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humans (254) 254
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hydrogen-ion concentration (135) 135
physiology (123) 123
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bicarbonates - metabolism (109) 109
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intracellular ph (76) 76
biochemistry & molecular biology (72) 72
molecular sequence data (72) 72
sodium-bicarbonate symporters (72) 72
cell biology (67) 67
carrier proteins - genetics (62) 62
gene expression (60) 60
proteins (60) 60
bicarbonate (58) 58
rna, messenger - metabolism (58) 58
sodium-bicarbonate cotransporter (58) 58
sodium-bicarbonate symporters - chemistry (56) 56
sodium-bicarbonate symporters - physiology (56) 56
amino acid sequence (54) 54
kidney - metabolism (54) 54
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sodium-hydrogen exchangers - metabolism (50) 50
xenopus laevis (50) 50
sodium-hydrogen exchangers - genetics (49) 49
carbonates (48) 48
cells (48) 48
cells, cultured (47) 47
cloning (47) 47
urology & nephrology (47) 47
cloning, molecular (46) 46
mice, knockout (45) 45
mutation (45) 45
renal tubular-acidosis (45) 45
tissue distribution (45) 45
carrier proteins - metabolism (44) 44
reverse transcriptase polymerase chain reaction (41) 41
cell membrane - metabolism (40) 40
functional-characterization (40) 40
immunohistochemistry (40) 40
mice, inbred c57bl (40) 40
transport (40) 40
rna, messenger - genetics (39) 39
sodium (39) 39
cotransporter (38) 38
article (36) 36
4,4'-diisothiocyanostilbene-2,2'-disulfonic acid - pharmacology (35) 35
na+-hco3-cotransporter (35) 35
neurosciences (35) 35
intracellular ph regulation (34) 34
proximal tubule (34) 34
kidney (33) 33
kidney tubules, proximal - metabolism (33) 33
acidosis, renal tubular - genetics (32) 32
rodents (32) 32
physiological aspects (31) 31
sodium-bicarbonate symporters - antagonists & inhibitors (31) 31
xenopus (31) 31
functional expression (30) 30
gene expression regulation (30) 30
oocytes - metabolism (30) 30
rat-kidney (30) 30
research (30) 30
sodium bicarbonate (30) 30
ion transport (29) 29
transfection (29) 29
blotting, western (28) 28
rats, wistar (28) 28
hco (27) 27
ocular abnormalities (27) 27
electrogenic na+-hco3-cotransporter (26) 26
localization (26) 26
patch-clamp techniques (26) 26
transporters (26) 26
biological transport (25) 25
na+/hco3-cotransporter (25) 25
protein isoforms - genetics (25) 25
sodium-hydrogen exchanger 3 (25) 25
rats, sprague-dawley (24) 24
acidosis (23) 23
adult (23) 23
electrophysiology (23) 23
genetics & heredity (23) 23
sequence homology, amino acid (23) 23
base sequence (22) 22
carbonic-anhydrase (22) 22
chloride-bicarbonate antiporters - metabolism (22) 22
hypertension (22) 22
multidisciplinary sciences (22) 22
research article (22) 22
acidosis, renal tubular - metabolism (21) 21
bicarbonate transport (21) 21
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Journal of Clinical Investigation, ISSN 0021-9738, 07/2011, Volume 121, Issue 7, pp. 2845 - 2854
In addition to its role as an essential neurotransmitter, dopamine serves important physiologic functions in organs such as the kidney. Although the kidney... 
