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Planta Medica, ISSN 0032-0943, 08/2017, Volume 83, Issue 12/13, pp. 985 - 993
Journal Article
PloS one, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, pp. e54442 - e54442
Sodium/glucose cotransporter 2 (SGLT2) inhibitors are oral hypoglycemic agents used to treat patients with diabetes mellitus... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Diabetes Mellitus - pathology | Epithelial Cells - metabolism | Gene Expression - drug effects | Diabetes Mellitus - genetics | Transcription Factor AP-1 - genetics | Epithelial Cells - drug effects | Humans | Diabetic Nephropathies - drug therapy | NF-kappa B - metabolism | Smad3 Protein - metabolism | Transcription Factor AP-1 - metabolism | Sodium-Glucose Transporter 1 - genetics | Smad3 Protein - genetics | Sodium-Glucose Transporter 1 - metabolism | Phosphorylation - drug effects | Interleukin-6 - metabolism | Transforming Growth Factor beta1 - pharmacology | Sodium-Glucose Transporter 2 - genetics | Collagen Type IV - metabolism | Sodium-Glucose Transporter 1 - antagonists & inhibitors | Promoter Regions, Genetic | Diabetic Nephropathies - pathology | Glucosides - pharmacology | Kidney Tubules, Proximal - pathology | Interleukin-6 - genetics | Sodium-Glucose Transporter 2 - metabolism | Diabetic Nephropathies - metabolism | Diabetes Mellitus - drug therapy | Diabetes Mellitus - metabolism | Toll-Like Receptor 4 - genetics | Diabetic Nephropathies - genetics | Epithelial Cells - pathology | Glucose - pharmacology | Toll-Like Receptor 4 - metabolism | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Hypoglycemic Agents - pharmacology | NF-kappa B - genetics | Kidney Tubules, Proximal - metabolism | Collagen Type IV - genetics | Protein Binding | Benzhydryl Compounds - pharmacology | Kidney Tubules, Proximal - drug effects | Physiological aspects | Care and treatment | Genetic aspects | Research | Transforming growth factors | Diabetic nephropathies | Chromatin | Immunoprecipitation | Transforming growth factor-b | Interleukin | Clinical trials | Systematic review | Smad3 protein | Glucose | Kinases | Interleukin 6 | Proteins | Hyperglycemia | Rodents | Toll-like receptors | Collagen (type IV) | Hypoglycemic agents | Inhibition | Growth factors | Deoxyribonucleic acid--DNA | Immune system | Binding | Glucose transporter | Medical research | NF-κB protein | Diabetes mellitus | Markers | Activator protein 1 | Blocking | Reabsorption | Inflammation | Gene expression | Glucose transport | Medicine | High mobility group proteins | Hospitals | Inhibitors | Nephropathy | Sodium | Fibrosis | Kidney diseases | Diabetes | Transporter | Adenosine triphosphatase | Kidney transplantation | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Journal Article
Clinical pharmacokinetics, ISSN 0312-5963, 01/2014, Volume 53, Issue 1, pp. 17 - 27
Sodium-glucose co-transporter 2 (SGLT2) is predominantly expressed in the S1 segment of the proximal tubule of the kidney and is the major transporter responsible for mediating renal glucose reabsorption... 
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Glucosides - pharmacology | Hypoglycemic Agents - pharmacokinetics | Animals | Drug Interactions | Benzhydryl Compounds | Humans | Glucosides - pharmacokinetics | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Hypoglycemic Agents - pharmacology
Journal Article
Journal of the American Society of Hypertension, ISSN 1933-1711, 04/2014, Volume 8, Issue 4, pp. 262 - 275.e9
Abstract Sodium-glucose co-transporter 2 (SGLT2) inhibitors represent a new class of antihyperglycemic agents that block renal sodium and glucose reabsorption and may reduce blood pressure (BP... 
Cardiovascular | meta-analysis | blood pressure | diabetes mellitus | SGLT2 inhibitors | Hypoglycemic Agents - therapeutic use | Hypertension - drug therapy | Blood Pressure - drug effects | Humans | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Index Medicus
Journal Article
Diabetes & vascular disease research, ISSN 1752-8984, 02/2015, Volume 12, Issue 2, pp. 101 - 110
The sodium-dependent glucose transporter 2 (SGLT2) inhibitors are an important emerging class for the treatment of diabetes... 
sotagliflozin | type 1 | glucagon-like peptide 1 | sodium-glucose transporter 2 | diabetes mellitus | LX4211 | sodium-glucose transporter 1 | diabetes mellitus type 2 | Endocrinology & Metabolism | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Humans | Molecular Targeted Therapy | Renal Reabsorption - drug effects | Sodium-Glucose Transporter 1 - metabolism | Hypoglycemic Agents - therapeutic use | Kidney Tubules, Proximal - physiopathology | Sodium-Glucose Transporter 1 - antagonists & inhibitors | Sodium-Glucose Transporter 2 - metabolism | Diabetes Mellitus, Type 1 - physiopathology | Renal Elimination - drug effects | Treatment Outcome | Clinical Trials as Topic | Drug Discovery | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Diabetes Mellitus, Type 1 - drug therapy | Blood Glucose - drug effects | Diabetes Mellitus, Type 1 - diagnosis | Diabetes Mellitus, Type 2 - diagnosis | Diabetes Mellitus, Type 2 - blood | Animals | Diabetes Mellitus, Type 2 - physiopathology | Diabetes Mellitus, Type 1 - blood | Kidney Tubules, Proximal - metabolism | Glycosides - adverse effects | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Hypoglycemic Agents - adverse effects | Glycosides - therapeutic use | Kidney Tubules, Proximal - drug effects | Index Medicus
Journal Article
American journal of physiology. Renal physiology, ISSN 1522-1466, 09/2017, Volume 313, Issue 3, pp. F826 - F834
.... In the membrane fraction of the kidney, the expression of urate transporter 1 (URAT1) was significantly decreased, whereas that of ATP-binding cassette subfamily G member 2 (ABCG2... 
Hyperinsulinemia | Urate transporters | Hypouricosuria | Kidney proximal tubule | Physiology | Life Sciences & Biomedicine | Urology & Nephrology | Science & Technology | Kidney Tubules - physiopathology | Diabetes Mellitus, Experimental - drug therapy | Streptozocin | Diabetes Mellitus, Type 1 - metabolism | Male | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - metabolism | Uric Acid - urine | Renal Reabsorption - drug effects | Time Factors | Diabetes Mellitus, Type 1 - chemically induced | Diabetes Mellitus, Experimental - chemically induced | Diabetes Mellitus, Experimental - metabolism | Kidney Tubules - metabolism | Diabetes Mellitus, Experimental - physiopathology | Cell Line | Insulin - pharmacology | Glucosides - pharmacology | Uric Acid - metabolism | Kidney Tubules - drug effects | Sodium-Glucose Transporter 2 - metabolism | Diabetes Mellitus, Type 1 - physiopathology | Thiophenes - pharmacology | Renal Elimination - drug effects | Anion Transport Proteins - metabolism | Rats, Sprague-Dawley | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Diabetes Mellitus, Type 1 - drug therapy | Hypoglycemic Agents - pharmacology | Blood Glucose - drug effects | Animals | Blood Glucose - metabolism | Carrier proteins | Physiological aspects | Physiological research | Uric acid | Research | G proteins | Insulin | Absorption (Physiology) | Index Medicus
Journal Article