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Diabetes, Obesity and Metabolism, ISSN 1462-8902, 09/2017, Volume 19, Issue 9, pp. 1289 - 1294
Aim To quantify the expression of sodium‐glucose co‐transporter (SGLT)2 and SGLT1, their cognate basolateral transporters, GLUT2 and GLUT1, and the... 
clinical physiology | SGLT2 inhibitor | type 2 diabetes | RAT | TRANSPORTERS | ALBUMINURIA | PROXIMAL TUBULAR CELLS | GLOMERULAR HYPERFILTRATION | NEPHROPATHY | HYPERGLYCEMIA | PROTEIN EXPRESSION | ENDOCRINOLOGY & METABOLISM | BRUSH-BORDER MEMBRANE | KIDNEY | Kidney Tubules - physiopathology | Kidney - pathology | Humans | Middle Aged | Male | Diabetes Mellitus, Type 2 - metabolism | Sodium-Glucose Transporter 1 - genetics | Kidney Neoplasms - surgery | Kidney - metabolism | Carcinoma - complications | Kidney Neoplasms - physiopathology | Nephrectomy | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Female | Retrospective Studies | Sodium-Glucose Transporter 1 - metabolism | Kidney Tubules - pathology | Carcinoma - pathology | Kidney Neoplasms - complications | Kidney Tubules - metabolism | Diabetes Mellitus, Type 2 - complications | Kidney - physiopathology | Sodium-Glucose Transporter 2 - genetics | Hypoglycemic Agents - therapeutic use | Reproducibility of Results | Glomerular Filtration Rate | Kidney - drug effects | Kidney Tubules - drug effects | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Sodium-Glucose Transporter 2 - metabolism | Carcinoma - surgery | Carcinoma - physiopathology | Gene Expression Regulation - drug effects | Kidney Neoplasms - pathology | Aged | Diabetes Mellitus, Type 2 - pathology | Diabetes Mellitus, Type 2 - drug therapy | Neoplasm Staging | Type 2 diabetes | Immunohistochemistry | Viral antibodies | Care and treatment | Antibodies | Glucose | Muscle proteins | Dextrose | Diabetes
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, p. e54442
Sodium/glucose cotransporter 2 (SGLT2) inhibitors are oral hypoglycemic agents used to treat patients with diabetes mellitus. SGLT2 inhibitors block... 
MATRIX | STIMULATION | MULTIDISCIPLINARY SCIENCES | DISEASE | HIGH GLUCOSE | GENE-EXPRESSION | PPAR-GAMMA AGONISTS | TRANSFORMING GROWTH FACTOR-BETA | Diabetes Mellitus - pathology | Epithelial Cells - metabolism | Gene Expression - drug effects | Diabetes Mellitus - genetics | Transcription Factor AP-1 - genetics | Epithelial Cells - drug effects | Humans | Diabetic Nephropathies - drug therapy | NF-kappa B - metabolism | Smad3 Protein - metabolism | Transcription Factor AP-1 - metabolism | Sodium-Glucose Transporter 1 - genetics | Smad3 Protein - genetics | Sodium-Glucose Transporter 1 - metabolism | Phosphorylation - drug effects | Interleukin-6 - metabolism | Transforming Growth Factor beta1 - pharmacology | Sodium-Glucose Transporter 2 - genetics | Collagen Type IV - metabolism | Sodium-Glucose Transporter 1 - antagonists & inhibitors | Promoter Regions, Genetic | Diabetic Nephropathies - pathology | Glucosides - pharmacology | Kidney Tubules, Proximal - pathology | Interleukin-6 - genetics | Sodium-Glucose Transporter 2 - metabolism | Diabetic Nephropathies - metabolism | Diabetes Mellitus - drug therapy | Diabetes Mellitus - metabolism | Toll-Like Receptor 4 - genetics | Diabetic Nephropathies - genetics | Epithelial Cells - pathology | Glucose - pharmacology | Toll-Like Receptor 4 - metabolism | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Hypoglycemic Agents - pharmacology | NF-kappa B - genetics | Kidney Tubules, Proximal - metabolism | Collagen Type IV - genetics | Protein Binding | Benzhydryl Compounds - pharmacology | Kidney Tubules, Proximal - drug effects | Physiological aspects | Care and treatment | Genetic aspects | Research | Transforming growth factors | Diabetic nephropathies | Chromatin | Immunoprecipitation | Transforming growth factor-b | Interleukin | Clinical trials | Systematic review | Smad3 protein | Glucose | Kinases | Interleukin 6 | Proteins | Hyperglycemia | Rodents | Toll-like receptors | Collagen (type IV) | Hypoglycemic agents | Inhibition | Growth factors | Deoxyribonucleic acid--DNA | Immune system | Binding | Glucose transporter | Medical research | NF-κB protein | Secretion | Diabetes mellitus | Markers | Activator protein 1 | Blocking | Reabsorption | Inflammation | Gene expression | Glucose transport | Medicine | High mobility group proteins | Hospitals | Inhibitors | Nephropathy | Sodium | Fibrosis | Kidney diseases | Diabetes | Transporter | Adenosine triphosphatase | Kidney transplantation | Deoxyribonucleic acid | DNA
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 01/2013, Volume 304, Issue 2, pp. F156 - F157
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2012, Volume 7, Issue 2, p. e30555
Background: Canagliflozin is a sodium glucose co-transporter (SGLT) 2 inhibitor in clinical development for the treatment of type 2 diabetes mellitus (T2DM).... 
