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Current Medicinal Chemistry, ISSN 0929-8673, 04/2013, Volume 20, Issue 10, pp. 1241 - 1285
... are: sleep disorders, anxiety, epilepsy, pain, etc. However, traditional channel blockers have multiple adverse events, mainly due to low specificity of mechanism of action... 
ASIC | TRP | Central nervous system | P2X | KCNQ | NMDA | CNS | Ion channels | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | GATED SODIUM-CHANNELS | SUBTYPE-SELECTIVE AGONIST | D-ASPARTATE RECEPTOR | ion channels | ACID-SENSING ION-CHANNEL-1 | central nervous system | GLYCINE ANTAGONIST GV150526 | TARANTULA TOXIN PSALMOTOXIN-1 | TRAUMATIC BRAIN-INJURY | ISCHEMIC CELL-DEATH | PHARMACOLOGY & PHARMACY | PERIPHERAL NEUROPATHIC PAIN | TRANSGENIC MOUSE MODEL | Ligand-Gated Ion Channels - antagonists & inhibitors | Transient Receptor Potential Channels - antagonists & inhibitors | Calcium Channels - metabolism | Humans | Calcium Channel Blockers - therapeutic use | Potassium Channel Blockers - therapeutic use | Sodium Channel Blockers - pharmacology | Calcium Channel Blockers - pharmacology | Ion Channels - antagonists & inhibitors | Potassium Channels - metabolism | Animals | Ion Channels - metabolism | Sodium Channels - chemistry | Calcium Channels - chemistry | Central Nervous System Diseases - drug therapy | Sodium Channels - metabolism | Calcium Channel Blockers - chemistry | Sodium Channel Blockers - therapeutic use | Potassium Channels - chemistry | Sodium Channel Blockers - chemistry | Transient Receptor Potential Channels - metabolism | Ligand-Gated Ion Channels - metabolism | Potassium Channel Blockers - chemistry | Potassium Channel Blockers - pharmacology
Journal Article
The Journal of neuroscience, ISSN 1529-2401, 2004, Volume 24, Issue 26, pp. 5922 - 5930
... channel agonist veratridine. The survival promoting effect of veratridine was reproduced by, but independent of, glial cell line-derived neurotrophic factor... 
Excitability | GDNF | Sodium | Channel | Trophic | Dopaminergic | TYROSINE-HYDROXYLASE | POTASSIUM CHANNELS | NEUROTROPHIC FACTOR | channel | trophic | NEUROSCIENCES | sodium | CYCLIC-AMP | excitability | CALCIUM-CHANNELS | SIGNALING PATHWAY | MEMBRANE-PROPERTIES | CENTRAL-NERVOUS-SYSTEM | dopaminergic | SMALL-CONDUCTANCE | PARKINSONS-DISEASE | Mesencephalon - cytology | Sodium-Potassium-Exchanging ATPase - physiology | Rats, Wistar | Apoptosis - drug effects | gamma-Aminobutyric Acid - metabolism | Cells, Cultured - cytology | Neurons - cytology | Sodium Channels - physiology | Apamin - pharmacology | Nerve Growth Factors - pharmacology | Neuroprotective Agents - pharmacology | Glial Cell Line-Derived Neurotrophic Factor | Ion Transport - drug effects | Neurons - metabolism | Aspirin - pharmacology | Tetrodotoxin - pharmacology | Neurons - drug effects | Dopamine - metabolism | Ouabain - pharmacology | Potassium Channel Blockers - pharmacology | Sodium - pharmacology | Cells, Cultured - drug effects | Nerve Tissue Proteins - physiology | Nifedipine - pharmacology | Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors | Biological Transport, Active - drug effects | Rats | Sodium Channel Blockers - pharmacology | Sodium Channels - drug effects | Calcium Channel Blockers - pharmacology | Nerve Tissue Proteins - drug effects | Veratridine - pharmacology | Scorpion Venoms - pharmacology | Animals | Calcium Channels, T-Type - drug effects | Serotonin - metabolism | Calcium Channel Agonists - pharmacology | Cells, Cultured - metabolism | Potassium Channels, Calcium-Activated - antagonists & inhibitors | Ion Channel Gating | Sodium - physiology | Tetrodotoxin | Neuroprotective Agents | Veratridine | Mesencephalon | Neurons and Cognition | Ouabain | Calcium Channel Agonists | Calcium Channels, T-Type | Potassium Channels, Calcium-Activated | Life Sciences | Biological Transport, Active | Sodium-Potassium-Exchanging ATPase | Ion Transport | Potassium Channel Blockers | gamma-Aminobutyric Acid | Aspirin | Apamin | Dopamine | Serotonin | Neurons | Sodium Channels | Cells, Cultured | Nerve Tissue Proteins | Nifedipine | Scorpion Venoms | Calcium Channel Blockers | Nerve Growth Factors | Sodium Channel Blockers | Apoptosis | Plasticity | Development | Repair
Journal Article
Nature neuroscience, ISSN 1546-1726, 2012, Volume 15, Issue 5, pp. 746 - 753
Endocannabinoid mediated spike timing-dependent depression (t-LTD) is crucially involved in the development of the sensory neocortex. t-LTD at excitatory... 
Astrocytes/drug effects | Electric Stimulation | Rats, Wistar | 2-Amino-5-phosphonovalerate/pharmacology | Calcium/metabolism | Synapses/drug effects | Time Factors | Naphthalenes/pharmacology | Sodium Channel Blockers/pharmacology | Thalamus/cytology | Long-Term Synaptic Depression/drug effects | Animals, Newborn | Calcium Channel Blockers/pharmacology | Excitatory Amino Acid Antagonists/pharmacology | Dizocilpine Maleate/pharmacology | Excitatory Postsynaptic Potentials/drug effects | Probability | Rats | Benzoxazines/pharmacology | Biophysics | Signal Transduction/drug effects | Neocortex/cytology | Patch-Clamp Techniques | Animals | Glutamic Acid/metabolism | Morpholines/pharmacology | Pyrazoles/pharmacology | Piperidines/pharmacology | Tetrodotoxin/pharmacology | In Vitro Techniques | Receptor, Cannabinoid, CB1/antagonists & inhibitors | D-SERINE | NEUROTRANSMITTER RELEASE | INHIBITORY SYNAPSES | PYRAMIDAL CELLS | SYNAPTIC-TRANSMISSION | RAT SOMATOSENSORY CORTEX | LONG-TERM POTENTIATION | GLIAL-CELLS | PRESYNAPTIC NMDA | NEUROSCIENCES | PLASTICITY | Calcium - metabolism | 2-Amino-5-phosphonovalerate - pharmacology | Long-Term Synaptic Depression - drug effects | Excitatory Postsynaptic Potentials - drug effects | Piperidines - pharmacology | Tetrodotoxin - pharmacology | Pyrazoles - pharmacology | Astrocytes - drug effects | Long-Term Synaptic Depression - physiology | Synapses - drug effects | Synapses - physiology | Morpholines - pharmacology | Sodium Channel Blockers - pharmacology | Synapses - ultrastructure | Excitatory Amino Acid Antagonists - pharmacology | Calcium Channel Blockers - pharmacology | Naphthalenes - pharmacology | Astrocytes - ultrastructure | Astrocytes - physiology | Signal Transduction - drug effects | Benzoxazines - pharmacology | Thalamus - cytology | Neocortex - cytology | Signal Transduction - physiology | Glutamic Acid - metabolism | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Dizocilpine Maleate - pharmacology | Methyl aspartate | Depression, Mental | Physiological aspects | Genetic aspects | Research | Risk factors | Synapses
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2015, Volume 58, Issue 18, pp. 7093 - 7118
Journal Article
Journal Article
Trends in Pharmacological Sciences, ISSN 0165-6147, 2013, Volume 34, Issue 3, pp. 154 - 161
.... This has been illustrated in earlier studies on the action of local anesthetics, sodium channel activators, as well as blockers of potassium and calcium channels. Here, we discuss the available data with a view to understanding the use-, voltage-, and current carrying cation-dependence of the ligand action, paradoxes in structure–activity relationships, and effects of mutations in these ion channels. 
