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Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2010, Volume 53, Issue 3, pp. 951 - 965
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2016, Volume 59, Issue 4, pp. 1271 - 1298
Bromodomains, small protein modules that recognize acetylated lysine on histones, play a significant role in the epigenome, where they function as “readers”... 
CHEMISTRY, MEDICINAL | SWI/SNF COMPLEXES | SMALL-MOLECULE INHIBITORS | PROSTATE-CANCER | SELECTIVE INHIBITORS | GENE-EXPRESSION | CHEMICAL PROBE | TUMOR-SUPPRESSOR | BET INHIBITORS | HISTONE ACETYLTRANSFERASE | PHD FINGER | Small Molecule Libraries - pharmacology | Antigens, Nuclear - metabolism | Humans | Drug Discovery - methods | CREB-Binding Protein - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - antagonists & inhibitors | DNA-Binding Proteins - metabolism | CREB-Binding Protein - metabolism | Protein Processing, Post-Translational - drug effects | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Lysine - metabolism | Protein-Serine-Threonine Kinases - metabolism | RNA-Binding Proteins - antagonists & inhibitors | Nerve Tissue Proteins - antagonists & inhibitors | ATPases Associated with Diverse Cellular Activities | DNA-Binding Proteins - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - metabolism | Carrier Proteins - antagonists & inhibitors | Adenosine Triphosphatases - metabolism | Models, Molecular | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Adenosine Triphosphatases - antagonists & inhibitors | DNA Helicases - metabolism | Small Molecule Libraries - chemistry | Acetylation - drug effects | Animals | Carrier Proteins - metabolism | Nuclear Proteins - antagonists & inhibitors | DNA Helicases - antagonists & inhibitors | Histones - metabolism | Adaptor Proteins, Signal Transducing - metabolism | RNA-Binding Proteins - metabolism
Journal Article
Journal Article
Nature Reviews Cancer, ISSN 1474-175X, 01/2017, Volume 17, Issue 2, pp. 93 - 115
Journal Article
Journal Article
Nature Reviews Drug Discovery, ISSN 1474-1776, 04/2018, Volume 17, Issue 5, pp. 353 - 376
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 05/2016, Volume 55, Issue 19, pp. 5745 - 5748
Elevated expression of the immunoproteasome has been associated with autoimmune diseases, inflammatory diseases, and various types of cancer. Selective... 
inhibitors | immunoproteasome | irreversible inhibition | drug design | small-molecule inhibitors | ACTIVE-SITE | CONSTITUTIVE PROTEASOME | RESISTANCE | COVALENT DRUGS | LIGAND | CHEMISTRY, MULTIDISCIPLINARY | Chymotrypsin | Enzyme inhibitors | Rodents
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2006, Volume 49, Issue 23, pp. 6819 - 6832
Journal Article
Journal Article
BioFactors, ISSN 0951-6433, 09/2012, Volume 38, Issue 5, pp. 349 - 359
Journal Article