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1. Full Text Outcomes after Angiography with Sodium Bicarbonate and Acetylcysteine
by Weisbord, Steven D and Gallagher, Martin and Jneid, Hani and Garcia, Santiago and Cass, Alan and Thwin, Soe-Soe and Conner, Todd A and Chertow, Glenn M and Bhatt, Deepak L and Shunk, Kendrick and Parikh, Chirag R and McFalls, Edward O and Brophy, Mary and Ferguson, Ryan and Wu, Hongsheng and Androsenko, Maria and Myles, John and Kaufman, James and Palevsky, Paul M and PRESERVE Trial Grp and PRESERVE Trial Group
The New England Journal of Medicine, ISSN 0028-4793, 02/2018, Volume 378, Issue 7, pp. 603 - 614
Among high-risk patients undergoing angiography, there was no benefit of intravenous sodium bicarbonate over sodium chloride or of oral acetylcysteine over... 
MORTALITY | ACUTE KIDNEY INJURY | MEDICINE, GENERAL & INTERNAL | PERCUTANEOUS CORONARY INTERVENTION | METAANALYSIS | ACUTE-RENAL-FAILURE | N-ACETYLCYSTEINE | CONTRAST-INDUCED NEPHROPATHY | RANDOMIZED CONTROLLED-TRIAL | PREVENTION STRATEGIES | PREDICTION | Fluid Therapy | Sodium Bicarbonate - therapeutic use | Double-Blind Method | Administration, Oral | Humans | Middle Aged | Risk Factors | Male | Treatment Outcome | Sodium Chloride - therapeutic use | Acute Kidney Injury - prevention & control | Angiography - adverse effects | Renal Insufficiency, Chronic - therapy | Contrast Media - adverse effects | Creatinine - blood | Female | Acute Kidney Injury - chemically induced | Aged | Acetylcysteine - therapeutic use | Infusions, Intravenous | Renal Dialysis | Intervention | Creatinine | Intravenous administration | Medical imaging | Kidneys | Angiography | Acetylcysteine | Sodium chloride | Patients | Clinical outcomes | Studies | Prevention | Bicarbonate | Chloride | Sodium bicarbonate
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2. Full Text Prevention of Contrast-Induced Nephropathy With Sodium Bicarbonate: A Randomized Controlled Trial
by Merten, Gregory J and Burgess, W. Patrick and Gray, Lee V and Holleman, Jeremiah H and Roush, Timothy S and Kowalchuk, Glen J and Bersin, Robert M and Van Moore, Arl and Simonton III, Charles A and Rittase, Robert A and Norton, H. James and Kennedy, Thomas P
JAMA, ISSN 0098-7484, 05/2004, Volume 291, Issue 19, pp. 2328 - 2334
CONTEXT Contrast-induced nephropathy remains a common complication of radiographic procedures. Pretreatment with sodium bicarbonate is more protective than... 
RADIOCONTRAST | MEDICINE, GENERAL & INTERNAL | HIGH-RISK PATIENTS | EPITHELIAL-CELLS | RADIOGRAPHIC-CONTRAST | NITRIC-OXIDE | ACUTE-RENAL-FAILURE | N-ACETYLCYSTEINE | HYPOXIA | OXYGEN-FREE-RADICALS | NEPHROTOXICITY | Sodium Bicarbonate - therapeutic use | Glomerular Filtration Rate | Prospective Studies | Humans | Middle Aged | Male | Renal Insufficiency - prevention & control | Sodium Chloride - therapeutic use | Radiography | Contrast Media - adverse effects | Renal Insufficiency - chemically induced | Aged, 80 and over | Creatinine - blood | Iopamidol - adverse effects | Adult | Female | Aged | Water-Electrolyte Balance | Rehydration Solutions - therapeutic use | Clinical trials | Kidneys | Preventive medicine | Disease | Sodium
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3. Full Text A Comparison of Treating Metabolic Acidosis in CKD Stage 4 Hypertensive Kidney Disease with Fruits and Vegetables or Sodium Bicarbonate
by Nimrit Goraya and Jan Simoni and Chan-Hee Jo and Donald E. Wesson
Clinical Journal of the American Society of Nephrology, ISSN 1555-9041, 03/2013, Volume 8, Issue 3, pp. 371 - 381
Background and objectives Current guidelines recommend Na+-based alkali for CKD with metabolic acidosis and plasma total CO2 (PTCO2) < 22 mM. Because diets in... 
