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Nature chemical biology, ISSN 1552-4469, 2009, Volume 5, Issue 9, pp. 647 - 654
Journal Article
Nature (London), ISSN 0028-0836, 2018, Volume 559, Issue 7713, pp. 269 - 273
.... Progress in understanding the molecular mechanisms of innate immune pathways has led to the promise of targeted therapeutic approaches, but the development of drugs that act specifically on molecules... 
SYNTHASE | 2ND-MESSENGER | CELLS | CYCLIC GMP-AMP | ACTIVATION | AICARDI-GOUTIERES SYNDROME | MULTIDISCIPLINARY SCIENCES | CGAS | SENSOR | CYTOSOLIC-DNA | AUTOIMMUNE-DISEASE | Cell Line | Small Molecule Libraries - analysis | Small Molecule Libraries - pharmacology | Golgi Apparatus - drug effects | Humans | Mice, Inbred C57BL | Lipoylation - drug effects | Small Molecule Libraries - metabolism | Hereditary Autoinflammatory Diseases - drug therapy | Small Molecule Libraries - chemistry | Hereditary Autoinflammatory Diseases - metabolism | Animals | Membrane Proteins - antagonists & inhibitors | Signal Transduction - drug effects | Protein Binding - drug effects | Golgi Apparatus - metabolism | Cysteine - metabolism | Mice | Binding Sites | Immune response | Interferon | Nucleotide sequencing | Observations | Health aspects | Methods | DNA sequencing | Target recognition | Disease | Palmitoylation | Amino acids | Intracellular signalling | Activation | Antagonists | Drug development | Kinases | Immunosuppressive agents | Proteins | Stimulators | Signal transduction | Pathways | Chemical bonds | Deoxyribonucleic acid--DNA | Lupus | Medical treatment | Pharmacology | Inflammation | Gene expression | Golgi apparatus | Molecular modelling | Inhibitors | Scientific imaging | Mass spectrometry
Journal Article
Chemical Society reviews, ISSN 1460-4744, 2011, Volume 40, Issue 12, pp. 5707 - 5717
Journal Article
Scientific reports, ISSN 2045-2322, 2017, Volume 7, Issue 1, p. 42717
To be effective as a drug, a potent molecule must reach its target in the body in sufficient concentration, and stay there in a bioactive form long enough for the expected biologic events to occur... 
SCREENING LIBRARIES | DESIGN | POLAR SURFACE-AREA | TRANSPORTERS | MULTIDISCIPLINARY SCIENCES | CYP ENZYMES | PARTITION-COEFFICIENT | DISCOVERY | COMPOUND DATABASES | PREDICTION | SOLUBILITY
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 09/2014, Volume 53, Issue 38, pp. 10056 - 10059
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 01/2018, Volume 10, Issue 1, pp. 22 - 31
Journal Article