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Circulation, ISSN 0009-7322, 10/2007, Volume 116, Issue 16, pp. 1821 - 1831
Background - The recent discovery that nitrite is an intrinsic vasodilator and signaling molecule at near-physiological concentrations has raised the... 
Hemoglobin | Endothelium-derived factors | Free radicals | Nitric oxide | Nitroglycerin | OXIDE SYNTHASE ACTIVITY | free radicals | nitric oxide | CARDIAC & CARDIOVASCULAR SYSTEMS | DIRECTLY ACTING VASODILATOR | SODIUM-NITRITE | REGIONAL BLOOD-FLOW | SIGNALING MOLECULE | hemoglobin | endothelium-derived factors | ISCHEMIA-REPERFUSION INJURY | PLASMA NITRITE | nitroglycerin | IN-VIVO | EMERGING BIOLOGY | PERIPHERAL VASCULAR DISEASE | CIRCULATING NITRITE | Vasodilator Agents - pharmacokinetics | Sodium Nitrite - administration & dosage | Humans | Macaca fascicularis | Endothelium, Vascular - drug effects | Male | Enzyme Inhibitors - administration & dosage | Regional Blood Flow - drug effects | Endocrine System - drug effects | Adult | Female | Xanthine Oxidase - metabolism | Oxidation-Reduction | Drug Tolerance | Hemoglobins - metabolism | Ascorbic Acid - administration & dosage | Oxypurinol - administration & dosage | Vasodilator Agents - blood | Animals | Sodium Nitrite - blood | Endothelium, Vascular - metabolism | Antioxidants - administration & dosage | Vasodilation - drug effects | Nitric Oxide - metabolism | Sodium Nitrite - pharmacokinetics | Vasodilator Agents - administration & dosage | Infusions, Intra-Arterial | Physiological aspects | Vascular endothelium | Dosage and administration | Research | Pharmacokinetics | Nitrites
Journal Article
Circulation, ISSN 0009-7322, 01/2010, Volume 121, Issue 1, pp. 98 - 109
Background-Pulmonary arterial hypertension is a progressive proliferative vasculopathy of the small pulmonary arteries that is characterized by a primary... 
Hypoxia | Nitric oxide | Pulmonary artery smooth muscle cells | Xanthine oxidoreductase | Monocrotaline sodium | hypoxia | nitric oxide | xanthine oxidoreductase | ISCHEMIA/REPERFUSION INJURY | CARDIAC & CARDIOVASCULAR SYSTEMS | ORGANIC NITRATES | monocrotaline sodium | ACTIVATED-PROTEIN-KINASE | CELL-PROLIFERATION | EXERCISE CAPACITY | pulmonary artery smooth muscle cells | SYNTHASE | L-ARGININE | IN-VIVO | PERIPHERAL VASCULAR DISEASE | ISCHEMIA-REPERFUSION | HEMATOLOGY | EXPRESSION | Xanthine Dehydrogenase - metabolism | Hypoxia - drug therapy | Xanthine Dehydrogenase - antagonists & inhibitors | Male | Hypertension, Pulmonary - chemically induced | Hypoxia - metabolism | Sodium Nitrite - pharmacology | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Hypertension, Pulmonary - drug therapy | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - cytology | Disease Models, Animal | Myocytes, Smooth Muscle - enzymology | Mice, Inbred C57BL | Cells, Cultured | Administration, Inhalation | Rats | Hypertension, Pulmonary - metabolism | Monocrotaline - toxicity | Rats, Sprague-Dawley | Cell Division - drug effects | Mice, Knockout | Pulmonary Artery - cytology | Animals | Mice | Nitric Oxide - metabolism | Sodium Nitrite - pharmacokinetics | Chronic Disease | Cell proliferation | Control | Nitrites | Physiological aspects | Smooth muscle | Research | Pulmonary hypertension
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 06/2013, Volume 169, Issue 3, pp. 659 - 670
Background and Purpose Nitrite (NO2−) has recently been shown to represent a potential source of NO, in particular under hypoxic conditions. The aim of the... 