GLOMERULAR-FILTRATION-RATE | BODY-WEIGHT | GFR | DIET | CYSTATIN-C | UROLOGY & NEPHROLOGY | ENDOTHELIN | POTASSIUM | BLOOD-PRESSURE | PROGRESSION | DECLINE | Sodium Bicarbonate - therapeutic use | Biomarkers - urine | Sodium Bicarbonate - adverse effects | Vegetables | Renal Insufficiency, Chronic - etiology | Diet - adverse effects | Humans | Middle Aged | Hypertension - drug therapy | Male | Sodium Bicarbonate - administration & dosage | Renal Insufficiency, Chronic - drug therapy | Glomerular Filtration Rate - drug effects | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Time Factors | Female | Renal Insufficiency, Chronic - diagnosis | Renal Insufficiency, Chronic - diet therapy | Kidney - physiopathology | Kidney - drug effects | Acidosis - etiology | Fruit | Acidosis - drug therapy | Administration, Oral | Acidosis - diet therapy | Treatment Outcome | Biomarkers - blood | Antihypertensive Agents - therapeutic use | Acid-Base Equilibrium - drug effects | Texas | Acidosis - diagnosis | Hypertension - complications | Potassium - blood | Original
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4. Full Text Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre, open-label, randomised controlled, phase 3 trial
by Jaber, Samir and Paugam, Catherine and Futier, Emmanuel and Lefrant, Jean-Yves and Lasocki, Sigismond and Lescot, Thomas and Pottecher, Julien and Demoule, Alexandre and Ferrandière, Martine and Asehnoune, Karim and Dellamonica, Jean and Velly, Lionel and Abback, Paër-Sélim and de Jong, Audrey and Brunot, Vincent and Belafia, Fouad and Roquilly, Antoine and Chanques, Gérald and Muller, Laurent and Constantin, Jean Michel and Constantin, Jean-Michel and Bertet, Helena and Klouche, Kada and Molinari, Nicolas and Jung, Boris and Monnin, Marion and Delay, Jean-Marc and Cissé, Moussa and Geniez, Marie and Conseil, Matthieu and Souche, Bruno and Noll, Eric and Morawiec, Elise and Robert, Alexandre and Triglia, Thibaut and Mechati, Malika and Arnal, Jean-Michel and Durand-Gasselin, Jacques and Demoly, Didier and Hraiech, Sami and Papazian, Laurent and Gilles, Vincent and Rimmelé, Thomas and Riu, Béatrice and Cougot, Pierre and Fourcade, Olivier and Seguin, Philippe and Charbit, Jonathan and Capdevila, Xavier and Leone, Marc and Zieleskiewicz, Laurent and Ichai, Carole and Orban, Jean Christophe and Darmon, Michael and Azoulay, Elie and Lemiale, Virginie and Zafrani, Lara and Debbat, Karim and Mimoz, Oliver and Guérin, Claude and Kipnis, Eric and BICAR-ICU Study Grp and BICAR-ICU Study Group
The Lancet, ISSN 0140-6736, 07/2018, Volume 392, Issue 10141, pp. 31 - 40
Acute acidaemia is frequently observed during critical illness. Sodium bicarbonate infusion for the treatment of severe metabolic acidaemia is a possible... 
