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Biochemical Pharmacology, ISSN 0006-2952, 06/2014, Volume 89, Issue 4, pp. 464 - 476
We previously identified salicylate as a novel catalytic inhibitor of human DNA topoisomerase II (topo II; EC 5.99.1.3) that preferentially targets the alpha... 
Salicylate | Sulfasalazine | Catalytic inhibitor | Diflunisal | Topoisomerase II | DOSE ASPIRIN | ACID | MECHANISM | POISONS | CLEAVAGE | CANCER | GREEN TEA | HORMONE | DISEASE | PHARMACOLOGY & PHARMACY | DNA TOPOISOMERASES | Hydrolysis - drug effects | DNA, Neoplasm - metabolism | Doxorubicin - antagonists & inhibitors | Humans | Neoplasm Proteins - antagonists & inhibitors | Sulfasalazine - pharmacology | Neoplasm Proteins - metabolism | Sodium Salicylate - analogs & derivatives | Antigens, Neoplasm - chemistry | Sodium Salicylate - pharmacology | DNA, Neoplasm - chemistry | Salicylates - chemistry | DNA-Binding Proteins - metabolism | Salicylates - pharmacology | Sulfasalazine - chemistry | Sodium Salicylate - chemistry | MCF-7 Cells | Biocatalysis - drug effects | Adenosine Triphosphate - metabolism | Enzyme Inhibitors - chemistry | DNA Topoisomerases, Type II - chemistry | DNA, Superhelical - chemistry | Antigens, Neoplasm - metabolism | Antineoplastic Agents - pharmacology | DNA Fragmentation - drug effects | DNA, Catenated - chemistry | Molecular Conformation - drug effects | DNA Topoisomerases, Type II - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Antineoplastic Agents - antagonists & inhibitors | Diflunisal - pharmacology | Enzyme Inhibitors - pharmacology | Models, Molecular | Neoplasm Proteins - chemistry | Antineoplastic Agents - chemistry | DNA, Catenated - metabolism | DNA-Binding Proteins - chemistry | Plasmids - metabolism | Diflunisal - chemistry | DNA, Kinetoplast - chemistry | Plasmids - chemistry | DNA, Kinetoplast - metabolism | Adenosine Triphosphate - chemistry | DNA, Superhelical - metabolism | Doxorubicin - pharmacology | Index Medicus
Journal Article
Journal Article
The Journal of Supercritical Fluids, ISSN 0896-8446, 10/2016, Volume 116, pp. 62 - 69
[Display omitted] •Simulation of salicylic acid, acetylsalicylic acid, methyl salicylate, salicylamide, sodium salicylate in supercritical CO2 is... 
Salicylic acid | Sodium salicylate | Supercritical carbon dioxide | Polar cosolvent | Molecular dynamics | Salicylamide | Acetylsalicylic acid | Methyl salicylate | Hydrogen bond | BEHAVIOR | CHEMISTRY, PHYSICAL | SOLUBILITY | MIXTURES | ENGINEERING, CHEMICAL | DYNAMICS | Phenols | Esters | Aspirin | Salicylates | Hydrogen | Sodium salicylates | Solvation | Hydrogen bonds | Methyl alcohol | Carbon dioxide
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2016, Volume 11, Issue 4, p. e0153386
This study investigated the effect of systemic salicylate on central auditory and non-auditory structures in mice. Since cochlear hair cells are known to be... 
