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1990, ISBN 9783540517122, Volume 115., 140
Book
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 06/2015, Volume 1851, Issue 6, pp. 844 - 856
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2017, Volume 12, Issue 7, p. e0180154
Ion channels regulate a variety of physiological processes and represent an important class of drug target. Among the many methods of studying ion channel... 
Cricetulus | High-Throughput Screening Assays - instrumentation | NAV1.3 Voltage-Gated Sodium Channel - genetics | NAV1.1 Voltage-Gated Sodium Channel - genetics | NAV1.5 Voltage-Gated Sodium Channel - metabolism | NAV1.1 Voltage-Gated Sodium Channel - metabolism | NAV1.4 Voltage-Gated Sodium Channel - metabolism | Kv1.3 Potassium Channel - genetics | NAV1.2 Voltage-Gated Sodium Channel - metabolism | NAV1.3 Voltage-Gated Sodium Channel - metabolism | Patch-Clamp Techniques - methods | Kv1.3 Potassium Channel - deficiency | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Sodium Channels - metabolism | NAV1.7 Voltage-Gated Sodium Channel - genetics | NAV1.5 Voltage-Gated Sodium Channel - genetics | Drug Evaluation, Preclinical | Transgenes | Potassium Channel Blockers - pharmacology | CHO Cells | High-Throughput Screening Assays - methods | Gene Expression | NAV1.4 Voltage-Gated Sodium Channel - genetics | NAV1.2 Voltage-Gated Sodium Channel - genetics | Rats | Sodium Channel Blockers - pharmacology | Membrane Potentials - physiology | Animals | T-Lymphocytes - cytology | NAV1.6 Voltage-Gated Sodium Channel - metabolism | NAV1.7 Voltage-Gated Sodium Channel - metabolism | NAV1.6 Voltage-Gated Sodium Channel - genetics | Sodium Channels - genetics | Primary Cell Culture | Patch-Clamp Techniques - instrumentation | Ion channels | Information management | Drug discovery | T cells | Modules | Electrophysiology | Patching | Lymphocytes T | Boundaries | Assaying | Channels | Step voltage | Immunology | Pain | Lymphocytes | Sodium channels (voltage-gated) | Physiology | Potassium channels (voltage-gated) | Gold | Platforms | Data points | Automation | Cloning | Pharmacology | Sodium | Antigen-presenting cells | Ligands | Mutation | Recording | Potassium
Journal Article
Frontiers in Pharmacology, ISSN 1663-9812, 2011, Volume SEP, p. 53
Voltage-gated Na+ channels (VGSCs) in mammals contain a pore-forming a subunit and one or more alpha subunits. There are five mammalian beta subunits in total:... 
Development | Excitability | channel | β Subunit | Voltage-gated Na | Adhesion | voltage-gated Na+ channel | PHARMACOLOGY & PHARMACY | beta subunit | development | excitability | adhesion | voltage-gated sodium channel
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 04/2013, Volume 20, Issue 10, pp. 1241 - 1285
Ion channel targeted drugs have always been related with either the central nervous system (CNS), the peripheral nervous system, or the cardiovascular system.... 
ASIC | TRP | Central nervous system | P2X | KCNQ | NMDA | CNS | Ion channels | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | GATED SODIUM-CHANNELS | SUBTYPE-SELECTIVE AGONIST | D-ASPARTATE RECEPTOR | ion channels | ACID-SENSING ION-CHANNEL-1 | central nervous system | GLYCINE ANTAGONIST GV150526 | TARANTULA TOXIN PSALMOTOXIN-1 | TRAUMATIC BRAIN-INJURY | ISCHEMIC CELL-DEATH | PHARMACOLOGY & PHARMACY | PERIPHERAL NEUROPATHIC PAIN | TRANSGENIC MOUSE MODEL | Ligand-Gated Ion Channels - antagonists & inhibitors | Transient Receptor Potential Channels - antagonists & inhibitors | Calcium Channels - metabolism | Humans | Calcium Channel Blockers - therapeutic use | Potassium Channel Blockers - therapeutic use | Sodium Channel Blockers - pharmacology | Calcium Channel Blockers - pharmacology | Ion Channels - antagonists & inhibitors | Potassium Channels - metabolism | Animals | Ion Channels - metabolism | Sodium Channels - chemistry | Calcium Channels - chemistry | Central Nervous System Diseases - drug therapy | Sodium Channels - metabolism | Calcium Channel Blockers - chemistry | Sodium Channel Blockers - therapeutic use | Potassium Channels - chemistry | Sodium Channel Blockers - chemistry | Transient Receptor Potential Channels - metabolism | Ligand-Gated Ion Channels - metabolism | Potassium Channel Blockers - chemistry | Potassium Channel Blockers - pharmacology
Journal Article
Journal Article
Circulation Research, ISSN 0009-7330, 06/2015, Volume 116, Issue 12, pp. 1971 - 1988
The movement of ions across specific channels embedded on the membrane of individual cardiomyocytes is crucial for the generation and propagation of the... 
arrhythmias, cardiac | death, sudden, cardiac | multiprotein complexes | ion channels | RECTIFIER POTASSIUM CHANNELS | LATE SODIUM CURRENT | CARDIAC & CARDIOVASCULAR SYSTEMS | FUNCTIONAL INTERACTION | death | CA2+ CHANNELS | BETA-SUBUNITS | LONG-QT SYNDROME | BRUGADA-SYNDROME | TRANSIENT OUTWARD CURRENT | arrhythmias | ANCHORING PROTEIN SAP97 | sudden | K-ATP CHANNEL | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | cardiac | Protein Subunits | KATP Channels - physiology | Channelopathies - complications | Channelopathies - physiopathology | Humans | Ion Channels - drug effects | Death, Sudden, Cardiac - etiology | Ion Channels - physiology | Potassium Channels, Inwardly Rectifying - chemistry | Arrhythmias, Cardiac - physiopathology | Cell Compartmentation | Ion Channel Gating - physiology | Macromolecular Substances - chemistry | Membrane Proteins - physiology | KATP Channels - chemistry | Ion Channels - chemistry | Arrhythmias, Cardiac - genetics | Calcium Channels, L-Type - chemistry | Disease Models, Animal | Calcium Channels, L-Type - physiology | Arrhythmias, Cardiac - etiology | NAV1.5 Voltage-Gated Sodium Channel - physiology | Protein Interaction Mapping | Channelopathies - genetics | Animals | Heart Conduction System - physiopathology | Potassium Channels, Inwardly Rectifying - physiology | Mice | NAV1.5 Voltage-Gated Sodium Channel - chemistry | Ion Channel Gating - drug effects | Ion channels | genetics | sudden cardiac death
Journal Article