heart failure | sodium nitrite | vascular effects | OXIDE SYNTHASE ACTIVITY | STABLE ANGINA | XANTHINE OXIDOREDUCTASE | ALDEHYDE DEHYDROGENASE | ISOSORBIDE-DINITRATE | DIASTOLIC VENTRICULAR INTERACTION | PLASMA NITRITE | RADIONUCLIDE PLETHYSMOGRAPHY | NITRATE TOLERANCE | PHARMACOLOGY & PHARMACY | SEVERE PULMONARY-EDEMA | Vasodilator Agents - pharmacokinetics | Sodium Nitrite - administration & dosage | Humans | Middle Aged | Heart Failure - physiopathology | Vasomotor System - drug effects | Male | Metabolic Clearance Rate | Nitric Oxide - analogs & derivatives | Nitroglycerin - pharmacology | Sodium Nitrite - pharmacology | Forearm | Regional Blood Flow - drug effects | Nitroglycerin - pharmacokinetics | Vasomotor System - physiopathology | Vasodilator Agents - metabolism | Nitroglycerin - administration & dosage | Female | Nitroglycerin - metabolism | Vasodilator Agents - pharmacology | Drug Tolerance | Heart Failure - metabolism | Saphenous Vein - physiopathology | Nitric Oxide - administration & dosage | Heart Failure - drug therapy | Nitric Oxide - pharmacokinetics | Sodium Nitrite - metabolism | Aged | Brachial Artery | Hemodynamics - drug effects | Oxidative Stress - drug effects | Vasodilation - drug effects | In Vitro Techniques | Nitric Oxide - metabolism | Sodium Nitrite - pharmacokinetics | Vasodilator Agents - administration & dosage | Saphenous Vein - drug effects | Cohort Studies | Infusions, Intra-Arterial | Congestive heart failure | Drug therapy | Analysis | Protein binding | Research Papers
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 1, p. e14504
Background: Infusion of sodium nitrite could provide sustained therapeutic concentrations of nitric oxide (NO) for the treatment of a variety of vascular... 
ISCHEMIA-REPERFUSION INJURY | PRIMATE MODEL | PLASMA NITRITE | OXIDE METABOLITES | MULTIDISCIPLINARY SCIENCES | IN-VIVO | SUBARACHNOID HEMORRHAGE | CEREBRAL VASOSPASM | HUMAN CIRCULATION | CEREBROSPINAL-FLUID | BLOOD-FLOW | Sodium Nitrite - administration & dosage | Humans | Middle Aged | Half-Life | Male | Feasibility Studies | Maximum Tolerated Dose | Time Factors | Drug-Related Side Effects and Adverse Reactions | Adult | Female | Sodium Nitrite - toxicity | Infusions, Intravenous | Sodium Nitrite - pharmacokinetics | Stroke (Disease) | Hypertension | Medical research | Care and treatment | Nitric oxide | Medicine, Experimental | Transplantation of organs, tissues, etc | Health aspects | Heart | Intravenous administration | Toxicity | Syngeneic grafts | Liver | Nitrites | Disorders | Nitrates | Neurosurgery | Males | Sodium nitrite | Hemorrhage | Infusion | Allografts | Ischemia | Blood-brain barrier | Blood pressure | Intravenous infusion | Safety | Neurological disorders | Stroke | Subarachnoid hemorrhage | Heart transplantation | Vasoconstriction | Feasibility studies | Transplants | Radioactive half-life | Methemoglobin | Pharmacology | Metabolism | Chromatography | Endothelium | Neurology | Brain research | Sodium | Scientific imaging | Females | Protocol (computers) | Mass spectrometry | Kidney transplantation | Cancer
Journal Article
JOURNAL OF NEUROSURGERY, ISSN 0022-3085, 09/2013, Volume 119, Issue 3, pp. 634 - 641
Object. Intravenous sodium nitrite has been shown to prevent and reverse cerebral vasospasm in a primate model of subarachnoid hemorrhage (SAH). The present... 
SURGERY | PRIMATE MODEL | nitric oxide | OXIDE | TOLERANCE | INJURY | vasospasm | vascular disorders | CLINICAL NEUROLOGY | REVERSAL | sodium nitrite | subarachnoid hemorrhage | INFUSIONS | CEREBRAL VASOSPASM
Journal Article
Annals of Biomedical Engineering, ISSN 0090-6964, 8/2016, Volume 44, Issue 8, pp. 2417 - 2430
Biocompatibility of artificial lungs can be improved by endothelialization of hollow fibers. Bioavailability of growth-inducing and anti-thrombotic agents on... 
