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1. Full Text DNA-Encoded Chemical Libraries: Advancing beyond Conventional Small-Molecule Libraries
by Franzini, Raphael M and Neri, Dario and Scheuermann, Jörg
Accounts of chemical research, ISSN 0001-4842, 04/2014, Volume 47, Issue 4, pp. 1247 - 1255
Physical Sciences | Chemistry | Chemistry, Multidisciplinary | Science & Technology | Drug Evaluation, Preclinical - methods | Small Molecule Libraries - chemistry | Small Molecule Libraries - pharmacology | DNA - chemistry | Chemistry Techniques, Synthetic | Small Molecule Libraries - economics | Time Factors | Structure-Activity Relationship | Drug Discovery | Index Medicus | Drugs | Screening | Synthesis (chemistry) | Deoxyribonucleic acid | Tools | Encoding | Libraries | Phage
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2. Full Text Design, synthesis and selection of DNA-encoded small-molecule libraries
by Ding, Yun and Yao, Gang and Arico-Muendel, Christopher C and Clark, Matthew A and Zhao, Baoguang and Franzen, Kurt D and Carlson, Neil R and Li, Fan and Mataruse, Sibongile and Lind, Kenneth and Chiu, Cynthia H and Acharya, Raksha A and Hansen, Nils J V and Davie, Christopher P and Satz, Alexander L and Belyanskaya, Svetlana L and Myers, Paul and Kavarana, Malcolm J and Israel, David I and Cuozzo, John W and Kelley, Michael S and Tang, Lujia and O'Keefe, Heather and Centrella, Paolo A and Jiang, Jinwei and Messer, Jeffrey A and Gefter, Malcolm L and Svendsen, Jennifer L and Creaser, Steffen P and Oliff, Matthew C and Kollmann, Christopher S and Wagner, Richard W and Morgan, Barry A and Hale, Steven P and Skinner, Steven R and Franklin, G Joseph and Rise, Cecil E and Benjamin, Dennis R and van Vloten, Kurt and Medeiros, Patricia F
Nature Chemical Biology, ISSN 1552-4450, 09/2009, Volume 5, Issue 9, pp. 647 - 654
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Protein Kinase Inhibitors - chemical synthesis | Small Molecule Libraries - pharmacology | Models, Molecular | Small Molecule Libraries - chemical synthesis | Aurora Kinases | DNA - genetics | Small Molecule Libraries - chemistry | DNA - chemistry | Protein Kinase Inhibitors - chemistry | Animals | Combinatorial Chemistry Techniques | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Drug Design | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Proteins | Biochemistry | Biomedical research | Molecular biology | Deoxyribonucleic acid--DNA | Index Medicus
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3. Full Text Smart Design of Small‐Molecule Libraries: When Organic Synthesis Meets Cheminformatics
by Lenci, Elena and Trabocchi, Andrea
Chembiochem : a European journal of chemical biology, ISSN 1439-4227, 05/2019, Volume 20, Issue 9, pp. 1115 - 1123
molecular diversity | chemical biology | drug discovery | diversity-oriented synthesis | cheminformatics | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Small Molecule Libraries - chemical synthesis | Small Molecule Libraries - pharmacology | Cheminformatics | Humans | Drug Design | HEK293 Cells | Drug discovery | Case studies | Organic chemistry | Chemists | Chemical reactions | Libraries | Chemical synthesis | Informatics | Complexity | Index Medicus
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4. Full Text PNA-encoded chemical libraries
by Zambaldo, Claudio and Barluenga, Sofia and Winssinger, Nicolas
Current opinion in chemical biology, ISSN 1367-5931, 06/2015, Volume 26, pp. 8 - 15
Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Fluorescent Dyes - chemistry | Gene Library | Glycoconjugates - chemistry | HSP70 Heat-Shock Proteins - antagonists & inhibitors | Small Molecule Libraries - chemical synthesis | Heterocyclic Compounds - chemical synthesis | Peptide Library | Drug Discovery | Glycoconjugates - chemical synthesis | Solid-Phase Synthesis Techniques | Small Molecule Libraries - chemistry | Combinatorial Chemistry Techniques | Heterocyclic Compounds - chemistry | Peptide Nucleic Acids - chemical synthesis | Ligands | HSP70 Heat-Shock Proteins - chemistry | Peptide Nucleic Acids - chemistry | Lectins - chemistry | Libraries | Peptides | Lectins | Nucleic acids | Index Medicus
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5. Full Text Automated radial synthesis of organic molecules
by Chatterjee, Sourav and Guidi, Mara and Seeberger, Peter H and Gilmore, Kerry
Nature (London), ISSN 0028-0836, 03/2020, Volume 579, Issue 7799, pp. 379 - 384
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Oxidation-Reduction | Anticonvulsants - chemical synthesis | Triazoles - chemistry | Chemistry Techniques, Synthetic - instrumentation | Small Molecule Libraries - chemical synthesis | Automation - instrumentation | Carbon - chemistry | Chemistry Techniques, Synthetic - methods | Photochemical Processes | Solutions - chemistry | Small Molecule Libraries - chemistry | Nitrogen - chemistry | Anticonvulsants - chemistry | Automation - methods | Triazoles - chemical synthesis | Software | Indicators and Reagents - chemistry | Production increases | Automation | Nuclear magnetic resonance--NMR | Modules | Chemical reactions | Photochemicals | Flow rates | Biopolymers | Continuous flow | Intermediates | Organic chemistry | Anticonvulsants | Reactors | Barriers | Reagents | Flow velocity | Chemical synthesis | Reconfiguration | Index Medicus
