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Drug Metabolism and Disposition, ISSN 0090-9556, 02/2013, Volume 41, Issue 2, pp. 256 - 262
.... Although much has been learned, significant gaps still exist in our understanding of the spectrum of drug metabolism and transport genes affected, gestational age-dependent changes in the activity... 
WOMEN | METFORMIN | CLEARANCE | IN-VITRO | PHARMACOKINETICS | PLASMA-CONCENTRATIONS | 3RD TRIMESTER | ZIDOVUDINE | PHARMACOLOGY & PHARMACY | HUMAN-IMMUNODEFICIENCY-VIRUS | EXPRESSION | Smoking - adverse effects | Estrogens - pharmacology | Liver - enzymology | Cholestasis - metabolism | Minor Histocompatibility Antigens | Taurocholic Acid - metabolism | Humans | Kidney - enzymology | Cytochrome P-450 Enzyme System - metabolism | Male | Hepatocytes - metabolism | Organic Anion Transporters - metabolism | Intestine, Small - enzymology | Lung - enzymology | Glucuronosyltransferase - genetics | RNA, Messenger - biosynthesis | Kidney - metabolism | Estrogen Receptor alpha - agonists | Liver - drug effects | Cotinine - metabolism | Maternal Behavior | ATP-Binding Cassette Transporters - metabolism | Female | Membrane Transport Proteins - metabolism | Pesticides - metabolism | Adrenal Glands - enzymology | Progesterone - pharmacology | Estradiol - pharmacology | Hepatocytes - drug effects | Retinoic Acid 4-Hydroxylase | Multidrug Resistance-Associated Proteins - drug effects | Gene Expression Regulation, Developmental - drug effects | Placenta - enzymology | Ethinyl Estradiol - pharmacology | Aryldialkylphosphatase - metabolism | Carboxylesterase - metabolism | Fetus - drug effects | Placenta - drug effects | Pregnancy | Animals | Glucuronosyltransferase - metabolism | Cytochrome P-450 Enzyme System - biosynthesis | Cytochrome P-450 Enzyme System - genetics | Hydroxyprogesterones - metabolism | Special Section on Drug Metabolizing Enzymes and Transporters in Pregnancy
Journal Article
Molecular carcinogenesis, ISSN 0899-1987, 2013, Volume 52, Issue 2, pp. 155 - 166
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway is involved in immune function and cell growth. We evaluated... 
cigarette smoking | STAT | estrogen | JAK | colon cancer | NSAIDs | rectal cancer | SOCS | Colon cancer | Rectal cancer | Estrogen | Cigarette smoking | OXIDATIVE STRESS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | RISK | ENERGY-BALANCE | INHIBITION | ONCOLOGY | JANUS KINASES | COLORECTAL-CANCER | INFLAMMATION | PHYSICAL-ACTIVITY | Smoking - adverse effects | Colonic Neoplasms - genetics | Receptors, Estrogen - metabolism | Colorectal Neoplasms - genetics | Humans | Middle Aged | STAT Transcription Factors - metabolism | STAT4 Transcription Factor - metabolism | TYK2 Kinase - metabolism | Suppressor of Cytokine Signaling 1 Protein | Male | Janus Kinases - metabolism | Interferon-gamma - metabolism | Case-Control Studies | Colonic Neoplasms - metabolism | Janus Kinase 1 - metabolism | STAT1 Transcription Factor - metabolism | Rectal Neoplasms - genetics | Janus Kinase 1 - genetics | Janus Kinase 2 - metabolism | Adult | Female | Interferon-gamma - genetics | Interleukin-6 - metabolism | Colorectal Neoplasms - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Colonic Neoplasms - mortality | Genetic Predisposition to Disease | Interleukin-6 - genetics | Janus Kinases - genetics | Signal Transduction | Janus Kinase 2 - genetics | Suppressor of Cytokine Signaling Proteins - genetics | Survival Rate | STAT1 Transcription Factor - genetics | Rectal Neoplasms - mortality | STAT Transcription Factors - genetics | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | STAT4 Transcription Factor - genetics | Aged | Polymorphism, Single Nucleotide | Rectal Neoplasms - metabolism | Suppressor of Cytokine Signaling Proteins - metabolism | TYK2 Kinase - genetics | Aspirin | Analysis | Oncology, Experimental | Research | Public health | Smoking | Cancer | Genetic diversity | Kinases | Risk factors | Colorectal cancer
Journal Article
Digestive and Liver Disease, ISSN 1590-8658, 2015, Volume 48, Issue 3, pp. 223 - 230
Journal Article
The Journal of pathology, ISSN 0022-3417, 2014, Volume 233, Issue 3, pp. 294 - 307
Journal Article
世界胃肠病学杂志:英文版, ISSN 1007-9327, 2012, Volume 18, Issue 18, pp. 2180 - 2187
AIM:To investigate the effect of side-stream smoking on gut microflora composition,intestinal inflammation and expression of tight junction... 