SELECTIVE SGLT2 INHIBITOR | SODIUM | HOMEOSTASIS | HYPERGLYCEMIA | DAPAGLIFLOZIN | TRANSPORTERS | MULTIDISCIPLINARY SCIENCES | INSULIN-SECRETION | COTRANSPORTER | PROXIMAL TUBULAR CELLS | T-1095 | Thiophenes - therapeutic use | Diabetes Mellitus, Experimental - drug therapy | Humans | Body Weight - drug effects | Male | Muscle, Skeletal - metabolism | Muscle, Skeletal - cytology | Hyperglycemia - drug therapy | Sodium-Glucose Transporter 1 - genetics | Muscle, Skeletal - drug effects | Hyperglycemia - pathology | Sodium-Glucose Transport Proteins - metabolism | Glucosides - therapeutic use | Weight Gain - drug effects | Sodium-Glucose Transporter 1 - metabolism | Diabetes Mellitus, Experimental - metabolism | Kidney - physiopathology | Sodium-Glucose Transport Proteins - genetics | CHO Cells | Sodium-Glucose Transporter 2 - genetics | Cricetinae | Glucose Tolerance Test | Kidney - drug effects | Sodium-Glucose Transporter 2 - metabolism | Mice, Inbred C57BL | Cells, Cultured | Rats | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Hyperglycemia - metabolism | Rats, Zucker | Animals | Canagliflozin | Diabetes Mellitus, Experimental - pathology | Mice, Obese | Mice | Blood Glucose - metabolism | Type 2 diabetes | Glucose metabolism | Obesity | Blood sugar | Analysis | Body weight | Glycosylated hemoglobin | Diabetes therapy | Cell culture | Animal models | Renal function | Laboratories | Liver | Homeostasis | Fuel consumption | Diabetic neuropathy | Glucose | Oocytes | Hyperglycemia | Rodents | Hemoglobin | Glucose transporter | Excretion | Kidneys | Secretion | Research & development--R&D | Diabetes mellitus | Pharmacology | Insulin | Body weight gain | Myoblasts | Beta cells | Sodium | Weight reduction | Insulin resistance | Diabetes | Mutation | Transporter | Kidney transplantation | Pharmaceuticals | Research & development | R&D
Journal Article
Veterinary Microbiology, ISSN 0378-1135, 08/2014, Volume 172, Issue 1-2, pp. 195 - 201
The gastrointestinal tract represents the first barrier against pathogens. However, the interaction of with intestinal epithelial cells and its effects on the... 
Peptide transporter | Amino acid transporter | Chicken | Monosaccharide transporter | Campylobacter jejuni | CELLS | BROILER-CHICKENS | MICROBIOLOGY | GLUCOSE-TRANSPORT | COLONIZATION | IN-VITRO | EPITHELIUM | AMINO-ACIDS | GROWTH | VETERINARY SCIENCES | LAYING HENS | INFECTION | Glucose Transporter Type 2 - genetics | Body Weight | Campylobacter Infections - veterinary | Campylobacter Infections - metabolism | Cationic Amino Acid Transporter 2 - metabolism | Campylobacter jejuni - physiology | Cecum - microbiology | RNA, Messenger - metabolism | Poultry Diseases - metabolism | Glucose Transporter Type 2 - metabolism | Sodium-Glucose Transporter 1 - genetics | Jejunum - metabolism | Duodenum - microbiology | Cecum - metabolism | Duodenum - metabolism | Sodium-Glucose Transporter 1 - metabolism | Poultry Diseases - genetics | Specific Pathogen-Free Organisms | Peptide Transporter 1 | RNA, Messenger - genetics | Gene Expression Regulation | Jejunum - microbiology | Chickens - microbiology | Campylobacter Infections - genetics | Excitatory Amino Acid Transporter 3 - genetics | Campylobacter Infections - microbiology | Cationic Amino Acid Transporter 2 - genetics | Symporters - metabolism | Host-Pathogen Interactions | Animals | Excitatory Amino Acid Transporter 3 - metabolism | Symporters - genetics | Poultry Diseases - microbiology | Glucose | Bacterial genetics | Genes | Dextrose | Public health
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 01/2014, Volume 306, Issue 2, pp. F188 - F193
Journal Article
Clinical Journal of the American Society of Nephrology, ISSN 1555-9041, 01/2010, Volume 5, Issue 1, pp. 133 - 141
Journal Article
Diabetologia, ISSN 0012-186X, 10/2018, Volume 61, Issue 10, pp. 2087 - 2097
The concentration of glucose in plasma is held within narrow limits (4–10 mmol/l), primarily to ensure fuel supply to the brain. Kidneys play a role in glucose... 