FLUIDS | MEDICINE, GENERAL & INTERNAL | MANAGEMENT | SCORE | SEDATION | ACUTE-RENAL-FAILURE | LACTIC-ACIDOSIS | SEPSIS | HEMODYNAMICS | Sodium Bicarbonate - therapeutic use | Intensive Care Units | Acidosis - drug therapy | Humans | Renal Replacement Therapy | Survival Analysis | Acidosis - mortality | Infusions, Intravenous | Cohort Studies | Hydrogen-Ion Concentration | Sodium bicarbonate | Product development | Carbonates | Analysis | Pneumonia | Intensive care | Intravenous administration | pH effects | Clinical outcomes | Intensive care units | Infusion | Randomization | Motivation | Failure analysis | Physiology | Ventilators | Chemical industry | Kidneys | Complications | Mortality | Metabolism | Patients | Survival | Studies | Hospitals | Sodium | Medical prognosis | Sepsis | Lactic acid | Mercury | Alkalosis
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5. Full Text Sodium bicarbonate therapy for the prevention of contrast-induced acute kidney injury- A systematic review and meta-analysis
by Jang, Jae-Sik and Jin, Han-Young and Seo, Jeong-Sook and Yang, Tae-Hyun and Kim, Dae-Kyeong and Kim, Tae Hee and Urm, Sang-Hwa and Kim, Dong-Soo and Kim, Dong-Kie and Seol, Sang-Hoon and Kim, Doo-Il and Cho, Kyoung-Im and Kim, Bo-Hyun and Park, Yong Hyun and Je, Hyung-Gon and Ahn, Jung-Min and Kim, Won-Jang and Lee, Jong-Young and Lee, Seung-Whan
Circulation Journal, ISSN 1346-9843, 2012, Volume 76, Issue 9, pp. 2255 - 2265
Background: Sodium bicarbonate has been postulated to prevent contrast-induced acute kidney injury (CI-AKI) by various mechanisms, although the reports are... 
Contrast media | Kidneys | Meta-analysis | HOSPITALIZED-PATIENTS | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | INDUCED NEPHROPATHY | INSUFFICIENCY | PLUS N-ACETYLCYSTEINE | ACUTE-RENAL-FAILURE | RANDOMIZED CONTROLLED-TRIAL | PERCUTANEOUS CORONARY INTERVENTION | PROGNOSTIC IMPORTANCE | OXYGEN-FREE-RADICALS | MEDLINE | Sodium Bicarbonate - therapeutic use | Contrast Media - adverse effects | Contrast Media - administration & dosage | Humans | Renal Replacement Therapy | Female | Male | Acute Kidney Injury - chemically induced | Sodium Chloride - therapeutic use | Acute Kidney Injury - prevention & control
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6. Full Text Effectiveness of prevention strategies for contrast-induced nephropathy a systematic review and meta-analysis
by Subramaniam, Rathan M and Suarez-Cuervo, Catalina and Wilson, Renee F and Turban, Sharon and Zhang, Allen and Sherrod, Cheryl and Aboagye, Jonathan and Eng, John and Choi, Michael J and Hutfless, Susan and Bass, Eric B
Annals of Internal Medicine, ISSN 0003-4819, 03/2016, Volume 164, Issue 6, pp. 406 - 416
Background: N-acetylcysteine, sodium bicarbonate, statins, and ascorbic acid have been studied for reducing contrast-induced nephropathy (CIN). Purpose: To... 
ACUTE KIDNEY INJURY | MEDICINE, GENERAL & INTERNAL | PERCUTANEOUS CORONARY INTERVENTION | SODIUM-BICARBONATE | HIGH-DOSE ATORVASTATIN | MEDIA-INDUCED NEPHROPATHY | RENAL-FUNCTION | TERM ROSUVASTATIN TREATMENT | RANDOMIZED CONTROLLED-TRIAL | ELEVATION MYOCARDIAL-INFARCTION | INTRAVENOUS N-ACETYLCYSTEINE | Sodium Bicarbonate - therapeutic use | Kidney Diseases - prevention & control | United States | Humans | Sodium Chloride - therapeutic use | Antioxidants - therapeutic use | Contrast Media - adverse effects | Ascorbic Acid - therapeutic use | Contrast Media - administration & dosage | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Kidney Diseases - chemically induced | Free Radical Scavengers - therapeutic use | Acetylcysteine - therapeutic use | Infusions, Intravenous | Odds Ratio | Infusions, Intra-Arterial | Prevention | Complications and side effects | Dosage and administration | Kidney diseases | Research | Contrast media | Risk factors
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7. Full Text Sodium Bicarbonate Therapy for Prevention of Contrast-Induced Nephropathy: A Systematic Review and Meta-analysis
by Navaneethan, Sankar D., MD, MPH and Singh, Sonal, MD, MPH and Appasamy, Suresh, MD and Wing, Richard E., MD and Sehgal, Ashwini R., MD
American Journal of Kidney Diseases, ISSN 0272-6386, 2009, Volume 53, Issue 4, pp. 617 - 627
Background Optimal hydration measures to prevent contrast-induced nephropathy are controversial. Study Design We conducted a systematic review and... 