Advanced Basic Science | cardiovascular drugs | local anesthetics | batrachotoxin | use dependence | immunosuppressants | voltage dependence | PORE REGION | CRYSTAL-STRUCTURE | NA+ CHANNELS | MOLECULAR DETERMINANTS | LOCAL-ANESTHETICS | SLOW INACTIVATION | PHARMACOLOGY & PHARMACY | CA2+ POTENTIATION | K+ CHANNEL | STATE-DEPENDENT BLOCK | C-TYPE-INACTIVATION | Calcium Channel Agonists - chemistry | Calcium Channels - metabolism | Cations - metabolism | Humans | Structure-Activity Relationship | Potassium Channels - metabolism | Sodium Channels - metabolism | Molecular Targeted Therapy - methods | Potassium Channel Blockers - pharmacology | Toxins, Biological - pharmacology | Sodium Channel Agonists - chemistry | Sodium Channel Agonists - pharmacology | Models, Molecular | Sodium Channel Blockers - pharmacology | Calcium Channel Blockers - pharmacology | Sodium Channels - chemistry | Calcium Channels - chemistry | Potassium Channels - agonists | Calcium Channel Blockers - chemistry | Calcium Channel Agonists - pharmacology | Ligands | Potassium Channels - chemistry | Sodium Channel Blockers - chemistry | Toxins, Biological - chemistry | Potassium Channel Blockers - chemistry | Calcium channels | Anesthetics | Analysis | Immunosuppressive agents
Journal Article
Journal Article
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 2016, Volume 68, Issue 17, pp. 1881 - 1894
.... The effects of flecainide, a sodium (Na+ )-channel blocker, and d,l-sotalol, a potassium channel blocker, were studied in littermate mice with normal and reduced... 
Cardiovascular | Internal Medicine | drug targets | antiarrhythmic drugs | atrial fibrillation | electrophysiology | personalized medicine | rhythm control | POST-REPOLARIZATION REFRACTORINESS | FIBRILLATION | POSTREPOLARIZATION REFRACTORINESS | CARDIAC & CARDIOVASCULAR SYSTEMS | MECHANISMS | EXPERIMENTAL-MODEL | PLEXUS ABLATION | RANOLAZINE | TASK-1 | DRONEDARONE | K+ CHANNEL | Transcription Factors - physiology | Atrial Fibrillation - drug therapy | Anti-Arrhythmia Agents - pharmacology | Humans | Middle Aged | Gene Expression Regulation | Male | Transcription Factors - genetics | Atrial Fibrillation - physiopathology | Membrane Potentials - physiology | Homeodomain Proteins - genetics | Animals | Voltage-Gated Sodium Channel Blockers - therapeutic use | Adult | Female | Aged | Mice | Electrophysiological Phenomena | Heart Atria - physiopathology | Homeodomain Proteins - physiology | Flecainide - therapeutic use | Heart | Medical colleges | Hospitals | Atrial fibrillation | Anti-arrhythmia drugs | Cardiology | Gene expression | Pharmaceutical industry | Electric properties | Cardiac arrhythmia | Transcription factors | Sodium | Velocity | Rodents | Deoxyribonucleic acid--DNA | LAA, left atrial appendage | PITX2, paired like homeodomain-2 | APD, action potential duration | ERP, effective refractory period | LA, left atrium | TASK-2, TWIK-related acid-sensitive K+ channel | RMP, resting membrane potential | HEK, human embryonic kidney | Na, sodium | SNP, single nucleotide polymorphism | PRR, post-repolarization refractoriness | mRNA, messenger ribonucleic acid | Original Investigation | AAD, antiarrhythmic drug
Journal Article