OUTER HAIR-CELLS | RESONANCE-IMAGING MEMRI | INDUCED TINNITUS | BEHAVIORAL PARADIGM | GUINEA-PIG COCHLEA | ANTI-INFLAMMATORY DRUGS | MULTIDISCIPLINARY SCIENCES | RAT INFERIOR COLLICULUS | PRIMARY AUDITORY-CORTEX | NEURAL ACTIVITY | NOISE-INDUCED HYPERACTIVITY | Amygdala - chemistry | Kanamycin - toxicity | Auditory Cortex - metabolism | Male | Salicylates - chemistry | Cochlea - metabolism | Female | Salicylates - metabolism | Hypothalamus - chemistry | Hearing Loss - chemically induced | Auditory Cortex - drug effects | Amygdala - diagnostic imaging | Hypothalamus - diagnostic imaging | Amygdala - metabolism | Hearing Loss - pathology | Manganese - chemistry | Auditory Threshold | Radiography | Magnetic Resonance Imaging | Animals | Hypothalamus - metabolism | Manganese - metabolism | Cochlea - drug effects | Hearing Loss - diagnostic imaging | Mice | Complications and side effects | Care and treatment | Kanamycin | Research | Salicylates | Health aspects | Risk factors | Hearing loss | Neuroimaging | Brain | Neurosciences | Nuclear magnetic resonance--NMR | Amygdala | Calcium | Noise | Hyperactivity | Hair cells | Otolaryngology | Hypothalamus | Medical schools | Rodents | Tinnitus | Hair | Salicylic acid | Preoptic area | Data processing | Pharmacology | Hearing impairment | Trauma | Studies | Sodium salicylate | Brain research | Hypothalamus (anterior) | Magnetic resonance imaging | Sodium | Auditory system | Cochlea | Potassium | Manganese | Nuclear magnetic resonance | NMR
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2016, Volume 11, Issue 8, pp. e0160157 - e0160157
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2016, Volume 11, Issue 11, p. e0166973
Neuropeptide Y (NPY)/Agouti-related peptide (AgRP)-expressing neurons in the hypothalamus induce feeding and decrease energy expenditure. With consumption of a... 
DIABETES-MELLITUS | TUMOR-NECROSIS-FACTOR | TARGETED DISRUPTION | ACTIVATED PROTEIN-KINASE | SODIUM-SALICYLATE | FOOD-INTAKE | MULTIDISCIPLINARY SCIENCES | ENDOPLASMIC-RETICULUM STRESS | HYPOTHALAMIC NEURONS | INDUCED INSULIN-RESISTANCE | I-KAPPA-B | Embryo, Mammalian - drug effects | Inflammation - chemically induced | Neurons - pathology | Male | Neuropeptide Y - genetics | Embryo, Mammalian - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Neuropeptide Y - metabolism | Salicylates - pharmacology | Inflammation - metabolism | Palmitates - pharmacology | Female | Neurons - metabolism | Hypothalamus - drug effects | Phosphorylation - drug effects | Neurons - drug effects | Biomarkers - metabolism | Metformin - pharmacology | Cells, Cultured | Hypothalamus - pathology | Agouti-Related Protein - metabolism | Hypoglycemic Agents - pharmacology | Gene Expression Regulation - drug effects | Tumor Necrosis Factor-alpha - pharmacology | Animals | Hypothalamus - metabolism | Embryo, Mammalian - cytology | Agouti-Related Protein - genetics | Mice | Mice, Inbred BALB C | Phosphorylation | Peptides | Gene regulation | Homeostasis | Neuropeptides | Hypothalamus | Kinases | Palmitic acid | High fat diet | Interleukin 6 | Proteins | Signal transduction | Rodents | Tumor necrosis factor-TNF | Physiology | Pretreatment | Drug dosages | Neuropeptide Y | Obesity | NF-κB protein | Salicylic acid | Adenosine | Cytokines | Neurons | Diabetes mellitus | Extracellular signal-regulated kinase | Energy expenditure | JNK protein | Inflammation | Tumor necrosis factor-α | Metabolism | Gene expression | Fatty acids | Feeding | Medicine | Sodium salicylate | Sodium | Insulin resistance | Metformin | Diabetes | Endoplasmic reticulum | Endocrinology | Apoptosis
Journal Article
eLife, ISSN 2050-084X, 05/2016, Volume 5, Issue 2016
Salicylate and acetylsalicylic acid are potent and widely used anti-inflammatory drugs. They are thought to exert their therapeutic effects through multiple... 