RENAL PROXIMAL TUBULE | CROSS-TALK | MEDICINE, RESEARCH & EXPERIMENTAL | ANGIOTENSIN-II TYPE-1 | SALT SENSITIVITY | RAT NEPHRON | AMINO-ACID TRANSPORTERS | RECEPTORS | CORTICAL CYCLOOXYGENASE-2 EXPRESSION | BLOOD-PRESSURE | MACULA DENSA | Renin - metabolism | Receptors, Drug - genetics | Sodium-Bicarbonate Symporters - genetics | Sodium-Potassium-Chloride Symporters - metabolism | Sodium-Hydrogen Exchangers - metabolism | Dopamine - deficiency | Dopamine - urine | Aldosterone - metabolism | Kidney - metabolism | Cyclooxygenase 2 - genetics | Sodium-Hydrogen Exchangers - genetics | Aromatic-L-Amino-Acid Decarboxylases - metabolism | Kidney Tubules, Proximal - enzymology | Kidney - physiopathology | Sodium-Potassium-Chloride Symporters - genetics | Kidney - anatomy & histology | Hypertension - physiopathology | Receptors, Drug - metabolism | Sodium-Bicarbonate Symporters - metabolism | Symporters - metabolism | Mice, Knockout | Aquaporin 2 - metabolism | Solute Carrier Family 12, Member 1 | Animals | Solute Carrier Family 12, Member 3 | Symporters - genetics | Cyclooxygenase 2 - metabolism | Mice | Aquaporin 2 - genetics | Longevity - physiology | Aromatic-L-Amino-Acid Decarboxylases - genetics | Sodium-Hydrogen Exchanger 3 | Hypertension | Physiological aspects | Dopamine | Research | Risk factors | Decarboxylases | Index Medicus | Abridged Index Medicus
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 02/2015, Volume 24, Issue 3, pp. 865 - 874
Journal Article
by Antoniou, Antonis C and Beesley, Jonathan and McGuffog, Lesley and Sinilnikova, Olga M and Healey, Sue and Neuhausen, Susan L and Ding, Yuan Chun and Rebbeck, Timothy R and Weitzel, Jeffrey N and Lynch, Henry T and Isaacs, Claudine and Ganz, Patricia A and Tomlinson, Gail and Olopade, Olufunmilayo I and Couch, Fergus J and Wang, Xianshu and Lindor, Noralane M and Pankratz, Vernon S and Radice, Paolo and Manoukian, Siranoush and Peissel, Bernard and Zaffaroni, Daniela and Barile, Monica and Viel, Alessana and Allavena, Anna and Dall'olio, Valentina and Peterlongo, Paolo and Szabo, Csilla I and Zikan, Michal and Claes, Kathleen and Poppe, Bruce and Foretova, Lenka and Mai, Phuong L and Greene, Mark H and Rennert, Gad and Lejbkowicz, Flavio and Glendon, Gord and Ozcelik, Hilmi and Anulis, Irene L and Thomassen, Mads and Gerdes, Anne-Marie and Sunde, Lone and Cruger, Dorthe and Birk Jensen, Uffe and Caligo, Maria and Friedman, Eitan and Kaufman, Bella and Laitman, Yael and Milgrom, Roni and Dubrovsky, Maya and Cohen, Shimrit and Borg, Ake and Jernström, Helena and Lindblom, Annika and Rantala, Johanna and Stenmark-Askmalm, Marie and Melin, Beatrice and Nathanson, Kate and Domchek, Susan and Jakubowska, Ania and Lubinski, Jan and Huzarski, Tomasz and Osorio, Ana and Lasa, Aiana and Durán, Mercedes and Tejada, Maria-Isabel and Godino, Javier and Benitez, Javier and Hamann, Ute and Kriege, Mieke and Hoogerbrugge, Nicoline and Luijt, Rob B. van der and Asperen, Christi J. van and Devilee, Peter and Meijers-Heijboer, E. J and Blok, Marinus J and Aalfs, Cora M and Hogervorst, Frans and Rookus, Matti and Cook, Margaret and Oliver, Clare and Frost, Debra and Conroy, Don and Evans, D. Gareth and Lalloo, Fiona and Pichert, Gabriella and Davidson, Rosemarie and Cole, Trevor and Cook, Jackie and Paterson, Joan and Hodgson, Shirley and Morrison, Patrick J and Porteous, Mary E and Walker, Lisa and Kennedy, M. John and Dorkins, Huw and Peock, Susan and Godwin, Anew K and Stoppa-Lyonnet, Dominique and Pauw, Antoine de and ... and Ontario Canc Genetics Network and EMBRACE and CIMBA and GEMO and HEBON and Breast Canc Family Registry and kConFab and SWE-BRCA and Ontario Cancer Genetics Network and Breast Cancer Family Registry and for kConFab and for EMBRACE and for HEBON and for SWE-BRCA and for GEMO and on behalf of CIMBA and for the Ontario Cancer Genetics Network and for the Breast Cancer Family Registry
Cancer research, ISSN 0008-5472, 2010, Volume 70, Issue 23, pp. 9742 - 9754
The known breast cancer susceptibility polymorphisms in FGFR2, TNRC9/TOX3, MAP3K1, LSP1, and 2q35 confer increased risks of breast cancer for BRCA1 or BRCA2... 
