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Biochemical Journal, ISSN 0264-6021, 03/2005, Volume 386, Issue 3, pp. 461 - 470
Inhibitory Smad, Smad7, is a potent inhibitor of TGF-beta (transforming growth factor-beta) superfamily signalling. By binding to activated type I receptors,... 
Developmentally down-regulated 4-2 (NEDD4-2) | Bone morphogenetic protein (BMP) | Smad | Neural precursor cell expressed | Homologous to the E6-accessory protein C-terminus (HECT) | Transforming growth factor-β (TGF-β) | Humans | Protein-Serine-Threonine Kinases | Ubiquitin - metabolism | Cytoplasm - metabolism | RNA, Messenger - metabolism | DNA-Binding Proteins - metabolism | Bone Morphogenetic Proteins - metabolism | Cell Nucleus - metabolism | Trans-Activators - genetics | Nedd4 Ubiquitin Protein Ligases | Transcription, Genetic | Proto-Oncogene Proteins - metabolism | Smad7 Protein | Cell Line | Signal Transduction | Smad6 Protein | Endosomal Sorting Complexes Required for Transport | RNA, Messenger - genetics | Ubiquitin-Protein Ligases - metabolism | Intracellular Signaling Peptides and Proteins | Activin Receptors, Type I - metabolism | DNA-Binding Proteins - genetics | Protein Transport | Two-Hybrid System Techniques | Smad3 Protein | Animals | Receptors, Transforming Growth Factor beta - metabolism | Cell Line, Tumor | Protein Binding | Ligands | Trans-Activators - metabolism | Mice | Ubiquitin-Protein Ligases - genetics | Transforming Growth Factor beta - metabolism | Smad2 Protein | BMPR-IB, BMP type IB receptor | TβR-I, transforming growth factor-β type I receptor | developmentally down-regulated 4-2 (NEDD4-2) | Ski-related novel protein N (SnoN) | I-Smad, inhibitory Smad | transforming growth factor-β (TGF-β) | homologous to the E6-accessory protein C-terminus (HECT) | R-Smad, receptor-regulated Smad | SnoN, Ski-related novel protein N | RING, really interesting new gene | F-box protein | bone morphogenetic protein (BMP) | ROC1, regulator of Cullins 1 | HECT, homologous to the E6-accessory protein C-terminus | siRNA, small interfering RNA | NEDD4-2, neural precursor cell expressed, developmentally down-regulated 4-2 | SCF, Skp1 | neural precursor cell expressed | Smurf, Smad ubiquitin regulatory factor | TGF-β, transforming growth factor-β | Cullin1 | BMP, bone morphogenetic protein | Co-Smad, common-partner Smad
Journal Article
by Chi, C and Liu, XY and Hou, F and Yu, XZ and Li, CY and Cui, LJ and Liu, RX and Yin, CH
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, ISSN 1472-6882, 02/2018, Volume 18
Background: This study was to evaluate the effects of herbal compound 861 (Cpd861) on ski-related novel protein N (SnoN) and transforming growth factor-beta 1... 
Hepatic fibrosis | TARGET | ACTIVATION | TGF-beta 1 | LIVER FIBROSIS | Ski-related novel protein N | EPITHELIAL-MESENCHYMAL TRANSITION | SKI | STELLATE CELL-PROLIFERATION | INTEGRATIVE & COMPLEMENTARY MEDICINE | Herbal compound 861 | SNON | EXPRESSION
Journal Article
Biochemical Journal, ISSN 0264-6021, 06/2007, Volume 404, Issue 2, pp. 235 - 245
Smad4 in partnership with R-Smads (receptor-regulated Smads) activates TGF-beta (transforming growth factor-beta)-dependent signalling pathways essential for... 