INDUCIBLE CYCLOOXYGENASE | ACTIVATED PROTEIN-KINASE | TRANSCRIPTIONAL COACTIVATOR P300 | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | SODIUM-SALICYLATE | G1/S TRANSITION | BIOLOGY | RANDOMIZED-TRIAL | HISTONE ACETYLTRANSFERASE | NF-KAPPA-B | TERMINAL KINASE | Leukocytes - pathology | Oncogene Proteins, Fusion - metabolism | p300-CBP Transcription Factors - antagonists & inhibitors | Humans | Structure-Activity Relationship | Leukocytes - enzymology | Salicylic Acid - chemistry | Leukemia, Myeloid, Acute - enzymology | Salicylic Acid - pharmacology | p300-CBP Transcription Factors - genetics | Enzyme Inhibitors - chemistry | HEK293 Cells | Leukemia, Myeloid, Acute - drug therapy | RUNX1 Translocation Partner 1 Protein - genetics | Antineoplastic Agents - pharmacology | RUNX1 Translocation Partner 1 Protein - metabolism | Binding, Competitive | Catalytic Domain | Core Binding Factor Alpha 2 Subunit - metabolism | Signal Transduction | Diflunisal - pharmacology | Leukemia, Myeloid, Acute - pathology | Enzyme Inhibitors - pharmacology | Gene Expression Regulation, Leukemic | Antineoplastic Agents - chemistry | Mice, SCID | Acetyl Coenzyme A - metabolism | Xenograft Model Antitumor Assays | p300-CBP Transcription Factors - metabolism | Acetylation - drug effects | Diflunisal - chemistry | Animals | Oncogene Proteins, Fusion - genetics | Cell Line, Tumor | Protein Binding | Leukocytes - drug effects | Acetyl Coenzyme A - antagonists & inhibitors | Mice | Core Binding Factor Alpha 2 Subunit - genetics | Leukemia, Myeloid, Acute - genetics | Metabolites | Salicylic acid | Health aspects | Event-related potentials | Acetylsalicylic acid | Cell fusion | Kinases | Confidence intervals | Proteins | Coenzyme A | Acetyltransferase | Acetylation | Fusion protein | Drug dosages | NF-κB protein | Medical research | Immunoglobulins | Oral administration | Inflammation | Tumor cell lines | Anti-inflammatory agents | Medicine | AML1 protein | Acids | Sodium | Lysine | Insulin resistance | Antitumor activity | Software | Cancer | Apoptosis
Journal Article
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 01/2018, Volume 119, Issue 1, pp. 850 - 860
Sodium salicylate (NaSal) is a nonsteroidal anti‐inflammatory drug. The putative mechanisms for NaSal's pharmacologic actions include the inhibition of... 
cytokine | lipopolysaccharide (LPS) | proliferation | AMP‐activated protein kinase (AMPK) | signal transducer and activator of transcription 3 (STAT3) | apoptosis | sodium salicylate (NaSal) | AMP-activated protein kinase (AMPK) | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | STAT3 | KAPPA-B | ENERGY SENSOR | NEUROBLASTOMA-CELLS | CANCER | ASPIRIN | CELL BIOLOGY | INHIBITION | UP-REGULATION | Gene Expression Regulation - drug effects | Cell Survival - drug effects | AMP-Activated Protein Kinases - metabolism | Cytokines - metabolism | Humans | THP-1 Cells | Cell Proliferation - drug effects | Enzyme Activation | Lipopolysaccharides - adverse effects | Sodium Salicylate - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Apoptosis | Protein kinases | Mitogens | Cell proliferation | Flow cytometry | Phosphorylation | Bcl-2 protein | Activation | Kinases | AMP-activated protein kinase | Western blotting | Lipopolysaccharides | Interleukin 6 | Proteins | Mitochondria | Cell growth | Proliferating cell nuclear antigen | Interleukin 1 | Oxidation | Inhibition | Enzyme-linked immunosorbent assay | NF-κB protein | Salicylic acid | AMP | Cytokines | Thromboxane A2 | Stat3 protein | Pharmacology | Inflammation | Fatty acids | Sodium salicylate | Cytometry | Signaling | Monocytes | Sodium | Annexin V
Journal Article