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Scientific reports, ISSN 2045-2322, 2017, Volume 7, Issue 1, p. 42717
To be effective as a drug, a potent molecule must reach its target in the body in sufficient concentration, and stay there in a bioactive form long enough for the expected biologic events to occur... 
SCREENING LIBRARIES | DESIGN | POLAR SURFACE-AREA | TRANSPORTERS | MULTIDISCIPLINARY SCIENCES | CYP ENZYMES | PARTITION-COEFFICIENT | DISCOVERY | COMPOUND DATABASES | PREDICTION | SOLUBILITY | Small Molecule Libraries - adverse effects | Small Molecule Libraries - chemistry | Small Molecule Libraries - pharmacology | Drug Discovery - methods | Software | Small Molecule Libraries - pharmacokinetics
Journal Article
Journal Article
Nature biotechnology, ISSN 1546-1696, 2012, Volume 30, Issue 7, pp. 715 - 720
Journal Article
Cell stem cell, ISSN 1934-5909, 2009, Volume 5, Issue 5, pp. 491 - 503
.... These uncertainties could be overcome if each transgenic factor were replaced with a small molecule that either directly activated its expression from the somatic genome or in some way compensated for its activity... 
STEMCELL | PLURIPOTENT STEM-CELLS | OCT4 | POTENT | MOUSE | HUMAN FIBROBLASTS | GENERATION | INDUCTION | DIFFERENTIATION | CELL & TISSUE ENGINEERING | CELL BIOLOGY
Journal Article
Nature chemical biology, ISSN 1552-4469, 2009, Volume 5, Issue 9, pp. 647 - 654
Journal Article
Nature (London), ISSN 0028-0836, 2018, Volume 559, Issue 7713, pp. 269 - 273
.... Progress in understanding the molecular mechanisms of innate immune pathways has led to the promise of targeted therapeutic approaches, but the development of drugs that act specifically on molecules... 
SYNTHASE | 2ND-MESSENGER | CELLS | CYCLIC GMP-AMP | ACTIVATION | AICARDI-GOUTIERES SYNDROME | MULTIDISCIPLINARY SCIENCES | CGAS | SENSOR | CYTOSOLIC-DNA | AUTOIMMUNE-DISEASE | Cell Line | Small Molecule Libraries - analysis | Small Molecule Libraries - pharmacology | Golgi Apparatus - drug effects | Humans | Mice, Inbred C57BL | Lipoylation - drug effects | Small Molecule Libraries - metabolism | Hereditary Autoinflammatory Diseases - drug therapy | Small Molecule Libraries - chemistry | Hereditary Autoinflammatory Diseases - metabolism | Animals | Membrane Proteins - antagonists & inhibitors | Signal Transduction - drug effects | Protein Binding - drug effects | Golgi Apparatus - metabolism | Cysteine - metabolism | Mice | Binding Sites | Immune response | Interferon | Nucleotide sequencing | Observations | Health aspects | Methods | DNA sequencing | Target recognition | Disease | Palmitoylation | Amino acids | Intracellular signalling | Activation | Antagonists | Drug development | Kinases | Immunosuppressive agents | Proteins | Stimulators | Signal transduction | Pathways | Chemical bonds | Deoxyribonucleic acid--DNA | Lupus | Medical treatment | Pharmacology | Inflammation | Gene expression | Golgi apparatus | Molecular modelling | Inhibitors | Scientific imaging | Mass spectrometry
Journal Article
PLoS biology, ISSN 1545-7885, 2012, Volume 10, Issue 1, p. e1001237
Journal Article
Current Opinion in Chemical Biology, ISSN 1367-5931, 08/2016, Volume 33, pp. 58 - 66
Journal Article
Nature communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, pp. 2035 - 2035
Journal Article
Nature communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, pp. 2261 - 9
Journal Article