Embryonic | Gene targetting | Smad4 | Transforming growth factor-β signal | Nucleocytoplasmic shuttling | Nuclear export | TRANSCRIPTION FACTORS | nucleocy-toplasmic shuttling | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEXES | COMBINATORIAL ACTIVITIES | transforming growth factor-beta signal | CANCER | BETA | ELEMENTS | embryonic | INTERACTION MOTIF | nuclear export | EARLY MOUSE EMBRYO | TUMOR-SUPPRESSOR | gene targetting | EXPRESSION | Gene Targeting | Signal Transduction | Transcriptional Activation | Cells, Cultured | Transforming Growth Factor beta - physiology | Cytoplasm - metabolism | DNA Primers | Smad4 Protein - metabolism | Mice, Knockout | RNA Splicing | Animals | Cell Nucleus - metabolism | Smad4 Protein - genetics | Mice, Mutant Strains | Base Sequence | Alleles | Mice | nucleocytoplasmic shuttling | transforming growth factor-β signal | RPA, ribonuclease protection assay | NES, nuclear export signal | R-Smad, receptor-regulated Smad | SnoN, Ski-related novel protein N | CRM1, chromosomal region maintenance 1 | NLS, nuclear localization signal | BMP, bone morphogenetic proteins | d.p.c., days post-coitum | MH domain, Mad homology domain | ES cell, embryonic stem cell | TGF-β, transforming growth factor-β | GDF, growth and differentiation factor | LMB, leptomycin B | MEF, murine embryonic fibroblast | FBS, foetal bovine serum
Journal Article
Molecular Medicine Reports, ISSN 1791-2997, 03/2017, Volume 16, Issue 3, pp. 3308 - 3314
The present study aimed to identify any association between bone morphogenetic protein-7 (BMP-7) and the expression of the transcriptional co-repressor... 
Smurf2 | bone morphogenetic protein-7 | Arkadia | SnoN | diabetic nephropathy | TGF-β1/Smads signaling pathway | FIBROSIS | MEDICINE, RESEARCH & EXPERIMENTAL | TGF-BETA | TGF-beta 1/Smads signaling pathway | DOWN-REGULATION | RATS | UBIQUITIN-DEPENDENT DEGRADATION | DIABETIC-NEPHROPATHY | MESENCHYMAL TRANSITION | SKI | ONCOLOGY | KIDNEY | Cell Line | Diabetic Nephropathies - pathology | Epithelial Cells - metabolism | Diabetic Nephropathies - metabolism | Rats | Epithelial Cells - pathology | Male | Transcription Factors - biosynthesis | Glucose - pharmacology | Rats, Sprague-Dawley | Gene Expression Regulation - drug effects | RNA, Messenger - biosynthesis | Animals | Bone Morphogenetic Protein 7 - metabolism | Fibrosis | Nerve Tissue Proteins - biosynthesis | Kidney Tubules - pathology | Kidney Tubules - metabolism | Immunohistochemistry | Transformation | Renal function | Mesenchyme | Epithelial cells | Reverse transcription | Smooth muscle | Glucose | E-cadherin | Western blotting | Proteins | Veins | Actin | Rodents | Extracellular matrix | Ubiquitin-protein ligase | Urine | Immunoglobulins | Kidneys | Diabetes mellitus | Collagen (type III) | Gene expression | Ski protein | Polymerase chain reaction | Studies | Nephropathy | Diabetes | Immunofluorescence | Clear cell-type renal cell carcinoma | Bone morphogenetic protein 7 | Kidney transplantation | TGF-β1 | Smads signaling pathway
Journal Article
International Journal of Molecular Medicine, ISSN 1107-3756, 02/2016, Volume 37, Issue 2, pp. 415 - 422
Transforming growth factor (TGF)-β1 is a profibrotic cytokine that plays a critical role in the progression of diabetic nephropathy (DN). Previous studies have... 
Smad ubiquitination regulatory factor-2 | Smad2 | transforming growth factor-β1 | SnoN | diabetic nephropathy | Diabetic nephropathy | Transforming growth factor-β1 | Proteins | Enzymes | Phosphorylation | Laboratories | Pathogenesis | Rodents | Diabetes | Kinases
Journal Article
Annals of Surgical Oncology, ISSN 1068-9265, 10/2008, Volume 15, Issue 10, pp. 2965 - 2975
Earlier studies have identified the minimal overlapping region of amplification at 3q26 in esophageal squamous cell carcinoma (ESCC) by comparative genomic... 
