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The New England Journal of Medicine, ISSN 0028-4793, 03/2011, Volume 364, Issue 9, pp. 797 - 805
Journal Article
Lancet Neurology, The, ISSN 1474-4422, 2015, Volume 14, Issue 5, pp. 469 - 477
Journal Article
Journal Article
Science, ISSN 0036-8075, 12/2006, Volume 314, Issue 5806, pp. 1788 - 1792
We report a signaling mechanism in rats between mother and fetus aimed at preparing fetal neurons for delivery. In immature neurons, γ-aminobutyric acid (GABA)... 
Brain | Neuroscience | Neurons | Pyramidal cells | Chlorides | Fetus | GABA antagonists | Reports | Hormones | Hippocampus | Oxytocin receptors | CELLS | SLICES | NEONATAL HIPPOCAMPUS | SEIZURES | SYNAPSES | MULTIDISCIPLINARY SCIENCES | NEURONS | VASOPRESSIN | EXCITATORY ACTIONS | CHANNELS | OSCILLATIONS | Parturition | Neural Inhibition | Oxytocin - pharmacology | Sodium Potassium Chloride Symporter Inhibitors | Rats, Wistar | Sodium-Potassium-Chloride Symporters - metabolism | Fetus - physiology | gamma-Aminobutyric Acid - physiology | Action Potentials | Chlorides - metabolism | Neurons - physiology | Female | Indoles - pharmacology | Benzamides - pharmacology | Animals, Newborn | Hippocampus - embryology | GABA-A Receptor Antagonists | Signal Transduction | Maternal-Fetal Exchange | Receptors, Oxytocin - antagonists & inhibitors | Oxytocin - physiology | Rats | Vasotocin - pharmacology | Fetal Hypoxia - physiopathology | Hippocampus - cytology | Vasotocin - analogs & derivatives | Pregnancy | GABA-A Receptor Agonists | Patch-Clamp Techniques | Animals | Solute Carrier Family 12, Member 2 | Receptors, GABA-A - physiology | Hippocampus - physiology | In Vitro Techniques | GABA | Fetal brain | Research | Oxytocin | Fetal monitoring | Analysis | Receptors, Oxytocin | Sodium-Potassium-Chloride Symporters | Receptors, GABA-A | Cellular Biology | Life Sciences | Vasotocin | Indoles | Fetal Hypoxia | gamma-Aminobutyric Acid | Benzamides
Journal Article
Journal Article
Annals of Neurology, ISSN 0364-5134, 02/2008, Volume 63, Issue 2, pp. 222 - 235
Objectives High levels of expression of the Na+‐K+‐2Cl− (NKCC1) cotransporter in immature neurons cause the accumulation of intracellular chloride and,... 
K-CL COTRANSPORTER | STRUCTURES IN-VITRO | CORTICOHIPPOCAMPAL FORMATION | CATION-CHLORIDE COTRANSPORTERS | EPILEPTIFORM ACTIVITY | RAT HIPPOCAMPAL SLICE | EXCITATORY ACTIONS | ANTIEPILEPTIC DRUGS | NEUROSCIENCES | DEVELOPING BRAIN | CLINICAL NEUROLOGY | GAMMA-AMINOBUTYRIC ACID | Phenobarbital - pharmacology | Chloride Channels - drug effects | Magnesium Deficiency - physiopathology | Sodium Potassium Chloride Symporter Inhibitors - therapeutic use | Sodium Potassium Chloride Symporter Inhibitors - pharmacology | Seizures - drug therapy | Male | Hippocampus - drug effects | Sodium-Potassium-Chloride Symporters - metabolism | Anticonvulsants - pharmacology | Sodium-Potassium-Chloride Symporters - drug effects | Bumetanide - therapeutic use | Neural Inhibition - physiology | Seizures - physiopathology | Epilepsy, Benign Neonatal - drug therapy | Magnesium Deficiency - complications | Chlorides - metabolism | Receptors, GABA-A - drug effects | Ion Transport - drug effects | Drug Therapy, Combination | Hippocampus - growth & development | Organ Culture Techniques | Membrane Potentials - drug effects | Epilepsy, Benign Neonatal - physiopathology | Anticonvulsants - therapeutic use | Rats | Membrane Potentials - physiology | Rats, Sprague-Dawley | Bumetanide - pharmacology | Chloride Channels - metabolism | Drug Synergism | Patch-Clamp Techniques | Phenobarbital - therapeutic use | Animals | Solute Carrier Family 12, Member 2 | Models, Biological | Receptors, GABA-A - metabolism | Ion Transport - physiology | Hippocampus - physiopathology | Neural Inhibition - drug effects
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 01/2015, Volume 746, pp. 167 - 173
Bumetanide is increasingly being used for experimental treatment of brain disorders, including neonatal seizures, epilepsy, and autism, because the neuronal... 
Neonatal seizures | Drug transport | Cation chloride cotransporters | Epilepsy | Blood–brain barrier | Blood-brain barrier | ACID | CATION-CHLORIDE COTRANSPORTERS | RENAL TRANSPORT | MRP4 | NEONATAL SEIZURES | Epilepsy Neonatal seizures | P-GLYCOPROTEIN | DRUG TRANSPORTERS | DISEASE | RESISTANCE | PHARMACOLOGY & PHARMACY | EPILEPSY | Bumetanide - metabolism | Diuretics - pharmacokinetics | Sodium Potassium Chloride Symporter Inhibitors - pharmacology | Humans | Sodium Potassium Chloride Symporter Inhibitors - pharmacokinetics | Half-Life | Organic Anion Transporters - metabolism | Brain - metabolism | Kidney - metabolism | Organic Anion Transporters - genetics | Drug Interactions | Membrane Transport Modulators - pharmacology | Female | Animals, Outbred Strains | Biological Transport - drug effects | Neurons - metabolism | Neurons - drug effects | Diuretics - blood | Diuretics - metabolism | Recombinant Proteins - metabolism | Cell Line | Nerve Tissue Proteins - antagonists & inhibitors | Anticonvulsants - blood | Anticonvulsants - pharmacokinetics | Organic Anion Transporters - antagonists & inhibitors | Kidney - drug effects | Probenecid - pharmacology | Anticonvulsants - metabolism | Bumetanide - blood | Recombinant Proteins - chemistry | Bumetanide - pharmacokinetics | Blood-Brain Barrier - drug effects | Nerve Tissue Proteins - genetics | Bumetanide - pharmacology | Blood-Brain Barrier - metabolism | Brain - drug effects | Nerve Tissue Proteins - metabolism | Animals | Dogs | Sodium Potassium Chloride Symporter Inhibitors - metabolism | Mice | Sodium Potassium Chloride Symporter Inhibitors - blood | Diuretics | Seizures (Medicine) | Ionization | Probenecid | Protein binding | Index Medicus
Journal Article