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Journal Article
Lancet Neurology, The, ISSN 1474-4422, 2015, Volume 14, Issue 5, pp. 469 - 477
Journal Article
Circulation, ISSN 0009-7322, 03/2006, Volume 113, Issue 9, pp. 1213 - 1225
Journal Article
Journal Article
Annals of Neurology, ISSN 0364-5134, 02/2008, Volume 63, Issue 2, pp. 222 - 235
Objectives High levels of expression of the Na+‐K+‐2Cl− (NKCC1) cotransporter in immature neurons cause the accumulation of intracellular chloride and,... 
K-CL COTRANSPORTER | STRUCTURES IN-VITRO | CORTICOHIPPOCAMPAL FORMATION | CATION-CHLORIDE COTRANSPORTERS | EPILEPTIFORM ACTIVITY | RAT HIPPOCAMPAL SLICE | EXCITATORY ACTIONS | ANTIEPILEPTIC DRUGS | NEUROSCIENCES | DEVELOPING BRAIN | CLINICAL NEUROLOGY | GAMMA-AMINOBUTYRIC ACID | Phenobarbital - pharmacology | Chloride Channels - drug effects | Magnesium Deficiency - physiopathology | Sodium Potassium Chloride Symporter Inhibitors - therapeutic use | Sodium Potassium Chloride Symporter Inhibitors - pharmacology | Seizures - drug therapy | Male | Hippocampus - drug effects | Sodium-Potassium-Chloride Symporters - metabolism | Anticonvulsants - pharmacology | Sodium-Potassium-Chloride Symporters - drug effects | Bumetanide - therapeutic use | Neural Inhibition - physiology | Seizures - physiopathology | Epilepsy, Benign Neonatal - drug therapy | Magnesium Deficiency - complications | Chlorides - metabolism | Receptors, GABA-A - drug effects | Ion Transport - drug effects | Drug Therapy, Combination | Hippocampus - growth & development | Organ Culture Techniques | Membrane Potentials - drug effects | Epilepsy, Benign Neonatal - physiopathology | Anticonvulsants - therapeutic use | Rats | Membrane Potentials - physiology | Rats, Sprague-Dawley | Bumetanide - pharmacology | Chloride Channels - metabolism | Drug Synergism | Patch-Clamp Techniques | Phenobarbital - therapeutic use | Animals | Solute Carrier Family 12, Member 2 | Models, Biological | Receptors, GABA-A - metabolism | Ion Transport - physiology | Hippocampus - physiopathology | Neural Inhibition - drug effects
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 01/2015, Volume 746, pp. 167 - 173
Bumetanide is increasingly being used for experimental treatment of brain disorders, including neonatal seizures, epilepsy, and autism, because the neuronal... 
Neonatal seizures | Drug transport | Cation chloride cotransporters | Epilepsy | Blood–brain barrier | Blood-brain barrier | ACID | CATION-CHLORIDE COTRANSPORTERS | RENAL TRANSPORT | MRP4 | NEONATAL SEIZURES | Epilepsy Neonatal seizures | P-GLYCOPROTEIN | DRUG TRANSPORTERS | DISEASE | RESISTANCE | PHARMACOLOGY & PHARMACY | EPILEPSY | Bumetanide - metabolism | Diuretics - pharmacokinetics | Sodium Potassium Chloride Symporter Inhibitors - pharmacology | Humans | Sodium Potassium Chloride Symporter Inhibitors - pharmacokinetics | Half-Life | Organic Anion Transporters - metabolism | Brain - metabolism | Kidney - metabolism | Organic Anion Transporters - genetics | Drug Interactions | Membrane Transport Modulators - pharmacology | Female | Animals, Outbred Strains | Biological Transport - drug effects | Neurons - metabolism | Neurons - drug effects | Diuretics - blood | Diuretics - metabolism | Recombinant Proteins - metabolism | Cell Line | Nerve Tissue Proteins - antagonists & inhibitors | Anticonvulsants - blood | Anticonvulsants - pharmacokinetics | Organic Anion Transporters - antagonists & inhibitors | Kidney - drug effects | Probenecid - pharmacology | Anticonvulsants - metabolism | Bumetanide - blood | Recombinant Proteins - chemistry | Bumetanide - pharmacokinetics | Blood-Brain Barrier - drug effects | Nerve Tissue Proteins - genetics | Bumetanide - pharmacology | Blood-Brain Barrier - metabolism | Brain - drug effects | Nerve Tissue Proteins - metabolism | Animals | Dogs | Sodium Potassium Chloride Symporter Inhibitors - metabolism | Mice | Sodium Potassium Chloride Symporter Inhibitors - blood | Diuretics | Seizures (Medicine) | Ionization | Probenecid | Protein binding | Index Medicus
Journal Article
Journal of Cell Science, ISSN 0021-9533, 03/2008, Volume 121, Issue 5, pp. 675 - 684
Journal Article
Expert Review of Cardiovascular Therapy, ISSN 1477-9072, 06/2010, Volume 8, Issue 6, pp. 793 - 802
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 09/2015, Volume 35, Issue 35, pp. 12172 - 12187
Spreading depolarizations (SDs) are waves of sustained neuronal and glial depolarization that propagate massive disruptions of ion gradients through the brain.... 
Two-photon microscopy | Neuronal swelling | Cl-cotransporters | Cotransporters | Spreading depression | Dendritic beading | INTRACELLULAR CHLORIDE | MONOCARBOXYLATE TRANSPORTER | DEPRESSION-LIKE DEPOLARIZATION | BRAIN CORTEX | cotransporters | ANOXIC DEPOLARIZATION | BLOOD-FLOW | NEUROSCIENCES | spreading depression | neuronal swelling | IN-VIVO | two-photon microscopy | EXTRACELLULAR PH CHANGES | dendritic beading | RAT HIPPOCAMPAL SLICES | CEREBRAL-ISCHEMIA | Chlorates - pharmacology | Pyramidal Cells - metabolism | CA1 Region, Hippocampal - cytology | Sodium Potassium Chloride Symporter Inhibitors - pharmacology | Male | Cortical Spreading Depression - physiology | Adenosine Triphosphate - pharmacology | Excitatory Postsynaptic Potentials - physiology | Dendrites - physiology | Female | Pyramidal Cells - drug effects | Receptors, Chemokine - genetics | Thiazolidines - pharmacology | Ouabain - pharmacology | Pyramidal Cells - cytology | Dendrites - metabolism | CA1 Region, Hippocampal - physiology | 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid - pharmacology | Receptors, Chemokine - metabolism | Mice, Transgenic | Symporters - metabolism | Cortical Spreading Depression - drug effects | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Animals | Symporters - genetics | Mice | Furosemide - pharmacology | In Vitro Techniques | CX3C Chemokine Receptor 1
Journal Article
Annals of Neurology, ISSN 0364-5134, 04/2014, Volume 75, Issue 4, pp. 550 - 562
Objective There is considerable interest in using bumetanide, a chloride importer Na‐K‐Cl cotransporter antagonist, for treatment of neurological diseases,... 
IN-VITRO | TEMPORAL-LOBE EPILEPSY | CATION-CHLORIDE COTRANSPORTERS | TRANSPORTERS | DRUGS | RAT HIPPOCAMPUS | NKCC1 | MODEL | DIURETICS | NEUROSCIENCES | CLINICAL NEUROLOGY | GABA UPTAKE