Biochemistry, general | Biophysics and Biological Physics | Silicone hollow fibers | Biomimetic collagen coating | Thrombus deposition | Biomedicine general | Nitrite bioavailability | Biomedical Engineering | Endothelialization | Biomedicine | Biohybrid artificial lungs | Mechanics | Shear stress | Finite element modeling | OXIDE PRODUCTION | ENGINEERING, BIOMEDICAL | MEMBRANE | HEPARIN | ADHESION | TRANSPORT | SHEAR-STRESS | ENDOTHELIAL-CELLS | BLOOD | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Delayed-Action Preparations - chemistry | Bioartificial Organs | Sodium Nitrite - pharmacology | Biomimetic Materials - pharmacokinetics | Human Growth Hormone - pharmacology | Delayed-Action Preparations - pharmacology | Delayed-Action Preparations - pharmacokinetics | Human Growth Hormone - chemistry | Lung - metabolism | Biomimetic Materials - chemistry | Sodium Nitrite - chemistry | Thrombosis - physiopathology | Models, Cardiovascular | Lung - physiopathology | Biomimetic Materials - pharmacology | Thrombosis - metabolism | Blood Flow Velocity | Nanostructures - chemistry | Liposomes | Lung - blood supply | Sodium Nitrite - pharmacokinetics | Silicon - chemistry | Human Growth Hormone - pharmacokinetics | Somatotropin | Biomimetics | Collagen | Analysis | Resveratrol | Models | Silicones | Thrombosis | Cells | Blood clot | Endothelium | Finite element method | Conjugates | Nitrites | Bioavailability | Coating | Fibers
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 10/2015, Volume 172, Issue 20, pp. 4864 - 4874
Background and Purpose As the pathogenesis of postoperative ileus (POI) involves inflammation and oxidative stress, comparable to ischaemia/reperfusion injury... 
ISCHEMIA-REPERFUSION INJURY | OXIDE SYNTHASE | ISCHEMIA/REPERFUSION INJURY | INHIBITION | REDUCTION | PEROXYNITRITE | IN-VIVO | SMALL-INTESTINE | PHARMACOLOGY & PHARMACY | DYSFUNCTION | INFLAMMATORY RESPONSE | Tumor Necrosis Factor-alpha - metabolism | Ileus - metabolism | Reactive Oxygen Species - metabolism | Postoperative Complications - metabolism | Male | Postoperative Complications - immunology | Jejunum - metabolism | Jejunum - drug effects | Sodium Nitrite - pharmacology | Chemokine CCL2 - metabolism | Postoperative Complications - drug therapy | Ileus - immunology | Interleukin-6 - metabolism | Postoperative Complications - physiopathology | Jejunum - physiology | Ileus - physiopathology | Mice, Inbred C57BL | Neutrophils - physiology | Gastrointestinal Transit - drug effects | Ileus - drug therapy | Animals | Cyclic GMP - metabolism | Sodium Nitrite - blood | Muscle Contraction - drug effects | Sodium Nitrite - therapeutic use | Sodium Nitrite - pharmacokinetics | Nitric Oxide Synthase Type II - metabolism | Intestines | Obstructions | Small intestine | Nitric oxide | Rodents | Neutrophils | Oxidative stress | Reactive oxygen species | Pathogenesis | Nitrites | Fluorescence | Guanylate cyclase | Sodium nitrite | Proteins | Electron transport chain | Mitochondria | Reperfusion | Ischemia | Cyclic GMP | Fluoroscopic imaging | NADH-ubiquinone oxidoreductase | Contractility | Muscles | Inflammation | Muscle contraction | Nitric-oxide synthase | Sodium | Tumor necrosis factor | Mice | Infiltration | Monocyte chemoattractant protein 1 | Research Papers | Research Paper
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 06/2002, Volume 30, Issue 6, pp. 676 - 683
A biologically based mathematical model was created to characterize time and dose-dependent relationships between exposure to nitrite and induction of... 
OXIDATION | PHARMACOLOGY & PHARMACY | OXYHEMOGLOBIN | MODEL | Rats, Inbred F344 | Rats | Male | Animals | Sodium Nitrite - blood | Models, Biological | Female | Methemoglobinemia - blood | Sodium Nitrite - toxicity | Sodium Nitrite - pharmacokinetics | Hemoglobins - analysis | Methemoglobinemia - metabolism | Methemoglobin - analysis
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 08/2008, Volume 295, Issue 2, pp. 743 - 754
Journal Article