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Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2010, Volume 53, Issue 3, pp. 951 - 965
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2006, Volume 49, Issue 23, pp. 6819 - 6832
Journal Article
Journal Article
Cell Stem Cell, ISSN 1934-5909, 11/2009, Volume 5, Issue 5, pp. 491 - 503
The combined activity of three transcription factors can reprogram adult cells into induced pluripotent stem cells (iPSCs). However, the transgenic methods... 
STEMCELL | PLURIPOTENT STEM-CELLS | SOMATIC-CELLS | DEFINED FACTORS | POTENT | MOUSE | HUMAN FIBROBLASTS | SUPERFAMILY | GENERATION | INDUCTION | DIFFERENTIATION | CELL & TISSUE ENGINEERING | CELL BIOLOGY
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2009, Volume 19, Issue 19, pp. 5576 - 5581
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2016, Volume 59, Issue 4, pp. 1271 - 1298
Bromodomains, small protein modules that recognize acetylated lysine on histones, play a significant role in the epigenome, where they function as “readers”... 
CHEMISTRY, MEDICINAL | SWI/SNF COMPLEXES | SMALL-MOLECULE INHIBITORS | PROSTATE-CANCER | SELECTIVE INHIBITORS | GENE-EXPRESSION | CHEMICAL PROBE | TUMOR-SUPPRESSOR | BET INHIBITORS | HISTONE ACETYLTRANSFERASE | PHD FINGER | Small Molecule Libraries - pharmacology | Antigens, Nuclear - metabolism | Humans | Drug Discovery - methods | CREB-Binding Protein - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - antagonists & inhibitors | DNA-Binding Proteins - metabolism | CREB-Binding Protein - metabolism | Protein Processing, Post-Translational - drug effects | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Lysine - metabolism | Protein-Serine-Threonine Kinases - metabolism | RNA-Binding Proteins - antagonists & inhibitors | Nerve Tissue Proteins - antagonists & inhibitors | ATPases Associated with Diverse Cellular Activities | DNA-Binding Proteins - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - metabolism | Carrier Proteins - antagonists & inhibitors | Adenosine Triphosphatases - metabolism | Models, Molecular | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Adenosine Triphosphatases - antagonists & inhibitors | DNA Helicases - metabolism | Small Molecule Libraries - chemistry | Acetylation - drug effects | Animals | Carrier Proteins - metabolism | Nuclear Proteins - antagonists & inhibitors | DNA Helicases - antagonists & inhibitors | Histones - metabolism | Adaptor Proteins, Signal Transducing - metabolism | RNA-Binding Proteins - metabolism
Journal Article
Nature Reviews Cancer, ISSN 1474-175X, 01/2017, Volume 17, Issue 2, pp. 93 - 115
Journal Article
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 02/2017, Volume 56, Issue 9, pp. 2423 - 2428
Small‐molecule inhibition of the interaction between the KRas oncoprotein and the chaperone PDE6δ impairs KRas spatial organization and signaling in cells.... 
Ras protein | drug design | structure–activity relationships | PDEδ | medicinal chemistry | ACTIVATION | NUCLEOTIDE EXCHANGE | SMALL MOLECULES | PDE delta | ONCOGENIC KRAS | IDENTIFICATION | PLASMA-MEMBRANE | RAS ONCOGENES | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | structure-activity relationships | K-RAS | MODULATION
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 09/2017, Volume 137, pp. 176 - 195
Recent years have seen much effort to discover new chemotypes of BRD4 inhibitors. Interestingly, some kinase inhibitors have been demonstrated to be potent... 
BI-2536 | Dihydroquinoxalin-2(1H)-one | BRD4 inhibitor | Kinase | CHEMISTRY, MEDICINAL | SMALL-MOLECULE INHIBITORS | READER | BROMODOMAIN | BINDING | BRD4 | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Cell Cycle Proteins - antagonists & inhibitors | Dose-Response Relationship, Drug | Neoplasms, Experimental - pathology | Quinoxalines - pharmacology | Protein Kinase Inhibitors - chemistry | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Female | Antineoplastic Agents - pharmacology | Molecular Structure | Quinoxalines - chemical synthesis | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Protein Kinase Inhibitors - chemical synthesis | Proto-Oncogene Proteins - antagonists & inhibitors | Cell Cycle Proteins - metabolism | Quinoxalines - chemistry | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Antineoplastic Agents - chemistry | Drug Discovery | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Protein Kinase Inhibitors - pharmacology | Neoplasms, Experimental - drug therapy | Anisotropy | Drug therapy, Combination
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2011, Volume 54, Issue 6, pp. 1812 - 1824
Journal Article
Journal Article