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6. Full Text Chemical Space Overlap with Critical Protein–Protein Interface Residues in Commercial and Specialized Small‐Molecule Libraries
by Si, Yubing and Xu, David and Bum‐Erdene, Khuchtumur and Ghozayel, Mona K and Yang, Baocheng and Clemons, Paul A and Meroueh, Samy O
ChemMedChem, ISSN 1860-7179, 01/2019, Volume 14, Issue 1, pp. 119 - 131
protein–protein interactions | virtual screening | computational chemistry | compound libraries | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Adaptor Proteins, Signal Transducing - chemistry | Small Molecule Libraries - pharmacology | Urokinase-Type Plasminogen Activator - antagonists & inhibitors | Transcription Factors - chemistry | Calcium Channels - metabolism | Humans | Biological Products - pharmacology | Phosphoproteins - antagonists & inhibitors | Structure-Activity Relationship | Phosphoproteins - metabolism | Phosphoproteins - chemistry | DNA-Binding Proteins - metabolism | Dose-Response Relationship, Drug | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Muscle Proteins - metabolism | Muscle Proteins - antagonists & inhibitors | Urokinase-Type Plasminogen Activator - chemistry | Molecular Structure | Receptors, Urokinase Plasminogen Activator - chemistry | DNA-Binding Proteins - antagonists & inhibitors | Small Molecule Libraries - chemical synthesis | Transcription Factors - antagonists & inhibitors | DNA-Binding Proteins - chemistry | Receptors, Urokinase Plasminogen Activator - antagonists & inhibitors | Protein Interaction Mapping | Receptors, Urokinase Plasminogen Activator - metabolism | Transcription Factors - metabolism | Biological Products - chemical synthesis | Small Molecule Libraries - chemistry | Biological Products - chemistry | Urokinase-Type Plasminogen Activator - metabolism | Calcium Channels - chemistry | Protein Binding | Muscle Proteins - chemistry | Adaptor Proteins, Signal Transducing - metabolism | Library collections | Residues | Hot spots | Chemical reactions | Chains | Universe | Pharmacology | Interfaces | Proteins | Molecular conformation | Organic chemistry | Screening | Receptors | Data collection | Collection | Docking | Libraries | Receptor mechanisms | Protein interaction | Chemical synthesis | Physicochemical properties | Binding sites | Index Medicus
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7. Full Text Synthesis and screening of small-molecule α-helix mimetic libraries targeting protein–protein interactions
by Moon, Heejo and Lim, Hyun-Suk
Current opinion in chemical biology, ISSN 1367-5931, 02/2015, Volume 24, pp. 38 - 47
Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Small Molecule Libraries - chemistry | Small Molecule Libraries - pharmacology | Biomimetics - methods | Animals | Proteins - metabolism | Protein Structure, Secondary | Protein Interaction Maps - drug effects | Humans | Small Molecule Libraries - chemical synthesis | Drug Discovery - methods | Proteins - chemistry | Chemistry Techniques, Synthetic - methods | Index Medicus
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8. Full Text Chemical Space of DNA-Encoded Libraries
by Franzini, Raphael M and Randolph, Cassie
Journal of medicinal chemistry, ISSN 0022-2623, 07/2016, Volume 59, Issue 14, pp. 6629 - 6644
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Small Molecule Libraries - chemistry | Small Molecule Libraries - pharmacology | DNA - chemistry | Combinatorial Chemistry Techniques | Proteins - metabolism | DNA - pharmacology | Small Molecule Libraries - chemical synthesis | Molecular Structure | Structure-Activity Relationship | Drug Discovery | Proteins - antagonists & inhibitors | Index Medicus
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9. Full Text Bright photoactivatable fluorophores for single-molecule imaging
by Grimm, Jonathan B and English, Brian P and Choi, Heejun and Muthusamy, Anand K and Mehl, Brian P and Dong, Peng and Brown, Timothy A and Lippincott-Schwartz, Jennifer and Liu, Zhe and Lionnet, Timothée and Lavis, Luke D
Nature methods, ISSN 1548-7091, 12/2016, Volume 13, Issue 12, pp. 985 - 988
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Biochemical Research Methods | Science & Technology | Fluorescent Dyes - chemical synthesis | Humans | Cell Membrane Permeability | Fluorescent Dyes - metabolism | Small Molecule Libraries - metabolism | Fluorescent Dyes - radiation effects | Recombinant Fusion Proteins - metabolism | Photochemical Processes | Photochemistry - methods | Light | Molecular Structure | Cell Culture Techniques | Fluorescent Dyes - chemistry | Small Molecule Libraries - chemical synthesis | Small Molecule Libraries - radiation effects | Spectrometry, Fluorescence | Single Molecule Imaging - methods | Spectrophotometry, Ultraviolet | Small Molecule Libraries - chemistry | Animals | Staining and Labeling | Cell Line, Tumor | Ligands | Mice | Embryonic Stem Cells | COS Cells | Microscopy, Fluorescence | Diagnosis, Fluoroscopic | Molecular diagnostic techniques | Research | Molecules | Medical imaging | Dyes | Microscopy | Index Medicus
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