma - pathology | Small Cell Lung Carcinoma - diagnosis | Carcinoma, Non-Small-Cell Lung - blood | Aged | Biomarkers, Tumor - genetics | Lung Neoplasms - blood | Carcinoma, Non-Small-Cell Lung - drug therapy | Lung Neoplasms - diagnosis | Neoplasms - pathology | Medicine, Experimental | Medical research | Respiratory tract diseases | Peptides | Lung cancer, Non-small cell | Health aspects | Chemotherapy | Small cell lung carcinoma | Efficiency | Lung cancer | Lung diseases | Non-small cell lung carcinoma | Biomarkers | Diagnostic systems | Lesions | Patients | Original
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2013, Volume 8, Issue 6, p. e67466
Background: Epithelial cell adhesion molecule (EpCAM)-based enumeration of circulating tumor cells (CTC) has prognostic value in patients with solid tumors,... 
BREAST-CANCER | SURVIVAL | IMPACT | MULTIDISCIPLINARY SCIENCES | PERIPHERAL-BLOOD | PROGRESSION | CLINICAL-SIGNIFICANCE | Prognosis | Prospective Studies | Neoplastic Cells, Circulating - pathology | Cell Count | Humans | Lung Neoplasms - metabolism | Middle Aged | Neoplastic Cells, Circulating - metabolism | Lung Neoplasms - pathology | Male | Tissue Array Analysis - methods | Small Cell Lung Carcinoma - blood | Epithelial Cell Adhesion Molecule | Small Cell Lung Carcinoma - metabolism | Aged, 80 and over | Antigens, Neoplasm - metabolism | Adult | Female | Carcinoma, Non-Small-Cell Lung - pathology | Cell Adhesion Molecules - metabolism | Small Cell Lung Carcinoma - pathology | Cell Line, Tumor | Carcinoma, Non-Small-Cell Lung - blood | Aged | Lung Neoplasms - blood | Medical research | Care and treatment | Medicine, Experimental | Metastasis | Comparative analysis | Lung cancer, Non-small cell | Prostate cancer | Biotechnology | Epithelial cells | Lung cancer | Oncology | Statistical methods | Metastases | Cell adhesion molecules | Engineering | Colon cancer | Cell adhesion | Peripheral blood | Clusters | Life sciences | Colon | Enumeration | Statistical analysis | Research & development--R&D | Tumor cells | Non-small cell lung carcinoma | Breast cancer | Statistics | Patients | Chemotherapy | Solid tumors | Median (statistics) | Prostate | Tumors | Cancer | Research & development | R&D
Journal Article
Journal of Thoracic Oncology, ISSN 1556-0864, 01/2018, Volume 13, Issue 1, pp. 97 - 105
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2014, Volume 9, Issue 5, p. e97070
Proangiogenic enzyme thymidine phosphorylase (TP) is a promising target for anticancer therapy, yet its action in non-small cell lung carcinoma (NSCLC) is not... 
IN-VITRO | IL-8 EXPRESSION | A549 CELLS | MULTIDISCIPLINARY SCIENCES | TUMOR-CELLS | PROLIFERATION | HEME OXYGENASE-1 | CARCINOMA | ENDOTHELIAL GROWTH-FACTOR | PROMOTES ANGIOGENESIS | MOLECULAR-MECHANISMS | Carcinoma, Non-Small-Cell Lung - pathology | Heme Oxygenase-1 - metabolism | Cell Proliferation | Lung Neoplasms - enzymology | Cytokines - metabolism | Carcinoma, Non-Small-Cell Lung - blood supply | Humans | Lung Neoplasms - metabolism | Carcinoma, Non-Small-Cell Lung - metabolism | Gene Expression Regulation, Neoplastic | Neovascularization, Pathologic | Lung Neoplasms - pathology | Animals | NF-E2-Related Factor 2 - metabolism | Cell Line, Tumor | Female | Mice | Carcinoma, Non-Small-Cell Lung - enzymology | Endothelial Cells - pathology | Thymidine Phosphorylase - metabolism | Cell Movement | Lung Neoplasms - blood supply | Antioxidants | Enzymes | Analysis | Acetylcysteine | Lung cancer, Non-small cell | Gene expression | Vascular endothelial growth factor | Cell proliferation | Pediatrics | Biotechnology | Thoracic surgery | Crosstalk | Lung cancer | Thymidine | Biochemistry | Metastasis | Kinases | Drug resistance | Cancer therapies | Cell adhesion & migration | Interleukin 6 | Angiogenesis | Cell growth | Rodents | Heme | NRF2 protein | Interleukin 8 | Squamous cell carcinoma | Small cell lung carcinoma | Cytokines | Heme oxygenase (decyclizing) | Non-small cell lung carcinoma | Lung carcinoma | Inflammation | Biophysics | Phosphorylase | Endothelial cells | Endothelium | Oxygenase | Chemotherapy | Plasmids | Medical prognosis | Polish Americans | Oxygenation | Cell migration | Tumors | Cancer | Endothelial Cells | Carcinoma, Non-Small-Cell Lung | Lung Neoplasms | Life Sciences | Thymidine Phosphorylase | NF-E2-Related Factor 2 | Heme Oxygenase-1
Journal Article
Lancet, The, ISSN 0140-6736, 2017, Volume 390, Issue 10089, pp. 29 - 39
Summary Background Alectinib, a potent, highly selective, CNS-active inhibitor of anaplastic lymphoma kinase (ALK), showed promising efficacy and tolerability... 