GLUTs | Human Physiology | SGLTs | Metabolic Diseases | Internal Medicine | Glucose | Review | Type 2 diabetes mellitus | Gliflozins | Kidney | Proximal tubule | Phlorizin | Inhibitors | Medicine & Public Health | SODIUM | FANCONI-BICKEL-SYNDROME | LOW-AFFINITY | NA+/GLUCOSE COTRANSPORTER SGLT2 | TRANSPORT | THERAPEUTIC TARGET | ENDOCRINOLOGY & METABOLISM | PHLORHIZIN | EXPRESSION | BINDING | Glucose Transporter Type 2 - genetics | Humans | Sodium-Glucose Transporter 2 Inhibitors - pharmacology | Homeostasis | Diabetes Mellitus, Type 2 - metabolism | Sodium-Glucose Transporter 1 - physiology | Sodium-Glucose Transporter 1 - genetics | Glycosuria - metabolism | Hypoglycemic Agents - pharmacology | Mice, Knockout | Sodium-Glucose Transporter 2 - physiology | Kidney - metabolism | Animals | Glucose Transporter Type 2 - physiology | Drug Design | HEK293 Cells | Kidney Tubules, Proximal - metabolism | Glucose - metabolism | Mice | Blood Glucose - metabolism | Kidney Tubules - metabolism | Phlorhizin - pharmacology | Sodium-Glucose Transporter 2 - genetics | Type 2 diabetes | Medical colleges | Analysis | Physiological aspects | Hypoglycemic agents | Dextrose | Membrane proteins | Glucose transporter | Urine | Excretion | Intravenous administration | Renal function | Kidneys | Diabetes mellitus | Reabsorption | Sodium | Physiology | Diabetes | Diabetes mellitus (non-insulin dependent)
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 11, p. e108994
Background and Objective: Sodium glucose cotransporter 2 (SGLT2) is the main luminal glucose transporter in the kidney. SGLT2 inhibition results in glycosuria... 
CELLS | HYPERGLYCEMIA | SGLT2 | TRANSPORTERS | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | DISEASE | INJURY | PPAR-GAMMA AGONISTS | TRANSFORMING GROWTH FACTOR-BETA | PROGRESSION | Benzoates - therapeutic use | Toll-Like Receptor 2 - genetics | Diabetic Nephropathies - etiology | Transforming Growth Factor beta1 - metabolism | Glucose Transporter Type 1 - metabolism | Male | RNA, Messenger - metabolism | Nitric Oxide Synthase Type III - deficiency | Glucosides - therapeutic use | Chemokine CCL2 - metabolism | Diabetes Mellitus, Experimental - chemically induced | Diabetes Mellitus, Experimental - complications | Diabetes Mellitus, Experimental - metabolism | Benzhydryl Compounds - therapeutic use | Diabetic Nephropathies - prevention & control | Benzimidazoles - therapeutic use | Sodium-Glucose Transporter 2 - genetics | Hypoglycemic Agents - therapeutic use | Glucosides - pharmacology | Kidney Tubules, Proximal - pathology | Albuminuria - etiology | Blood Glucose - analysis | Sodium-Glucose Transporter 2 - metabolism | Diabetic Nephropathies - metabolism | Mice, Inbred C57BL | Chemokine CCL2 - genetics | Transforming Growth Factor beta1 - genetics | Toll-Like Receptor 2 - metabolism | Nitric Oxide Synthase Type III - genetics | Fibronectins - metabolism | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Hypoglycemic Agents - pharmacology | Mice, Knockout | Animals | Glucose Transporter Type 1 - genetics | Kidney Tubules, Proximal - metabolism | Benzoates - pharmacology | Benzimidazoles - pharmacology | Benzhydryl Compounds - pharmacology | Fibronectins - genetics | Mice | Streptozocin - toxicity | Blood Glucose - metabolism | Kidney Tubules, Proximal - drug effects | Drugs | Transcription | Syngeneic grafts | Streptozocin | Genomics | Transforming growth factor | Glucose | Macrophages | Blood | Fibronectin | Proteins | Atrophy | Hyperglycemia | Rodents | Toll-like receptors | Physiology | Inhibition | Protein transport | Immune system | Creatinine | Glucose transporter | Medical research | Kidneys | Cytokines | Diabetes mellitus | Reabsorption | Histology | Inflammation | Metabolism | Gene expression | Nephropathy | Sodium | Nitric oxide | Fibrosis | Angiotensin | Insulin resistance | Research design | Kidney diseases | Diabetes | Transporter | Monocyte chemoattractant protein 1 | Kidney transplantation | Best practice
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 01/2013, Volume 304, Issue 2, pp. E117 - E130
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 05/2013, Volume 345, Issue 2, pp. 250 - 259
LX4211 [(2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triol], a dual sodium/glucose cotransporter 1 (SGLT1)... 
GLP-1 | HYPERGLYCEMIA | HEALTHY-SUBJECTS | POSTPRANDIAL GLUCOSE | PHARMACOLOGY & PHARMACY | DEPENDENT INSULINOTROPIC POLYPEPTIDE | IMPROVED GLYCEMIC CONTROL | INHIBITOR |