侧流 | 紧密连接 | p38蛋白激酶 | 蛋白表达 | 白细胞介素-6 | 肠道菌群 | 吸烟 | 炎症反应 | Side-stream smoking | Microbiota | Inflammation | Tight junction protein | Intestine | EPITHELIAL BARRIER | OXIDATIVE STRESS | ULCERATIVE-COLITIS | MAST-CELLS | REAL-TIME PCR | MATERNAL NUTRIENT RESTRICTION | SKELETAL-MUSCLE | IN-VITRO | CIGARETTE-SMOKING | GROWTH SIGNALING PATHWAYS | GASTROENTEROLOGY & HEPATOLOGY | Tumor Necrosis Factor-alpha - metabolism | Up-Regulation | AMP-Activated Protein Kinases - metabolism | Intestinal Mucosa - metabolism | Phosphorylation | Oxidative Stress | Tumor Necrosis Factor-alpha - genetics | JNK Mitogen-Activated Protein Kinases - metabolism | I-kappa B Proteins - metabolism | Phosphoproteins - metabolism | RNA, Messenger - metabolism | Inflammatory Bowel Diseases - metabolism | Occludin | Feces - microbiology | Intestine, Large - metabolism | Intestine, Large - microbiology | Claudins - metabolism | Inflammatory Bowel Diseases - pathology | Inflammation Mediators - metabolism | Inflammatory Bowel Diseases - genetics | Female | Membrane Proteins - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Interleukin-6 - metabolism | Tight Junctions - metabolism | Claudins - genetics | Inflammatory Bowel Diseases - prevention & control | NF-KappaB Inhibitor alpha | Interleukin-6 - genetics | Membrane Proteins - genetics | Mice, Inbred C57BL | Phosphoproteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Claudin-3 | Animals | Zonula Occludens-1 Protein | Transcription Factor RelA - metabolism | Intestine, Large - pathology | Inflammatory Bowel Diseases - microbiology | Tobacco Smoke Pollution | Mice | Zonula Occludens-2 Protein | Intestinal Mucosa - pathology | Original
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2013, Volume 123, Issue 3, pp. 1241 - 1261
MicroRNAs are critical mediators of stem cell pluripotency, differentiation, and malignancy. Limited information exists regarding microRNA alterations that... 
CELL LUNG-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | STEM-CELLS | DNA METHYLATION | CHROMATIN | SEQUENCES | TRANSFORMING GROWTH-FACTOR-BETA-1 LEVEL | GENE-EXPRESSION | PROGNOSTIC MARKER | GENOME | MICRORNA | Proto-Oncogene Proteins p21(ras) | Adenocarcinoma - etiology | Epigenesis, Genetic | Humans | Lung Neoplasms - metabolism | Middle Aged | Male | MicroRNAs - metabolism | Wnt-5a Protein | Wnt Proteins - metabolism | Polycomb Repressive Complex 1 - genetics | Adenocarcinoma - metabolism | Lung Neoplasms - etiology | RNA Interference | Cell Transformation, Neoplastic - genetics | Cellular Senescence | Base Sequence | Binding Sites | Genes, Tumor Suppressor | Gene Expression | Smoke - adverse effects | Chromatin Assembly and Disassembly | Transforming Growth Factor beta1 - physiology | Adenocarcinoma - secondary | Mice, Nude | Cell Line, Tumor | CpG Islands | Tobacco - chemistry | Mice | MicroRNAs - genetics | Proto-Oncogene Proteins c-myc - genetics | Histones - metabolism | Polycomb Repressive Complex 2 - metabolism | Smoking - adverse effects | Neoplasm Transplantation | ras Proteins - genetics | Polycomb Repressive Complex 2 - genetics | Polycomb Repressive Complex 1 - metabolism | Gene Expression Regulation, Neoplastic | ras Proteins - metabolism | Lung Neoplasms - pathology | Hepatocyte Nuclear Factor 1-alpha - metabolism | DNA Methylation | Wnt Proteins - genetics | Female | Adenocarcinoma - genetics | Lung Neoplasms - genetics | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - genetics | Cell Transformation, Neoplastic - metabolism | Proto-Oncogene Proteins c-myc - metabolism | Animals | Hepatocyte Nuclear Factor 1-alpha - physiology | MicroRNA | Lung cancer | Physiological aspects | Development and progression | Genetic aspects | Research | Health aspects | Smoking
Journal Article
Journal of allergy and clinical immunology, ISSN 0091-6749, 2015, Volume 136, Issue 3, pp. 769 - 780
Background Inflammation and oxidative stress play critical roles in patients with chronic obstructive pulmonary disease (COPD). Mitochondrial oxidative stress... 