Internal Medicine | ANAPLASTIC LYMPHOMA KINASE | MEDICINE, GENERAL & INTERNAL | SAFETY | CH5424802 | AF-001JP | ADVANCED NSCLC | INHIBITORS | CHEMOTHERAPY | Single-Blind Method | Lung Neoplasms - drug therapy | Pyrazoles - therapeutic use | Humans | Middle Aged | Lung Neoplasms - pathology | Male | Antineoplastic Agents - therapeutic use | Protein Kinase Inhibitors - adverse effects | Piperidines - blood | Brain Neoplasms - secondary | Pyridines - adverse effects | Carcinoma, Non-Small-Cell Lung - secondary | Neoplasm Grading | Antineoplastic Agents - adverse effects | Pyrazoles - blood | Aged, 80 and over | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Adult | Female | Carbazoles - blood | Pyrazoles - adverse effects | Pyridines - therapeutic use | Carcinoma, Non-Small-Cell Lung - pathology | Carbazoles - adverse effects | Lung Neoplasms - enzymology | Kaplan-Meier Estimate | Receptor Protein-Tyrosine Kinases - metabolism | Protein Kinase Inhibitors - blood | Pyridines - blood | Piperidines - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Piperidines - adverse effects | Antineoplastic Agents - blood | Aged | Carbazoles - therapeutic use | Carcinoma, Non-Small-Cell Lung - drug therapy | Carcinoma, Non-Small-Cell Lung - enzymology | Medical colleges | Respiratory agents | Care and treatment | Lymphomas | Lung cancer, Non-small cell | Product development | Pharmaceutical industry | Analysis | Toxicity | Funding | Lung cancer | Central nervous system | Metastasis | Kinases | Evidence-based medicine | Recruitment | Motivation | Audio frequencies | Safety | Toxic diseases | Drug dosages | Protein-tyrosine kinase | Effectiveness | Cut-off | Data processing | Group dynamics | Patients | Survival | Lymphoma | Chemotherapy | Inhibitors | Interactive systems | Death | Mutation | Cancer | Pharmaceuticals
Journal Article
Cancer Research, ISSN 0008-5472, 02/2018, Volume 78, Issue 3, pp. 809 - 816
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2015, Volume 10, Issue 8, p. e0136023
Background Immunotherapy can become a crucial therapeutic option to improve prognosis for lung cancer patients. First clinical trials with therapies targeting... 
CELL LUNG-CANCER | TUMOR-INFILTRATING LYMPHOCYTES | INTERLEUKIN-2 | GEFITINIB | IMPACT | MULTIDISCIPLINARY SCIENCES | ANTIBODY | B7-H1 | T-CELLS | CHEMOTHERAPY | LIGAND 1 EXPRESSION | Adenocarcinoma - pathology | Prognosis | Follow-Up Studies | Lung Neoplasms - mortality | Carcinoma, Large Cell - pathology | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Male | Carcinoma, Large Cell - mortality | Immunoenzyme Techniques | Adenocarcinoma - metabolism | Carcinoma, Squamous Cell - mortality | Neoplasm Grading | Biomarkers, Tumor - metabolism | Female | Retrospective Studies | Carcinoma, Non-Small-Cell Lung - pathology | Carcinoma, Large Cell - metabolism | Carcinoma, Non-Small-Cell Lung - metabolism | Carcinoma, Squamous Cell - therapy | Programmed Cell Death 1 Receptor - metabolism | Survival Rate | Combined Modality Therapy | Lung Neoplasms - therapy | Carcinoma, Non-Small-Cell Lung - mortality | B7-H1 Antigen - metabolism | Carcinoma, Non-Small-Cell Lung - therapy | Adenocarcinoma - therapy | Aged | Neoplasm Staging | Carcinoma, Large Cell - therapy | Adenocarcinoma - mortality | Care and treatment | Physiological aspects | Genetic aspects | Research | Lung cancer, Non-small cell | Apoptosis | Immunohistochemistry | Thoracic surgery | PD-1 protein | Lung cancer | Clinical trials | Oncology | Cancer therapies | Lymph nodes | Subgroups | Proteins | Rank tests | Regression models | Bcl-x protein | Lymphocytes | Immunotherapy | Medical research | Immunoglobulins | Squamous cell carcinoma | Cell survival | Cytokines | Hematology | Tumor cells | Non-small cell lung carcinoma | Breast cancer | Regression analysis | Patients | Medicine | Pathology | Chemotherapy | Hospitals | Cell death | Medical prognosis | PD-L1 protein | Ligands | Diagnostic systems | Solid tumors | Cancer | Tumors
Journal Article
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 05/2018, Volume 378, Issue 21, pp. 1976 - 1986
Journal Article