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Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 01/2015, Volume 746, pp. 167 - 173
Bumetanide is increasingly being used for experimental treatment of brain disorders, including neonatal seizures, epilepsy, and autism, because the neuronal... 
Neonatal seizures | Drug transport | Cation chloride cotransporters | Epilepsy | Blood–brain barrier | Blood-brain barrier | ACID | CATION-CHLORIDE COTRANSPORTERS | RENAL TRANSPORT | MRP4 | NEONATAL SEIZURES | Epilepsy Neonatal seizures | P-GLYCOPROTEIN | DRUG TRANSPORTERS | DISEASE | RESISTANCE | PHARMACOLOGY & PHARMACY | EPILEPSY | Bumetanide - metabolism | Diuretics - pharmacokinetics | Sodium Potassium Chloride Symporter Inhibitors - pharmacology | Humans | Sodium Potassium Chloride Symporter Inhibitors - pharmacokinetics | Half-Life | Organic Anion Transporters - metabolism | Brain - metabolism | Kidney - metabolism | Organic Anion Transporters - genetics | Drug Interactions | Membrane Transport Modulators - pharmacology | Female | Animals, Outbred Strains | Biological Transport - drug effects | Neurons - metabolism | Neurons - drug effects | Diuretics - blood | Diuretics - metabolism | Recombinant Proteins - metabolism | Cell Line | Nerve Tissue Proteins - antagonists & inhibitors | Anticonvulsants - blood | Anticonvulsants - pharmacokinetics | Organic Anion Transporters - antagonists & inhibitors | Kidney - drug effects | Probenecid - pharmacology | Anticonvulsants - metabolism | Bumetanide - blood | Recombinant Proteins - chemistry | Bumetanide - pharmacokinetics | Blood-Brain Barrier - drug effects | Nerve Tissue Proteins - genetics | Bumetanide - pharmacology | Blood-Brain Barrier - metabolism | Brain - drug effects | Nerve Tissue Proteins - metabolism | Animals | Dogs | Sodium Potassium Chloride Symporter Inhibitors - metabolism | Mice | Sodium Potassium Chloride Symporter Inhibitors - blood | Diuretics | Seizures (Medicine) | Ionization | Probenecid | Protein binding | Index Medicus
Journal Article
Expert Review of Cardiovascular Therapy, ISSN 1477-9072, 06/2010, Volume 8, Issue 6, pp. 793 - 802
Journal Article
European Journal of Neuroscience, ISSN 0953-816X, 02/2014, Volume 39, Issue 4, pp. 673 - 687
Journal Article
Neuropharmacology, ISSN 0028-3908, 12/2018, Volume 143, pp. 186 - 204
Based on the potential role of Na-K-Cl cotransporters (NKCCs) in epileptic seizures, the loop diuretic bumetanide, which blocks the NKCC1 isoforms NKCC1 and... 
Giant depolarizing potentials | GABA | Neonatal seizures | Anti-seizure drugs | Epilepsy | GABA ACTIONS | CATION-CHLORIDE COTRANSPORTERS | DRUG DISCOVERY | AQUAPORIN 4 | WATER PERMEABILITY | NEUROSCIENCES | PYRAMIDAL NEURONS | PILOCARPINE MODEL | ANIMAL-MODELS | PHARMACOLOGY & PHARMACY | KINDLED RATS | Phenobarbital - pharmacology | Bumetanide - analogs & derivatives | Benzylamines - chemical synthesis | Rats, Wistar | Sodium Potassium Chloride Symporter Inhibitors - pharmacology | Seizures - drug therapy | Sodium Potassium Chloride Symporter Inhibitors - pharmacokinetics | Epilepsy - metabolism | Seizures - metabolism | Anticonvulsants - pharmacology | Oocytes | Brain - metabolism | Bumetanide - chemistry | Female | Drug Evaluation, Preclinical | Solute Carrier Family 12, Member 2 - metabolism | Anticonvulsants - pharmacokinetics | Anticonvulsants - chemical synthesis | Tissue Culture Techniques | Xenopus laevis | Phenobarbital - pharmacokinetics | Bumetanide - pharmacokinetics | Bumetanide - pharmacology | Brain - drug effects | Drug Synergism | Benzylamines - chemistry | Animals | Anticonvulsants - chemistry | Sodium Potassium Chloride Symporter Inhibitors - chemistry | Epilepsy - drug therapy | Mice | Benzylamines - pharmacokinetics | Benzylamines - pharmacology | Phenobarbital | Neurons | Analysis | Diuretics | Seizures (Medicine) | Permeability
Journal Article
European Journal of Heart Failure, ISSN 1388-9842, 03/2019, Volume 21, Issue 3, pp. 337 - 341
Aims To assess differences in diuretic dose requirements in patients treated with sacubitril/valsartan compared with enalapril in the Prospective comparison of... 
Diuretics | Sacubitril/valsartan | Heart failure with reduced ejection fraction | Randomized clinical trial | Enalapril | MORTALITY | SYSTEM | NEPRILYSIN | CARDIAC & CARDIOVASCULAR SYSTEMS | DEATH | HOSPITALIZATION | INHIBITION | PROGRESSIVE HEART-FAILURE | Furosemide - administration & dosage | Angiotensin Receptor Antagonists - pharmacokinetics | Humans | Middle Aged | Heart Failure - physiopathology | Medication Therapy Management - statistics & numerical data | Sodium Potassium Chloride Symporter Inhibitors - pharmacokinetics | Biological Availability | Male | Drug Monitoring - methods | Dose-Response Relationship, Drug | Aminobutyrates - pharmacokinetics | Tetrazoles - administration & dosage | Female | Aminobutyrates - administration & dosage | Enalapril - administration & dosage | Outcome Assessment, Health Care | Sodium Potassium Chloride Symporter Inhibitors - administration & dosage | Enalapril - pharmacokinetics | Furosemide - pharmacokinetics | Heart Failure - drug therapy | Stroke Volume | Drug Monitoring - statistics & numerical data | Aged | Tetrazoles - pharmacokinetics | Angiotensin Receptor Antagonists - administration & dosage | valsartan | Short Report | Sacubitril | Clinical Trials | death | hospitalization | inhibition | Kardiologi | progressive heart-failure | Cardiac and Cardiovascular Systems | system | neprilysin | Cardiovascular System & Cardiology | mortality
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