LOCI | VARIANTS | ONCOLOGY | ESTROGEN-RECEPTOR | GENOME-WIDE ASSOCIATION | Genetic Predisposition to Disease - genetics | Risk Assessment | Humans | Middle Aged | Risk Factors | Sodium-Bicarbonate Symporters - genetics | Vesicular Transport Proteins - genetics | Genotype | Receptors, Progesterone - genetics | BRCA1 Protein - genetics | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Alleles | Survival Analysis | Aged, 80 and over | Adult | Female | Heterozygote | Aged | Polymorphism, Single Nucleotide | Mutation | BRCA2 Protein - genetics | Index Medicus | genetic counseling | genome-wide association study | penetrance | common variant | BRCA1 | BRCA2 | genetic modifier | risk assessment | Medical and Health Sciences | Medicin och hälsovetenskap | single nucleotide polymorphism | major clinical study | attributable risk | Klinisk medicin | clinical evaluation | heterozygote | Breast Neoplasms | Single Nucleotide | follow up | 80 and over | Receptors | priority journal | female | human | tumor suppressor gene | Vesicular Transport Proteins | BRCA2 protein | Genetic Predisposition to Disease | cancer susceptibility | BRCA1 protein | gene mutation | probability | aged | breast cancer | article | gene frequency | genotype | Clinical Medicine | controlled study | cancer risk | Progesterone | Cancer and Oncology | adult | Sodium-Bicarbonate Symporters | Cancer och onkologi | Polymorphism
Journal Article
CIRCULATION, ISSN 0009-7322, 10/2011, Volume 124, Issue 17, pp. 1819 - U119
Background-Disturbances in pH affect artery function, but the mechanistic background remains controversial. We investigated whether Na+, HCO3- cotransporter... 
blood pressure | nitric oxide | CARDIAC & CARDIOVASCULAR SYSTEMS | NITRIC-OXIDE SYNTHASE | PROTEIN-KINASE | INTRACELLULAR PH | ANGIOTENSIN-II | KNOCKOUT MICE | BLOOD-PRESSURE | HYPOTENSION PREDICTS MORTALITY | ENDOTHELIAL-CELLS | DISEASE | rho-kinase | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | hypertension | Mesenteric Arteries - physiology | Sodium-Bicarbonate Symporters - genetics | Endothelium, Vascular - drug effects | Mesenteric Arteries - drug effects | Muscle, Smooth, Vascular - physiopathology | Endothelium, Vascular - physiology | Calcium - physiology | Hypertension - prevention & control | Sodium-Hydrogen Exchangers - genetics | Hypertension - genetics | Vasodilation - physiology | Sodium-Bicarbonate Symporters - biosynthesis | Organ Culture Techniques | Sodium-Hydrogen Exchangers - antagonists & inhibitors | Muscle, Smooth, Vascular - drug effects | Nitric Oxide - antagonists & inhibitors | Mice, Inbred C57BL | Sodium-Bicarbonate Symporters - deficiency | Nitric Oxide - physiology | Mesenteric Arteries - metabolism | Hypertension - metabolism | Mice, Knockout | Animals | Endothelium, Vascular - metabolism | Sodium-Hydrogen Exchangers - biosynthesis | Mice | Vasodilation - drug effects | Calcium Signaling - genetics | Hypertension | Measurement | Nitric oxide | Ion transport | Development and progression | Blood pressure | Regulation | Research | Hydrogen-ion concentration | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 10/2016, Volume 36, Issue 42, pp. 10750 - 10758
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2012, Volume 287, Issue 5, pp. 3392 - 3402
Journal Article
Cardiovascular Research, ISSN 0008-6363, 08/2016, Volume 111, Issue 3, pp. 227 - 239
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 13, pp. 3744 - 3755
Journal Article
Cancer Letters, ISSN 0304-3835, 04/2012, Volume 317, Issue 2, pp. 172 - 183
We and others have shown central roles of the Na /H exchanger NHE1 in cell motility. The aim of this study was to determine the roles of NHE1 and of the Na ,... 
