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Journal Article
Science, ISSN 0036-8075, 10/2009, Volume 326, Issue 5952, pp. 572 - 574
The Hedgehog (Hh) signaling pathway is inappropriately activated in certain human cancers, including medulloblastoma, an aggressive brain tumor. GDC-0449, a... 
Receptors | Relapse | Basal cell carcinoma | Medulloblastoma | Amino acids | Biopsies | Reports | Genetic mutation | Tumors | Resistance mechanisms | Cancer | PROTEIN-COUPLED RECEPTORS | CYCLOPAMINE | CANCER | MULTIDISCIPLINARY SCIENCES | Anilides - therapeutic use | Receptors, G-Protein-Coupled - metabolism | Humans | Brain Neoplasms - pathology | Hedgehog Proteins - metabolism | Molecular Sequence Data | Drug Resistance, Neoplasm | Antineoplastic Agents - therapeutic use | Mutation, Missense | Antineoplastic Agents - metabolism | Neoplasm Metastasis | Hedgehog Proteins - genetics | Medulloblastoma - pathology | Smoothened Receptor | Veratrum Alkaloids - pharmacology | Antineoplastic Agents - pharmacology | Patched Receptors | Medulloblastoma - genetics | Mutant Proteins - antagonists & inhibitors | Pyridines - therapeutic use | Amino Acid Sequence | Signal Transduction | Anilides - metabolism | Brain Neoplasms - genetics | Receptors, Cell Surface - metabolism | Mutant Proteins - metabolism | Hedgehog Proteins - antagonists & inhibitors | Brain Neoplasms - drug therapy | Cinnamates - pharmacology | Animals | Pyridines - metabolism | Mutant Proteins - chemistry | Anilides - pharmacology | Receptors, G-Protein-Coupled - antagonists & inhibitors | Cell Line, Tumor | Protein Conformation | Mice | Pyridines - pharmacology | Receptors, G-Protein-Coupled - genetics | Medulloblastoma - drug therapy | Receptors, G-Protein-Coupled - chemistry | Amino Acid Substitution | Receptors, Cell Surface - genetics | Gene mutations | Development and progression | Genetic aspects | Diagnosis | Drug resistance | Identification and classification | Signal transduction | Genotype & phenotype | Inhibitor drugs | Cellular biology | Brain cancer | Mutation | Index Medicus
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 05/2017, Volume 8, Issue 1, pp. 15383 - 15383
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2019, Volume 62, Issue 1, pp. 24 - 45
G-protein-coupled receptors (GPCRs) are the largest class of signaling receptors that are most frequently targeted by therapeutic drugs. Allosteric modulators... 
CHEMISTRY, MEDICINAL | 1 MGLUR1 | GLUCAGON-LIKE PEPTIDE-1 | BITOPIC LIGANDS | STRUCTURAL BASIS | CRYSTAL-STRUCTURE | BINDING-SITES | SMOOTHENED REGULATION | CHEMOKINE RECEPTORS | P2Y RECEPTOR | DISCOVERY
Journal Article
Journal Article