Nephrology | contrast-induced nephropathy | acute renal failure | Hydration | sodium bicarbonate | MORTALITY | RADIOCONTRAST-INDUCED NEPHROPATHY | HOSPITALIZED-PATIENTS | RANDOMIZED-TRIAL | ACUTE-RENAL-FAILURE | N-ACETYLCYSTEINE | CONTROLLED-TRIALS | CLINICAL-TRIALS | UROLOGY & NEPHROLOGY | CORONARY PROCEDURES | CHRONIC KIDNEY-DISEASE | Sodium Bicarbonate - therapeutic use | Contrast Media - adverse effects | Kidney Diseases - prevention & control | Humans | Kidney Diseases - chemically induced | Adult | Sodium Bicarbonate - administration & dosage | Sodium Chloride - administration & dosage | Treatment Outcome | Infusions, Intravenous | Sodium Chloride - therapeutic use | Randomized Controlled Trials as Topic | Index Medicus
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8. Full Text Bicarbonate therapy for prevention of chronic kidney disease progression
by Łoniewski, Igor and Wesson, Donald E
Kidney International, ISSN 0085-2538, 03/2014, Volume 85, Issue 3, pp. 529 - 535
Kidney injury in chronic kidney disease (CKD) is likely multifactorial, but recent data support that a component is mediated by mechanisms used by the kidney... 
alkali therapy | chronic kidney disease | bicarbonate | MORTALITY | ORAL SODIUM-BICARBONATE | DECLINE | SERUM BICARBONATE | GLOMERULAR-FILTRATION-RATE | GFR | HYPERTENSIVE NEPHROPATHY | METABOLIC-ACIDOSIS | UROLOGY & NEPHROLOGY | ENDOTHELIN | CKD | Renal Insufficiency, Chronic - prevention & control | Sodium Bicarbonate - therapeutic use | Sodium Bicarbonate - adverse effects | Humans | Sodium Bicarbonate - metabolism | Sodium Bicarbonate - pharmacology | Disease Progression
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9. Full Text Sodium bicarbonate, N -acetylcysteine, and saline for prevention of radiocontrast-induced nephropathy. A comparison of 3 regimens for protecting contrast-induced nephropathy in patients undergoing coronary procedures. A single-center prospective controlled trial
by Ozcan, Emin E., MD and Guneri, Sema, MD and Akdeniz, Bahri, MD and Akyıldız, İlke Z., MD and Senaslan, Omer, MD and Baris, Nezihi, MD and Aslan, Ozgur, MD and Badak, Ozer, MD
American Heart Journal, ISSN 0002-8703, 2007, Volume 154, Issue 3, pp. 539 - 544
Background Several protective therapies have been developed to prevent contrast-induced nephropathy (CIN). We aimed to investigate the efficacy of sodium... 