Signaling | Cytoskeleton | Motility | pH-regulation | HER2 | Adhesion | PH-regulation | MIGRATION | PH NANOENVIRONMENT | ACTIVATION | ERM PROTEINS | PHOSPHORYLATION | INTEGRIN | MEMBRANE | SURFACE PH | ONCOLOGY | MELANOMA-CELLS | Phosphorylation | Receptor, ErbB-2 - genetics | Sodium-Bicarbonate Symporters - antagonists & inhibitors | Humans | Sodium-Bicarbonate Symporters - genetics | Receptor, ErbB-2 - metabolism | Amiloride - analogs & derivatives | Immunoblotting | Phosphatidylinositol 3-Kinases - metabolism | Cell Movement - genetics | Cell Movement - physiology | Breast Neoplasms - metabolism | Sodium-Hydrogen Exchangers - metabolism | Cation Transport Proteins - metabolism | Cation Transport Proteins - genetics | Cytoskeletal Proteins - metabolism | Female | Sodium-Hydrogen Exchangers - genetics | Benzamides - pharmacology | Membrane Proteins - metabolism | Microfilament Proteins - metabolism | Chromones - pharmacology | Culture Media, Serum-Free - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Cell Adhesion - genetics | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Cell Adhesion - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Sulfonamides - pharmacology | Sodium-Bicarbonate Symporters - metabolism | Integrin beta1 - metabolism | Cell Movement - drug effects | Breast Neoplasms - genetics | Signal Transduction - drug effects | Breast Neoplasms - pathology | Cell Adhesion - physiology | Amiloride - pharmacology | Cell Line, Tumor | Sodium-Hydrogen Exchanger 1 | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Hydrogen-Ion Concentration | Proteins | Studies | Medical prognosis | Collagen | Acidification | Breast cancer | Kinases | Cell adhesion & migration | Tumors | Index Medicus
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 04/2012, Volume 227, Issue 4, pp. 1776 - 1785
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2012, Volume 7, Issue 3, pp. e32907 - e32907
Hypertension is a complex disorder with high prevalence rates all over the world. We conducted the first genome-wide gene-based association scan for... 
GLUCOSE-HOMEOSTASIS | FACTOR-I GENE | MULTIDISCIPLINARY SCIENCES | GROWTH | PROMOTER REGION | TUMOR-SUPPRESSOR | MICE | POLYMORPHISM | LINKAGE | LOCUS | BLOOD-PRESSURE | Genetic Predisposition to Disease - genetics | Oligonucleotide Array Sequence Analysis | Oxidoreductases - genetics | Gene Frequency | Humans | Sodium-Bicarbonate Symporters - genetics | Asian Continental Ancestry Group - genetics | Repressor Proteins - genetics | Genotype | Logistic Models | Gene Expression Profiling | Insulin-Like Growth Factor I - genetics | Case-Control Studies | WW Domain-Containing Oxidoreductase | China | Hypertension - ethnology | Tumor Suppressor Proteins - genetics | Polymorphism, Single Nucleotide | Hypertension - genetics | Genome-Wide Association Study - methods | Quantitative genetics | Hypertension | Genes | Analysis | Genomics | Development and progression | Disease susceptibility | Genetic aspects | Genomes | Gene expression | Genetic polymorphisms | Health care | Biometrics | Populations | Laboratories | Insulin-like growth factor I | Body weight | Science | Homeostasis | Association analysis | Population studies | Cardiovascular disease | Epidemiology | Bicarbonate | Etiology | Sodium bicarbonate | Genetics | Population | Blood pressure | Carbonates | Cardiology | Bioinformatics | Public health | Permutations | Internal medicine | Mortality | Principal components analysis | Data processing | Preventive medicine | Hypoglycemia | Insulin | Patients | Quantitative trait loci | Studies | Hospitals | Sodium | Body size | Hyperphosphatemia | Mice | Adults | Psychiatry | Metabolic disorders | Polymorphism | Index Medicus
Journal Article