Allergy and Immunology | airway hyperresponsiveness | antioxidant | proliferation | MitoQ | inflammation | mitochondria | airway smooth muscle | Ozone | oxidative stress | chronic obstructive pulmonary disease | ASTHMA FEATURES | MECHANISMS | IMMUNOLOGY | FRAGMENTATION | HYPERRESPONSIVENESS | BETA | RESPONSES | ALLERGY | ENERGY-METABOLISM | EXPRESSION | COPD | Respiratory System - pathology | Reactive Oxygen Species - metabolism | Humans | Middle Aged | Male | Pulmonary Disease, Chronic Obstructive - pathology | Bronchial Hyperreactivity - genetics | Ubiquinone - pharmacology | Muscle, Smooth - drug effects | Smoking - physiopathology | Organophosphorus Compounds - pharmacology | Myocytes, Smooth Muscle - drug effects | Pneumonia - genetics | Pulmonary Disease, Chronic Obstructive - genetics | Bronchial Hyperreactivity - chemically induced | Signal Transduction | Mitochondria - pathology | Smoking - metabolism | Bronchial Hyperreactivity - pathology | Reactive Oxygen Species - antagonists & inhibitors | Electron Transport Chain Complex Proteins - metabolism | Pulmonary Disease, Chronic Obstructive - chemically induced | Respiratory System - drug effects | Airway Remodeling - genetics | Mice | Oxidative Stress - drug effects | Bronchial Hyperreactivity - drug therapy | Myocytes, Smooth Muscle - pathology | Pneumonia - pathology | Membrane Potential, Mitochondrial - drug effects | Pneumonia - chemically induced | Adult | Female | Pulmonary Disease, Chronic Obstructive - metabolism | Myocytes, Smooth Muscle - metabolism | Ubiquinone - analogs & derivatives | Gene Expression Regulation | Hydrogen Peroxide - pharmacology | Electron Transport Chain Complex Proteins - genetics | Mitochondria - metabolism | Antioxidants - pharmacology | Mitochondria - drug effects | Muscle, Smooth - metabolism | Animals | Pneumonia - drug therapy | Respiratory System - metabolism | Aged | Muscle, Smooth - pathology | Oxidative stress | Care and treatment | Lung diseases, Obstructive | Inflammation | Pharmaceutical industry | Biomedical research | Disease | Laboratories | Mortality | Colleges & universities | Smooth muscle | Mitochondrial DNA | Metabolism | Defects | Antioxidants | Mitochondria | Hospitals | Biopsy | Chronic obstructive pulmonary disease | Apoptosis | Smoking | NO, Nitric oxide | ΔΨm, Mitochondrial membrane potential | ASM, Airway smooth muscle | NAC, N-acetylcysteine | RL, Lung resistance | BAL, Bronchoalveolar lavage | OCR, Oxygen consumption rate | dTPP, Decyltriphenylphosphonium bromide | AHR, Airway hyperresponsiveness | logPC100, Concentration of acetylcholine that increased lung resistance by 100 | GOLD, Global Initiative for Chronic Obstructive Lung Disease | ATP, Adenosine triphosphate | KC, Keratinocyte-derived cytokine | JC-1, 5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethylbenzimidazolylcarbocyanine iodide | COPD, Chronic obstructive pulmonary disease | ROS, Reactive oxygen species | Mechanisms of Allergy and Clinical Immunology
Journal Article
9.