SCCRO | Medicine & Public Health | TERC | Surgery | Ski-related novel oncogene | EVI-1 | Oncology | Esophageal squamous cell carcinoma | TGF-β | Surgical Oncology | SnoN | SURGERY | esophageal squamous cell carcinoma | LUNG | INCREASED EXPRESSION | POSSIBLE INVOLVEMENT | ski-related novel oncogene | CANCER | PROBABLE TARGET | SKI | TGF-beta | GROWTH-FACTOR-BETA | ONCOGENE | AMPLIFICATION | ONCOLOGY | COMPARATIVE GENOMIC HYBRIDIZATION | Prognosis | Carcinoma, Squamous Cell - metabolism | Humans | Middle Aged | Male | Intracellular Signaling Peptides and Proteins - metabolism | RNA, Messenger - metabolism | Immunoenzyme Techniques | Esophageal Neoplasms - pathology | RNA - genetics | DNA-Binding Proteins - metabolism | Proto-Oncogenes - genetics | Carcinoma, Squamous Cell - mortality | Telomerase - genetics | Esophageal Neoplasms - metabolism | Aged, 80 and over | Antigens, Neoplasm - metabolism | Esophageal Neoplasms - mortality | Female | Telomerase - metabolism | Tumor Cells, Cultured | Intracellular Signaling Peptides and Proteins - genetics | RNA - metabolism | Proto-Oncogene Proteins - metabolism | Antigens, Neoplasm - genetics | Transforming Growth Factor beta1 | Serpins - genetics | Serpins - metabolism | RNA, Messenger - genetics | Esophagus - metabolism | Proto-Oncogene Proteins - genetics | Survival Rate | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Transcription Factors - metabolism | Esophagus - pathology | Fluorescent Antibody Technique | Carcinoma, Squamous Cell - secondary | Aged | MDS1 and EVI1 Complex Locus Protein | Chromosomes, Human, Pair 3 - genetics | Immunohistochemistry | Care and treatment | Squamous cell carcinoma | Patient outcomes | Phospholipids | Transforming growth factors | Anopheles | Messenger RNA | Analysis | Medical law | Cytogenetics | Telomerase | Esophageal cancer
Journal Article
by Li, XJ and Diao, ZL and Ding, JX and Liu, RX and Wang, LY and Huang, W and Liu, WH
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, ISSN 1107-3756, 02/2016, Volume 37, Issue 2, pp. 415 - 422
Transforming growth factor (TGF)-beta 1 is a profibrotic cytokine that plays a critical role in the progression of diabetic nephropathy (DN). Previous studies... 
MEDICINE, RESEARCH & EXPERIMENTAL | TGF-BETA | UBIQUITIN LIGASE | DIABETIC-NEPHROPATHY | MESENCHYMAL TRANSITION | transforming growth factor-beta 1 | SKI | Smad2 | GROWTH-FACTOR-BETA | Smad ubiquitination regulatory factor-2 | FIBROTIC KIDNEY | SMAD TRANSCRIPTIONAL COREPRESSORS | NEGATIVE REGULATORS | DEGRADATION | SnoN | diabetic nephropathy
Journal Article
Molecular Medicine Reports, ISSN 1791-2997, 09/2017, Volume 16, Issue 3, pp. 3308 - 3314
Journal Article
Journal Article
Cellular Signalling, ISSN 0898-6568, 04/2012, Volume 24, Issue 4, pp. 922 - 930
Journal Article
Laboratory Investigation, ISSN 0023-6837, 11/2005, Volume 85, Issue 11, pp. 1330 - 1341
The Sloan Kettering Virus ( Ski) family of nuclear oncoproteins represses transforming growth factor-beta (TGF-beta) signaling through inhibition of... 
Cerebellum | Signaling | Inhibitor | Smad | Ski family | Transforming growth factor | ski family | MEDICINE, RESEARCH & EXPERIMENTAL | NERVOUS-SYSTEM | LOCALIZATION | C-SKI | signaling | SMAD PROTEINS | PATHOLOGY | cerebellum | MEDIATED REPRESSION | inhibitor | ONCOPROTEIN SKI | FACTOR-BETA-S | TRANSFORMING-GROWTH-FACTOR | transforming growth factor | SNON | ACTS | Oncogene Proteins - genetics | Molecular Weight | Nerve Tissue - metabolism | Humans | Molecular Sequence Data | Proto-Oncogene Proteins - chemistry | Smad3 Protein - metabolism | RNA, Messenger - metabolism | Bone Morphogenetic Proteins - metabolism | Nerve Tissue Proteins - chemistry | Cloning, Molecular | Conserved Sequence | Transforming Growth Factor beta - antagonists & inhibitors | Nuclear Proteins - genetics | Bone Morphogenetic Proteins - genetics | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Cell Line | Gene Expression | Oncogene Proteins - chemistry | Oncogene Proteins - metabolism | Smad2 Protein - metabolism | Intracellular Signaling Peptides and Proteins | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Embryonic Development | Nuclear Proteins - chemistry | Nerve Tissue Proteins - genetics | Amino Acid Motifs | Nerve Tissue Proteins - metabolism | Sequence Homology, Amino Acid | Animals | Transforming Growth Factor beta - genetics | Chromosomes, Human, Pair 18 | Cell Line, Tumor | Mice
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2017, Volume 12, Issue 5, p. e0177639
Journal Article
Journal Article