Cardiovascular | MODERATE | ANGIOGRAPHY | CARDIAC & CARDIOVASCULAR SYSTEMS | RANDOMIZED-TRIAL | MEDIA | ACUTE-RENAL-FAILURE | INTERVENTION | HYDRATION | ORAL ACETYLCYSTEINE | NEPHROTOXICITY | Sodium Bicarbonate - therapeutic use | Prospective Studies | Kidney Diseases - prevention & control | Humans | Middle Aged | Male | Sodium Chloride - therapeutic use | Angioplasty, Balloon, Coronary | Coronary Angiography | Contrast Media - adverse effects | Kidney Diseases - chemically induced | Aged, 80 and over | Adult | Female | Aged | Acetylcysteine - therapeutic use | Clinical trials | Acetylcysteine | Sodium bicarbonate | Carbonates | Comparative analysis | Hypertension | Intervention | Heart failure | Medical imaging | Free radicals | Dopamine | Hydration | Mortality | Cardiovascular disease | Studies | Contrast agents | Body mass index | Intubation | Diabetes | Cardiology | Drug therapy
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10. Full Text Sodium bicarbonate use during in-hospital pediatric pulseless cardiac arrest – A report from the American Heart Association Get With The Guidelines® -Resuscitation
by Raymond, Tia T and Stromberg, Daniel and Stigall, William and Burton, Grant and Zaritsky, Arno and Amer Heart Association's Get Guide and American Heart Association's Get With The Guidelines-Resuscitation Investigators
Resuscitation, ISSN 0300-9572, 2015, Volume 89, Issue C, pp. 106 - 113
Abstract Background Despite limited recommendations for using sodium bicarbonate (SB) during cardiopulmonary resuscitation (CPR), we hypothesized that SB... 
Emergency | Pediatrics | Sodium bicarbonate | Survival | Cardiopulmonary resuscitation | Cardiac arrest | STATEMENT | HEALTH-CARE PROFESSIONALS | NATIONAL REGISTRY | CARDIOPULMONARY-RESUSCITATION | TASK-FORCE | EMERGENCY MEDICINE | CATEGORY | OUTCOMES | CRITICAL CARE MEDICINE | Sodium Bicarbonate - therapeutic use | Outcome Assessment (Health Care) | United States | Humans | Pulse | Child, Preschool | Infant | Logistic Models | Male | Survival Rate | Hospitalization | American Heart Association | Cardiopulmonary Resuscitation | Heart Arrest - mortality | Adolescent | Critical Care | Female | Registries | Child | Heart Arrest - therapy | Practice Guidelines as Topic | Index Medicus
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11. Full Text Sodium Bicarbonate and Renal Function after Cardiac Surgery: A Prospectively Planned Individual Patient Meta-analysis
by Bailey, Michael and McGuinness, Shay and Haase, Michael and Haase-Fielitz, Anja and Parke, Rachael and Hodgson, Carol L and Forbes, Andrew and Bagshaw, Sean M and Bellomo, Rinaldo
Anesthesiology, ISSN 0003-3022, 02/2015, Volume 122, Issue 2, pp. 294 - 306
BACKGROUND:The effect of urinary alkalinization in cardiac surgery patients at risk of acute kidney injury (AKI) is controversial and trial findings... 
SERUM CREATININE | ACUTE KIDNEY INJURY | HIGH-RISK PATIENTS | HOSPITALIZED-PATIENTS | DOUBLE-BLIND | PHASE-II | ANESTHESIOLOGY | N-ACETYLCYSTEINE | RANDOMIZED CONTROLLED-TRIAL | FAILURE | CARE | Length of Stay | Sodium Bicarbonate - therapeutic use | Kidney - drug effects | Prospective Studies | Double-Blind Method | Hospital Mortality | Acute Kidney Injury - drug therapy | Humans | Middle Aged | Male | Sodium Bicarbonate - administration & dosage | Treatment Outcome | Kidney Function Tests | Female | Aged | Cardiac Surgical Procedures - methods | Postoperative Complications - drug therapy | Acute Kidney Injury - etiology
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12. Full Text Bicarbonate therapy, phosphate binders, and risk for vascular calcification
by Fernandez-Fernandez, Beatriz and Martin-Cleary, Catalina and Ortiz, Alberto
Kidney International, ISSN 0085-2538, 11/2014, Volume 86, Issue 5, pp. 1056 - 1056
UROLOGY & NEPHROLOGY | Renal Insufficiency, Chronic - prevention & control | Sodium Bicarbonate - therapeutic use | Humans
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